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DED81 DED81 ILS1 ILS1 CDC60 CDC60 ISM1 ISM1 GLN4 GLN4 MSE1 MSE1 NAM2 NAM2 MST1 MST1 THS1 THS1 VAS1 VAS1 GUS1 GUS1 SLM5 SLM5
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Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
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empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
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textmining
co-expression
protein homology
Your Input:
DED81Asparagine--tRNA ligase, cytoplasmic; Cytosolic asparaginyl-tRNA synthetase; required for protein synthesis, catalyzes the specific attachment of asparagine to its cognate tRNA; Belongs to the class-II aminoacyl-tRNA synthetase family. (554 aa)
ILS1Isoleucine--tRNA ligase, cytoplasmic; Cytoplasmic isoleucine-tRNA synthetase; target of the G1-specific inhibitor reveromycin A. (1072 aa)
CDC60Leucine--tRNA ligase, cytoplasmic; Cytosolic leucyl tRNA synthetase; ligates leucine to the appropriate tRNA; human homolog LARS can complement yeast temperature-sensitive mutant at restrictive temperature. (1090 aa)
ISM1Isoleucine--tRNA ligase, mitochondrial; Mitochondrial isoleucyl-tRNA synthetase; null mutant is deficient in respiratory growth; human homolog IARS2 implicated in mitochondrial diseases, can partially complement yeast null mutant. (1002 aa)
GLN4Glutamine--tRNA ligase; Glutamine tRNA synthetase; monomeric class I tRNA synthetase that catalyzes the specific glutaminylation of tRNA(Gln); N-terminal domain proposed to be involved in enzyme-tRNA interactions; Belongs to the class-I aminoacyl-tRNA synthetase family. (809 aa)
MSE1Glutamate--tRNA ligase, mitochondrial; Mitochondrial glutamyl-tRNA synthetase; predicted to be palmitoylated; Belongs to the class-I aminoacyl-tRNA synthetase family. Glutamate--tRNA ligase type 1 subfamily. (536 aa)
NAM2Leucine--tRNA ligase, mitochondrial; Mitochondrial leucyl-tRNA synthetase; also has direct role in splicing of several mitochondrial group I introns; indirectly required for mitochondrial genome maintenance; human homolog LARS2 can complement yeast null mutant, and is implicated in Perrault syndrome; Belongs to the class-I aminoacyl-tRNA synthetase family. (894 aa)
MST1Threonine--tRNA ligase, mitochondrial; Mitochondrial threonyl-tRNA synthetase; aminoacylates both the canonical threonine tRNA tT(UGU)Q1 and the unusual threonine tRNA tT(UAG)Q2 in vitro; lacks a typical editing domain, but has pre-transfer editing activity stimulated by the unusual tRNA-Thr. (462 aa)
THS1Threonine--tRNA ligase, cytoplasmic; Threonyl-tRNA synthetase; essential cytoplasmic protein; human homolog TARS can complement yeast null mutant. (734 aa)
VAS1Valine--tRNA ligase, mitochondrial; Mitochondrial and cytoplasmic valyl-tRNA synthetase; human homolog VARS2 implicated in mitochondrial diseases, can partially complement yeast null mutant; Belongs to the class-I aminoacyl-tRNA synthetase family. (1104 aa)
GUS1Glutamate--tRNA ligase, cytoplasmic; Glutamyl-tRNA synthetase (GluRS); forms a complex with methionyl-tRNA synthetase (Mes1p) and Arc1p; complex formation increases the catalytic efficiency of both tRNA synthetases and ensures their correct localization to the cytoplasm; protein abundance increases in response to DNA replication stress; Belongs to the class-I aminoacyl-tRNA synthetase family. Glutamate--tRNA ligase type 2 subfamily. (708 aa)
SLM5Asparagine--tRNA ligase, mitochondrial; Mitochondrial asparaginyl-tRNA synthetase. (492 aa)
Your Current Organism:
Saccharomyces cerevisiae
NCBI taxonomy Id: 4932
Other names: ATCC 18824, Candida robusta, Mycoderma cerevisiae, NRRL Y-12632, S. cerevisiae, Saccharomyces capensis, Saccharomyces italicus, Saccharomyces oviformis, Saccharomyces uvarum var. melibiosus, yeast
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