STRINGSTRING
VDAG_00681 VDAG_00681 VDAG_00019 VDAG_00019 VDAG_01418 VDAG_01418 VDAG_03357 VDAG_03357 VDAG_03031 VDAG_03031 VDAG_04751 VDAG_04751 NCS2 NCS2 VDAG_06670 VDAG_06670 VDAG_06775 VDAG_06775 VDAG_06917 VDAG_06917 NCS6 NCS6 VDAG_08388 VDAG_08388 VDAG_08450 VDAG_08450 URM1 URM1 VDAG_09201 VDAG_09201 VDAG_10429 VDAG_10429 uba4 uba4
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
VDAG_00681Uncharacterized protein. (479 aa)
VDAG_00019Uncharacterized protein. (245 aa)
VDAG_01418Trm112p-like protein. (127 aa)
VDAG_03357Fe2OG dioxygenase domain-containing protein. (239 aa)
VDAG_03031N(5)-glutamine methyltransferase MTQ2. (263 aa)
VDAG_04751Elongator complex protein 3; Catalytic tRNA acetyltransferase subunit of the RNA polymerase II elongator complex, which is a component of the RNA polymerase II (Pol II) holoenzyme and is involved in transcriptional elongation. (578 aa)
NCS2Cytoplasmic tRNA 2-thiolation protein 2; Plays a central role in 2-thiolation of mcm(5)S(2)U at tRNA wobble positions of tRNA(Lys), tRNA(Glu) and tRNA(Gln). May act by forming a heterodimer with NCS6 that ligates sulfur from thiocarboxylated URM1 onto the uridine of tRNAs at wobble position. Prior mcm(5) tRNA modification by the elongator complex is required for 2-thiolation. May also be involved in protein urmylation. (394 aa)
VDAG_06670RNA polymerase II elongator complex subunit. (327 aa)
VDAG_06775tRNA (Uracil-5-)-methyltransferase TRM9. (282 aa)
VDAG_06917Elongator complex protein 1; Component of the RNA polymerase II elongator complex, a multiprotein complex associated with the RNA polymerase II (Pol II) holoenzyme, and which is involved in transcriptional elongation. Belongs to the ELP1/IKA1 family. (1303 aa)
NCS6Cytoplasmic tRNA 2-thiolation protein 1; Plays a central role in 2-thiolation of mcm(5)S(2)U at tRNA wobble positions of tRNA(Lys), tRNA(Glu) and tRNA(Gln). Directly binds tRNAs and probably acts by catalyzing adenylation of tRNAs, an intermediate required for 2-thiolation. It is unclear whether it acts as a sulfurtransferase that transfers sulfur from thiocarboxylated URM1 onto the uridine of tRNAs at wobble position. Prior mcm(5) tRNA modification by the elongator complex is required for 2-thiolation. May also be involved in protein urmylation. (399 aa)
VDAG_08388Uncharacterized protein. (198 aa)
VDAG_08450Elongator complex protein. (824 aa)
URM1Ubiquitin-related modifier 1; Acts as a sulfur carrier required for 2-thiolation of mcm(5)S(2)U at tRNA wobble positions of cytosolic tRNA(Lys), tRNA(Glu) and tRNA(Gln). Serves as sulfur donor in tRNA 2-thiolation reaction by being thiocarboxylated (-COSH) at its C-terminus by the MOCS3 homolog UBA4. The sulfur is then transferred to tRNA to form 2-thiolation of mcm(5)S(2)U. Prior mcm(5) tRNA modification by the elongator complex is required for 2-thiolation. Also acts as a ubiquitin-like protein (UBL) that is covalently conjugated via an isopeptide bond to lysine residues of target pr [...] (112 aa)
VDAG_09201Uncharacterized protein. (97 aa)
VDAG_10429Paxneb protein superfamily. (117 aa)
uba4Adenylyltransferase and sulfurtransferase uba4; Plays a central role in 2-thiolation of mcm(5)S(2)U at tRNA wobble positions of cytosolic tRNA(Lys), tRNA(Glu) and tRNA(Gln). Also essential during biosynthesis of the molybdenum cofactor. Acts by mediating the C-terminal thiocarboxylation of sulfur carriers urm1 and MOCS2A. Its N-terminus first activates urm1 and MOCS2A as acyl- adenylates (-COAMP), then the persulfide sulfur on the catalytic cysteine is transferred to urm1 and MOCS2A to form thiocarboxylation (- COSH) of their C-terminus. The reaction probably involves hydrogen sulfide [...] (478 aa)
Your Current Organism:
Verticillium dahliae
NCBI taxonomy Id: 498257
Other names: V. dahliae VdLs.17, Verticillium dahliae VdLs.17
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