node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
PRO1 | PRO2 | YDR300C | YOR323C | Glutamate 5-kinase; Gamma-glutamyl kinase; catalyzes the first step in proline biosynthesis; required for nitrogen starvation-induced ribophagy but not for nonselective autophagy; PRO1 has a paralog, YHR033W, that arose from the whole genome duplication; Belongs to the glutamate 5-kinase family. | Gamma-glutamyl phosphate reductase; catalyzes the second step in proline biosynthesis. | 0.999 |
PRO1 | PRO3 | YDR300C | YER023W | Glutamate 5-kinase; Gamma-glutamyl kinase; catalyzes the first step in proline biosynthesis; required for nitrogen starvation-induced ribophagy but not for nonselective autophagy; PRO1 has a paralog, YHR033W, that arose from the whole genome duplication; Belongs to the glutamate 5-kinase family. | Delta 1-pyrroline-5-carboxylate reductase; catalyzes the last step in proline biosynthesis. | 0.997 |
PRO1 | PUT1 | YDR300C | YLR142W | Glutamate 5-kinase; Gamma-glutamyl kinase; catalyzes the first step in proline biosynthesis; required for nitrogen starvation-induced ribophagy but not for nonselective autophagy; PRO1 has a paralog, YHR033W, that arose from the whole genome duplication; Belongs to the glutamate 5-kinase family. | Proline oxidase; nuclear-encoded mitochondrial protein involved in utilization of proline as sole nitrogen source; PUT1 transcription is induced by Put3p in the presence of proline and the absence of a preferred nitrogen source. | 0.914 |
PRO1 | PUT2 | YDR300C | YHR037W | Glutamate 5-kinase; Gamma-glutamyl kinase; catalyzes the first step in proline biosynthesis; required for nitrogen starvation-induced ribophagy but not for nonselective autophagy; PRO1 has a paralog, YHR033W, that arose from the whole genome duplication; Belongs to the glutamate 5-kinase family. | Delta-1-pyrroline-5-carboxylate dehydrogenase; nuclear-encoded mitochondrial protein involved in utilization of proline as sole nitrogen source; deficiency of human homolog ALDH4A1 causes type II hyperprolinemia (HPII), an autosomal recessive inborn error of metabolism; human homolog ALDH4A1 can complement yeast null mutant. | 0.988 |
PRO1 | PUT3 | YDR300C | YKL015W | Glutamate 5-kinase; Gamma-glutamyl kinase; catalyzes the first step in proline biosynthesis; required for nitrogen starvation-induced ribophagy but not for nonselective autophagy; PRO1 has a paralog, YHR033W, that arose from the whole genome duplication; Belongs to the glutamate 5-kinase family. | Proline utilization trans-activator; Transcriptional activator; binds specific gene recruitment sequences and is required for DNA zip code-mediated targeting of genes to nuclear periphery; regulates proline utilization genes, constitutively binds PUT1 and PUT2 promoters as a dimer, undergoes conformational change to form active state; binds other promoters only under activating conditions; differentially phosphorylated in presence of different nitrogen sources; has a Zn(2)-Cys(6) binuclear cluster domain. | 0.584 |
PRO2 | PRO1 | YOR323C | YDR300C | Gamma-glutamyl phosphate reductase; catalyzes the second step in proline biosynthesis. | Glutamate 5-kinase; Gamma-glutamyl kinase; catalyzes the first step in proline biosynthesis; required for nitrogen starvation-induced ribophagy but not for nonselective autophagy; PRO1 has a paralog, YHR033W, that arose from the whole genome duplication; Belongs to the glutamate 5-kinase family. | 0.999 |
PRO2 | PRO3 | YOR323C | YER023W | Gamma-glutamyl phosphate reductase; catalyzes the second step in proline biosynthesis. | Delta 1-pyrroline-5-carboxylate reductase; catalyzes the last step in proline biosynthesis. | 0.997 |
PRO2 | PUT1 | YOR323C | YLR142W | Gamma-glutamyl phosphate reductase; catalyzes the second step in proline biosynthesis. | Proline oxidase; nuclear-encoded mitochondrial protein involved in utilization of proline as sole nitrogen source; PUT1 transcription is induced by Put3p in the presence of proline and the absence of a preferred nitrogen source. | 0.841 |
PRO2 | PUT2 | YOR323C | YHR037W | Gamma-glutamyl phosphate reductase; catalyzes the second step in proline biosynthesis. | Delta-1-pyrroline-5-carboxylate dehydrogenase; nuclear-encoded mitochondrial protein involved in utilization of proline as sole nitrogen source; deficiency of human homolog ALDH4A1 causes type II hyperprolinemia (HPII), an autosomal recessive inborn error of metabolism; human homolog ALDH4A1 can complement yeast null mutant. | 0.990 |
PRO2 | PUT3 | YOR323C | YKL015W | Gamma-glutamyl phosphate reductase; catalyzes the second step in proline biosynthesis. | Proline utilization trans-activator; Transcriptional activator; binds specific gene recruitment sequences and is required for DNA zip code-mediated targeting of genes to nuclear periphery; regulates proline utilization genes, constitutively binds PUT1 and PUT2 promoters as a dimer, undergoes conformational change to form active state; binds other promoters only under activating conditions; differentially phosphorylated in presence of different nitrogen sources; has a Zn(2)-Cys(6) binuclear cluster domain. | 0.621 |
PRO3 | PRO1 | YER023W | YDR300C | Delta 1-pyrroline-5-carboxylate reductase; catalyzes the last step in proline biosynthesis. | Glutamate 5-kinase; Gamma-glutamyl kinase; catalyzes the first step in proline biosynthesis; required for nitrogen starvation-induced ribophagy but not for nonselective autophagy; PRO1 has a paralog, YHR033W, that arose from the whole genome duplication; Belongs to the glutamate 5-kinase family. | 0.997 |
PRO3 | PRO2 | YER023W | YOR323C | Delta 1-pyrroline-5-carboxylate reductase; catalyzes the last step in proline biosynthesis. | Gamma-glutamyl phosphate reductase; catalyzes the second step in proline biosynthesis. | 0.997 |
PRO3 | PUT1 | YER023W | YLR142W | Delta 1-pyrroline-5-carboxylate reductase; catalyzes the last step in proline biosynthesis. | Proline oxidase; nuclear-encoded mitochondrial protein involved in utilization of proline as sole nitrogen source; PUT1 transcription is induced by Put3p in the presence of proline and the absence of a preferred nitrogen source. | 0.991 |
PRO3 | PUT2 | YER023W | YHR037W | Delta 1-pyrroline-5-carboxylate reductase; catalyzes the last step in proline biosynthesis. | Delta-1-pyrroline-5-carboxylate dehydrogenase; nuclear-encoded mitochondrial protein involved in utilization of proline as sole nitrogen source; deficiency of human homolog ALDH4A1 causes type II hyperprolinemia (HPII), an autosomal recessive inborn error of metabolism; human homolog ALDH4A1 can complement yeast null mutant. | 0.992 |
PRO3 | PUT3 | YER023W | YKL015W | Delta 1-pyrroline-5-carboxylate reductase; catalyzes the last step in proline biosynthesis. | Proline utilization trans-activator; Transcriptional activator; binds specific gene recruitment sequences and is required for DNA zip code-mediated targeting of genes to nuclear periphery; regulates proline utilization genes, constitutively binds PUT1 and PUT2 promoters as a dimer, undergoes conformational change to form active state; binds other promoters only under activating conditions; differentially phosphorylated in presence of different nitrogen sources; has a Zn(2)-Cys(6) binuclear cluster domain. | 0.642 |
PUT1 | PRO1 | YLR142W | YDR300C | Proline oxidase; nuclear-encoded mitochondrial protein involved in utilization of proline as sole nitrogen source; PUT1 transcription is induced by Put3p in the presence of proline and the absence of a preferred nitrogen source. | Glutamate 5-kinase; Gamma-glutamyl kinase; catalyzes the first step in proline biosynthesis; required for nitrogen starvation-induced ribophagy but not for nonselective autophagy; PRO1 has a paralog, YHR033W, that arose from the whole genome duplication; Belongs to the glutamate 5-kinase family. | 0.914 |
PUT1 | PRO2 | YLR142W | YOR323C | Proline oxidase; nuclear-encoded mitochondrial protein involved in utilization of proline as sole nitrogen source; PUT1 transcription is induced by Put3p in the presence of proline and the absence of a preferred nitrogen source. | Gamma-glutamyl phosphate reductase; catalyzes the second step in proline biosynthesis. | 0.841 |
PUT1 | PRO3 | YLR142W | YER023W | Proline oxidase; nuclear-encoded mitochondrial protein involved in utilization of proline as sole nitrogen source; PUT1 transcription is induced by Put3p in the presence of proline and the absence of a preferred nitrogen source. | Delta 1-pyrroline-5-carboxylate reductase; catalyzes the last step in proline biosynthesis. | 0.991 |
PUT1 | PUT2 | YLR142W | YHR037W | Proline oxidase; nuclear-encoded mitochondrial protein involved in utilization of proline as sole nitrogen source; PUT1 transcription is induced by Put3p in the presence of proline and the absence of a preferred nitrogen source. | Delta-1-pyrroline-5-carboxylate dehydrogenase; nuclear-encoded mitochondrial protein involved in utilization of proline as sole nitrogen source; deficiency of human homolog ALDH4A1 causes type II hyperprolinemia (HPII), an autosomal recessive inborn error of metabolism; human homolog ALDH4A1 can complement yeast null mutant. | 0.999 |
PUT1 | PUT3 | YLR142W | YKL015W | Proline oxidase; nuclear-encoded mitochondrial protein involved in utilization of proline as sole nitrogen source; PUT1 transcription is induced by Put3p in the presence of proline and the absence of a preferred nitrogen source. | Proline utilization trans-activator; Transcriptional activator; binds specific gene recruitment sequences and is required for DNA zip code-mediated targeting of genes to nuclear periphery; regulates proline utilization genes, constitutively binds PUT1 and PUT2 promoters as a dimer, undergoes conformational change to form active state; binds other promoters only under activating conditions; differentially phosphorylated in presence of different nitrogen sources; has a Zn(2)-Cys(6) binuclear cluster domain. | 0.992 |