(50 nodes) Heterochromatin assembly network (Penicillium rubens)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	Pc22g02750	Pc22g02750 protein. (303 aa)
	Pc22g06860	Histone acetyltransferase; Belongs to the MYST (SAS/MOZ) family. (1096 aa)
	Pc22g11850	Pc22g11850 protein. (247 aa)
	MCM7	DNA replication licensing factor MCM7; Acts as component of the mcm2-7 complex (mcm complex) which is the putative replicative helicase essential for 'once per cell cycle' DNA replication initiation and elongation in eukaryotic cells. The active ATPase sites in the mcm2-7 ring are formed through the interaction surfaces of two neighboring subunits such that a critical structure of a conserved arginine finger motif is provided in trans relative to the ATP-binding site of the Walker A box of the adjacent subunit. The six ATPase active sites, however, are likely to contribute differential [...] (812 aa)
	Pc22g03550	Pc22g03550 protein. (1454 aa)
	Pc22g07980	Pc22g07980 protein. (521 aa)
	Pc22g21370	Pc22g21370 protein. (486 aa)
	Pc22g08490	NAD-dependent protein deacetylase; Belongs to the sirtuin family. Class I subfamily. (361 aa)
	Pc22g05260	Pc22g05260 protein. (486 aa)
	Pc13g10110	Pc13g10110 protein. (1923 aa)
	Pc12g04480	tRNA dimethylallyltransferase; Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37; Belongs to the IPP transferase family. (462 aa)
	Pc12g07220	Pc12g07220 protein. (253 aa)
	Pc12g07210	Pc12g07210 protein. (652 aa)
	Pc12g07170	Pc12g07170 protein. (1665 aa)
	Pc14g00270	NAD-dependent protein deacetylase; Belongs to the sirtuin family. Class I subfamily. (340 aa)
	Pc14g00650	Pc14g00650 protein. (597 aa)
	Pc14g01900	Pc14g01900 protein. (452 aa)
	Pc16g08300	DNA helicase; Belongs to the MCM family. (879 aa)
	Pc16g04140	Pc16g04140 protein. (565 aa)
	Pc16g04600	Pc16g04600 protein. (840 aa)
	Pc16g09820	Serine/threonine-protein phosphatase; Belongs to the PPP phosphatase family. (324 aa)
	Pc16g14000	Pc16g14000 protein. (477 aa)
	Pc18g00330	Pc18g00330 protein. (848 aa)
	Pc20g07250	Pc20g07250 protein. (1119 aa)
	Pc20g08590	Histone H2A; Belongs to the histone H2A family. (132 aa)
	Pc20g09120	Pc20g09120 protein. (611 aa)
	Pc20g02950	RNA-dependent RNA polymerase. (1368 aa)
	Pc20g00850	Pc20g00850 protein. (117 aa)
	Pc20g14310	Histone acetyltransferase type B catalytic subunit; Catalytic component of the histone acetylase B (HAT-B) complex. Has intrinsic substrate specificity that modifies lysine in recognition sequence GXGKXG. Involved in DNA double-strand break repair; Belongs to the HAT1 family. (500 aa)
	Pc21g00720	Pc21g00720 protein. (1019 aa)
	Pc21g10170	Pc21g10170 protein. (189 aa)
	Pc21g14540	Histone H2A; Belongs to the histone H2A family. (139 aa)
	Pc13g02790	Pc13g02790 protein. (515 aa)
	Pc12g06450	Pc12g06450 protein. (410 aa)
	Pc21g14570	Histone deacetylase; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. (767 aa)
	Pc12g05980	FACT complex subunit POB3; Component of the FACT complex, a general chromatin factor that acts to reorganize nucleosomes. The FACT complex is involved in multiple processes that require DNA as a template such as mRNA elongation, DNA replication and DNA repair. During transcription elongation the FACT complex acts as a histone chaperone that both destabilizes and restores nucleosomal structure. It facilitates the passage of RNA polymerase II and transcription by promoting the dissociation of one histone H2A-H2B dimer from the nucleosome, then subsequently promotes the reestablishment of [...] (558 aa)
	Pc12g05640	Pc12g05640 protein. (697 aa)
	Pc12g01880	Pc12g01880 protein. (1084 aa)
	Pc12g01620	Pc12g01620 protein. (889 aa)
	Pc12g09130	Pc12g09130 protein. (241 aa)
	Pc12g15930	Histone acetyltransferase; Belongs to the MYST (SAS/MOZ) family. (354 aa)
	Pc12g15620	Pc12g15620 protein. (756 aa)
	Pc21g06310	Pc21g06310 protein. (899 aa)
	Pc21g19440	Pc21g19440 protein. (542 aa)
	Pc21g15650	DNA helicase; Belongs to the MCM family. (719 aa)
	Pc21g07230	Histone-lysine N-methyltransferase, H3 lysine-79 specific; Histone methyltransferase that specifically methylates histone H3 to form H3K79me. This methylation is required for telomere silencing and for the pachytene checkpoint during the meiotic cell cycle by allowing the recruitment of RAD9 to double strand breaks. Nucleosomes are preferred as substrate compared to free histones. (505 aa)
	Pc21g17110	Pc21g17110 protein. (1177 aa)
	Pc21g08640	Pc21g08640 protein. (1184 aa)
	Pc21g08680	Pc21g08680 protein; Belongs to the cullin family. (854 aa)
	Pc22g02950	Pc22g02950 protein. (1088 aa)

Your Current Organism:

Penicillium rubens

NCBI taxonomy Id: 500485
Other names: P. rubens Wisconsin 54-1255, Penicillium rubens Wisconsin 54-1255

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
MCM7	Pc12g05980	B6HQS3	B6GZX1	DNA replication licensing factor MCM7; Acts as component of the mcm2-7 complex (mcm complex) which is the putative replicative helicase essential for 'once per cell cycle' DNA replication initiation and elongation in eukaryotic cells. The active ATPase sites in the mcm2-7 ring are formed through the interaction surfaces of two neighboring subunits such that a critical structure of a conserved arginine finger motif is provided in trans relative to the ATP-binding site of the Walker A box of the adjacent subunit. The six ATPase active sites, however, are likely to contribute differential [...]	FACT complex subunit POB3; Component of the FACT complex, a general chromatin factor that acts to reorganize nucleosomes. The FACT complex is involved in multiple processes that require DNA as a template such as mRNA elongation, DNA replication and DNA repair. During transcription elongation the FACT complex acts as a histone chaperone that both destabilizes and restores nucleosomal structure. It facilitates the passage of RNA polymerase II and transcription by promoting the dissociation of one histone H2A-H2B dimer from the nucleosome, then subsequently promotes the reestablishment of [...]	0.629
MCM7	Pc16g08300	B6HQS3	B6H830	DNA replication licensing factor MCM7; Acts as component of the mcm2-7 complex (mcm complex) which is the putative replicative helicase essential for 'once per cell cycle' DNA replication initiation and elongation in eukaryotic cells. The active ATPase sites in the mcm2-7 ring are formed through the interaction surfaces of two neighboring subunits such that a critical structure of a conserved arginine finger motif is provided in trans relative to the ATP-binding site of the Walker A box of the adjacent subunit. The six ATPase active sites, however, are likely to contribute differential [...]	DNA helicase; Belongs to the MCM family.	0.999
MCM7	Pc20g00850	B6HQS3	B6HGD5	DNA replication licensing factor MCM7; Acts as component of the mcm2-7 complex (mcm complex) which is the putative replicative helicase essential for 'once per cell cycle' DNA replication initiation and elongation in eukaryotic cells. The active ATPase sites in the mcm2-7 ring are formed through the interaction surfaces of two neighboring subunits such that a critical structure of a conserved arginine finger motif is provided in trans relative to the ATP-binding site of the Walker A box of the adjacent subunit. The six ATPase active sites, however, are likely to contribute differential [...]	Pc20g00850 protein.	0.567
MCM7	Pc21g14540	B6HQS3	B6HI57	DNA replication licensing factor MCM7; Acts as component of the mcm2-7 complex (mcm complex) which is the putative replicative helicase essential for 'once per cell cycle' DNA replication initiation and elongation in eukaryotic cells. The active ATPase sites in the mcm2-7 ring are formed through the interaction surfaces of two neighboring subunits such that a critical structure of a conserved arginine finger motif is provided in trans relative to the ATP-binding site of the Walker A box of the adjacent subunit. The six ATPase active sites, however, are likely to contribute differential [...]	Histone H2A; Belongs to the histone H2A family.	0.484
MCM7	Pc21g15650	B6HQS3	B6HJW3	DNA replication licensing factor MCM7; Acts as component of the mcm2-7 complex (mcm complex) which is the putative replicative helicase essential for 'once per cell cycle' DNA replication initiation and elongation in eukaryotic cells. The active ATPase sites in the mcm2-7 ring are formed through the interaction surfaces of two neighboring subunits such that a critical structure of a conserved arginine finger motif is provided in trans relative to the ATP-binding site of the Walker A box of the adjacent subunit. The six ATPase active sites, however, are likely to contribute differential [...]	DNA helicase; Belongs to the MCM family.	0.999
Pc12g01620	Pc21g00720	B6GZ35	B6HHF5	Pc12g01620 protein.	Pc21g00720 protein.	0.545
Pc12g05640	Pc12g15620	B6GZG3	B6GY31	Pc12g05640 protein.	Pc12g15620 protein.	0.712
Pc12g05640	Pc21g14570	B6GZG3	B6HI60	Pc12g05640 protein.	Histone deacetylase; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events.	0.603
Pc12g05980	MCM7	B6GZX1	B6HQS3	FACT complex subunit POB3; Component of the FACT complex, a general chromatin factor that acts to reorganize nucleosomes. The FACT complex is involved in multiple processes that require DNA as a template such as mRNA elongation, DNA replication and DNA repair. During transcription elongation the FACT complex acts as a histone chaperone that both destabilizes and restores nucleosomal structure. It facilitates the passage of RNA polymerase II and transcription by promoting the dissociation of one histone H2A-H2B dimer from the nucleosome, then subsequently promotes the reestablishment of [...]	DNA replication licensing factor MCM7; Acts as component of the mcm2-7 complex (mcm complex) which is the putative replicative helicase essential for 'once per cell cycle' DNA replication initiation and elongation in eukaryotic cells. The active ATPase sites in the mcm2-7 ring are formed through the interaction surfaces of two neighboring subunits such that a critical structure of a conserved arginine finger motif is provided in trans relative to the ATP-binding site of the Walker A box of the adjacent subunit. The six ATPase active sites, however, are likely to contribute differential [...]	0.629
Pc12g05980	Pc14g01900	B6GZX1	B6H618	FACT complex subunit POB3; Component of the FACT complex, a general chromatin factor that acts to reorganize nucleosomes. The FACT complex is involved in multiple processes that require DNA as a template such as mRNA elongation, DNA replication and DNA repair. During transcription elongation the FACT complex acts as a histone chaperone that both destabilizes and restores nucleosomal structure. It facilitates the passage of RNA polymerase II and transcription by promoting the dissociation of one histone H2A-H2B dimer from the nucleosome, then subsequently promotes the reestablishment of [...]	Pc14g01900 protein.	0.494
Pc12g05980	Pc20g08590	B6GZX1	B6HEY9	FACT complex subunit POB3; Component of the FACT complex, a general chromatin factor that acts to reorganize nucleosomes. The FACT complex is involved in multiple processes that require DNA as a template such as mRNA elongation, DNA replication and DNA repair. During transcription elongation the FACT complex acts as a histone chaperone that both destabilizes and restores nucleosomal structure. It facilitates the passage of RNA polymerase II and transcription by promoting the dissociation of one histone H2A-H2B dimer from the nucleosome, then subsequently promotes the reestablishment of [...]	Histone H2A; Belongs to the histone H2A family.	0.878
Pc12g05980	Pc21g14540	B6GZX1	B6HI57	FACT complex subunit POB3; Component of the FACT complex, a general chromatin factor that acts to reorganize nucleosomes. The FACT complex is involved in multiple processes that require DNA as a template such as mRNA elongation, DNA replication and DNA repair. During transcription elongation the FACT complex acts as a histone chaperone that both destabilizes and restores nucleosomal structure. It facilitates the passage of RNA polymerase II and transcription by promoting the dissociation of one histone H2A-H2B dimer from the nucleosome, then subsequently promotes the reestablishment of [...]	Histone H2A; Belongs to the histone H2A family.	0.565
Pc12g05980	Pc21g15650	B6GZX1	B6HJW3	FACT complex subunit POB3; Component of the FACT complex, a general chromatin factor that acts to reorganize nucleosomes. The FACT complex is involved in multiple processes that require DNA as a template such as mRNA elongation, DNA replication and DNA repair. During transcription elongation the FACT complex acts as a histone chaperone that both destabilizes and restores nucleosomal structure. It facilitates the passage of RNA polymerase II and transcription by promoting the dissociation of one histone H2A-H2B dimer from the nucleosome, then subsequently promotes the reestablishment of [...]	DNA helicase; Belongs to the MCM family.	0.540
Pc12g05980	Pc22g21370	B6GZX1	B6HSH2	FACT complex subunit POB3; Component of the FACT complex, a general chromatin factor that acts to reorganize nucleosomes. The FACT complex is involved in multiple processes that require DNA as a template such as mRNA elongation, DNA replication and DNA repair. During transcription elongation the FACT complex acts as a histone chaperone that both destabilizes and restores nucleosomal structure. It facilitates the passage of RNA polymerase II and transcription by promoting the dissociation of one histone H2A-H2B dimer from the nucleosome, then subsequently promotes the reestablishment of [...]	Pc22g21370 protein.	0.994
Pc12g07170	Pc20g08590	B6GWR0	B6HEY9	Pc12g07170 protein.	Histone H2A; Belongs to the histone H2A family.	0.844
Pc12g07170	Pc22g11850	B6GWR0	B6HQP0	Pc12g07170 protein.	Pc22g11850 protein.	0.454
Pc12g09130	Pc20g02950	B6GYX9	B6HF55	Pc12g09130 protein.	RNA-dependent RNA polymerase.	0.505
Pc12g09130	Pc20g08590	B6GYX9	B6HEY9	Pc12g09130 protein.	Histone H2A; Belongs to the histone H2A family.	0.514
Pc12g09130	Pc21g08680	B6GYX9	B6HMC6	Pc12g09130 protein.	Pc21g08680 protein; Belongs to the cullin family.	0.582
Pc12g09130	Pc21g14540	B6GYX9	B6HI57	Pc12g09130 protein.	Histone H2A; Belongs to the histone H2A family.	0.756