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pfp pfp tpiA tpiA pgk pgk gap gap ldh ldh EEF84196.1 EEF84196.1 nagA nagA nagB nagB EEF84610.1 EEF84610.1 EEF84774.1 EEF84774.1 eno eno pyk pyk mgsA mgsA manA manA EEF84410.1 EEF84410.1 EEF84236.1 EEF84236.1 fbaA fbaA EEF84339.1 EEF84339.1 EEF84396.1 EEF84396.1 EEF84274.1 EEF84274.1 EEF84261.1 EEF84261.1 EEF84343.1 EEF84343.1 ptsP ptsP EEF84315.1 EEF84315.1 gnd gnd ackA ackA EEF84454.1 EEF84454.1 pfkB pfkB zwf zwf EEF84550.1 EEF84550.1 rpiA rpiA gpmA gpmA EEF84579.1 EEF84579.1 pfkA pfkA pgi pgi EEF84891.1 EEF84891.1 EEF84907.1 EEF84907.1 glpK glpK EEF84623.1 EEF84623.1 EEF84803.1 EEF84803.1 pta pta nanE nanE
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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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query proteins and first shell of interactors
white nodes:
second shell of interactors
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proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
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pfpDiphosphate--fructose-6-phosphate 1-phosphotransferase; Catalyzes the phosphorylation of D-fructose 6-phosphate, the first committing step of glycolysis. Uses inorganic phosphate (PPi) as phosphoryl donor instead of ATP like common ATP-dependent phosphofructokinases (ATP-PFKs), which renders the reaction reversible, and can thus function both in glycolysis and gluconeogenesis. Consistently, PPi-PFK can replace the enzymes of both the forward (ATP- PFK) and reverse (fructose-bisphosphatase (FBPase)) reactions. (555 aa)
tpiATriose-phosphate isomerase; Involved in the gluconeogenesis. Catalyzes stereospecifically the conversion of dihydroxyacetone phosphate (DHAP) to D- glyceraldehyde-3-phosphate (G3P); Belongs to the triosephosphate isomerase family. (253 aa)
pgkPhosphoglycerate kinase; Identified by match to protein family HMM PF00162; Belongs to the phosphoglycerate kinase family. (393 aa)
gapGlyceraldehyde-3-phosphate dehydrogenase, type I; Identified by match to protein family HMM PF00044; match to protein family HMM PF02800; match to protein family HMM TIGR01534; Belongs to the glyceraldehyde-3-phosphate dehydrogenase family. (335 aa)
ldhL-lactate dehydrogenase; Catalyzes the conversion of lactate to pyruvate. Belongs to the LDH/MDH superfamily. LDH family. (316 aa)
EEF84196.1Pts system, maltose and glucose-specific iiabc component; Identified by match to protein family HMM PF00367; match to protein family HMM PF02378. (564 aa)
nagAN-acetylglucosamine-6-phosphate deacetylase; Identified by match to protein family HMM PF01979; match to protein family HMM TIGR00221. (401 aa)
nagBGlucosamine-6-phosphate deaminase; Catalyzes the reversible isomerization-deamination of glucosamine 6-phosphate (GlcN6P) to form fructose 6-phosphate (Fru6P) and ammonium ion; Belongs to the glucosamine/galactosamine-6-phosphate isomerase family. NagB subfamily. (268 aa)
EEF84610.16-phosphogluconolactonase; Identified by match to protein family HMM PF01182. (235 aa)
EEF84774.1Glycerol uptake facilitator; Identified by match to protein family HMM PF00230; match to protein family HMM TIGR00861; Belongs to the MIP/aquaporin (TC 1.A.8) family. (254 aa)
enoPhosphopyruvate hydratase; Catalyzes the reversible conversion of 2-phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis; Belongs to the enolase family. (433 aa)
pykPyruvate kinase; Identified by match to protein family HMM PF00224; match to protein family HMM PF02887; match to protein family HMM TIGR01064; Belongs to the pyruvate kinase family. (477 aa)
mgsAMethylglyoxal synthase; Catalyzes the formation of methylglyoxal from dihydroxyacetone phosphate. (127 aa)
manAMannose-6-phosphate isomerase, class I; Identified by match to protein family HMM PF01238; match to protein family HMM TIGR00218. (371 aa)
EEF84410.1Pts system, fructose-specific iiabc component; Identified by match to protein family HMM PF00359; match to protein family HMM PF02378; match to protein family HMM PF02379; match to protein family HMM TIGR00829; match to protein family HMM TIGR00848; match to protein family HMM TIGR01427. (625 aa)
EEF84236.1Identified by match to protein family HMM PF05014. (182 aa)
fbaAFructose-bisphosphate aldolase, class II; Catalyzes the aldol condensation of dihydroxyacetone phosphate (DHAP or glycerone-phosphate) with glyceraldehyde 3-phosphate (G3P) to form fructose 1,6-bisphosphate (FBP) in gluconeogenesis and the reverse reaction in glycolysis; Belongs to the class II fructose-bisphosphate aldolase family. (359 aa)
EEF84339.1Na+/H+ antiporter; Identified by match to protein family HMM PF00999. (701 aa)
EEF84396.1Phosphocarrier protein HPr; Identified by match to protein family HMM PF00381; match to protein family HMM TIGR01003. (91 aa)
EEF84274.1Ribose-phosphate diphosphokinase; Identified by match to protein family HMM PF00156; match to protein family HMM TIGR01251; Belongs to the ribose-phosphate pyrophosphokinase family. (406 aa)
EEF84261.1Xylulokinase; Identified by match to protein family HMM PF00370; match to protein family HMM PF02782. (454 aa)
EEF84343.1Phosphocarrier protein HPr; Identified by match to protein family HMM PF00381; match to protein family HMM TIGR01003. (86 aa)
ptsPPhosphoenolpyruvate-protein phosphotransferase; General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr). (573 aa)
EEF84315.1PTS system, glucose-specific IIA component; Identified by match to protein family HMM PF00358; match to protein family HMM TIGR00830. (189 aa)
gnd6-phosphogluconate dehydrogenase, decarboxylating; Catalyzes the oxidative decarboxylation of 6-phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH. (464 aa)
ackAAcetate kinase; Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction; Belongs to the acetokinase family. (405 aa)
EEF84454.1Pts system, fructose-specific iiabc component; Identified by match to protein family HMM PF00359; match to protein family HMM PF02378; match to protein family HMM PF02379; match to protein family HMM TIGR00829; match to protein family HMM TIGR00848; match to protein family HMM TIGR01427. (620 aa)
pfkB1-phosphofructokinase; Identified by match to protein family HMM PF00294; match to protein family HMM TIGR03168; Belongs to the carbohydrate kinase PfkB family. (307 aa)
zwfGlucose-6-phosphate dehydrogenase; Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone. (478 aa)
EEF84550.1Pts system, iibc component; Identified by match to protein family HMM PF00367; match to protein family HMM PF02378; match to protein family HMM TIGR00826; match to protein family HMM TIGR00852. (514 aa)
rpiARibose 5-phosphate isomerase A; Identified by match to protein family HMM PF06026; match to protein family HMM TIGR00021. (228 aa)
gpmAPhosphoglycerate mutase family protein; Catalyzes the interconversion of 2-phosphoglycerate and 3- phosphoglycerate. (248 aa)
EEF84579.1Xylose operon regulatory protein; Identified by match to protein family HMM PF00480. (402 aa)
pfkAPhosphofructokinase; Catalyzes the phosphorylation of D-fructose 6-phosphate to fructose 1,6-bisphosphate by ATP, the first committing step of glycolysis; Belongs to the phosphofructokinase type A (PFKA) family. PPi-dependent PFK group II subfamily. Atypical ATP-dependent clade 'X' sub-subfamily. (447 aa)
pgiGlucose-6-phosphate isomerase; Identified by match to protein family HMM PF00342; Belongs to the GPI family. (530 aa)
EEF84891.1Xylose operon regulatory protein; Identified by match to protein family HMM PF00480. (311 aa)
EEF84907.1Phosphomannomutase; Identified by match to protein family HMM PF02878; match to protein family HMM PF02879; match to protein family HMM PF02880. (569 aa)
glpKGlycerol kinase; Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate; Belongs to the FGGY kinase family. (502 aa)
EEF84623.1Conserved hypothetical protein. (45 aa)
EEF84803.1Glycerol-3-phosphate dehydrogenase; Identified by match to protein family HMM PF01266. (522 aa)
ptaPhosphate acetyltransferase; Identified by match to protein family HMM PF01515; match to protein family HMM TIGR00651. (345 aa)
nanEPutative N-acetylmannosamine-6-phosphate 2-epimerase 1; Converts N-acetylmannosamine-6-phosphate (ManNAc-6-P) to N- acetylglucosamine-6-phosphate (GlcNAc-6-P). (206 aa)
Your Current Organism:
Borreliella spielmanii
NCBI taxonomy Id: 498742
Other names: B. spielmanii A14S, Borrelia spielmanii A14S, Borreliella spielmanii A14S
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