STRINGSTRING
B9J08_002850 B9J08_002850 B9J08_003447 B9J08_003447 B9J08_000044 B9J08_000044 B9J08_000752 B9J08_000752 B9J08_001075 B9J08_001075 B9J08_001093 B9J08_001093 B9J08_001649 B9J08_001649 B9J08_003774 B9J08_003774 SGF11 SGF11 B9J08_001302 B9J08_001302 B9J08_004932 B9J08_004932 B9J08_005356 B9J08_005356 B9J08_004747 B9J08_004747 B9J08_004862 B9J08_004862 SUS1 SUS1
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
B9J08_002850Histone deacetylase; Belongs to the histone deacetylase family. HD Type 1 subfamily. (452 aa)
B9J08_003447Chromatin modification-related protein. (368 aa)
B9J08_000044Histone-lysine N-methyltransferase, H3 lysine-79 specific; Histone methyltransferase that specifically methylates histone H3 to form H3K79me. This methylation is required for telomere silencing and for the pachytene checkpoint during the meiotic cell cycle by allowing the recruitment of RAD9 to double strand breaks. Nucleosomes are preferred as substrate compared to free histones. (1119 aa)
B9J08_000752Histone deacetylase; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. (840 aa)
B9J08_001075Serine/threonine-protein kinase Tel1; Serine/threonine protein kinase which activates checkpoint signaling upon genotoxic stresses such as ionizing radiation (IR), ultraviolet light (UV), or DNA replication stalling, thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]- Q. Phosphorylates histone H2A to form H2AS128ph (gamma-H2A) at sites of DNA damage, involved in the regulation of DNA damage response mechanism. Required for the control of telomere length and genome stability; Belongs to the PI3/PI4-kinase family. ATM subfamily. (2844 aa)
B9J08_001093Protein HIR; Required for replication-independent chromatin assembly and for the periodic repression of histone gene transcription during the cell cycle; Belongs to the WD repeat HIR1 family. (983 aa)
B9J08_001649Protein HIR; Required for replication-independent chromatin assembly and for the periodic repression of histone gene transcription during the cell cycle; Belongs to the WD repeat HIR1 family. (959 aa)
B9J08_003774RuvB-like helicase; DNA helicase participates in several chromatin remodeling complexes, including the SWR1 and the INO80 complexes. (457 aa)
SGF11SAGA-associated factor 11; Functions as component of the transcription regulatory histone acetylation (HAT) complex SAGA. At the promoters, SAGA is required for recruitment of the basal transcription machinery. It influences RNA polymerase II transcriptional activity through different activities such as TBP interaction and promoter selectivity, interaction with transcription activators, and chromatin modification through histone acetylation and deubiquitination. SAGA acetylates nucleosomal histone H3 to some extent (to form H3K9ac, H3K14ac, H3K18ac and H3K23ac). SAGA interacts with DNA [...] (105 aa)
B9J08_001302E3 ubiquitin protein ligase. (676 aa)
B9J08_004932RuvB-like helicase; DNA helicase participates in several chromatin remodeling complexes, including the SWR1 and the INO80 complexes. (474 aa)
B9J08_005356Histone-lysine N-methyltransferase, H3 lysine-4 specific; Catalytic component of the COMPASS (Set1C) complex that specifically mono-, di- and trimethylates histone H3 to form H3K4me1/2/3, which subsequently plays a role in telomere length maintenance and transcription elongation regulation. (1054 aa)
B9J08_004747Histone deacetylase; Belongs to the histone deacetylase family. HD Type 1 subfamily. (504 aa)
B9J08_004862Chromatin modification-related protein. (259 aa)
SUS1Transcription and mRNA export factor SUS1; Involved in mRNA export coupled transcription activation by association with both the TREX-2 and the SAGA complexes. At the promoters, SAGA is required for recruitment of the basal transcription machinery. It influences RNA polymerase II transcriptional activity through different activities such as TBP interaction and promoter selectivity, interaction with transcription activators, and chromatin modification through histone acetylation and deubiquitination. Within the SAGA complex, participates to a subcomplex required for deubiquitination of [...] (96 aa)
Your Current Organism:
Candida auris
NCBI taxonomy Id: 498019
Other names: B11220, CBS 10913, CBS10913, CDC B11220, Candida auris Satoh & Makimura, 2009, Candida sp. KM-143, DSM 21092, JCM 15448, JCM15448, [. auris, [Candida] auris
Server load: low (16%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.