(132 nodes) Positive regulation of transcription by RNA polymerase II network (Penicillium rubens)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	Pc06g01740	Pc06g01740 protein. (1038 aa)
	Pc12g07170	Pc12g07170 protein. (1665 aa)
	Pc12g07570	Pc12g07570 protein. (799 aa)
	Pc12g11600	GATA transcription factor nreB-Penicillium chrysogenum. (298 aa)
	Pc12g15330	Pc12g15330 protein. (214 aa)
	Pc12g04570	Pc12g04570 protein. (463 aa)
	Pc12g04590	Pc12g04590 protein. (589 aa)
	Pc12g04670	Pc12g04670 protein. (266 aa)
	Pc12g01260	Pc12g01260 protein. (541 aa)
	Pc12g16450	Pc12g16450 protein. (427 aa)
	Pc12g13040	Pc12g13040 protein. (241 aa)
	Pc12g05460	Pc12g05460 protein. (679 aa)
	Pc12g09510	Pc12g09510 protein. (434 aa)
	Pc12g05980	FACT complex subunit POB3; Component of the FACT complex, a general chromatin factor that acts to reorganize nucleosomes. The FACT complex is involved in multiple processes that require DNA as a template such as mRNA elongation, DNA replication and DNA repair. During transcription elongation the FACT complex acts as a histone chaperone that both destabilizes and restores nucleosomal structure. It facilitates the passage of RNA polymerase II and transcription by promoting the dissociation of one histone H2A-H2B dimer from the nucleosome, then subsequently promotes the reestablishment of [...] (558 aa)
	Pc12g02480	Serine/threonine-protein kinase. (1143 aa)
	Pc12g02800	Pc12g02800 protein. (527 aa)
	Pc12g06750	Pc12g06750 protein. (857 aa)
	Pc12g14500	Pc12g14500 protein. (611 aa)
	Pc13g02690	Pc13g02690 protein; Belongs to the AAA ATPase family. (462 aa)
	Pc13g02130	Pc13g02130 protein. (657 aa)
	Pc13g03120	Pc13g03120 protein. (760 aa)
	Pc13g03170	Pc13g03170 protein. (319 aa)
	Pc13g03180	Pc13g03180 protein. (1515 aa)
	Pc13g04530	Pc13g04530 protein. (257 aa)
	Pc13g15400	Pc13g15400 protein. (765 aa)
	Pc13g05760	Pc13g05760 protein; Belongs to the AAA ATPase family. (389 aa)
	Pc13g12780	Pc13g12780 protein. (1397 aa)
	Pc13g12950	Pc13g12950 protein. (401 aa)
	Pc13g13130	Pc13g13130 protein. (1402 aa)
	Pc13g06620	Pc13g06620 protein. (1069 aa)
	Pc13g09440	Pc13g09440 protein. (729 aa)
	Pc13g09660	Pc13g09660 protein; Belongs to the AAA ATPase family. (422 aa)
	Pc13g08420	Pc13g08420 protein. (859 aa)
	Pc13g09070	Pc13g09070 protein. (492 aa)
	Pc13g11590	Pc13g11590 protein. (235 aa)
	Pc13g12010	Pc13g12010 protein. (326 aa)
	Pc14g00630	Pc14g00630 protein. (315 aa)
	Pc14g00760	Transcription initiation factor IIF subunit alpha; TFIIF is a general transcription initiation factor that binds to RNA polymerase II and helps to recruit it to the initiation complex in collaboration with TFIIB. It promotes transcription elongation. Belongs to the TFIIF alpha subunit family. (691 aa)
	Pc14g01630	Pc14g01630 protein. (212 aa)
	Pc14g01750	Pc14g01750 protein; Belongs to the AAA ATPase family. (390 aa)
	Pc15g00590	Pc15g00590 protein. (443 aa)
	Pc16g00930	Pc16g00930 protein. (838 aa)
	Pc16g02300	Pc16g02300 protein. (435 aa)
	Pc16g06560	Pc16g06560 protein. (496 aa)
	Pc16g06920	Pc16g06920 protein. (352 aa)
	Pc16g03960	Pc16g03960 protein. (801 aa)
	Pc16g05420	Pc16g05420 protein. (559 aa)
	Pc16g07970	Pc16g07970 protein. (768 aa)
	Pc16g05890	Pc16g05890 protein. (553 aa)
	Pc16g05930	Pc16g05930 protein. (345 aa)
	Pc16g02960	Pc16g02960 protein. (396 aa)
	Pc16g04450	Pc16g04450 protein. (878 aa)
	Pc16g04610	Pc16g04610 protein. (164 aa)
	Pc16g04030	Pc16g04030 protein. (352 aa)
	Pc16g11170	Pc16g11170 protein. (544 aa)
	Pc16g11930	Pc16g11930 protein. (142 aa)
	Pc17g00340	Pc17g00340 protein. (486 aa)
	Pc17g00660	Pc17g00660 protein. (134 aa)
	Pc17g00690	Pc17g00690 protein. (528 aa)
	Pc18g03030	Pc18g03030 protein. (335 aa)
	Pc18g03580	Pc18g03580 protein. (796 aa)
	Pc18g04030	Pc18g04030 protein. (367 aa)
	Pc18g00250	Pc18g00250 protein. (277 aa)
	pacC	Transcription factor pacC-Penicillium chrysogenum. (643 aa)
	Pc18g00430	Pc18g00430 protein. (718 aa)
	Pc18g06160	Pc18g06160 protein. (276 aa)
	Pc18g02440	Pc18g02440 protein. (366 aa)
	Pc18g02520	Pc18g02520 protein. (274 aa)
	Pc18g02690	Pc18g02690 protein. (684 aa)
	Pc18g02700	Pc18g02700 protein. (605 aa)
	Pc19g00220	Pc19g00220 protein. (566 aa)
	Pc19g00580	Pc19g00580 protein. (537 aa)
	Pc20g07370	Pc20g07370 protein. (390 aa)
	KAE1	tRNA N6-adenosine threonylcarbamoyltransferase; Component of the EKC/KEOPS complex that is required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. The complex is probably involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37. KAE1 likely plays a direct catalytic role in this reaction, but requires other protein(s) of the complex to fulfill this activity. The EKC/KEOPS complex also promotes both telomere uncapping and telomere elongation. Th [...] (364 aa)
	Pc20g12130	Pc20g12130 protein. (657 aa)
	Pc20g15260	Pc20g15260 protein. (723 aa)
	Pc20g05030	Pc20g05030 protein. (609 aa)
	Pc20g07700	Pc20g07700 protein. (788 aa)
	Pc20g08080	Transcription elongation factor Spt6; Plays a role in maintenance of chromatin structure during RNA polymerase II transcription elongation thereby repressing transcription initiation from cryptic promoters. Mediates the reassembly of nucleosomes onto the promoters of at least a selected set of genes during repression; the nucleosome reassembly is essential for transcriptional repression; Belongs to the SPT6 family. (1409 aa)
	Pc20g09050	Pc20g09050 protein; Belongs to the protein kinase superfamily. (404 aa)
	Pc20g09120	Pc20g09120 protein. (611 aa)
	Pc20g02860	Pc20g02860 protein. (666 aa)
	Pc20g09600	Pc20g09600 protein. (791 aa)
	Pc20g00540	Pc20g00540 protein. (537 aa)
	Pc20g03270	Pc20g03270 protein. (584 aa)
	Pc20g11250	Pc20g11250 protein. (851 aa)
	Pc20g03580	Pc20g03580 protein. (154 aa)
	Pc20g14170	Pc20g14170 protein. (875 aa)
	Pc20g14610	Pc20g14610 protein. (428 aa)
	Pc21g05540	Pc21g05540 protein. (631 aa)
	sreP	GATA transcription factor sreP-Penicillium chrysogenum. (532 aa)
	Pc21g14570	Histone deacetylase; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. (767 aa)
	Pc21g18680	Pc21g18680 protein. (414 aa)
	Pc21g19600	Pc21g19600 protein. (360 aa)
	Pc21g11110	Pc21g11110 protein. (1634 aa)
	Pc21g02570	Transcription initiation factor IIA subunit 2; TFIIA is a component of the transcription machinery of RNA polymerase II and plays an important role in transcriptional activation; Belongs to the TFIIA subunit 2 family. (111 aa)
	Pc21g02700	Pc21g02700 protein. (551 aa)
	Pc21g11840	Pc21g11840 protein. (768 aa)
	Pc21g16250	Pc21g16250 protein. (1078 aa)
	Pc21g03530	Pc21g03530 protein. (1025 aa)
	Pc21g08380	Pc21g08380 protein. (671 aa)
	Pc21g21760	Pc21g21760 protein. (366 aa)
	Pc21g04200	Pc21g04200 protein. (204 aa)
	Pc21g17380	Pc21g17380 protein. (1399 aa)
	Pc21g13790	Pc21g13790 protein. (135 aa)
	Pc21g18040	Pc21g18040 protein. (341 aa)
	Pc22g00120	Pc22g00120 protein. (528 aa)
	Pc22g03090	Mediator of RNA polymerase II transcription subunit 1; Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. (782 aa)
	Pc22g19920	Pc22g19920 protein. (425 aa)
	Pc22g06790	Pc22g06790 protein. (194 aa)
	Pc22g06860	Histone acetyltransferase; Belongs to the MYST (SAS/MOZ) family. (1096 aa)
	Pc22g24340	Pc22g24340 protein. (210 aa)
	Pc22g11570	Pc22g11570 protein. (683 aa)
	Pc22g16000	Pc22g16000 protein. (284 aa)
	Pc22g03590	Pc22g03590 protein. (1100 aa)
	Pc22g04440	Pc22g04440 protein. (626 aa)
	Pc22g08800	Pc22g08800 protein. (481 aa)
	Pc22g13790	Pc22g13790 protein. (337 aa)
	Pc22g13920	Pc22g13920 protein. (509 aa)
	Pc22g14010	Pc22g14010 protein. (1424 aa)
	Pc22g26920	Pc22g26920 protein. (734 aa)
	Pc22g05530	Pc22g05530 protein. (387 aa)
	Pc22g05580	Pc22g05580 protein. (513 aa)
	Pc22g05830	Pc22g05830 protein. (230 aa)
	phoG	Acid phosphatase phoG-Penicillium chrysogenum. (593 aa)
	Pc22g10290	Cyclin-dependent kinases regulatory subunit; Binds to the catalytic subunit of the cyclin dependent kinases and is essential for their biological function. (114 aa)
	Pc22g06240	Pc22g06240 protein. (651 aa)
	Pc22g23820	Pc22g23820 protein. (373 aa)
	Pc23g00420	Pc23g00420 protein. (636 aa)
	Pc24g00540	Pc24g00540 protein. (386 aa)
	Pc24g02200	Pc24g02200 protein. (270 aa)
	Pc24g02480	Pc24g02480 protein. (284 aa)

Your Current Organism:

Penicillium rubens

NCBI taxonomy Id: 500485
Other names: P. rubens Wisconsin 54-1255, Penicillium rubens Wisconsin 54-1255

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
Pc12g02480	Pc12g06750	B6H026	B6H0N5	Serine/threonine-protein kinase.	Pc12g06750 protein.	0.530
Pc12g02480	Pc13g15400	B6H026	B6H2U3	Serine/threonine-protein kinase.	Pc13g15400 protein.	0.511
Pc12g02480	Pc18g00430	B6H026	B6HBT5	Serine/threonine-protein kinase.	Pc18g00430 protein.	0.501
Pc12g02480	Pc20g03270	B6H026	B6HFQ8	Serine/threonine-protein kinase.	Pc20g03270 protein.	0.532
Pc12g02480	Pc21g04200	B6H026	B6HM93	Serine/threonine-protein kinase.	Pc21g04200 protein.	0.580
Pc12g02480	Pc21g13790	B6H026	B6HNQ4	Serine/threonine-protein kinase.	Pc21g13790 protein.	0.414
Pc12g02480	Pc22g10290	B6H026	B6HVK8	Serine/threonine-protein kinase.	Cyclin-dependent kinases regulatory subunit; Binds to the catalytic subunit of the cyclin dependent kinases and is essential for their biological function.	0.471
Pc12g02480	Pc22g14010	B6H026	B6HU31	Serine/threonine-protein kinase.	Pc22g14010 protein.	0.741
Pc12g04570	pacC	B6GXY0	B6HBT4	Pc12g04570 protein.	Transcription factor pacC-Penicillium chrysogenum.	0.400
Pc12g04590	Pc20g14170	B6GY70	B6HHA3	Pc12g04590 protein.	Pc20g14170 protein.	0.946
Pc12g04670	Pc14g01630	B6GY78	B6H5Z1	Pc12g04670 protein.	Pc14g01630 protein.	0.998
Pc12g04670	Pc22g13920	B6GY78	B6HU22	Pc12g04670 protein.	Pc22g13920 protein.	0.993
Pc12g04670	sreP	B6GY78	B6HHZ5	Pc12g04670 protein.	GATA transcription factor sreP-Penicillium chrysogenum.	0.688
Pc12g05980	Pc12g16450	B6GZX1	B6GZ15	FACT complex subunit POB3; Component of the FACT complex, a general chromatin factor that acts to reorganize nucleosomes. The FACT complex is involved in multiple processes that require DNA as a template such as mRNA elongation, DNA replication and DNA repair. During transcription elongation the FACT complex acts as a histone chaperone that both destabilizes and restores nucleosomal structure. It facilitates the passage of RNA polymerase II and transcription by promoting the dissociation of one histone H2A-H2B dimer from the nucleosome, then subsequently promotes the reestablishment of [...]	Pc12g16450 protein.	0.950
Pc12g05980	Pc13g02130	B6GZX1	B6H1I1	FACT complex subunit POB3; Component of the FACT complex, a general chromatin factor that acts to reorganize nucleosomes. The FACT complex is involved in multiple processes that require DNA as a template such as mRNA elongation, DNA replication and DNA repair. During transcription elongation the FACT complex acts as a histone chaperone that both destabilizes and restores nucleosomal structure. It facilitates the passage of RNA polymerase II and transcription by promoting the dissociation of one histone H2A-H2B dimer from the nucleosome, then subsequently promotes the reestablishment of [...]	Pc13g02130 protein.	0.406
Pc12g05980	Pc14g00760	B6GZX1	B6H5Q4	FACT complex subunit POB3; Component of the FACT complex, a general chromatin factor that acts to reorganize nucleosomes. The FACT complex is involved in multiple processes that require DNA as a template such as mRNA elongation, DNA replication and DNA repair. During transcription elongation the FACT complex acts as a histone chaperone that both destabilizes and restores nucleosomal structure. It facilitates the passage of RNA polymerase II and transcription by promoting the dissociation of one histone H2A-H2B dimer from the nucleosome, then subsequently promotes the reestablishment of [...]	Transcription initiation factor IIF subunit alpha; TFIIF is a general transcription initiation factor that binds to RNA polymerase II and helps to recruit it to the initiation complex in collaboration with TFIIB. It promotes transcription elongation. Belongs to the TFIIF alpha subunit family.	0.695
Pc12g05980	Pc15g00590	B6GZX1	B6H6K5	FACT complex subunit POB3; Component of the FACT complex, a general chromatin factor that acts to reorganize nucleosomes. The FACT complex is involved in multiple processes that require DNA as a template such as mRNA elongation, DNA replication and DNA repair. During transcription elongation the FACT complex acts as a histone chaperone that both destabilizes and restores nucleosomal structure. It facilitates the passage of RNA polymerase II and transcription by promoting the dissociation of one histone H2A-H2B dimer from the nucleosome, then subsequently promotes the reestablishment of [...]	Pc15g00590 protein.	0.995
Pc12g05980	Pc16g02300	B6GZX1	B6H7B3	FACT complex subunit POB3; Component of the FACT complex, a general chromatin factor that acts to reorganize nucleosomes. The FACT complex is involved in multiple processes that require DNA as a template such as mRNA elongation, DNA replication and DNA repair. During transcription elongation the FACT complex acts as a histone chaperone that both destabilizes and restores nucleosomal structure. It facilitates the passage of RNA polymerase II and transcription by promoting the dissociation of one histone H2A-H2B dimer from the nucleosome, then subsequently promotes the reestablishment of [...]	Pc16g02300 protein.	0.999
Pc12g05980	Pc20g00540	B6GZX1	B6HFP2	FACT complex subunit POB3; Component of the FACT complex, a general chromatin factor that acts to reorganize nucleosomes. The FACT complex is involved in multiple processes that require DNA as a template such as mRNA elongation, DNA replication and DNA repair. During transcription elongation the FACT complex acts as a histone chaperone that both destabilizes and restores nucleosomal structure. It facilitates the passage of RNA polymerase II and transcription by promoting the dissociation of one histone H2A-H2B dimer from the nucleosome, then subsequently promotes the reestablishment of [...]	Pc20g00540 protein.	0.658
Pc12g05980	Pc20g05030	B6GZX1	B6HEC7	FACT complex subunit POB3; Component of the FACT complex, a general chromatin factor that acts to reorganize nucleosomes. The FACT complex is involved in multiple processes that require DNA as a template such as mRNA elongation, DNA replication and DNA repair. During transcription elongation the FACT complex acts as a histone chaperone that both destabilizes and restores nucleosomal structure. It facilitates the passage of RNA polymerase II and transcription by promoting the dissociation of one histone H2A-H2B dimer from the nucleosome, then subsequently promotes the reestablishment of [...]	Pc20g05030 protein.	0.992