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YNL040W YNL040W YNL247W YNL247W MSE1 MSE1 WRS1 WRS1 GLN4 GLN4 ISM1 ISM1 CDC60 CDC60 HTS1 HTS1 DTD1 DTD1 KRS1 KRS1 ILS1 ILS1 SLM5 SLM5 MSW1 MSW1 YDR341C YDR341C CCA1 CCA1 GUS1 GUS1 VAS1 VAS1 DED81 DED81 MSR1 MSR1 THS1 THS1 MST1 MST1 NAM2 NAM2 MSK1 MSK1
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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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query proteins and first shell of interactors
white nodes:
second shell of interactors
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empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
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textmining
co-expression
protein homology
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YNL040WPutative alanyl-tRNA editing protein alaX; Protein of unknown function; has strong similarity to alanyl-tRNA synthases from Eubacteria; null mutant displays decreased translation rate and increased readthrough of premature stop codons; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm; YNL040W is not an essential gene. (456 aa)
YNL247WCysteine--tRNA ligase; Cysteinyl-tRNA synthetase; may interact with ribosomes, based on co-purification experiments; human gene CARS allows growth of the yeast haploid null mutant after sporulation of a heterozygous diploid. (767 aa)
MSE1Glutamate--tRNA ligase, mitochondrial; Mitochondrial glutamyl-tRNA synthetase; predicted to be palmitoylated; Belongs to the class-I aminoacyl-tRNA synthetase family. Glutamate--tRNA ligase type 1 subfamily. (536 aa)
WRS1Tryptophan--tRNA ligase, cytoplasmic; Cytoplasmic tryptophanyl-tRNA synthetase; aminoacylates tryptophanyl-tRNA; human homolog WARS can complement yeast null mutant; Belongs to the class-I aminoacyl-tRNA synthetase family. (432 aa)
GLN4Glutamine--tRNA ligase; Glutamine tRNA synthetase; monomeric class I tRNA synthetase that catalyzes the specific glutaminylation of tRNA(Gln); N-terminal domain proposed to be involved in enzyme-tRNA interactions; Belongs to the class-I aminoacyl-tRNA synthetase family. (809 aa)
ISM1Isoleucine--tRNA ligase, mitochondrial; Mitochondrial isoleucyl-tRNA synthetase; null mutant is deficient in respiratory growth; human homolog IARS2 implicated in mitochondrial diseases, can partially complement yeast null mutant. (1002 aa)
CDC60Leucine--tRNA ligase, cytoplasmic; Cytosolic leucyl tRNA synthetase; ligates leucine to the appropriate tRNA; human homolog LARS can complement yeast temperature-sensitive mutant at restrictive temperature. (1090 aa)
HTS1Histidine--tRNA ligase, mitochondrial; Cytoplasmic and mitochondrial histidine tRNA synthetase; efficient mitochondrial localization requires both a presequence and an amino-terminal sequence; mutations in human ortholog HARS2 are associated with Perrault syndrome; Belongs to the class-II aminoacyl-tRNA synthetase family. (546 aa)
DTD1D-Tyr-tRNA(Tyr) deacylase; functions in protein translation, may affect nonsense suppression via alteration of the protein synthesis machinery; ubiquitous among eukaryotes; Belongs to the DTD family. (150 aa)
KRS1Lysine--tRNA ligase, cytoplasmic; Lysyl-tRNA synthetase. (591 aa)
ILS1Isoleucine--tRNA ligase, cytoplasmic; Cytoplasmic isoleucine-tRNA synthetase; target of the G1-specific inhibitor reveromycin A. (1072 aa)
SLM5Asparagine--tRNA ligase, mitochondrial; Mitochondrial asparaginyl-tRNA synthetase. (492 aa)
MSW1Tryptophan--tRNA ligase, mitochondrial; Mitochondrial tryptophanyl-tRNA synthetase; Belongs to the class-I aminoacyl-tRNA synthetase family. (379 aa)
YDR341CArginine--tRNA ligase, cytoplasmic; Arginyl-tRNA synthetase; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies; YDR341C has a paralog, MSR1, that arose from the whole genome duplication. (607 aa)
CCA1CCA tRNA nucleotidyltransferase, mitochondrial; ATP (CTP):tRNA-specific tRNA nucleotidyltransferase; different forms targeted to the nucleus, cytosol, and mitochondrion are generated via the use of multiple transcriptional and translational start sites; human homolog TRNT1 complements yeast null mutant. (546 aa)
GUS1Glutamate--tRNA ligase, cytoplasmic; Glutamyl-tRNA synthetase (GluRS); forms a complex with methionyl-tRNA synthetase (Mes1p) and Arc1p; complex formation increases the catalytic efficiency of both tRNA synthetases and ensures their correct localization to the cytoplasm; protein abundance increases in response to DNA replication stress; Belongs to the class-I aminoacyl-tRNA synthetase family. Glutamate--tRNA ligase type 2 subfamily. (708 aa)
VAS1Valine--tRNA ligase, mitochondrial; Mitochondrial and cytoplasmic valyl-tRNA synthetase; human homolog VARS2 implicated in mitochondrial diseases, can partially complement yeast null mutant; Belongs to the class-I aminoacyl-tRNA synthetase family. (1104 aa)
DED81Asparagine--tRNA ligase, cytoplasmic; Cytosolic asparaginyl-tRNA synthetase; required for protein synthesis, catalyzes the specific attachment of asparagine to its cognate tRNA; Belongs to the class-II aminoacyl-tRNA synthetase family. (554 aa)
MSR1Arginine--tRNA ligase, mitochondrial; Mitochondrial arginyl-tRNA synthetase; mutations in human ortholog are associated with pontocerebellar hypoplasia type 6; MSR1 has a paralog, YDR341C, that arose from the whole genome duplication; Belongs to the class-I aminoacyl-tRNA synthetase family. (643 aa)
THS1Threonine--tRNA ligase, cytoplasmic; Threonyl-tRNA synthetase; essential cytoplasmic protein; human homolog TARS can complement yeast null mutant. (734 aa)
MST1Threonine--tRNA ligase, mitochondrial; Mitochondrial threonyl-tRNA synthetase; aminoacylates both the canonical threonine tRNA tT(UGU)Q1 and the unusual threonine tRNA tT(UAG)Q2 in vitro; lacks a typical editing domain, but has pre-transfer editing activity stimulated by the unusual tRNA-Thr. (462 aa)
NAM2Leucine--tRNA ligase, mitochondrial; Mitochondrial leucyl-tRNA synthetase; also has direct role in splicing of several mitochondrial group I introns; indirectly required for mitochondrial genome maintenance; human homolog LARS2 can complement yeast null mutant, and is implicated in Perrault syndrome; Belongs to the class-I aminoacyl-tRNA synthetase family. (894 aa)
MSK1Lysine--tRNA ligase, mitochondrial; Mitochondrial lysine-tRNA synthetase; required for import of both aminoacylated and deacylated forms of tRNA(Lys) into mitochondria and for aminoacylation of mitochondrially encoded tRNA(Lys). (576 aa)
Your Current Organism:
Saccharomyces cerevisiae
NCBI taxonomy Id: 4932
Other names: ATCC 18824, Candida robusta, Mycoderma cerevisiae, NRRL Y-12632, S. cerevisiae, Saccharomyces capensis, Saccharomyces italicus, Saccharomyces oviformis, Saccharomyces uvarum var. melibiosus, yeast
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