(7 nodes) Proteasome core complex, alpha-subunit complex network (Saccharomyces cerevisiae)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

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proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

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Predicted Interactions

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Your Input:
	PRE6	Alpha 4 subunit of the 20S proteasome; may replace alpha 3 subunit (Pre9p) under stress conditions to create a more active proteasomal isoform; GFP-fusion protein relocates from cytosol to the mitochondrial surface upon oxidative stress; Belongs to the peptidase T1A family. (254 aa)
	SCL1	Alpha 1 subunit of the 20S proteasome; involved in the degradation of ubiquitinated substrates; 20S proteasome is the core complex of the 26S proteasome; essential for growth; detected in the mitochondria; Belongs to the peptidase T1A family. (252 aa)
	PRE9	Alpha 3 subunit of the 20S proteasome; the only nonessential 20S subunit; may be replaced by the alpha 4 subunit (Pre6p) under stress conditions to create a more active proteasomal isoform; Belongs to the peptidase T1A family. (258 aa)
	PUP2	Alpha 5 subunit of the 20S proteasome; involved in ubiquitin-dependent catabolism; human homolog is subunit zeta; Belongs to the peptidase T1A family. (260 aa)
	PRE8	Alpha 2 subunit of the 20S proteasome; Belongs to the peptidase T1A family. (250 aa)
	PRE5	Alpha 6 subunit of the 20S proteasome; protein abundance increases in response to DNA replication stress; Belongs to the peptidase T1A family. (234 aa)
	PRE10	Alpha 7 subunit of the 20S proteasome; protein abundance increases in response to DNA replication stress. (288 aa)

Your Current Organism:

Saccharomyces cerevisiae

NCBI taxonomy Id: 4932
Other names: ATCC 18824, Candida robusta, Mycoderma cerevisiae, NRRL Y-12632, S. cerevisiae, Saccharomyces capensis, Saccharomyces italicus, Saccharomyces oviformis, Saccharomyces uvarum var. melibiosus, yeast

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
PRE10	PRE5	YOR362C	YMR314W	Alpha 7 subunit of the 20S proteasome; protein abundance increases in response to DNA replication stress.	Alpha 6 subunit of the 20S proteasome; protein abundance increases in response to DNA replication stress; Belongs to the peptidase T1A family.	0.999
PRE10	PRE6	YOR362C	YOL038W	Alpha 7 subunit of the 20S proteasome; protein abundance increases in response to DNA replication stress.	Alpha 4 subunit of the 20S proteasome; may replace alpha 3 subunit (Pre9p) under stress conditions to create a more active proteasomal isoform; GFP-fusion protein relocates from cytosol to the mitochondrial surface upon oxidative stress; Belongs to the peptidase T1A family.	0.999
PRE10	PRE8	YOR362C	YML092C	Alpha 7 subunit of the 20S proteasome; protein abundance increases in response to DNA replication stress.	Alpha 2 subunit of the 20S proteasome; Belongs to the peptidase T1A family.	0.999
PRE10	PRE9	YOR362C	YGR135W	Alpha 7 subunit of the 20S proteasome; protein abundance increases in response to DNA replication stress.	Alpha 3 subunit of the 20S proteasome; the only nonessential 20S subunit; may be replaced by the alpha 4 subunit (Pre6p) under stress conditions to create a more active proteasomal isoform; Belongs to the peptidase T1A family.	0.999
PRE10	PUP2	YOR362C	YGR253C	Alpha 7 subunit of the 20S proteasome; protein abundance increases in response to DNA replication stress.	Alpha 5 subunit of the 20S proteasome; involved in ubiquitin-dependent catabolism; human homolog is subunit zeta; Belongs to the peptidase T1A family.	0.999
PRE10	SCL1	YOR362C	YGL011C	Alpha 7 subunit of the 20S proteasome; protein abundance increases in response to DNA replication stress.	Alpha 1 subunit of the 20S proteasome; involved in the degradation of ubiquitinated substrates; 20S proteasome is the core complex of the 26S proteasome; essential for growth; detected in the mitochondria; Belongs to the peptidase T1A family.	0.999
PRE5	PRE10	YMR314W	YOR362C	Alpha 6 subunit of the 20S proteasome; protein abundance increases in response to DNA replication stress; Belongs to the peptidase T1A family.	Alpha 7 subunit of the 20S proteasome; protein abundance increases in response to DNA replication stress.	0.999
PRE5	PRE6	YMR314W	YOL038W	Alpha 6 subunit of the 20S proteasome; protein abundance increases in response to DNA replication stress; Belongs to the peptidase T1A family.	Alpha 4 subunit of the 20S proteasome; may replace alpha 3 subunit (Pre9p) under stress conditions to create a more active proteasomal isoform; GFP-fusion protein relocates from cytosol to the mitochondrial surface upon oxidative stress; Belongs to the peptidase T1A family.	0.999
PRE5	PRE8	YMR314W	YML092C	Alpha 6 subunit of the 20S proteasome; protein abundance increases in response to DNA replication stress; Belongs to the peptidase T1A family.	Alpha 2 subunit of the 20S proteasome; Belongs to the peptidase T1A family.	0.999
PRE5	PRE9	YMR314W	YGR135W	Alpha 6 subunit of the 20S proteasome; protein abundance increases in response to DNA replication stress; Belongs to the peptidase T1A family.	Alpha 3 subunit of the 20S proteasome; the only nonessential 20S subunit; may be replaced by the alpha 4 subunit (Pre6p) under stress conditions to create a more active proteasomal isoform; Belongs to the peptidase T1A family.	0.999
PRE5	PUP2	YMR314W	YGR253C	Alpha 6 subunit of the 20S proteasome; protein abundance increases in response to DNA replication stress; Belongs to the peptidase T1A family.	Alpha 5 subunit of the 20S proteasome; involved in ubiquitin-dependent catabolism; human homolog is subunit zeta; Belongs to the peptidase T1A family.	0.999
PRE5	SCL1	YMR314W	YGL011C	Alpha 6 subunit of the 20S proteasome; protein abundance increases in response to DNA replication stress; Belongs to the peptidase T1A family.	Alpha 1 subunit of the 20S proteasome; involved in the degradation of ubiquitinated substrates; 20S proteasome is the core complex of the 26S proteasome; essential for growth; detected in the mitochondria; Belongs to the peptidase T1A family.	0.999
PRE6	PRE10	YOL038W	YOR362C	Alpha 4 subunit of the 20S proteasome; may replace alpha 3 subunit (Pre9p) under stress conditions to create a more active proteasomal isoform; GFP-fusion protein relocates from cytosol to the mitochondrial surface upon oxidative stress; Belongs to the peptidase T1A family.	Alpha 7 subunit of the 20S proteasome; protein abundance increases in response to DNA replication stress.	0.999
PRE6	PRE5	YOL038W	YMR314W	Alpha 4 subunit of the 20S proteasome; may replace alpha 3 subunit (Pre9p) under stress conditions to create a more active proteasomal isoform; GFP-fusion protein relocates from cytosol to the mitochondrial surface upon oxidative stress; Belongs to the peptidase T1A family.	Alpha 6 subunit of the 20S proteasome; protein abundance increases in response to DNA replication stress; Belongs to the peptidase T1A family.	0.999
PRE6	PRE8	YOL038W	YML092C	Alpha 4 subunit of the 20S proteasome; may replace alpha 3 subunit (Pre9p) under stress conditions to create a more active proteasomal isoform; GFP-fusion protein relocates from cytosol to the mitochondrial surface upon oxidative stress; Belongs to the peptidase T1A family.	Alpha 2 subunit of the 20S proteasome; Belongs to the peptidase T1A family.	0.999
PRE6	PRE9	YOL038W	YGR135W	Alpha 4 subunit of the 20S proteasome; may replace alpha 3 subunit (Pre9p) under stress conditions to create a more active proteasomal isoform; GFP-fusion protein relocates from cytosol to the mitochondrial surface upon oxidative stress; Belongs to the peptidase T1A family.	Alpha 3 subunit of the 20S proteasome; the only nonessential 20S subunit; may be replaced by the alpha 4 subunit (Pre6p) under stress conditions to create a more active proteasomal isoform; Belongs to the peptidase T1A family.	0.999
PRE6	PUP2	YOL038W	YGR253C	Alpha 4 subunit of the 20S proteasome; may replace alpha 3 subunit (Pre9p) under stress conditions to create a more active proteasomal isoform; GFP-fusion protein relocates from cytosol to the mitochondrial surface upon oxidative stress; Belongs to the peptidase T1A family.	Alpha 5 subunit of the 20S proteasome; involved in ubiquitin-dependent catabolism; human homolog is subunit zeta; Belongs to the peptidase T1A family.	0.999
PRE6	SCL1	YOL038W	YGL011C	Alpha 4 subunit of the 20S proteasome; may replace alpha 3 subunit (Pre9p) under stress conditions to create a more active proteasomal isoform; GFP-fusion protein relocates from cytosol to the mitochondrial surface upon oxidative stress; Belongs to the peptidase T1A family.	Alpha 1 subunit of the 20S proteasome; involved in the degradation of ubiquitinated substrates; 20S proteasome is the core complex of the 26S proteasome; essential for growth; detected in the mitochondria; Belongs to the peptidase T1A family.	0.999
PRE8	PRE10	YML092C	YOR362C	Alpha 2 subunit of the 20S proteasome; Belongs to the peptidase T1A family.	Alpha 7 subunit of the 20S proteasome; protein abundance increases in response to DNA replication stress.	0.999
PRE8	PRE5	YML092C	YMR314W	Alpha 2 subunit of the 20S proteasome; Belongs to the peptidase T1A family.	Alpha 6 subunit of the 20S proteasome; protein abundance increases in response to DNA replication stress; Belongs to the peptidase T1A family.	0.999

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