STRINGSTRING
IMA3 IMA3 SCW4 SCW4 BGL2 BGL2 IMA1 IMA1 MAL12 MAL12 EGH1 EGH1 IMA5 IMA5 CTS1 CTS1 EXG1 EXG1 GAS2 GAS2 GAS3 GAS3 SCW10 SCW10 GAS1 GAS1 GAS5 GAS5 GAS4 GAS4 IMA2 IMA2 SPR1 SPR1 GDB1 GDB1 MAL32 MAL32 ROT2 ROT2 YBR056W YBR056W EXG2 EXG2 CTS2 CTS2 GLC3 GLC3 SCW11 SCW11
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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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query proteins and first shell of interactors
white nodes:
second shell of interactors
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proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
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Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
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textmining
co-expression
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IMA3Oligo-1,6-glucosidase IMA3; Alpha-glucosidase; weak, but broad substrate specificity for alpha-1,4- and alpha-1,6-glucosides; member of IMA isomaltase family; not required for isomaltose utilization, but Ima3p overexpression allows the ima1 null mutant to grow on isomaltose; lower activitiy and thermostability in vitro than Ima2p despite sequence difference of only 3 amino acids; cleaves alpha-1,3 linkage of nigerose and turanose, but not alpha-1,5 of leucrose; identical to IMA4; Belongs to the glycosyl hydrolase 13 family. (589 aa)
SCW4Probable family 17 glucosidase SCW4; Cell wall protein with similarity to glucanases; scw4 scw10 double mutants exhibit defects in mating; SCW4 has a paralog, SCW10, that arose from the whole genome duplication; Belongs to the glycosyl hydrolase 17 family. (386 aa)
BGL2Endo-beta-1,3-glucanase; major protein of the cell wall, involved in cell wall maintenance; involved in incorporation of newly synthesized mannoprotein molecules into the cell wall. (313 aa)
IMA1Oligo-1,6-glucosidase IMA1; Major isomaltase (alpha-1,6-glucosidase/alpha-methylglucosidase); required for isomaltose utilization; preferred specificity for isomaltose, alpha-methylglucoside, and palatinose, but also exhibits alpha-1,2 glucosidase activity on sucrose and kojibiose, and can cleave the 1,3-alpha linkage of nigerose and turanose and the alpha-1,5 linkage of leucrose in vitro; member of the IMA isomaltase family; Belongs to the glycosyl hydrolase 13 family. (589 aa)
MAL12Alpha-glucosidase MAL12; Maltase (alpha-D-glucosidase); inducible protein involved in maltose catabolism; encoded in the MAL1 complex locus; hydrolyzes the disaccharides maltose, turanose, maltotriose, and sucrose; Belongs to the glycosyl hydrolase 13 family. (584 aa)
EGH1Ergosteryl-beta-glucosidase; Steryl-beta-glucosidase with broad specificity for aglycones; has a role in ergosteryl-beta-glucoside catabolism; required for normal vacuolar morphology; has similarity to the C. neoformans ergosteryl-beta-glucosidase EGCrP2; localizes to the cytosol. (764 aa)
IMA5Oligo-1,6-glucosidase IMA5; Alpha-glucosidase; specificity for isomaltose, maltose, and palatinose, but not alpha-methylglucoside; most distant member of the IMA isomaltase family, but with similar catalytic properties as Ima1p and Ima2p; not required for isomaltose utilization, but Ima5p overexpression allows the ima1 null mutant to grow on isomaltose; can cleave alpha-1,3 linkage of nigerose and turanose and alpha-1,5 linkage of leucrose and is very sensitive to temperature in vitro. (581 aa)
CTS1Endochitinase; required for cell separation after mitosis; transcriptional activation during the G1 phase of the cell cycle is mediated by transcription factor Ace2p. (562 aa)
EXG1Glucan 1,3-beta-glucosidase I/II; Major exo-1,3-beta-glucanase of the cell wall; involved in cell wall beta-glucan assembly; exists as three differentially glycosylated isoenzymes; EXG1 has a paralog, SPR1, that arose from the whole genome duplication; Belongs to the glycosyl hydrolase 5 (cellulase A) family. (448 aa)
GAS21,3-beta-glucanosyltransferase; involved with Gas4p in spore wall assembly; has similarity to Gas1p; Belongs to the glycosyl hydrolase 72 family. (555 aa)
GAS3Probable 1,3-beta-glucanosyltransferase GAS3; Putative 1,3-beta-glucanosyltransferase; has similarity go other GAS family members; low abundance, possibly inactive member of the GAS family of GPI-containing proteins; localizes to the cell wall; mRNA induced during sporulation. (524 aa)
SCW10Probable family 17 glucosidase SCW10; Cell wall protein with similarity to glucanases; may play a role in conjugation during mating based on mutant phenotype and its regulation by Ste12p; SWC10 has a paralog, SCW4, that arose from the whole genome duplication; Belongs to the glycosyl hydrolase 17 family. (389 aa)
GAS11,3-beta-glucanosyltransferase GAS1; Beta-1,3-glucanosyltransferase; required for cell wall assembly and also has a role in transcriptional silencing; localizes to cell surface via a glycosylphosphatidylinositol (GPI) anchor; also found at nuclear periphery; genetic interactions with histone H3 lysine acetyltransferases GCN5 and SAS3 indicate previously unsuspected functions for Gas1 in DNA damage response and cell cycle regulation; Belongs to the glycosyl hydrolase 72 family. (559 aa)
GAS51,3-beta-glucanosyltransferase; has similarity to Gas1p; localizes to the cell wall; Belongs to the glycosyl hydrolase 72 family. (484 aa)
GAS41,3-beta-glucanosyltransferase; involved with Gas2p in spore wall assembly; has similarity to Gas1p; localizes to the cell wall. (471 aa)
IMA2Oligo-1,6-glucosidase IMA2; Isomaltase (alpha-1,6-glucosidase/alpha-methylglucosidase); preferred specificity for isomaltose, alpha-methylglucoside, and palatinose, but also exhibits alpha-1,2 glucosidase activity on sucrose and kojibiose, and can cleave the 1,3-alpha linkage of nigerose and turanose and the alpha-1,5 linkage of leucrose in vitro; not required for isomaltose utilization, but Ima2p overexpression allows the ima1 null mutant to grow on isomaltose. (589 aa)
SPR1Sporulation-specific exo-1,3-beta-glucanase; contributes to ascospore thermoresistance; SPR1 has a paralog, EXG1, that arose from the whole genome duplication; Belongs to the glycosyl hydrolase 5 (cellulase A) family. (445 aa)
GDB1Amylo-alpha-1,6-glucosidase; Glycogen debranching enzyme; contains glucanotranferase and alpha-1,6-amyloglucosidase activities; required for glycogen degradation; phosphorylated in mitochondria; activity is inhibited by Igd1p; protein abundance increases in response to DNA replication stress. (1536 aa)
MAL32Alpha-glucosidase MAL32; Maltase (alpha-D-glucosidase); inducible protein involved in maltose catabolism; encoded in the MAL3 complex locus; functional in genomic reference strain S288C; hydrolyzes the disaccharides maltose, turanose, maltotriose, and sucrose; Belongs to the glycosyl hydrolase 13 family. (584 aa)
ROT2Glucosidase II catalytic subunit; required to trim the final glucose in N-linked glycans; required for normal cell wall synthesis; mutations in rot2 suppress tor2 mutations, and are synthetically lethal with rot1 mutations; Belongs to the glycosyl hydrolase 31 family. (954 aa)
YBR056WUncharacterized glycosyl hydrolase YBR056W; Putative glycoside hydrolase of the mitochondrial intermembrane space. (501 aa)
EXG2Glucan 1,3-beta-glucosidase 2; Exo-1,3-beta-glucanase; involved in cell wall beta-glucan assembly; may be anchored to the plasma membrane via a glycosylphosphatidylinositol (GPI) anchor. (562 aa)
CTS2Putative chitinase; functionally complements A. gossypii cts2 mutant sporulation defect. (511 aa)
GLC3Glycogen branching enzyme, involved in glycogen accumulation; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm in a punctate pattern; relocalizes from nucleus to cytoplasmic foci upon DNA replication stress; glycogen accumulation defect of the null mutant is functionally complemented by human GBE1, which is associated with glycogen storage disease; Belongs to the glycosyl hydrolase 13 family. GlgB subfamily. (704 aa)
SCW11Probable family 17 glucosidase SCW11; Cell wall protein with similarity to glucanases; may play a role in conjugation during mating based on its regulation by Ste12p. (542 aa)
Your Current Organism:
Saccharomyces cerevisiae
NCBI taxonomy Id: 4932
Other names: ATCC 18824, Candida robusta, Mycoderma cerevisiae, NRRL Y-12632, S. cerevisiae, Saccharomyces capensis, Saccharomyces italicus, Saccharomyces oviformis, Saccharomyces uvarum var. melibiosus, yeast
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