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LUC7 LUC7 SNU23 SNU23 PRP42 PRP42 SNU56 SNU56 PRP28 PRP28 LSM6 LSM6 PRP3 PRP3 LSM2 LSM2 YSF3 YSF3 LSM7 LSM7 CUS2 CUS2 TRM13 TRM13 SME1 SME1 PRP31 PRP31 PRP38 PRP38 SMD1 SMD1 SNU71 SNU71 PRP18 PRP18 SAD1 SAD1 SMX2 SMX2 BRR2 BRR2 SMX3 SMX3 PRP4 PRP4 URN1 URN1 SNU66 SNU66 RDS3 RDS3 DIB1 DIB1 LEA1 LEA1 HSH49 HSH49 IST3 IST3 SNP1 SNP1 PRP8 PRP8 LIN1 LIN1 NAM8 NAM8 MUD1 MUD1 SPP381 SPP381 BUD31 BUD31 PRP11 PRP11 SNU13 SNU13 SMB1 SMB1 LSM4 LSM4 LSM5 LSM5 HSH155 HSH155 AAR2 AAR2 PRP6 PRP6 PRP21 PRP21 LSM8 LSM8 PRP40 PRP40 SNU114 SNU114 SMD3 SMD3 SMD2 SMD2 YHC1 YHC1 LSM3 LSM3 PRP39 PRP39 RSE1 RSE1 CUS1 CUS1 PRP24 PRP24
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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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query proteins and first shell of interactors
white nodes:
second shell of interactors
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proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
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textmining
co-expression
protein homology
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LUC7Essential protein associated with the U1 snRNP complex; splicing factor involved in recognition of 5' splice site; contains two zinc finger motifs; N-terminal zinc finger binds pre-mRNA; relocalizes to the cytosol in response to hypoxia; Belongs to the Luc7 family. (261 aa)
SNU2323 kDa U4/U6.U5 small nuclear ribonucleoprotein component; Component of the U4/U6.U5 snRNP complex; involved in mRNA splicing via spliceosome. (194 aa)
PRP42U1 small nuclear ribonucleoprotein component PRP42; U1 snRNP protein involved in splicing; required for U1 snRNP biogenesis; contains multiple tetriatricopeptide repeats. (544 aa)
SNU5656 kDa U1 small nuclear ribonucleoprotein component; Component of U1 snRNP required for mRNA splicing via spliceosome; yeast specific, no metazoan counterpart; interacts with mRNA in commitment complex. (492 aa)
PRP28Pre-mRNA-splicing ATP-dependent RNA helicase PRP28; RNA binding protein; involved in RNA isomerization at the 5' splice site and for exchange of U6 for U1 snRNA at the 5' splice site; similar to the RNA helicases of the DEAD-box family. (588 aa)
LSM6U6 snRNA-associated Sm-like protein LSm6; Lsm (Like Sm) protein; part of heteroheptameric complexes (Lsm2p-7p and either Lsm1p or 8p): cytoplasmic Lsm1p complex involved in mRNA decay; nuclear Lsm8p complex part of U6 snRNP and possibly involved in processing tRNA, snoRNA, and rRNA; Belongs to the snRNP Sm proteins family. SmF/LSm6 subfamily. (86 aa)
PRP3U4/U6 small nuclear ribonucleoprotein PRP3; Splicing factor; component of the U4/U6-U5 snRNP complex. (469 aa)
LSM2U6 snRNA-associated Sm-like protein LSm2; Lsm (Like Sm) protein; part of heteroheptameric complexes (Lsm2p-7p and either Lsm1p or 8p): cytoplasmic Lsm1p complex involved in mRNA decay; nuclear Lsm8p complex part of U6 snRNP and possibly involved in processing tRNA, snoRNA, and rRNA; relocalizes from nucleus to cytoplasmic foci upon DNA replication stress. (95 aa)
YSF3RDS3 complex subunit 10; Component of the SF3b subcomplex of the U2 snRNP; essential protein required for splicing and for assembly of SF3b. (85 aa)
LSM7U6 snRNA-associated Sm-like protein LSm7; Lsm (Like Sm) protein; part of heteroheptameric complexes (Lsm2p-7p and either Lsm1p or 8p): cytoplasmic Lsm1p complex involved in mRNA decay; nuclear Lsm8p complex part of U6 snRNP and possibly involved in processing tRNA, snoRNA, and rRNA; protein abundance increases and forms cytoplasmic foci in response to DNA replication stress. (115 aa)
CUS2Putative checkpoint factor in transcription; binds to U2 snRNA and Prp11p; regulates toggling of the U2 snRNA stem II region between different structures; contains two RNA recognition motifs (RRMs). (285 aa)
TRM13tRNA:m(4)X modification enzyme TRM13; 2'-O-methyltransferase; responsible for modification of tRNA at position 4; C-terminal domain has similarity to Rossmann-fold (RFM) superfamily of RNA methyltransferases; Belongs to the methyltransferase TRM13 family. (476 aa)
SME1Small nuclear ribonucleoprotein E; Core Sm protein Sm E; part of heteroheptameric complex (with Smb1p, Smd1p, Smd2p, Smd3p, Smx3p, and Smx2p) that is part of the spliceosomal U1, U2, U4, and U5 snRNPs; homolog of human Sm E. (94 aa)
PRP31Pre-mRNA-processing factor 31; Splicing factor; component of the U4/U6-U5 snRNP complex; Belongs to the PRP31 family. (494 aa)
PRP38Pre-mRNA-splicing factor 38; Unique component of the U4/U6.U5 tri-snRNP particle; tri-snRNP is required for conformational changes which result in the catalytic activation of the spliceosome; dispensable for spliceosome assembly; Belongs to the PRP38 family. (242 aa)
SMD1Small nuclear ribonucleoprotein Sm D1; Core Sm protein Sm D1; part of heteroheptameric complex (with Smb1p, Smd2p, Smd3p, Sme1p, Smx3p, and Smx2p) that is part of the spliceosomal U1, U2, U4, and U5 snRNPs; relocalizes to the cytosol in response to hypoxia; homolog of human Sm D1; protein abundance increases in response to DNA replication stress. (146 aa)
SNU71U1 small nuclear ribonucleoprotein component SNU71; Component of U1 snRNP required for mRNA splicing via spliceosome; yeast specific, no metazoan counterpart; Belongs to the SNU71 family. (620 aa)
PRP18Pre-mRNA-splicing factor 18; Splicing factor and component of snRNP U5; factor involved in the positioning of the 3' splice site during the second catalytic step of splicing; interacts with Slu7p. (251 aa)
SAD1Pre-mRNA-splicing factor SAD1; Conserved zinc-finger domain protein involved in pre-mRNA splicing; critical for splicing of nearly all intron-containing genes; required for assembly of U4 snRNA into the U4/U6 particle. (448 aa)
SMX2Small nuclear ribonucleoprotein G; Core Sm protein Sm G; part of heteroheptameric complex (with Smb1p, Smd1p, Smd2p, Smd3p, Sme1p, and Smx3p) that is part of the spliceosomal U1, U2, U4, and U5 snRNPs; homolog of human Sm G. (77 aa)
BRR2Pre-mRNA-splicing helicase BRR2; RNA-dependent ATPase RNA helicase (DEIH box); required for disruption of U4/U6 base-pairing in native snRNPs to activate the spliceosome for catalysis; homologous to human U5-200kD. (2163 aa)
SMX3Small nuclear ribonucleoprotein F; Core Sm protein Sm F; part of heteroheptameric complex (with Smb1p, Smd1p, Smd2p, Smd3p, Sme1p, and Smx2p) that is part of the spliceosomal U1, U2, U4, and U5 snRNPs; homolog of human Sm F. (86 aa)
PRP4U4/U6 small nuclear ribonucleoprotein PRP4; Splicing factor; component of the U4/U6-U5 snRNP complex. (465 aa)
URN1Pre-mRNA-splicing factor URN1; Protein of unknown function containing WW and FF domains; overexpression causes accumulation of cells in G1 phase. (465 aa)
SNU6666 kDa U4/U6.U5 small nuclear ribonucleoprotein component; Component of the U4/U6.U5 snRNP complex; involved in pre-mRNA splicing via spliceosome; also required for pre-5S rRNA processing and may act in concert with Rnh70p; has homology to human SART-1. (587 aa)
RDS3Pre-mRNA-splicing factor RDS3; Component of the SF3b subcomplex of the U2 snRNP; zinc cluster protein involved in pre-mRNA splicing and cycloheximide resistance. (107 aa)
DIB1Spliceosomal protein DIB1; 17-kDa component of the U4/U6aU5 tri-snRNP; plays an essential role in pre-mRNA splicing; human ortholog TXNL4A (the human U5-specific 15-kDa protein) complements yeast dib1 null mutant; Belongs to the DIM1 family. (143 aa)
LEA1U2 small nuclear ribonucleoprotein A; Component of U2 snRNP complex; disruption causes reduced U2 snRNP levels; physically interacts with Msl1p; putative homolog of human U2A' snRNP protein; Belongs to the U2 small nuclear ribonucleoprotein A family. (238 aa)
HSH49Protein HSH49; U2-snRNP associated splicing factor; similar to the mammalian splicing factor SAP49; proposed to function as a U2-snRNP assembly factor along with Hsh155p and binding partner Cus1p; contains two RNA recognition motifs (RRM). (213 aa)
IST3Component of the U2 snRNP; required for the first catalytic step of splicing and for spliceosomal assembly; interacts with Rds3p and is required for Mer1p-activated splicing; diploid mutants have a specific defect in MATa1 pre-mRNA splicing which leads to haploid gene expression in diploids; Belongs to the IST3 family. (148 aa)
SNP1U1 small nuclear ribonucleoprotein 70 kDa homolog; Component of U1 snRNP required for mRNA splicing via spliceosome; substrate of the arginine methyltransferase Hmt1p; may interact with poly(A) polymerase to regulate polyadenylation; homolog of human U1 70K protein; protein abundance increases in response to DNA replication stress. (300 aa)
PRP8Pre-mRNA-splicing factor 8; Component of U4/U6-U5 snRNP complex; involved in second catalytic step of splicing; participates in spliceosomal assembly through its interaction with U1 snRNA; largest and most evolutionarily conserved protein of the spliceosome; mutations in human ortholog, PRPF8, cause Retinitis pigmentosa and missplicing in Myelodysplastic syndrome; mouse ortholog interacts with androgen receptor and may have a role in prostate cancer. (2413 aa)
LIN1Protein LIN1; Non-essential component of U5 snRNP; nuclear protein; physically interacts with Irr1p of cohesin complex; may link together proteins involved in chromosome segregation, mRNA splicing and DNA replication. (340 aa)
NAM8RNA binding protein, component of the U1 snRNP protein; mutants are defective in meiotic recombination and in formation of viable spores, involved in the formation of DSBs through meiosis-specific splicing of REC107 pre-mRNA; Nam8p regulon embraces the meiotic pre-mRNAs of REC107, HFM1, AMA1 SPO22 and PCH2; the putative RNA binding domains RRM2 and RRM3 are required for Nam8p meiotic function. (523 aa)
MUD1U1 snRNP A protein; homolog of human U1-A; involved in nuclear mRNA splicing; Belongs to the RRM U1 A/B'' family. (298 aa)
SPP381Pre-mRNA-splicing factor SPP381; mRNA splicing factor, component of U4/U6.U5 tri-snRNP; interacts genetically and physically with Prp38p; relocalizes to the cytosol in response to hypoxia; Belongs to the SPP381 family. (291 aa)
BUD31Pre-mRNA-splicing factor BUD31; Component of the SF3b subcomplex of the U2 snRNP; increases efficiency of first and second step pre-mRNA splicing; diploid mutants display a random budding pattern instead of the wild-type bipolar pattern; facilitates passage through G1/S Start, but is not required for G2/M transition or exit from mitosis. (157 aa)
PRP11Pre-mRNA-splicing factor PRP11; Subunit of the SF3a splicing factor complex; required for spliceosome assembly. (266 aa)
SNU1313 kDa ribonucleoprotein-associated protein; RNA binding protein; part of U3 snoRNP involved in rRNA processing, part of U4/U6-U5 tri-snRNP involved in mRNA splicing, similar to human 15.5K protein; Belongs to the eukaryotic ribosomal protein eL8 family. (126 aa)
SMB1Small nuclear ribonucleoprotein-associated protein B; Core Sm protein Sm B; part of heteroheptameric complex (with Smd1p, Smd2p, Smd3p, Sme1p, Smx3p, and Smx2p) that is part of the spliceosomal U1, U2, U4, and U5 snRNPs; homolog of human Sm B and Sm B'; Belongs to the snRNP SmB/SmN family. (196 aa)
LSM4U6 snRNA-associated Sm-like protein LSm4; Lsm (Like Sm) protein; part of heteroheptameric complexes (Lsm2p-7p and either Lsm1p or 8p): cytoplasmic Lsm1p complex involved in mRNA decay; nuclear Lsm8p complex part of U6 snRNP and possibly involved in processing tRNA, snoRNA, and rRNA; forms cytoplasmic foci upon DNA replication stress. (187 aa)
LSM5U6 snRNA-associated Sm-like protein LSm5; Lsm (Like Sm) protein; part of heteroheptameric complexes (Lsm2p-7p and either Lsm1p or 8p): cytoplasmic Lsm1p complex involved in mRNA decay; nuclear Lsm8p complex part of U6 snRNP and possibly involved in processing tRNA, snoRNA, and rRNA. (93 aa)
HSH155U2-snRNP associated splicing factor; forms extensive associations with the branch site-3' splice site-3' exon region upon prespliceosome formation; similarity to the mammalian U2 snRNP-associated splicing factor SAP155. (971 aa)
AAR2A1 cistron-splicing factor AAR2; Component of the U5 snRNP complex; required for splicing of U3 precursors; originally described as a splicing factor specifically required for splicing pre-mRNA of the MATa1 cistron; Belongs to the AAR2 family. (355 aa)
PRP6Splicing factor; component of the U4/U6-U5 snRNP complex. (899 aa)
PRP21Pre-mRNA-splicing factor PRP21; Subunit of the SF3a splicing factor complex; required for spliceosome assembly. (280 aa)
LSM8U6 snRNA-associated Sm-like protein LSm8; Lsm (Like Sm) protein; forms heteroheptameric complex (with Lsm2p, Lsm3p, Lsm4p, Lsm5p, Lsm6p, and Lsm7p) that is part of spliceosomal U6 snRNP and is also implicated in processing of pre-tRNA, pre-snoRNA, and pre-rRNA. (109 aa)
PRP40Pre-mRNA-processing protein PRP40; U1 snRNP protein involved in splicing; interacts with the branchpoint-binding protein during the formation of the second commitment complex. (583 aa)
SNU114Pre-mRNA-splicing factor SNU114; GTPase component of U5 snRNP involved in mRNA splicing via spliceosome; binds directly to U5 snRNA; proposed to be involved in conformational changes of the spliceosome; similarity to ribosomal translocation factor EF-2. (1008 aa)
SMD3Small nuclear ribonucleoprotein Sm D3; Core Sm protein Sm D3; part of heteroheptameric complex (with Smb1p, Smd1p, Smd2p, Sme1p, Smx3p, and Smx2p) that is part of the spliceosomal U1, U2, U4, and U5 snRNPs; homolog of human Sm D3. (101 aa)
SMD2Small nuclear ribonucleoprotein Sm D2; Core Sm protein Sm D2; part of heteroheptameric complex (with Smb1p, Smd1p, Smd3p, Sme1p, Smx3p, and Smx2p) that is part of the spliceosomal U1, U2, U4, and U5 snRNPs; homolog of human Sm D2. (110 aa)
YHC1U1 small nuclear ribonucleoprotein C; Component of the U1 snRNP complex required for pre-mRNA splicing; putative ortholog of human U1C protein, which is involved in formation of a complex between U1 snRNP and the pre-mRNA 5' splice site; Belongs to the U1 small nuclear ribonucleoprotein C family. (231 aa)
LSM3U6 snRNA-associated Sm-like protein LSm3; Lsm (Like Sm) protein; part of heteroheptameric complexes (Lsm2p-7p and either Lsm1p or 8p): cytoplasmic Lsm1p complex involved in mRNA decay; nuclear Lsm8p complex part of U6 snRNP and possibly involved in processing tRNA, snoRNA, and rRNA; protein increases in abundance and relocalizes from nucleus to cytoplasmic foci upon DNA replication stress. (89 aa)
PRP39Pre-mRNA-processing factor 39; U1 snRNP protein involved in splicing; contains multiple tetriatricopeptide repeats. (629 aa)
RSE1Pre-mRNA-splicing factor RSE1; Protein involved in pre-mRNA splicing; component of the pre-spliceosome; associates with U2 snRNA; involved in ER to Golgi transport; Belongs to the RSE1 family. (1361 aa)
CUS1Cold sensitive U2 snRNA suppressor 1; Protein required for assembly of U2 snRNP into the spliceosome; forms a complex with Hsh49p and Hsh155p. (436 aa)
PRP24U4/U6 snRNA-associated-splicing factor PRP24; Splicing factor that reanneals snRNPs during spliceosome recycling; reanneals U4 and U6 snRNPs. (444 aa)
Your Current Organism:
Saccharomyces cerevisiae
NCBI taxonomy Id: 4932
Other names: ATCC 18824, Candida robusta, Mycoderma cerevisiae, NRRL Y-12632, S. cerevisiae, Saccharomyces capensis, Saccharomyces italicus, Saccharomyces oviformis, Saccharomyces uvarum var. melibiosus, yeast
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