86 items (Candida auris) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

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proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

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Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	B9J08_002458	Histone acetyltransferase type B catalytic subunit; Catalytic component of the histone acetylase B (HAT-B) complex. Has intrinsic substrate specificity that modifies lysine in recognition sequence GXGKXG. Involved in DNA double-strand break repair; Belongs to the HAT1 family. (409 aa)
	B9J08_002085	Histone chaperone; Histone chaperone that facilitates histone deposition and histone exchange and removal during nucleosome assembly and disassembly. (240 aa)
	SGF11	SAGA-associated factor 11; Functions as component of the transcription regulatory histone acetylation (HAT) complex SAGA. At the promoters, SAGA is required for recruitment of the basal transcription machinery. It influences RNA polymerase II transcriptional activity through different activities such as TBP interaction and promoter selectivity, interaction with transcription activators, and chromatin modification through histone acetylation and deubiquitination. SAGA acetylates nucleosomal histone H3 to some extent (to form H3K9ac, H3K14ac, H3K18ac and H3K23ac). SAGA interacts with DNA [...] (105 aa)
	B9J08_001803	rRNA 2'-O-methyltransferase fibrillarin. (314 aa)
	B9J08_002988	Uncharacterized protein; Belongs to the actin family. (475 aa)
	B9J08_003150	WD_REPEATS_REGION domain-containing protein. (354 aa)
	B9J08_003319	RBR-type E3 ubiquitin transferase. (615 aa)
	B9J08_003257	CDC73_C domain-containing protein. (362 aa)
	B9J08_003426	HDAC_interact domain-containing protein. (1576 aa)
	B9J08_002281	Uncharacterized protein. (1138 aa)
	B9J08_002313	E3 ubiquitin-protein ligase PEP5. (1000 aa)
	B9J08_000225	Uncharacterized protein. (262 aa)
	B9J08_000395	Uncharacterized protein. (1101 aa)
	B9J08_000282	PHD-type domain-containing protein. (392 aa)
	B9J08_000281	WD_REPEATS_REGION domain-containing protein. (452 aa)
	B9J08_000860	Uncharacterized protein. (241 aa)
	B9J08_000044	Histone-lysine N-methyltransferase, H3 lysine-79 specific; Histone methyltransferase that specifically methylates histone H3 to form H3K79me. This methylation is required for telomere silencing and for the pachytene checkpoint during the meiotic cell cycle by allowing the recruitment of RAD9 to double strand breaks. Nucleosomes are preferred as substrate compared to free histones. (1119 aa)
	B9J08_000703	Uncharacterized protein. (217 aa)
	B9J08_000923	SANT domain-containing protein. (558 aa)
	B9J08_000852	Histone acetyltransferase. (404 aa)
	B9J08_000538	Uncharacterized protein. (216 aa)
	B9J08_000815	WD_REPEATS_REGION domain-containing protein. (641 aa)
	B9J08_000752	Histone deacetylase; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. (840 aa)
	B9J08_000704	Uncharacterized protein. (1470 aa)
	B9J08_000706	HSA domain-containing protein. (1095 aa)
	B9J08_000629	SAS4 domain-containing protein. (261 aa)
	B9J08_000550	Uncharacterized protein. (396 aa)
	B9J08_000667	Uncharacterized protein. (156 aa)
	B9J08_000531	Uncharacterized protein. (116 aa)
	B9J08_000533	Uncharacterized protein. (327 aa)
	B9J08_000869	Uncharacterized protein. (612 aa)
	B9J08_000303	Uncharacterized protein. (454 aa)
	B9J08_001302	E3 ubiquitin protein ligase. (676 aa)
	B9J08_004684	PHD-type domain-containing protein. (641 aa)
	B9J08_004899	Acetyltransf_6 domain-containing protein. (852 aa)
	B9J08_005074	MRG domain-containing protein. (336 aa)
	B9J08_005133	Histone acetyltransferase GCN5. (522 aa)
	B9J08_005401	Uncharacterized protein. (559 aa)
	B9J08_005406	Uncharacterized protein; Belongs to the PI3/PI4-kinase family. (3805 aa)
	B9J08_005408	Uncharacterized protein. (607 aa)
	B9J08_005442	WD_REPEATS_REGION domain-containing protein. (389 aa)
	B9J08_005058	Uncharacterized protein. (439 aa)
	B9J08_005240	RXT2_N domain-containing protein. (334 aa)
	B9J08_005356	Histone-lysine N-methyltransferase, H3 lysine-4 specific; Catalytic component of the COMPASS (Set1C) complex that specifically mono-, di- and trimethylates histone H3 to form H3K4me1/2/3, which subsequently plays a role in telomere length maintenance and transcription elongation regulation. (1054 aa)
	B9J08_004557	ANK_REP_REGION domain-containing protein. (1211 aa)
	B9J08_004585	Uncharacterized protein. (458 aa)
	B9J08_004747	Histone deacetylase; Belongs to the histone deacetylase family. HD Type 1 subfamily. (504 aa)
	B9J08_004836	Uncharacterized protein. (561 aa)
	B9J08_004875	Uncharacterized protein. (1538 aa)
	B9J08_004647	Ubiquitin-conjugating enzyme E2 2; Belongs to the ubiquitin-conjugating enzyme family. (163 aa)
	B9J08_004142	Protein kinase domain-containing protein; Belongs to the protein kinase superfamily. (340 aa)
	B9J08_004733	Uncharacterized protein. (219 aa)
	SUS1	Transcription and mRNA export factor SUS1; Involved in mRNA export coupled transcription activation by association with both the TREX-2 and the SAGA complexes. At the promoters, SAGA is required for recruitment of the basal transcription machinery. It influences RNA polymerase II transcriptional activity through different activities such as TBP interaction and promoter selectivity, interaction with transcription activators, and chromatin modification through histone acetylation and deubiquitination. Within the SAGA complex, participates to a subcomplex required for deubiquitination of [...] (96 aa)
	B9J08_004306	B30.2/SPRY domain-containing protein. (476 aa)
	B9J08_000637	Uncharacterized protein. (628 aa)
	B9J08_000541	Uncharacterized protein. (457 aa)
	B9J08_000486	Actin. (376 aa)
	B9J08_000294	Uncharacterized protein. (143 aa)
	B9J08_001346	Uncharacterized protein. (369 aa)
	B9J08_001320	Uncharacterized protein. (426 aa)
	B9J08_001075	Serine/threonine-protein kinase Tel1; Serine/threonine protein kinase which activates checkpoint signaling upon genotoxic stresses such as ionizing radiation (IR), ultraviolet light (UV), or DNA replication stalling, thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]- Q. Phosphorylates histone H2A to form H2AS128ph (gamma-H2A) at sites of DNA damage, involved in the regulation of DNA damage response mechanism. Required for the control of telomere length and genome stability; Belongs to the PI3/PI4-kinase family. ATM subfamily. (2844 aa)
	B9J08_001655	Uncharacterized protein. (644 aa)
	B9J08_001348	Uncharacterized protein. (311 aa)
	B9J08_001349	SCA7 domain-containing protein. (493 aa)
	B9J08_002525	Uncharacterized protein. (221 aa)
	B9J08_002562	Uncharacterized protein. (745 aa)
	B9J08_004454	Uncharacterized protein. (220 aa)
	B9J08_004247	Transcription initiation factor TFIID subunit 10; Functions as a component of the DNA-binding general transcription factor complex TFIID and the transcription regulatory histone acetylation (HAT) complexes SAGA and SLIK. Binding of TFIID to a promoter (with or without TATA element) is the initial step in preinitiation complex (PIC) formation. TFIID plays a key role in the regulation of gene expression by RNA polymerase II through different activities such as transcription activator interaction, core promoter recognition and selectivity, TFIIA and TFIIB interaction, chromatin modificati [...] (212 aa)
	B9J08_002196	Histone acetyltransferase; Belongs to the MYST (SAS/MOZ) family. (353 aa)
	B9J08_002171	N-acetyltransferase domain-containing protein. (153 aa)
	B9J08_002750	Bromo domain-containing protein. (1081 aa)
	B9J08_002859	WD_REPEATS_REGION domain-containing protein. (435 aa)
	B9J08_003022	PHD domain-containing protein. (318 aa)
	B9J08_003116	Uncharacterized protein. (480 aa)
	B9J08_003450	Uncharacterized protein; Belongs to the class V-like SAM-binding methyltransferase superfamily. Histone-lysine methyltransferase family. SET2 subfamily. (730 aa)
	B9J08_003505	Histone acetyltransferase; Belongs to the MYST (SAS/MOZ) family. (846 aa)
	B9J08_003638	Uncharacterized protein. (534 aa)
	B9J08_003779	Uncharacterized protein. (66 aa)
	B9J08_003807	Ubiquitin carboxyl-terminal hydrolase. (551 aa)
	B9J08_003814	Histone acetyltransferase; Belongs to the MYST (SAS/MOZ) family. (513 aa)
	B9J08_003594	USP domain-containing protein; Belongs to the peptidase C19 family. (675 aa)
	B9J08_003949	Uncharacterized protein. (757 aa)
	B9J08_002004	Uncharacterized protein. (730 aa)
	B9J08_002075	Uncharacterized protein. (345 aa)
	B9J08_001912	Elongator complex protein 3; Catalytic tRNA acetyltransferase subunit of the RNA polymerase II elongator complex, which is a component of the RNA polymerase II (Pol II) holoenzyme and is involved in transcriptional elongation. (551 aa)
	B9J08_002670	Uncharacterized protein. (994 aa)

Your Current Organism:

Candida auris

NCBI taxonomy Id: 498019
Other names: B11220, CBS 10913, CBS10913, CDC B11220, Candida auris Satoh & Makimura, 2009, Candida sp. KM-143, DSM 21092, JCM 15448, JCM15448, [. auris, [Candida] auris

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
B9J08_000044	B9J08_001302	A0A2H1A6V0	A0A2H0ZBL6	Histone-lysine N-methyltransferase, H3 lysine-79 specific; Histone methyltransferase that specifically methylates histone H3 to form H3K79me. This methylation is required for telomere silencing and for the pachytene checkpoint during the meiotic cell cycle by allowing the recruitment of RAD9 to double strand breaks. Nucleosomes are preferred as substrate compared to free histones.	E3 ubiquitin protein ligase.	0.579
B9J08_000044	B9J08_002196	A0A2H1A6V0	A0A2H0ZWP5	Histone-lysine N-methyltransferase, H3 lysine-79 specific; Histone methyltransferase that specifically methylates histone H3 to form H3K79me. This methylation is required for telomere silencing and for the pachytene checkpoint during the meiotic cell cycle by allowing the recruitment of RAD9 to double strand breaks. Nucleosomes are preferred as substrate compared to free histones.	Histone acetyltransferase; Belongs to the MYST (SAS/MOZ) family.	0.462
B9J08_000044	B9J08_003150	A0A2H1A6V0	A0A2H0ZS65	Histone-lysine N-methyltransferase, H3 lysine-79 specific; Histone methyltransferase that specifically methylates histone H3 to form H3K79me. This methylation is required for telomere silencing and for the pachytene checkpoint during the meiotic cell cycle by allowing the recruitment of RAD9 to double strand breaks. Nucleosomes are preferred as substrate compared to free histones.	WD_REPEATS_REGION domain-containing protein.	0.517
B9J08_000044	B9J08_003450	A0A2H1A6V0	A0A2H0ZMJ0	Histone-lysine N-methyltransferase, H3 lysine-79 specific; Histone methyltransferase that specifically methylates histone H3 to form H3K79me. This methylation is required for telomere silencing and for the pachytene checkpoint during the meiotic cell cycle by allowing the recruitment of RAD9 to double strand breaks. Nucleosomes are preferred as substrate compared to free histones.	Uncharacterized protein; Belongs to the class V-like SAM-binding methyltransferase superfamily. Histone-lysine methyltransferase family. SET2 subfamily.	0.968
B9J08_000044	B9J08_004306	A0A2H1A6V0	A0A2H0ZIK8	Histone-lysine N-methyltransferase, H3 lysine-79 specific; Histone methyltransferase that specifically methylates histone H3 to form H3K79me. This methylation is required for telomere silencing and for the pachytene checkpoint during the meiotic cell cycle by allowing the recruitment of RAD9 to double strand breaks. Nucleosomes are preferred as substrate compared to free histones.	B30.2/SPRY domain-containing protein.	0.477
B9J08_000044	B9J08_004647	A0A2H1A6V0	A0A2H0ZH62	Histone-lysine N-methyltransferase, H3 lysine-79 specific; Histone methyltransferase that specifically methylates histone H3 to form H3K79me. This methylation is required for telomere silencing and for the pachytene checkpoint during the meiotic cell cycle by allowing the recruitment of RAD9 to double strand breaks. Nucleosomes are preferred as substrate compared to free histones.	Ubiquitin-conjugating enzyme E2 2; Belongs to the ubiquitin-conjugating enzyme family.	0.515
B9J08_000044	B9J08_005356	A0A2H1A6V0	A0A2H0ZF26	Histone-lysine N-methyltransferase, H3 lysine-79 specific; Histone methyltransferase that specifically methylates histone H3 to form H3K79me. This methylation is required for telomere silencing and for the pachytene checkpoint during the meiotic cell cycle by allowing the recruitment of RAD9 to double strand breaks. Nucleosomes are preferred as substrate compared to free histones.	Histone-lysine N-methyltransferase, H3 lysine-4 specific; Catalytic component of the COMPASS (Set1C) complex that specifically mono-, di- and trimethylates histone H3 to form H3K4me1/2/3, which subsequently plays a role in telomere length maintenance and transcription elongation regulation.	0.971
B9J08_000225	B9J08_000533	A0A2H1A843	A0A2H1A517	Uncharacterized protein.	Uncharacterized protein.	0.993
B9J08_000225	B9J08_000541	A0A2H1A843	A0A2H1A3K1	Uncharacterized protein.	Uncharacterized protein.	0.692
B9J08_000225	B9J08_000550	A0A2H1A843	A0A2H1A594	Uncharacterized protein.	Uncharacterized protein.	0.479
B9J08_000225	B9J08_000637	A0A2H1A843	A0A2H1A3W4	Uncharacterized protein.	Uncharacterized protein.	0.994
B9J08_000225	B9J08_000667	A0A2H1A843	A0A2H1A570	Uncharacterized protein.	Uncharacterized protein.	0.994
B9J08_000225	B9J08_000704	A0A2H1A843	A0A2H1A5Q3	Uncharacterized protein.	Uncharacterized protein.	0.441
B9J08_000225	B9J08_000815	A0A2H1A843	A0A2H1A624	Uncharacterized protein.	WD_REPEATS_REGION domain-containing protein.	0.726
B9J08_000225	B9J08_000860	A0A2H1A843	A0A2H1A747	Uncharacterized protein.	Uncharacterized protein.	0.509
B9J08_000225	B9J08_001320	A0A2H1A843	A0A2H1A1M0	Uncharacterized protein.	Uncharacterized protein.	0.925
B9J08_000225	B9J08_001349	A0A2H1A843	A0A2H0ZZD3	Uncharacterized protein.	SCA7 domain-containing protein.	0.951
B9J08_000225	B9J08_002562	A0A2H1A843	A0A2H0ZWQ8	Uncharacterized protein.	Uncharacterized protein.	0.939
B9J08_000225	B9J08_002750	A0A2H1A843	A0A2H0ZKP1	Uncharacterized protein.	Bromo domain-containing protein.	0.986
B9J08_000225	B9J08_003807	A0A2H1A843	A0A2H0ZNI1	Uncharacterized protein.	Ubiquitin carboxyl-terminal hydrolase.	0.994

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