node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
FIT2 | FIT3 | YOR382W | YOR383C | Facilitator of iron transport 2; Mannoprotein that is incorporated into the cell wall; incorporated via a glycosylphosphatidylinositol (GPI) anchor; involved in the retention of siderophore-iron in the cell wall. | Facilitator of iron transport 3; Mannoprotein that is incorporated into the cell wall; incorporated via a glycosylphosphatidylinositol (GPI) anchor; involved in the retention of siderophore-iron in the cell wall. | 0.993 |
FIT2 | FRE5 | YOR382W | YOR384W | Facilitator of iron transport 2; Mannoprotein that is incorporated into the cell wall; incorporated via a glycosylphosphatidylinositol (GPI) anchor; involved in the retention of siderophore-iron in the cell wall. | Ferric reductase transmembrane component 5; Putative ferric reductase with similarity to Fre2p; expression induced by low iron levels; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies. | 0.895 |
FIT2 | YOR385W | YOR382W | YOR385W | Facilitator of iron transport 2; Mannoprotein that is incorporated into the cell wall; incorporated via a glycosylphosphatidylinositol (GPI) anchor; involved in the retention of siderophore-iron in the cell wall. | Uncharacterized protein YOR385W; Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm; YOR385W is not an essential gene. | 0.559 |
FIT3 | FIT2 | YOR383C | YOR382W | Facilitator of iron transport 3; Mannoprotein that is incorporated into the cell wall; incorporated via a glycosylphosphatidylinositol (GPI) anchor; involved in the retention of siderophore-iron in the cell wall. | Facilitator of iron transport 2; Mannoprotein that is incorporated into the cell wall; incorporated via a glycosylphosphatidylinositol (GPI) anchor; involved in the retention of siderophore-iron in the cell wall. | 0.993 |
FIT3 | FRE5 | YOR383C | YOR384W | Facilitator of iron transport 3; Mannoprotein that is incorporated into the cell wall; incorporated via a glycosylphosphatidylinositol (GPI) anchor; involved in the retention of siderophore-iron in the cell wall. | Ferric reductase transmembrane component 5; Putative ferric reductase with similarity to Fre2p; expression induced by low iron levels; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies. | 0.903 |
FIT3 | YOR385W | YOR383C | YOR385W | Facilitator of iron transport 3; Mannoprotein that is incorporated into the cell wall; incorporated via a glycosylphosphatidylinositol (GPI) anchor; involved in the retention of siderophore-iron in the cell wall. | Uncharacterized protein YOR385W; Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm; YOR385W is not an essential gene. | 0.597 |
FRE5 | FIT2 | YOR384W | YOR382W | Ferric reductase transmembrane component 5; Putative ferric reductase with similarity to Fre2p; expression induced by low iron levels; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies. | Facilitator of iron transport 2; Mannoprotein that is incorporated into the cell wall; incorporated via a glycosylphosphatidylinositol (GPI) anchor; involved in the retention of siderophore-iron in the cell wall. | 0.895 |
FRE5 | FIT3 | YOR384W | YOR383C | Ferric reductase transmembrane component 5; Putative ferric reductase with similarity to Fre2p; expression induced by low iron levels; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies. | Facilitator of iron transport 3; Mannoprotein that is incorporated into the cell wall; incorporated via a glycosylphosphatidylinositol (GPI) anchor; involved in the retention of siderophore-iron in the cell wall. | 0.903 |
FRE5 | PHR1 | YOR384W | YOR386W | Ferric reductase transmembrane component 5; Putative ferric reductase with similarity to Fre2p; expression induced by low iron levels; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies. | Deoxyribodipyrimidine photo-lyase, mitochondrial; DNA photolyase involved in photoreactivation; repairs pyrimidine dimers in the presence of visible light; induced by DNA damage; regulated by transcriptional repressor Rph1p. | 0.532 |
FRE5 | YOR385W | YOR384W | YOR385W | Ferric reductase transmembrane component 5; Putative ferric reductase with similarity to Fre2p; expression induced by low iron levels; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies. | Uncharacterized protein YOR385W; Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm; YOR385W is not an essential gene. | 0.754 |
OYE2 | YHR180W | YHR179W | YHR180W | NADPH dehydrogenase 2; Conserved NADPH oxidoreductase containing flavin mononucleotide (FMN); responsible for geraniol reduction into citronellol during fermentation; homologous to Oye3p with different ligand binding and catalytic properties; may be involved in sterol metabolism, oxidative stress response, and programmed cell death; protein abundance increases in response to DNA replication stress; Belongs to the NADH:flavin oxidoreductase/NADH oxidase family. | Uncharacterized protein YHR180W; Putative protein of unknown function; conserved among S. cerevisiae strains. | 0.697 |
OYE2 | YHR182W | YHR179W | YHR182W | NADPH dehydrogenase 2; Conserved NADPH oxidoreductase containing flavin mononucleotide (FMN); responsible for geraniol reduction into citronellol during fermentation; homologous to Oye3p with different ligand binding and catalytic properties; may be involved in sterol metabolism, oxidative stress response, and programmed cell death; protein abundance increases in response to DNA replication stress; Belongs to the NADH:flavin oxidoreductase/NADH oxidase family. | Uncharacterized protein YHR182W; Protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cell periphery and cytoplasm; relocalizes from bud neck to cytoplasm upon DNA replication stress. | 0.449 |
PHR1 | FRE5 | YOR386W | YOR384W | Deoxyribodipyrimidine photo-lyase, mitochondrial; DNA photolyase involved in photoreactivation; repairs pyrimidine dimers in the presence of visible light; induced by DNA damage; regulated by transcriptional repressor Rph1p. | Ferric reductase transmembrane component 5; Putative ferric reductase with similarity to Fre2p; expression induced by low iron levels; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies. | 0.532 |
PHR1 | YOR385W | YOR386W | YOR385W | Deoxyribodipyrimidine photo-lyase, mitochondrial; DNA photolyase involved in photoreactivation; repairs pyrimidine dimers in the presence of visible light; induced by DNA damage; regulated by transcriptional repressor Rph1p. | Uncharacterized protein YOR385W; Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm; YOR385W is not an essential gene. | 0.707 |
SIP5 | SNF1 | YMR140W | YDR477W | Protein of unknown function; interacts with both the Reg1p/Glc7p phosphatase and the Snf1p kinase; forms cytoplasmic foci upon DNA replication stress; Belongs to the SIP5 family. | AMP-activated S/T protein kinase; forms a complex with Snf4p and members of the Sip1p/Sip2p/Gal83p family; required for transcription of glucose-repressed genes, thermotolerance, sporulation, and peroxisome biogenesis; regulates nucleocytoplasmic shuttling of Hxk2p; regulates filamentous growth and acts as a non-canonical GEF, activating Arf3p during invasive growth; SUMOylation by Mms21p inhibits its function and targets Snf1p for destruction via the Slx5-Slx8 Ub ligase. | 0.756 |
SIP5 | VHS1 | YMR140W | YDR247W | Protein of unknown function; interacts with both the Reg1p/Glc7p phosphatase and the Snf1p kinase; forms cytoplasmic foci upon DNA replication stress; Belongs to the SIP5 family. | Serine/threonine-protein kinase VHS1; Cytoplasmic serine/threonine protein kinase; identified as a high-copy suppressor of the synthetic lethality of a sis2 sit4 double mutant, suggesting a role in G1/S phase progression; VHS1 has a paralog, SKS1, that arose from the whole genome duplication. | 0.794 |
SIP5 | YHR180W | YMR140W | YHR180W | Protein of unknown function; interacts with both the Reg1p/Glc7p phosphatase and the Snf1p kinase; forms cytoplasmic foci upon DNA replication stress; Belongs to the SIP5 family. | Uncharacterized protein YHR180W; Putative protein of unknown function; conserved among S. cerevisiae strains. | 0.470 |
SNF1 | SIP5 | YDR477W | YMR140W | AMP-activated S/T protein kinase; forms a complex with Snf4p and members of the Sip1p/Sip2p/Gal83p family; required for transcription of glucose-repressed genes, thermotolerance, sporulation, and peroxisome biogenesis; regulates nucleocytoplasmic shuttling of Hxk2p; regulates filamentous growth and acts as a non-canonical GEF, activating Arf3p during invasive growth; SUMOylation by Mms21p inhibits its function and targets Snf1p for destruction via the Slx5-Slx8 Ub ligase. | Protein of unknown function; interacts with both the Reg1p/Glc7p phosphatase and the Snf1p kinase; forms cytoplasmic foci upon DNA replication stress; Belongs to the SIP5 family. | 0.756 |
STB5 | YHR180W | YHR178W | YHR180W | Protein STB5; Transcription factor; involved in regulating multidrug resistance and oxidative stress response; forms a heterodimer with Pdr1p; contains a Zn(II)2Cys6 zinc finger domain that interacts with a pleiotropic drug resistance element in vitro. | Uncharacterized protein YHR180W; Putative protein of unknown function; conserved among S. cerevisiae strains. | 0.611 |
VHS1 | SIP5 | YDR247W | YMR140W | Serine/threonine-protein kinase VHS1; Cytoplasmic serine/threonine protein kinase; identified as a high-copy suppressor of the synthetic lethality of a sis2 sit4 double mutant, suggesting a role in G1/S phase progression; VHS1 has a paralog, SKS1, that arose from the whole genome duplication. | Protein of unknown function; interacts with both the Reg1p/Glc7p phosphatase and the Snf1p kinase; forms cytoplasmic foci upon DNA replication stress; Belongs to the SIP5 family. | 0.794 |