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| | argC | N-acetyl-gamma-glutamyl-phosphate reductase; Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde. Belongs to the NAGSA dehydrogenase family. Type 1 subfamily. (344 aa) |
| | aroD | 3-dehydroquinate dehydratase; Involved in the third step of the chorismate pathway, which leads to the biosynthesis of aromatic amino acids. Catalyzes the cis- dehydration of 3-dehydroquinate (DHQ) and introduces the first double bond of the aromatic ring to yield 3-dehydroshikimate. Belongs to the type-I 3-dehydroquinase family. (227 aa) |
| | ttdA_2 | L(+)-tartrate dehydratase subunit alpha. (278 aa) |
| | ywqN | Putative NAD(P)H-dependent FMN-containing oxidoreductase YwqN. (177 aa) |
| | dapF | Diaminopimelate epimerase; Catalyzes the stereoinversion of LL-2,6-diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso-DAP), a precursor of L- lysine. (293 aa) |
| | lysA | Diaminopimelate decarboxylase; Specifically catalyzes the decarboxylation of meso- diaminopimelate (meso-DAP) to L-lysine. (429 aa) |
| | argD | Acetylornithine aminotransferase; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. ArgD subfamily. (390 aa) |
| | metC | Cystathionine beta-lyase. (397 aa) |
| | mnmC | tRNA 5-methylaminomethyl-2-thiouridine biosynthesis bifunctional protein MnmC. (473 aa) |
| | KZX10173.1 | Thioesterase superfamily protein. (135 aa) |
| | vapC_10 | tRNA(fMet)-specific endonuclease VapC. (171 aa) |
| | aroA | 3-phosphoshikimate 1-carboxyvinyltransferase; Catalyzes the transfer of the enolpyruvyl moiety of phosphoenolpyruvate (PEP) to the 5-hydroxyl of shikimate-3-phosphate (S3P) to produce enolpyruvyl shikimate-3-phosphate and inorganic phosphate. (440 aa) |
| | hisF | Imidazole glycerol phosphate synthase subunit HisF; IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit. (274 aa) |
| | katA | Vegetative catalase; Belongs to the catalase family. (501 aa) |
| | fprA_2 | Nitric oxide reductase. (407 aa) |
| | KZX10388.1 | Aspartate aminotransferase. (370 aa) |
| | ttdA_1 | L(+)-tartrate dehydratase subunit alpha. (281 aa) |
| | mmgD | 2-methylcitrate synthase. (291 aa) |
| | KZX10582.1 | Hypothetical protein. (348 aa) |
| | tufA | Elongation factor Tu; This protein promotes the GTP-dependent binding of aminoacyl- tRNA to the A-site of ribosomes during protein biosynthesis. Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-Tu/EF-1A subfamily. (411 aa) |
| | purD | Phosphoribosylamine--glycine ligase; Belongs to the GARS family. (436 aa) |
| | KZX10767.1 | Acetyltransferase (GNAT) family protein. (154 aa) |
| | argF | Ornithine carbamoyltransferase; Belongs to the aspartate/ornithine carbamoyltransferase superfamily. OTCase family. (301 aa) |
| | gadB_2 | Glutamate decarboxylase. (463 aa) |
| | tyrA | T-protein. (438 aa) |
| | guaB_2 | Inosine-5'-monophosphate dehydrogenase; Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth. Belongs to the IMPDH/GMPR family. (493 aa) |
| | KZX10957.1 | Dinitrogenase iron-molybdenum cofactor. (112 aa) |
| | sgcG_2 | 2-amino-4-deoxychorismate dehydrogenase. (189 aa) |
| | paiA | Protease synthase and sporulation negative regulatory protein PAI 1. (150 aa) |
| | metX_2 | Homoserine O-acetyltransferase. (334 aa) |
| | KZX11062.1 | F420H2 dehydrogenase subunit F. (792 aa) |
| | cbiX | Sirohydrochlorin cobaltochelatase; Catalyzes the insertion of Co(2+) into sirohydrochlorin as part of the anaerobic pathway to cobalamin biosynthesis. Involved in the biosynthesis of the unique nickel-containing tetrapyrrole coenzyme F430, the prosthetic group of methyl-coenzyme M reductase (MCR), which plays a key role in methanogenesis and anaerobic methane oxidation. Catalyzes the insertion of Ni(2+) into sirohydrochlorin to yield Ni- sirohydrochlorin. (161 aa) |
| | KZX11057.1 | Hypothetical protein. (132 aa) |
| | rfbB | dTDP-glucose 4,6-dehydratase. (334 aa) |
| | rmlC | dTDP-4-dehydrorhamnose 3,5-epimerase; Catalyzes the epimerization of the C3' and C5'positions of dTDP-6-deoxy-D-xylo-4-hexulose, forming dTDP-6-deoxy-L-lyxo-4-hexulose. Belongs to the dTDP-4-dehydrorhamnose 3,5-epimerase family. (184 aa) |
| | ppsA | Phosphoenolpyruvate synthase; Catalyzes the phosphorylation of pyruvate to phosphoenolpyruvate; Belongs to the PEP-utilizing enzyme family. (770 aa) |
| | gadB_1 | Glutamate decarboxylase; Catalyzes the decarboxylation of L-tyrosine to produce tyramine for methanofuran biosynthesis. Can also catalyze the decarboxylation of L-aspartate to produce beta-alanine for coenzyme A (CoA) biosynthesis; Belongs to the group II decarboxylase family. MfnA subfamily. (390 aa) |
| | fni | Isopentenyl-diphosphate delta-isomerase; Involved in the biosynthesis of isoprenoids. Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its allylic isomer, dimethylallyl diphosphate (DMAPP). (350 aa) |
| | proB | Glutamate 5-kinase; Catalyzes the formation of isopentenyl diphosphate (IPP), the building block of all isoprenoids. (268 aa) |
| | thrB_3 | Homoserine kinase; Catalyzes the phosphorylation of (R)-mevalonate (MVA) to (R)- mevalonate 5-phosphate (MVAP). Functions in the mevalonate (MVA) pathway leading to isopentenyl diphosphate (IPP), a key precursor for the biosynthesis of isoprenoid compounds such as archaeal membrane lipids; Belongs to the GHMP kinase family. Mevalonate kinase subfamily. (321 aa) |
| | KZX11236.1 | Ferredoxin-3. (64 aa) |
| | eno | Enolase; Catalyzes the reversible conversion of 2-phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis; Belongs to the enolase family. (415 aa) |
| | cmk_2 | Cytidylate kinase; Belongs to the archaeal adenylate kinase family. (186 aa) |
| | algC | Phosphomannomutase/phosphoglucomutase; Belongs to the phosphohexose mutase family. (453 aa) |
| | ilvG | Acetolactate synthase isozyme 2 large subunit; Belongs to the TPP enzyme family. (592 aa) |
| | KZX11263.1 | Serine-pyruvate aminotransferase. (380 aa) |
| | sucC | succinyl-CoA ligase [ADP-forming] subunit beta; Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The beta subunit provides nucleotide specificity of the enzyme and binds the substrate succinate, while the binding sites for coenzyme A and phosphate are found in the alpha subunit. (367 aa) |
| | rmlA_2 | Glucose-1-phosphate thymidylyltransferase. (291 aa) |
| | strL | dTDP-4-dehydrorhamnose reductase. (287 aa) |
| | sgcG_1 | 2-amino-4-deoxychorismate dehydrogenase. (189 aa) |
| | fprA_1 | Nitric oxide reductase. (406 aa) |
| | proC | Pyrroline-5-carboxylate reductase. (307 aa) |
| | ttdB_2 | L(+)-tartrate dehydratase subunit beta. (168 aa) |
| | ino1 | Inositol-3-phosphate synthase. (368 aa) |
| | purO | IMP cyclohydrolase; Catalyzes the cyclization of 5-formylamidoimidazole-4- carboxamide ribonucleotide to IMP. (209 aa) |
| | porB | Pyruvate synthase subunit PorB. (288 aa) |
| | porA | Pyruvate synthase subunit PorA. (381 aa) |
| | porD | Pyruvate synthase subunit PorD. (80 aa) |
| | padE | NADH-dependent phenylglyoxylate dehydrogenase subunit gamma. (173 aa) |
| | mat | S-adenosylmethionine synthase; Catalyzes the formation of S-adenosylmethionine from methionine and ATP; Belongs to the AdoMet synthase 2 family. (409 aa) |
| | glyA | Serine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydromethanopterin (H4MPT) serving as the one-carbon carrier. Also exhibits a pteridine-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro- aldol mechanism; Belongs to the SHMT family. (423 aa) |
| | dmdB_2 | 2,3-dimethylmalate dehydratase small subunit; Catalyzes the isomerization between 2-isopropylmalate and 3- isopropylmalate, via the formation of 2-isopropylmaleate. Belongs to the LeuD family. LeuD type 2 subfamily. (160 aa) |
| | thrB_2 | Homoserine kinase. (287 aa) |
| | KZX11731.1 | Chorismate mutase. (115 aa) |
| | lysC | Aspartokinase 2; Belongs to the aspartokinase family. (408 aa) |
| | dapA | 4-hydroxy-tetrahydrodipicolinate synthase; Catalyzes the condensation of (S)-aspartate-beta-semialdehyde [(S)-ASA] and pyruvate to 4-hydroxy-tetrahydrodipicolinate (HTPA). (297 aa) |
| | dapB | 4-hydroxy-tetrahydrodipicolinate reductase; Catalyzes the conversion of 4-hydroxy-tetrahydrodipicolinate (HTPA) to tetrahydrodipicolinate; Belongs to the DapB family. (273 aa) |
| | asd | Aspartate-semialdehyde dehydrogenase; Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L-aspartyl- 4-phosphate; Belongs to the aspartate-semialdehyde dehydrogenase family. (349 aa) |
| | fabH | 3-oxoacyl-[acyl-carrier-protein] synthase 3; Belongs to the thiolase-like superfamily. UPF0219 family. (346 aa) |
| | pcaF | beta-ketoadipyl-CoA thiolase. (383 aa) |
| | ilvE | Branched-chain-amino-acid aminotransferase; Acts on leucine, isoleucine and valine. Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family. (308 aa) |
| | surE | 5'-nucleotidase SurE; Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates; Belongs to the SurE nucleotidase family. (260 aa) |
| | KZX11815.1 | Flavodoxin. (163 aa) |
| | KZX11812.1 | H/ACA RNA-protein complex component Cbf5p. (158 aa) |
| | purF_1 | Amidophosphoribosyltransferase precursor; Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine. (476 aa) |
| | nifH1_2 | Nitrogenase iron protein 1; Belongs to the NifH/BchL/ChlL family. (272 aa) |
| | asnB | Asparagine synthetase B. (552 aa) |
| | gtaB | UTP--glucose-1-phosphate uridylyltransferase. (284 aa) |
| | metX_1 | Homoserine O-acetyltransferase; Transfers an acetyl group from acetyl-CoA to L-homoserine, forming acetyl-L-homoserine. (488 aa) |
| | cysK1 | O-acetylserine sulfhydrylase. (318 aa) |
| | KZX12109.1 | Acetyltransferase (GNAT) family protein. (211 aa) |
| | KZX12148.1 | Indolepyruvate oxidoreductase subunit beta. (234 aa) |
| | ubiE | Ubiquinone/menaquinone biosynthesis C-methyltransferase UbiE. (126 aa) |
| | acsA_2 | Acetyl-coenzyme A synthetase. (561 aa) |
| | acsA_1 | Acetyl-coenzyme A synthetase. (556 aa) |
| | asnC | Regulatory protein AsnC. (159 aa) |
| | hisH1 | Imidazole glycerol phosphate synthase subunit HisH 1; IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the synthesis of IGP and AICAR. The resulting ammonia molecule is channeled to the active site of HisF. (200 aa) |
| | rimO | Ribosomal protein S12 methylthiotransferase RimO. (517 aa) |
| | ribL | D-beta-D-heptose 1-phosphate adenylyltransferase; Catalyzes the transfer of the AMP portion of ATP to flavin mononucleotide (FMN) to produce flavin adenine dinucleotide (FAD) coenzyme. (151 aa) |
| | hisA_2 | 1-(5-phosphoribosyl)-5-[(5- phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomerase. (243 aa) |
| | htpX | Hypothetical protein; Protease HtpX homolog; Belongs to the peptidase M48B family. (323 aa) |
| | KZX12369.1 | NADH oxidase. (333 aa) |
| | KZX12367.1 | ACT domain protein. (143 aa) |
| | ilvB | Acetolactate synthase large subunit. (569 aa) |
| | ilvH | Acetolactate synthase small subunit. (167 aa) |
| | leuA_2 | 2-isopropylmalate synthase; Belongs to the alpha-IPM synthase/homocitrate synthase family. (512 aa) |
| | KZX12657.1 | Hypothetical protein. (140 aa) |
| | metE | 5-methyltetrahydropteroyltriglutamate-- homocysteine methyltransferase. (323 aa) |
| | hisA_1 | 1-(5-phosphoribosyl)-5-[(5- phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomerase; Belongs to the HisA/HisF family. (227 aa) |
| | yjjG | Pyrimidine 5'-nucleotidase YjjG. (225 aa) |
| | prmA_1 | Ribosomal protein L11 methyltransferase. (288 aa) |
| | KZX12700.1 | Putative nickel-responsive regulator; Transcriptional regulator; Belongs to the transcriptional regulatory CopG/NikR family. (141 aa) |
| | hemB | Delta-aminolevulinic acid dehydratase; Belongs to the ALAD family. (324 aa) |
| | aroC | Chorismate synthase; Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system. (407 aa) |
| | ttdB_1 | L(+)-tartrate dehydratase subunit beta. (188 aa) |
| | ubiX | Putative aromatic acid decarboxylase; Flavin prenyltransferase that catalyzes the synthesis of the prenylated FMN cofactor (prenyl-FMN) for 4-hydroxy-3-polyprenylbenzoic acid decarboxylase UbiD. The prenyltransferase is metal-independent and links a dimethylallyl moiety from dimethylallyl monophosphate (DMAP) to the flavin N5 and C6 atoms of FMN; Belongs to the UbiX/PAD1 family. (183 aa) |
| | hemL | Glutamate-1-semialdehyde 2,1-aminomutase. (419 aa) |
| | dapL | LL-diaminopimelate aminotransferase; Involved in the synthesis of meso-diaminopimelate (m-DAP or DL-DAP), required for both lysine and peptidoglycan biosynthesis. Catalyzes the direct conversion of tetrahydrodipicolinate to LL- diaminopimelate. (412 aa) |
| | purL_2 | Phosphoribosylformylglycinamidine synthase 2; Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP- dependent manner. PurS interacts with PurQ and PurL and is thought to assist i [...] (721 aa) |
| | KZX12817.1 | B12 binding domain protein. (407 aa) |
| | map | Methionine aminopeptidase; Removes the N-terminal methionine from nascent proteins. The N-terminal methionine is often cleaved when the second residue in the primary sequence is small and uncharged (Met-Ala-, Cys, Gly, Pro, Ser, Thr, or Val); Belongs to the peptidase M24A family. Methionine aminopeptidase archaeal type 2 subfamily. (306 aa) |
| | KZX12921.1 | Hypothetical protein; Belongs to the PDCD5 family. (107 aa) |
| | KZX12914.1 | Hypothetical protein. (77 aa) |
| | KZX12913.1 | Hypothetical protein. (78 aa) |
| | nifD_2 | Nitrogenase molybdenum-iron protein alpha chain. (365 aa) |
| | ribBA | Riboflavin biosynthesis protein RibBA; Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate. (221 aa) |
| | trpB_2 | Tryptophan synthase beta chain; The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine. (430 aa) |
| | ribH_2 | 6,7-dimethyl-8-ribityllumazine synthase. (153 aa) |
| | thrC | Threonine synthase; Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine. (396 aa) |
| | ndk | Nucleoside diphosphate kinase; Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate. (150 aa) |
| | argB | Acetylglutamate kinase; Catalyzes the ATP-dependent phosphorylation of N-acetyl-L- glutamate; Belongs to the acetylglutamate kinase family. ArgB subfamily. (293 aa) |
| | hicd_2 | Homoisocitrate dehydrogenase. (331 aa) |
| | bchD_2 | Magnesium-chelatase 60 kDa subunit. (259 aa) |
| | bchI_2 | Magnesium-chelatase 38 kDa subunit. (443 aa) |
| | serB | Phosphoserine phosphatase. (621 aa) |
| | dmdA_2 | 2,3-dimethylmalate dehydratase large subunit; Catalyzes the isomerization between 2-isopropylmalate and 3- isopropylmalate, via the formation of 2-isopropylmaleate. (415 aa) |
| | dmdB_1 | 2,3-dimethylmalate dehydratase small subunit; Catalyzes the isomerization between 2-isopropylmalate and 3- isopropylmalate, via the formation of 2-isopropylmaleate. Belongs to the LeuD family. LeuD type 2 subfamily. (159 aa) |
| | hicd_1 | Homoisocitrate dehydrogenase. (326 aa) |
| | ribH_1 | 6,7-dimethyl-8-ribityllumazine synthase; Catalyzes the formation of 6,7-dimethyl-8-ribityllumazine by condensation of 5-amino-6-(D-ribitylamino)uracil with 3,4-dihydroxy-2- butanone 4-phosphate. This is the penultimate step in the biosynthesis of riboflavin. (138 aa) |
| | purE_1 | N5-carboxyaminoimidazole ribonucleotide mutase; Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR). (360 aa) |
| | cysG | Siroheme synthase. (218 aa) |
| | hemA | glutamyl-tRNA reductase; Catalyzes the NADPH-dependent reduction of glutamyl-tRNA(Glu) to glutamate 1-semialdehyde (GSA). (432 aa) |
| | gap | Glyceraldehyde-3-phosphate dehydrogenase. (337 aa) |
| | aspC | Aspartate aminotransferase. (409 aa) |
| | KZX13843.1 | Putative kinase; Broad-specificity nucleoside monophosphate (NMP) kinase that catalyzes the reversible transfer of the terminal phosphate group between nucleoside triphosphates and monophosphates. Belongs to the adenylate kinase family. AK6 subfamily. (196 aa) |
| | KZX13840.1 | Hypothetical protein; C-methyltransferase C-terminal domain. (405 aa) |
| | rfbC | dTDP-4-dehydrorhamnose 3,5-epimerase; Catalyzes the epimerization of the C3' and C5'positions of dTDP-6-deoxy-D-xylo-4-hexulose, forming dTDP-6-deoxy-L-lyxo-4-hexulose. Belongs to the dTDP-4-dehydrorhamnose 3,5-epimerase family. (182 aa) |
| | rpiA | Ribose-5-phosphate isomerase A; Catalyzes the reversible conversion of ribose-5-phosphate to ribulose 5-phosphate. (217 aa) |
| | serA | D-3-phosphoglycerate dehydrogenase; Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family. (524 aa) |
| | queC_1 | 7-cyano-7-deazaguanine synthase. (356 aa) |
| | argG | Argininosuccinate synthase; Belongs to the argininosuccinate synthase family. Type 1 subfamily. (393 aa) |
| | KZX14135.1 | Hypothetical protein. (217 aa) |
| | purB | Adenylosuccinate lyase; Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily. (451 aa) |
| | trpA | Tryptophan synthase alpha chain; The alpha subunit is responsible for the aldol cleavage of indoleglycerol phosphate to indole and glyceraldehyde 3-phosphate. Belongs to the TrpA family. (273 aa) |
| | trpB_1 | Tryptophan synthase beta chain; The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine. (402 aa) |
| | trpF | N-(5'-phosphoribosyl)anthranilate isomerase; Belongs to the TrpF family. (213 aa) |
| | trpC | Indole-3-glycerol phosphate synthase. (265 aa) |
| | trpD | Anthranilate phosphoribosyltransferase; Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'- phosphoribosyl)-anthranilate (PRA). (339 aa) |
| | purP | Hypothetical protein; Catalyzes the ATP- and formate-dependent formylation of 5- aminoimidazole-4-carboxamide-1-beta-d-ribofuranosyl 5'-monophosphate (AICAR) to 5-formaminoimidazole-4-carboxamide-1-beta-d-ribofuranosyl 5'-monophosphate (FAICAR) in the absence of folates. (363 aa) |
| | purL_1 | Phosphoribosylformylglycinamidine synthase 2. (325 aa) |
| | nifB_2 | FeMo cofactor biosynthesis protein NifB. (288 aa) |
| | nifB_1 | FeMo cofactor biosynthesis protein NifB. (110 aa) |
| | KZX14294.1 | Hypothetical protein. (143 aa) |
| | leuA_1 | 2-isopropylmalate synthase; Belongs to the alpha-IPM synthase/homocitrate synthase family. (391 aa) |
| | dmdA_1 | 2,3-dimethylmalate dehydratase large subunit; Catalyzes the isomerization between 2-isopropylmalate and 3- isopropylmalate, via the formation of 2-isopropylmaleate. (427 aa) |
| | glmM_2 | Phosphoglucosamine mutase; Belongs to the phosphohexose mutase family. (454 aa) |
| | hisG_2 | ATP phosphoribosyltransferase; Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity. Belongs to the ATP phosphoribosyltransferase family. Long subfamily. (286 aa) |
| | hom | Homoserine dehydrogenase. (429 aa) |
| | murE | UDP-N-acetylmuramoyl-L-alanyl-D-glutamate--2, 6-diaminopimelate ligase. (596 aa) |
| | hemC | Porphobilinogen deaminase; Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps. Belongs to the HMBS family. (302 aa) |
| | polX | DNA polymerase/3'-5' exonuclease PolX. (220 aa) |
| | griI | 2-amino-4, 5-dihydroxy-6-oxo-7-(phosphonooxy)heptanoate synthase; Catalyzes a transaldol reaction between 6-deoxy-5- ketofructose 1-phosphate (DKFP) and L-aspartate semialdehyde (ASA) with an elimination of hydroxypyruvaldehyde phosphate to yield 2-amino-3,7- dideoxy-D-threo-hept-6-ulosonate (ADH). Plays a key role in an alternative pathway of the biosynthesis of 3-dehydroquinate (DHQ), which is involved in the canonical pathway for the biosynthesis of aromatic amino acids. (263 aa) |
| | griH | 3-amino-4-hydroxybenzoic acid synthase; Catalyzes the oxidative deamination and cyclization of 2- amino-3,7-dideoxy-D-threo-hept-6-ulosonic acid (ADH) to yield 3- dehydroquinate (DHQ), which is fed into the canonical shikimic pathway of aromatic amino acid biosynthesis; Belongs to the archaeal-type DHQ synthase family. (376 aa) |
| | patB | Cystathionine beta-lyase PatB. (397 aa) |
| | pdhD | Dihydrolipoyl dehydrogenase. (432 aa) |
| | KZX14694.1 | Hypothetical protein. (95 aa) |
| | KZX14693.1 | Hypothetical protein. (167 aa) |
| | apgM_2 | 2,3-bisphosphoglycerate-independent phosphoglycerate mutase; Catalyzes the interconversion of 2-phosphoglycerate and 3- phosphoglycerate. (412 aa) |
| | rmlA_1 | Glucose-1-phosphate thymidylyltransferase. (430 aa) |
| | hisC | Histidinol-phosphate aminotransferase. (368 aa) |
| | fbp | Fructose-1,6-bisphosphatase; Catalyzes two subsequent steps in gluconeogenesis: the aldol condensation of dihydroxyacetone phosphate (DHAP) and glyceraldehyde-3- phosphate (GA3P) to fructose-1,6-bisphosphate (FBP), and the dephosphorylation of FBP to fructose-6-phosphate (F6P). (365 aa) |
| | yhhQ | Inner membrane protein YhhQ; Involved in the import of queuosine (Q) precursors, required for Q precursor salvage; Belongs to the vitamin uptake transporter (VUT/ECF) (TC 2.A.88) family. Q precursor transporter subfamily. (236 aa) |
| | corC | Magnesium and cobalt efflux protein CorC. (430 aa) |
| | hisG_1 | ATP phosphoribosyltransferase. (328 aa) |
| | porC | Pyruvate synthase subunit PorC. (181 aa) |
| | korB_1 | 2-oxoglutarate oxidoreductase subunit KorB. (307 aa) |
| | korA_1 | 2-oxoglutarate oxidoreductase subunit KorA. (375 aa) |
| | psaC | Photosystem I iron-sulfur center. (68 aa) |
| | hisD | Histidinol dehydrogenase; Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine. (428 aa) |
| | hepT | Heptaprenyl diphosphate synthase component 2; Belongs to the FPP/GGPP synthase family. (333 aa) |
| | glnS | glutamine--tRNA ligase; Catalyzes the attachment of glutamate to tRNA(Glu) in a two- step reaction: glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu). (572 aa) |
| | lutB | Lactate utilization protein B. (406 aa) |
| | KZX15296.1 | Putative inner membrane protein. (343 aa) |
| | purM | Phosphoribosylformylglycinamidine cyclo-ligase. (340 aa) |
| | apgM_1 | 2,3-bisphosphoglycerate-independent phosphoglycerate mutase; Catalyzes the interconversion of 2-phosphoglycerate and 3- phosphoglycerate. (412 aa) |
| | KZX15611.1 | Transcriptional regulator PadR-like family protein. (152 aa) |
| | bamB | Outer membrane protein assembly factor BamB precursor. (407 aa) |
| | hisB | Histidine biosynthesis bifunctional protein HisB. (192 aa) |
| | KZX15600.1 | Iron-sulfur flavoprotein. (195 aa) |
| | hisE | phosphoribosyl-ATP pyrophosphatase. (96 aa) |
| | argJ | Arginine biosynthesis bifunctional protein ArgJ; Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis: the synthesis of N-acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate. Belongs to the ArgJ family. (410 aa) |
| | ilvC | Ketol-acid reductoisomerase; Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol-acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3-dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3-hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate. (330 aa) |
| | pabA | Aminodeoxychorismate/anthranilate synthase component 2. (189 aa) |
| | trpE | Anthranilate synthase component 1. (494 aa) |
| | gpsA | Glycerol-3-phosphate dehydrogenase; Belongs to the NAD-dependent glycerol-3-phosphate dehydrogenase family. (328 aa) |
| | pheA | Prephenate dehydratase. (216 aa) |
| | ubiC | Chorismate pyruvate-lyase. (184 aa) |
| | KZX16361.1 | Dinitrogenase iron-molybdenum cofactor. (108 aa) |
| | argH1 | Argininosuccinate lyase 1. (476 aa) |
| | pgk | Phosphoglycerate kinase; Belongs to the phosphoglycerate kinase family. (404 aa) |
| | tpiA | Triosephosphate isomerase; Involved in the gluconeogenesis. Catalyzes stereospecifically the conversion of dihydroxyacetone phosphate (DHAP) to D- glyceraldehyde-3-phosphate (G3P); Belongs to the triosephosphate isomerase family. (225 aa) |
| | KZX16396.1 | Hypothetical protein; TfoX C-terminal domain. (84 aa) |
| | mvaA | 3-hydroxy-3-methylglutaryl-coenzyme A reductase; Belongs to the HMG-CoA reductase family. (400 aa) |
| | sucD_1 | succinyl-CoA ligase [ADP-forming] subunit alpha; Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit. (286 aa) |
| | cysE | Serine acetyltransferase. (212 aa) |
| | bchI_1 | Magnesium-chelatase 38 kDa subunit. (497 aa) |
| | bchD_1 | Magnesium-chelatase 60 kDa subunit. (280 aa) |
| | prs | Ribose-phosphate pyrophosphokinase; Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib- 5-P). (306 aa) |
| | aroE | Shikimate dehydrogenase; Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA). (300 aa) |
| | hisI | phosphoribosyl-AMP cyclohydrolase; Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP. (140 aa) |
