| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| RPB11 | RPB2 | YOL005C | YOR151C | RNA polymerase II subunit B12.5; part of central core; similar to Rpc19p and bacterial alpha subunit. | RNA polymerase II second largest subunit B150; part of central core; similar to bacterial beta subunit. | 0.999 |
| RPB11 | RPB3 | YOL005C | YIL021W | RNA polymerase II subunit B12.5; part of central core; similar to Rpc19p and bacterial alpha subunit. | RNA polymerase II third largest subunit B44; part of central core; similar to prokaryotic alpha subunit. | 0.999 |
| RPB11 | RPB4 | YOL005C | YJL140W | RNA polymerase II subunit B12.5; part of central core; similar to Rpc19p and bacterial alpha subunit. | RNA polymerase II subunit B32; forms dissociable heterodimer with Rpb7p; Rpb4/7 dissociates from RNAPII as Ser2 CTD phosphorylation increases; Rpb4/7 regulates cellular lifespan via mRNA decay process; involved in recruitment of 3'-end processing factors to transcribing RNAPII complex, export of mRNA to cytoplasm under stress conditions; also involved in translation initiation. | 0.999 |
| RPB11 | RPB7 | YOL005C | YDR404C | RNA polymerase II subunit B12.5; part of central core; similar to Rpc19p and bacterial alpha subunit. | RNA polymerase II subunit B16; forms dissociable heterodimer with Rpb4p; Rpb4/7 dissociates from RNAPII as Ser2 CTD phosphorylation increases; Rpb4/7 regulates cellular lifespan via mRNA decay process; involved in recruitment of 3'-end processing factors to transcribing RNA polymerase II complex, export of mRNA to cytoplasm under stress conditions; also involved in translation initiation. | 0.999 |
| RPB11 | RPO26 | YOL005C | YPR187W | RNA polymerase II subunit B12.5; part of central core; similar to Rpc19p and bacterial alpha subunit. | RNA polymerase subunit ABC23; common to RNA polymerases I, II, and III; part of central core; similar to bacterial omega subunit; Belongs to the archaeal RpoK/eukaryotic RPB6 RNA polymerase subunit family. | 0.999 |
| RPB11 | SPT15 | YOL005C | YER148W | RNA polymerase II subunit B12.5; part of central core; similar to Rpc19p and bacterial alpha subunit. | TATA-binding protein (TBP); general transcription factor that interacts with other factors to form the preinitiation complex at promoters; essential for viability, highly conserved; yeast gene can complement mutations in human homolog TBP. | 0.978 |
| RPB11 | SSL2 | YOL005C | YIL143C | RNA polymerase II subunit B12.5; part of central core; similar to Rpc19p and bacterial alpha subunit. | General transcription and DNA repair factor IIH helicase subunit XPB; Component of RNA polymerase transcription factor TFIIH holoenzyme; acts as dsDNA-dependent translocase in context of TFIIH, unwinds DNA strands during initiation and promotes transcription start site (TSS) scanning; has DNA-dependent ATPase/helicase activity; interacts functionally with TFIIB, has roles in TSS selection and gene looping to juxtapose initiation and termination regions; involved in DNA repair; relocalizes to cytosol under hypoxia; homolog of human ERCC3; Belongs to the helicase family. RAD25/XPB subfamily. | 0.982 |
| RPB11 | TFA1 | YOL005C | YKL028W | RNA polymerase II subunit B12.5; part of central core; similar to Rpc19p and bacterial alpha subunit. | Transcription initiation factor IIE subunit alpha; TFIIE large subunit; involved in recruitment of RNA polymerase II to the promoter, activation of TFIIH, and promoter opening. | 0.979 |
| RPB11 | TFG1 | YOL005C | YGR186W | RNA polymerase II subunit B12.5; part of central core; similar to Rpc19p and bacterial alpha subunit. | TFIIF (Transcription Factor II) largest subunit; involved in both transcription initiation and elongation of RNA polymerase II; homologous to human RAP74. | 0.996 |
| RPB11 | TFG2 | YOL005C | YGR005C | RNA polymerase II subunit B12.5; part of central core; similar to Rpc19p and bacterial alpha subunit. | TFIIF (Transcription Factor II) middle subunit; involved in both transcription initiation and elongation of RNA polymerase II; homologous to human RAP30. | 0.997 |
| RPB2 | RPB11 | YOR151C | YOL005C | RNA polymerase II second largest subunit B150; part of central core; similar to bacterial beta subunit. | RNA polymerase II subunit B12.5; part of central core; similar to Rpc19p and bacterial alpha subunit. | 0.999 |
| RPB2 | RPB3 | YOR151C | YIL021W | RNA polymerase II second largest subunit B150; part of central core; similar to bacterial beta subunit. | RNA polymerase II third largest subunit B44; part of central core; similar to prokaryotic alpha subunit. | 0.999 |
| RPB2 | RPB4 | YOR151C | YJL140W | RNA polymerase II second largest subunit B150; part of central core; similar to bacterial beta subunit. | RNA polymerase II subunit B32; forms dissociable heterodimer with Rpb7p; Rpb4/7 dissociates from RNAPII as Ser2 CTD phosphorylation increases; Rpb4/7 regulates cellular lifespan via mRNA decay process; involved in recruitment of 3'-end processing factors to transcribing RNAPII complex, export of mRNA to cytoplasm under stress conditions; also involved in translation initiation. | 0.999 |
| RPB2 | RPB7 | YOR151C | YDR404C | RNA polymerase II second largest subunit B150; part of central core; similar to bacterial beta subunit. | RNA polymerase II subunit B16; forms dissociable heterodimer with Rpb4p; Rpb4/7 dissociates from RNAPII as Ser2 CTD phosphorylation increases; Rpb4/7 regulates cellular lifespan via mRNA decay process; involved in recruitment of 3'-end processing factors to transcribing RNA polymerase II complex, export of mRNA to cytoplasm under stress conditions; also involved in translation initiation. | 0.999 |
| RPB2 | RPO26 | YOR151C | YPR187W | RNA polymerase II second largest subunit B150; part of central core; similar to bacterial beta subunit. | RNA polymerase subunit ABC23; common to RNA polymerases I, II, and III; part of central core; similar to bacterial omega subunit; Belongs to the archaeal RpoK/eukaryotic RPB6 RNA polymerase subunit family. | 0.999 |
| RPB2 | SPT15 | YOR151C | YER148W | RNA polymerase II second largest subunit B150; part of central core; similar to bacterial beta subunit. | TATA-binding protein (TBP); general transcription factor that interacts with other factors to form the preinitiation complex at promoters; essential for viability, highly conserved; yeast gene can complement mutations in human homolog TBP. | 0.994 |
| RPB2 | SSL2 | YOR151C | YIL143C | RNA polymerase II second largest subunit B150; part of central core; similar to bacterial beta subunit. | General transcription and DNA repair factor IIH helicase subunit XPB; Component of RNA polymerase transcription factor TFIIH holoenzyme; acts as dsDNA-dependent translocase in context of TFIIH, unwinds DNA strands during initiation and promotes transcription start site (TSS) scanning; has DNA-dependent ATPase/helicase activity; interacts functionally with TFIIB, has roles in TSS selection and gene looping to juxtapose initiation and termination regions; involved in DNA repair; relocalizes to cytosol under hypoxia; homolog of human ERCC3; Belongs to the helicase family. RAD25/XPB subfamily. | 0.987 |
| RPB2 | TFA1 | YOR151C | YKL028W | RNA polymerase II second largest subunit B150; part of central core; similar to bacterial beta subunit. | Transcription initiation factor IIE subunit alpha; TFIIE large subunit; involved in recruitment of RNA polymerase II to the promoter, activation of TFIIH, and promoter opening. | 0.996 |
| RPB2 | TFG1 | YOR151C | YGR186W | RNA polymerase II second largest subunit B150; part of central core; similar to bacterial beta subunit. | TFIIF (Transcription Factor II) largest subunit; involved in both transcription initiation and elongation of RNA polymerase II; homologous to human RAP74. | 0.999 |
| RPB2 | TFG2 | YOR151C | YGR005C | RNA polymerase II second largest subunit B150; part of central core; similar to bacterial beta subunit. | TFIIF (Transcription Factor II) middle subunit; involved in both transcription initiation and elongation of RNA polymerase II; homologous to human RAP30. | 0.999 |