| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| ALD2 | ALD3 | YMR170C | YMR169C | Cytoplasmic aldehyde dehydrogenase; involved in ethanol oxidation and beta-alanine biosynthesis; uses NAD+ as the preferred coenzyme; expression is stress induced and glucose repressed; very similar to Ald3p. | Cytoplasmic aldehyde dehydrogenase; involved in beta-alanine synthesis; uses NAD+ as the preferred coenzyme; very similar to Ald2p; expression is induced by stress and repressed by glucose. | 0.615 |
| ALD2 | FMS1 | YMR170C | YMR020W | Cytoplasmic aldehyde dehydrogenase; involved in ethanol oxidation and beta-alanine biosynthesis; uses NAD+ as the preferred coenzyme; expression is stress induced and glucose repressed; very similar to Ald3p. | Polyamine oxidase; converts spermine to spermidine, which is required for the essential hypusination modification of translation factor eIF-5A; also involved in pantothenic acid biosynthesis; Belongs to the flavin monoamine oxidase family. | 0.976 |
| ALD2 | PAN5 | YMR170C | YHR063C | Cytoplasmic aldehyde dehydrogenase; involved in ethanol oxidation and beta-alanine biosynthesis; uses NAD+ as the preferred coenzyme; expression is stress induced and glucose repressed; very similar to Ald3p. | 2-dehydropantoate 2-reductase; part of the pantothenic acid pathway, structurally homologous to E. coli panE. | 0.559 |
| ALD2 | PAN6 | YMR170C | YIL145C | Cytoplasmic aldehyde dehydrogenase; involved in ethanol oxidation and beta-alanine biosynthesis; uses NAD+ as the preferred coenzyme; expression is stress induced and glucose repressed; very similar to Ald3p. | Pantoate--beta-alanine ligase; Pantothenate synthase; also known as pantoate-beta-alanine ligase, required for pantothenic acid biosynthesis, deletion causes pantothenic acid auxotrophy, homologous to E. coli panC. | 0.938 |
| ALD3 | ALD2 | YMR169C | YMR170C | Cytoplasmic aldehyde dehydrogenase; involved in beta-alanine synthesis; uses NAD+ as the preferred coenzyme; very similar to Ald2p; expression is induced by stress and repressed by glucose. | Cytoplasmic aldehyde dehydrogenase; involved in ethanol oxidation and beta-alanine biosynthesis; uses NAD+ as the preferred coenzyme; expression is stress induced and glucose repressed; very similar to Ald3p. | 0.615 |
| ALD3 | FMS1 | YMR169C | YMR020W | Cytoplasmic aldehyde dehydrogenase; involved in beta-alanine synthesis; uses NAD+ as the preferred coenzyme; very similar to Ald2p; expression is induced by stress and repressed by glucose. | Polyamine oxidase; converts spermine to spermidine, which is required for the essential hypusination modification of translation factor eIF-5A; also involved in pantothenic acid biosynthesis; Belongs to the flavin monoamine oxidase family. | 0.971 |
| ALD3 | PAN5 | YMR169C | YHR063C | Cytoplasmic aldehyde dehydrogenase; involved in beta-alanine synthesis; uses NAD+ as the preferred coenzyme; very similar to Ald2p; expression is induced by stress and repressed by glucose. | 2-dehydropantoate 2-reductase; part of the pantothenic acid pathway, structurally homologous to E. coli panE. | 0.423 |
| ALD3 | PAN6 | YMR169C | YIL145C | Cytoplasmic aldehyde dehydrogenase; involved in beta-alanine synthesis; uses NAD+ as the preferred coenzyme; very similar to Ald2p; expression is induced by stress and repressed by glucose. | Pantoate--beta-alanine ligase; Pantothenate synthase; also known as pantoate-beta-alanine ligase, required for pantothenic acid biosynthesis, deletion causes pantothenic acid auxotrophy, homologous to E. coli panC. | 0.910 |
| ECM31 | FMS1 | YBR176W | YMR020W | Ketopantoate hydroxymethyltransferase; required for pantothenic acid biosynthesis, converts 2-oxoisovalerate into 2-dehydropantoate. | Polyamine oxidase; converts spermine to spermidine, which is required for the essential hypusination modification of translation factor eIF-5A; also involved in pantothenic acid biosynthesis; Belongs to the flavin monoamine oxidase family. | 0.698 |
| ECM31 | PAN5 | YBR176W | YHR063C | Ketopantoate hydroxymethyltransferase; required for pantothenic acid biosynthesis, converts 2-oxoisovalerate into 2-dehydropantoate. | 2-dehydropantoate 2-reductase; part of the pantothenic acid pathway, structurally homologous to E. coli panE. | 0.984 |
| ECM31 | PAN6 | YBR176W | YIL145C | Ketopantoate hydroxymethyltransferase; required for pantothenic acid biosynthesis, converts 2-oxoisovalerate into 2-dehydropantoate. | Pantoate--beta-alanine ligase; Pantothenate synthase; also known as pantoate-beta-alanine ligase, required for pantothenic acid biosynthesis, deletion causes pantothenic acid auxotrophy, homologous to E. coli panC. | 0.999 |
| FMS1 | ALD2 | YMR020W | YMR170C | Polyamine oxidase; converts spermine to spermidine, which is required for the essential hypusination modification of translation factor eIF-5A; also involved in pantothenic acid biosynthesis; Belongs to the flavin monoamine oxidase family. | Cytoplasmic aldehyde dehydrogenase; involved in ethanol oxidation and beta-alanine biosynthesis; uses NAD+ as the preferred coenzyme; expression is stress induced and glucose repressed; very similar to Ald3p. | 0.976 |
| FMS1 | ALD3 | YMR020W | YMR169C | Polyamine oxidase; converts spermine to spermidine, which is required for the essential hypusination modification of translation factor eIF-5A; also involved in pantothenic acid biosynthesis; Belongs to the flavin monoamine oxidase family. | Cytoplasmic aldehyde dehydrogenase; involved in beta-alanine synthesis; uses NAD+ as the preferred coenzyme; very similar to Ald2p; expression is induced by stress and repressed by glucose. | 0.971 |
| FMS1 | ECM31 | YMR020W | YBR176W | Polyamine oxidase; converts spermine to spermidine, which is required for the essential hypusination modification of translation factor eIF-5A; also involved in pantothenic acid biosynthesis; Belongs to the flavin monoamine oxidase family. | Ketopantoate hydroxymethyltransferase; required for pantothenic acid biosynthesis, converts 2-oxoisovalerate into 2-dehydropantoate. | 0.698 |
| FMS1 | PAN5 | YMR020W | YHR063C | Polyamine oxidase; converts spermine to spermidine, which is required for the essential hypusination modification of translation factor eIF-5A; also involved in pantothenic acid biosynthesis; Belongs to the flavin monoamine oxidase family. | 2-dehydropantoate 2-reductase; part of the pantothenic acid pathway, structurally homologous to E. coli panE. | 0.693 |
| FMS1 | PAN6 | YMR020W | YIL145C | Polyamine oxidase; converts spermine to spermidine, which is required for the essential hypusination modification of translation factor eIF-5A; also involved in pantothenic acid biosynthesis; Belongs to the flavin monoamine oxidase family. | Pantoate--beta-alanine ligase; Pantothenate synthase; also known as pantoate-beta-alanine ligase, required for pantothenic acid biosynthesis, deletion causes pantothenic acid auxotrophy, homologous to E. coli panC. | 0.772 |
| FMS1 | SPE1 | YMR020W | YKL184W | Polyamine oxidase; converts spermine to spermidine, which is required for the essential hypusination modification of translation factor eIF-5A; also involved in pantothenic acid biosynthesis; Belongs to the flavin monoamine oxidase family. | Ornithine decarboxylase; catalyzes the first step in polyamine biosynthesis; degraded in a proteasome-dependent manner in the presence of excess polyamines; deletion decreases lifespan, and increases necrotic cell death and ROS generation; Belongs to the Orn/Lys/Arg decarboxylase class-II family. | 0.978 |
| FMS1 | SPE2 | YMR020W | YOL052C | Polyamine oxidase; converts spermine to spermidine, which is required for the essential hypusination modification of translation factor eIF-5A; also involved in pantothenic acid biosynthesis; Belongs to the flavin monoamine oxidase family. | S-adenosylmethionine decarboxylase; required for the biosynthesis of spermidine and spermine; cells lacking Spe2p require spermine or spermidine for growth in the presence of oxygen but not when grown anaerobically; Belongs to the eukaryotic AdoMetDC family. | 0.585 |
| FMS1 | SPE3 | YMR020W | YPR069C | Polyamine oxidase; converts spermine to spermidine, which is required for the essential hypusination modification of translation factor eIF-5A; also involved in pantothenic acid biosynthesis; Belongs to the flavin monoamine oxidase family. | Spermidine synthase; involved in biosynthesis of spermidine and also in biosynthesis of pantothenic acid; spermidine is required for growth of wild-type cells. | 0.967 |
| FMS1 | SPE4 | YMR020W | YLR146C | Polyamine oxidase; converts spermine to spermidine, which is required for the essential hypusination modification of translation factor eIF-5A; also involved in pantothenic acid biosynthesis; Belongs to the flavin monoamine oxidase family. | Spermine synthase; required for the biosynthesis of spermine and also involved in biosynthesis of pantothenic acid. | 0.928 |