| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| BUR6 | SPT15 | YER159C | YER148W | Subunit of a heterodimeric NC2 transcription regulator complex; complex binds to TBP and can repress transcription by preventing preinitiation complex assembly or stimulate activated transcription; homologous to human NC2alpha; complex also includes Ncb2p; bur6 ncb2 double mutation is functionally complemented by coexpression of human DRAP1 and DR1, although the single bur6 mutation is not complemented by its ortholog DRAP1. | TATA-binding protein (TBP); general transcription factor that interacts with other factors to form the preinitiation complex at promoters; essential for viability, highly conserved; yeast gene can complement mutations in human homolog TBP. | 0.998 |
| BUR6 | SUA7 | YER159C | YPR086W | Subunit of a heterodimeric NC2 transcription regulator complex; complex binds to TBP and can repress transcription by preventing preinitiation complex assembly or stimulate activated transcription; homologous to human NC2alpha; complex also includes Ncb2p; bur6 ncb2 double mutation is functionally complemented by coexpression of human DRAP1 and DR1, although the single bur6 mutation is not complemented by its ortholog DRAP1. | Transcription factor TFIIB; a general transcription factor required for transcription initiation and start site selection by RNA polymerase II. | 0.901 |
| SPT15 | BUR6 | YER148W | YER159C | TATA-binding protein (TBP); general transcription factor that interacts with other factors to form the preinitiation complex at promoters; essential for viability, highly conserved; yeast gene can complement mutations in human homolog TBP. | Subunit of a heterodimeric NC2 transcription regulator complex; complex binds to TBP and can repress transcription by preventing preinitiation complex assembly or stimulate activated transcription; homologous to human NC2alpha; complex also includes Ncb2p; bur6 ncb2 double mutation is functionally complemented by coexpression of human DRAP1 and DR1, although the single bur6 mutation is not complemented by its ortholog DRAP1. | 0.998 |
| SPT15 | SUA7 | YER148W | YPR086W | TATA-binding protein (TBP); general transcription factor that interacts with other factors to form the preinitiation complex at promoters; essential for viability, highly conserved; yeast gene can complement mutations in human homolog TBP. | Transcription factor TFIIB; a general transcription factor required for transcription initiation and start site selection by RNA polymerase II. | 0.999 |
| SPT15 | TAF1 | YER148W | YGR274C | TATA-binding protein (TBP); general transcription factor that interacts with other factors to form the preinitiation complex at promoters; essential for viability, highly conserved; yeast gene can complement mutations in human homolog TBP. | TFIID subunit, involved in RNA pol II transcription initiation; possesses in vitro histone acetyltransferase activity but its role in vivo appears to be minor; involved in promoter binding and G1/S progression; relocalizes to the cytosol in response to hypoxia. | 0.999 |
| SPT15 | TAF14 | YER148W | YPL129W | TATA-binding protein (TBP); general transcription factor that interacts with other factors to form the preinitiation complex at promoters; essential for viability, highly conserved; yeast gene can complement mutations in human homolog TBP. | Transcription initiation factor TFIID subunit 14; Subunit of TFIID, TFIIF, INO80, SWI/SNF, and NuA3 complexes; involved in RNA polymerase II transcription initiation and in chromatin modification; contains a YEATS domain; Belongs to the TAF14 family. | 0.999 |
| SPT15 | TAF6 | YER148W | YGL112C | TATA-binding protein (TBP); general transcription factor that interacts with other factors to form the preinitiation complex at promoters; essential for viability, highly conserved; yeast gene can complement mutations in human homolog TBP. | Subunit (60 kDa) of TFIID and SAGA complexes; involved in transcription initiation of RNA polymerase II and in chromatin modification, similar to histone H4; relocalizes to the cytosol in response to hypoxia. | 0.999 |
| SPT15 | TFG1 | YER148W | YGR186W | TATA-binding protein (TBP); general transcription factor that interacts with other factors to form the preinitiation complex at promoters; essential for viability, highly conserved; yeast gene can complement mutations in human homolog TBP. | TFIIF (Transcription Factor II) largest subunit; involved in both transcription initiation and elongation of RNA polymerase II; homologous to human RAP74. | 0.998 |
| SPT15 | TOA2 | YER148W | YKL058W | TATA-binding protein (TBP); general transcription factor that interacts with other factors to form the preinitiation complex at promoters; essential for viability, highly conserved; yeast gene can complement mutations in human homolog TBP. | TFIIA small subunit; involved in transcriptional activation, acts as antirepressor or as coactivator; required, along with Toa1p, for ribosomal protein gene transcription in vivo; homologous to smallest subunit of human and Drosophila TFIIA; protein abundance increases in response to DNA replication stress. | 0.999 |
| SUA7 | BUR6 | YPR086W | YER159C | Transcription factor TFIIB; a general transcription factor required for transcription initiation and start site selection by RNA polymerase II. | Subunit of a heterodimeric NC2 transcription regulator complex; complex binds to TBP and can repress transcription by preventing preinitiation complex assembly or stimulate activated transcription; homologous to human NC2alpha; complex also includes Ncb2p; bur6 ncb2 double mutation is functionally complemented by coexpression of human DRAP1 and DR1, although the single bur6 mutation is not complemented by its ortholog DRAP1. | 0.901 |
| SUA7 | SPT15 | YPR086W | YER148W | Transcription factor TFIIB; a general transcription factor required for transcription initiation and start site selection by RNA polymerase II. | TATA-binding protein (TBP); general transcription factor that interacts with other factors to form the preinitiation complex at promoters; essential for viability, highly conserved; yeast gene can complement mutations in human homolog TBP. | 0.999 |
| SUA7 | TAF1 | YPR086W | YGR274C | Transcription factor TFIIB; a general transcription factor required for transcription initiation and start site selection by RNA polymerase II. | TFIID subunit, involved in RNA pol II transcription initiation; possesses in vitro histone acetyltransferase activity but its role in vivo appears to be minor; involved in promoter binding and G1/S progression; relocalizes to the cytosol in response to hypoxia. | 0.980 |
| SUA7 | TAF14 | YPR086W | YPL129W | Transcription factor TFIIB; a general transcription factor required for transcription initiation and start site selection by RNA polymerase II. | Transcription initiation factor TFIID subunit 14; Subunit of TFIID, TFIIF, INO80, SWI/SNF, and NuA3 complexes; involved in RNA polymerase II transcription initiation and in chromatin modification; contains a YEATS domain; Belongs to the TAF14 family. | 0.950 |
| SUA7 | TAF6 | YPR086W | YGL112C | Transcription factor TFIIB; a general transcription factor required for transcription initiation and start site selection by RNA polymerase II. | Subunit (60 kDa) of TFIID and SAGA complexes; involved in transcription initiation of RNA polymerase II and in chromatin modification, similar to histone H4; relocalizes to the cytosol in response to hypoxia. | 0.948 |
| SUA7 | TFG1 | YPR086W | YGR186W | Transcription factor TFIIB; a general transcription factor required for transcription initiation and start site selection by RNA polymerase II. | TFIIF (Transcription Factor II) largest subunit; involved in both transcription initiation and elongation of RNA polymerase II; homologous to human RAP74. | 0.999 |
| SUA7 | TOA2 | YPR086W | YKL058W | Transcription factor TFIIB; a general transcription factor required for transcription initiation and start site selection by RNA polymerase II. | TFIIA small subunit; involved in transcriptional activation, acts as antirepressor or as coactivator; required, along with Toa1p, for ribosomal protein gene transcription in vivo; homologous to smallest subunit of human and Drosophila TFIIA; protein abundance increases in response to DNA replication stress. | 0.998 |
| TAF1 | SPT15 | YGR274C | YER148W | TFIID subunit, involved in RNA pol II transcription initiation; possesses in vitro histone acetyltransferase activity but its role in vivo appears to be minor; involved in promoter binding and G1/S progression; relocalizes to the cytosol in response to hypoxia. | TATA-binding protein (TBP); general transcription factor that interacts with other factors to form the preinitiation complex at promoters; essential for viability, highly conserved; yeast gene can complement mutations in human homolog TBP. | 0.999 |
| TAF1 | SUA7 | YGR274C | YPR086W | TFIID subunit, involved in RNA pol II transcription initiation; possesses in vitro histone acetyltransferase activity but its role in vivo appears to be minor; involved in promoter binding and G1/S progression; relocalizes to the cytosol in response to hypoxia. | Transcription factor TFIIB; a general transcription factor required for transcription initiation and start site selection by RNA polymerase II. | 0.980 |
| TAF1 | TAF14 | YGR274C | YPL129W | TFIID subunit, involved in RNA pol II transcription initiation; possesses in vitro histone acetyltransferase activity but its role in vivo appears to be minor; involved in promoter binding and G1/S progression; relocalizes to the cytosol in response to hypoxia. | Transcription initiation factor TFIID subunit 14; Subunit of TFIID, TFIIF, INO80, SWI/SNF, and NuA3 complexes; involved in RNA polymerase II transcription initiation and in chromatin modification; contains a YEATS domain; Belongs to the TAF14 family. | 0.999 |
| TAF1 | TAF6 | YGR274C | YGL112C | TFIID subunit, involved in RNA pol II transcription initiation; possesses in vitro histone acetyltransferase activity but its role in vivo appears to be minor; involved in promoter binding and G1/S progression; relocalizes to the cytosol in response to hypoxia. | Subunit (60 kDa) of TFIID and SAGA complexes; involved in transcription initiation of RNA polymerase II and in chromatin modification, similar to histone H4; relocalizes to the cytosol in response to hypoxia. | 0.999 |