(6 nodes) (2022) RNA Polymerase II Transcription in Pneumocystis: TFIIB from Pneumocystis carinii Can Replace the Transcriptional Functions of Fission Yeast Schizosaccharomyces pombe TFIIB In Vivo and In Vitro. network (Saccharomyces cerevisiae)

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Your Input:
	SPT15	TATA-binding protein (TBP); general transcription factor that interacts with other factors to form the preinitiation complex at promoters; essential for viability, highly conserved; yeast gene can complement mutations in human homolog TBP. (240 aa)
	SUA7	Transcription factor TFIIB; a general transcription factor required for transcription initiation and start site selection by RNA polymerase II. (345 aa)
	NMT1	Glycylpeptide N-tetradecanoyltransferase; N-myristoyl transferase; catalyzes the cotranslational, covalent attachment of myristic acid to the N-terminal glycine residue of several proteins involved in cellular growth and signal transduction; Belongs to the NMT family. (455 aa)
	TFG2	TFIIF (Transcription Factor II) middle subunit; involved in both transcription initiation and elongation of RNA polymerase II; homologous to human RAP30. (400 aa)
	ACT1	Actin; structural protein involved in cell polarization, endocytosis, and other cytoskeletal functions. (375 aa)
	RPO21	RNA polymerase II largest subunit B220; part of central core; phosphorylation of C-terminal heptapeptide repeat domain regulates association with transcription and splicing factors; similar to bacterial beta-prime. (1733 aa)

Your Current Organism:

Saccharomyces cerevisiae

NCBI taxonomy Id: 4932
Other names: ATCC 18824, Candida robusta, Mycoderma cerevisiae, NRRL Y-12632, S. cerevisiae, Saccharomyces capensis, Saccharomyces italicus, Saccharomyces oviformis, Saccharomyces uvarum var. melibiosus, yeast

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ACT1	NMT1	YFL039C	YLR195C	Actin; structural protein involved in cell polarization, endocytosis, and other cytoskeletal functions.	Glycylpeptide N-tetradecanoyltransferase; N-myristoyl transferase; catalyzes the cotranslational, covalent attachment of myristic acid to the N-terminal glycine residue of several proteins involved in cellular growth and signal transduction; Belongs to the NMT family.	0.446
ACT1	RPO21	YFL039C	YDL140C	Actin; structural protein involved in cell polarization, endocytosis, and other cytoskeletal functions.	RNA polymerase II largest subunit B220; part of central core; phosphorylation of C-terminal heptapeptide repeat domain regulates association with transcription and splicing factors; similar to bacterial beta-prime.	0.716
ACT1	SPT15	YFL039C	YER148W	Actin; structural protein involved in cell polarization, endocytosis, and other cytoskeletal functions.	TATA-binding protein (TBP); general transcription factor that interacts with other factors to form the preinitiation complex at promoters; essential for viability, highly conserved; yeast gene can complement mutations in human homolog TBP.	0.835
NMT1	ACT1	YLR195C	YFL039C	Glycylpeptide N-tetradecanoyltransferase; N-myristoyl transferase; catalyzes the cotranslational, covalent attachment of myristic acid to the N-terminal glycine residue of several proteins involved in cellular growth and signal transduction; Belongs to the NMT family.	Actin; structural protein involved in cell polarization, endocytosis, and other cytoskeletal functions.	0.446
RPO21	ACT1	YDL140C	YFL039C	RNA polymerase II largest subunit B220; part of central core; phosphorylation of C-terminal heptapeptide repeat domain regulates association with transcription and splicing factors; similar to bacterial beta-prime.	Actin; structural protein involved in cell polarization, endocytosis, and other cytoskeletal functions.	0.716
RPO21	SPT15	YDL140C	YER148W	RNA polymerase II largest subunit B220; part of central core; phosphorylation of C-terminal heptapeptide repeat domain regulates association with transcription and splicing factors; similar to bacterial beta-prime.	TATA-binding protein (TBP); general transcription factor that interacts with other factors to form the preinitiation complex at promoters; essential for viability, highly conserved; yeast gene can complement mutations in human homolog TBP.	0.999
RPO21	SUA7	YDL140C	YPR086W	RNA polymerase II largest subunit B220; part of central core; phosphorylation of C-terminal heptapeptide repeat domain regulates association with transcription and splicing factors; similar to bacterial beta-prime.	Transcription factor TFIIB; a general transcription factor required for transcription initiation and start site selection by RNA polymerase II.	0.999
RPO21	TFG2	YDL140C	YGR005C	RNA polymerase II largest subunit B220; part of central core; phosphorylation of C-terminal heptapeptide repeat domain regulates association with transcription and splicing factors; similar to bacterial beta-prime.	TFIIF (Transcription Factor II) middle subunit; involved in both transcription initiation and elongation of RNA polymerase II; homologous to human RAP30.	0.999
SPT15	ACT1	YER148W	YFL039C	TATA-binding protein (TBP); general transcription factor that interacts with other factors to form the preinitiation complex at promoters; essential for viability, highly conserved; yeast gene can complement mutations in human homolog TBP.	Actin; structural protein involved in cell polarization, endocytosis, and other cytoskeletal functions.	0.835
SPT15	RPO21	YER148W	YDL140C	TATA-binding protein (TBP); general transcription factor that interacts with other factors to form the preinitiation complex at promoters; essential for viability, highly conserved; yeast gene can complement mutations in human homolog TBP.	RNA polymerase II largest subunit B220; part of central core; phosphorylation of C-terminal heptapeptide repeat domain regulates association with transcription and splicing factors; similar to bacterial beta-prime.	0.999
SPT15	SUA7	YER148W	YPR086W	TATA-binding protein (TBP); general transcription factor that interacts with other factors to form the preinitiation complex at promoters; essential for viability, highly conserved; yeast gene can complement mutations in human homolog TBP.	Transcription factor TFIIB; a general transcription factor required for transcription initiation and start site selection by RNA polymerase II.	0.999
SPT15	TFG2	YER148W	YGR005C	TATA-binding protein (TBP); general transcription factor that interacts with other factors to form the preinitiation complex at promoters; essential for viability, highly conserved; yeast gene can complement mutations in human homolog TBP.	TFIIF (Transcription Factor II) middle subunit; involved in both transcription initiation and elongation of RNA polymerase II; homologous to human RAP30.	0.999
SUA7	RPO21	YPR086W	YDL140C	Transcription factor TFIIB; a general transcription factor required for transcription initiation and start site selection by RNA polymerase II.	RNA polymerase II largest subunit B220; part of central core; phosphorylation of C-terminal heptapeptide repeat domain regulates association with transcription and splicing factors; similar to bacterial beta-prime.	0.999
SUA7	SPT15	YPR086W	YER148W	Transcription factor TFIIB; a general transcription factor required for transcription initiation and start site selection by RNA polymerase II.	TATA-binding protein (TBP); general transcription factor that interacts with other factors to form the preinitiation complex at promoters; essential for viability, highly conserved; yeast gene can complement mutations in human homolog TBP.	0.999
SUA7	TFG2	YPR086W	YGR005C	Transcription factor TFIIB; a general transcription factor required for transcription initiation and start site selection by RNA polymerase II.	TFIIF (Transcription Factor II) middle subunit; involved in both transcription initiation and elongation of RNA polymerase II; homologous to human RAP30.	0.999
TFG2	RPO21	YGR005C	YDL140C	TFIIF (Transcription Factor II) middle subunit; involved in both transcription initiation and elongation of RNA polymerase II; homologous to human RAP30.	RNA polymerase II largest subunit B220; part of central core; phosphorylation of C-terminal heptapeptide repeat domain regulates association with transcription and splicing factors; similar to bacterial beta-prime.	0.999
TFG2	SPT15	YGR005C	YER148W	TFIIF (Transcription Factor II) middle subunit; involved in both transcription initiation and elongation of RNA polymerase II; homologous to human RAP30.	TATA-binding protein (TBP); general transcription factor that interacts with other factors to form the preinitiation complex at promoters; essential for viability, highly conserved; yeast gene can complement mutations in human homolog TBP.	0.999
TFG2	SUA7	YGR005C	YPR086W	TFIIF (Transcription Factor II) middle subunit; involved in both transcription initiation and elongation of RNA polymerase II; homologous to human RAP30.	Transcription factor TFIIB; a general transcription factor required for transcription initiation and start site selection by RNA polymerase II.	0.999

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