(56 nodes) Nucleic acid-binding, OB-fold network (Penicillium rubens)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	Pc21g17430	Pc21g17430 protein. (254 aa)
	Pc22g23860	Pc22g23860 protein; Seems to be required for maximal rate of protein biosynthesis. Enhances ribosome dissociation into subunits and stabilizes the binding of the initiator Met-tRNA(I) to 40 S ribosomal subunits. (149 aa)
	Pc22g14740	Pc22g14740 protein; Belongs to the AAA ATPase family. (464 aa)
	Pc22g05390	Pc22g05390 protein; Belongs to the RNR ribonuclease family. (1031 aa)
	Pc22g05310	Pc22g05310 protein. (428 aa)
	Pc22g09050	mRNA-capping enzyme subunit alpha; Second step of mRNA capping. Transfer of the GMP moiety of GTP to the 5'-end of RNA via an enzyme-GMP covalent reaction intermediate; Belongs to the eukaryotic GTase family. (414 aa)
	Pc22g08870	Pc22g08870 protein. (577 aa)
	Pc22g21630	Pc22g21630 protein. (967 aa)
	MCM7	DNA replication licensing factor MCM7; Acts as component of the mcm2-7 complex (mcm complex) which is the putative replicative helicase essential for 'once per cell cycle' DNA replication initiation and elongation in eukaryotic cells. The active ATPase sites in the mcm2-7 ring are formed through the interaction surfaces of two neighboring subunits such that a critical structure of a conserved arginine finger motif is provided in trans relative to the ATP-binding site of the Walker A box of the adjacent subunit. The six ATPase active sites, however, are likely to contribute differential [...] (812 aa)
	Pc22g15660	Pc22g15660 protein. (145 aa)
	Pc22g02030	Pc22g02030 protein. (217 aa)
	Pc21g13500	Pc21g13500 protein. (1079 aa)
	Pc21g08830	Pc21g08830 protein. (68 aa)
	Pc21g08630	Pc21g08630 protein. (118 aa)
	Pc21g21700	Pc21g21700 protein. (276 aa)
	Pc21g03310	Pc21g03310 protein. (243 aa)
	Pc21g16040	Pc21g16040 protein. (1355 aa)
	Pc21g11440	Replication protein A subunit; As part of the replication protein A (RPA/RP-A), a single- stranded DNA-binding heterotrimeric complex, may play an essential role in DNA replication, recombination and repair. Binds and stabilizes single-stranded DNA intermediates, preventing complementary DNA reannealing and recruiting different proteins involved in DNA metabolism. (609 aa)
	Pc21g07170	DNA ligase. (990 aa)
	Pc21g07110	Pc21g07110 protein. (138 aa)
	Pc21g15650	DNA helicase; Belongs to the MCM family. (719 aa)
	Pc21g02360	Pc21g02360 protein. (444 aa)
	Pc21g15220	Pc21g15220 protein. (1057 aa)
	Pc21g10710	DNA helicase; Belongs to the MCM family. (953 aa)
	Pc21g02010	Pc21g02010 protein. (1806 aa)
	Pc21g01960	Pc21g01960 protein. (556 aa)
	Pc21g06420	Pc21g06420 protein; Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family. (537 aa)
	Pc21g10420	Pc21g10420 protein. (1231 aa)
	Pc21g10340	Pc21g10340 protein. (199 aa)
	Pc21g06060	DNA-directed RNA polymerases I, II, and III subunit RPABC3; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Common component of RNA polymerases I, II and III which synthesize ribosomal RNA precursors, mRNA precursors and many functional non- coding RNAs, and small RNAs, such as 5S rRNA and tRNAs, respectively. (143 aa)
	Pc21g05420	Pc21g05420 protein. (185 aa)
	Pc20g06040	Pc20g06040 protein; Belongs to the AAA ATPase family. (439 aa)
	Pc20g08110	Pc20g08110 protein. (391 aa)
	Pc18g06210	Pc18g06210 protein; Belongs to the universal ribosomal protein uS17 family. (160 aa)
	Pc16g13010	DNA ligase. (906 aa)
	Pc16g12100	Pc16g12100 protein. (136 aa)
	Pc16g09340	Lysine--tRNA ligase. (531 aa)
	Pc16g10450	DNA helicase; Belongs to the MCM family. (999 aa)
	Pc16g08300	DNA helicase; Belongs to the MCM family. (879 aa)
	Pc16g08430	Eukaryotic translation initiation factor 5A. (160 aa)
	Pc16g02610	Pc16g02610 protein; Belongs to the universal ribosomal protein uS12 family. (145 aa)
	Pc14g01750	Pc14g01750 protein; Belongs to the AAA ATPase family. (390 aa)
	Pc13g10160	Pc13g10160 protein. (807 aa)
	Pc13g08760	Pc13g08760 protein. (1368 aa)
	Pc13g08090	Pc13g08090 protein. (682 aa)
	Pc13g09660	Pc13g09660 protein; Belongs to the AAA ATPase family. (422 aa)
	Pc13g09370	DNA ligase. (833 aa)
	Pc13g05760	Pc13g05760 protein; Belongs to the AAA ATPase family. (389 aa)
	Pc13g15480	DNA helicase; Belongs to the MCM family. (896 aa)
	Pc13g02690	Pc13g02690 protein; Belongs to the AAA ATPase family. (462 aa)
	Pc12g03390	Pc12g03390 protein. (167 aa)
	Pc12g09250	Lysine--tRNA ligase. (624 aa)
	Pc12g16540	Pc12g16540 protein. (556 aa)
	Pc12g16300	Pc12g16300 protein. (272 aa)
	Pc12g15910	Pc12g15910 protein. (534 aa)
	Pc12g07200	Pc12g07200 protein. (282 aa)

Your Current Organism:

Penicillium rubens

NCBI taxonomy Id: 500485
Other names: P. rubens Wisconsin 54-1255, Penicillium rubens Wisconsin 54-1255

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a tab-delimited file describing the names, domains and descriptions of proteins in your network

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a tab-delimited file containing all known functional terms of proteins in your network

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
MCM7	Pc12g07200	B6HQS3	B6GWR3	DNA replication licensing factor MCM7; Acts as component of the mcm2-7 complex (mcm complex) which is the putative replicative helicase essential for 'once per cell cycle' DNA replication initiation and elongation in eukaryotic cells. The active ATPase sites in the mcm2-7 ring are formed through the interaction surfaces of two neighboring subunits such that a critical structure of a conserved arginine finger motif is provided in trans relative to the ATP-binding site of the Walker A box of the adjacent subunit. The six ATPase active sites, however, are likely to contribute differential [...]	Pc12g07200 protein.	0.748
MCM7	Pc13g09370	B6HQS3	B6H3T7	DNA replication licensing factor MCM7; Acts as component of the mcm2-7 complex (mcm complex) which is the putative replicative helicase essential for 'once per cell cycle' DNA replication initiation and elongation in eukaryotic cells. The active ATPase sites in the mcm2-7 ring are formed through the interaction surfaces of two neighboring subunits such that a critical structure of a conserved arginine finger motif is provided in trans relative to the ATP-binding site of the Walker A box of the adjacent subunit. The six ATPase active sites, however, are likely to contribute differential [...]	DNA ligase.	0.635
MCM7	Pc13g10160	B6HQS3	B6H4R6	DNA replication licensing factor MCM7; Acts as component of the mcm2-7 complex (mcm complex) which is the putative replicative helicase essential for 'once per cell cycle' DNA replication initiation and elongation in eukaryotic cells. The active ATPase sites in the mcm2-7 ring are formed through the interaction surfaces of two neighboring subunits such that a critical structure of a conserved arginine finger motif is provided in trans relative to the ATP-binding site of the Walker A box of the adjacent subunit. The six ATPase active sites, however, are likely to contribute differential [...]	Pc13g10160 protein.	0.993
MCM7	Pc13g15480	B6HQS3	B6H2T4	DNA replication licensing factor MCM7; Acts as component of the mcm2-7 complex (mcm complex) which is the putative replicative helicase essential for 'once per cell cycle' DNA replication initiation and elongation in eukaryotic cells. The active ATPase sites in the mcm2-7 ring are formed through the interaction surfaces of two neighboring subunits such that a critical structure of a conserved arginine finger motif is provided in trans relative to the ATP-binding site of the Walker A box of the adjacent subunit. The six ATPase active sites, however, are likely to contribute differential [...]	DNA helicase; Belongs to the MCM family.	0.999
MCM7	Pc16g08300	B6HQS3	B6H830	DNA replication licensing factor MCM7; Acts as component of the mcm2-7 complex (mcm complex) which is the putative replicative helicase essential for 'once per cell cycle' DNA replication initiation and elongation in eukaryotic cells. The active ATPase sites in the mcm2-7 ring are formed through the interaction surfaces of two neighboring subunits such that a critical structure of a conserved arginine finger motif is provided in trans relative to the ATP-binding site of the Walker A box of the adjacent subunit. The six ATPase active sites, however, are likely to contribute differential [...]	DNA helicase; Belongs to the MCM family.	0.999
MCM7	Pc16g10450	B6HQS3	B6H856	DNA replication licensing factor MCM7; Acts as component of the mcm2-7 complex (mcm complex) which is the putative replicative helicase essential for 'once per cell cycle' DNA replication initiation and elongation in eukaryotic cells. The active ATPase sites in the mcm2-7 ring are formed through the interaction surfaces of two neighboring subunits such that a critical structure of a conserved arginine finger motif is provided in trans relative to the ATP-binding site of the Walker A box of the adjacent subunit. The six ATPase active sites, however, are likely to contribute differential [...]	DNA helicase; Belongs to the MCM family.	0.999
MCM7	Pc16g13010	B6HQS3	B6HAJ2	DNA replication licensing factor MCM7; Acts as component of the mcm2-7 complex (mcm complex) which is the putative replicative helicase essential for 'once per cell cycle' DNA replication initiation and elongation in eukaryotic cells. The active ATPase sites in the mcm2-7 ring are formed through the interaction surfaces of two neighboring subunits such that a critical structure of a conserved arginine finger motif is provided in trans relative to the ATP-binding site of the Walker A box of the adjacent subunit. The six ATPase active sites, however, are likely to contribute differential [...]	DNA ligase.	0.728
MCM7	Pc21g05420	B6HQS3	B6HHI8	DNA replication licensing factor MCM7; Acts as component of the mcm2-7 complex (mcm complex) which is the putative replicative helicase essential for 'once per cell cycle' DNA replication initiation and elongation in eukaryotic cells. The active ATPase sites in the mcm2-7 ring are formed through the interaction surfaces of two neighboring subunits such that a critical structure of a conserved arginine finger motif is provided in trans relative to the ATP-binding site of the Walker A box of the adjacent subunit. The six ATPase active sites, however, are likely to contribute differential [...]	Pc21g05420 protein.	0.575
MCM7	Pc21g07170	B6HQS3	B6HK40	DNA replication licensing factor MCM7; Acts as component of the mcm2-7 complex (mcm complex) which is the putative replicative helicase essential for 'once per cell cycle' DNA replication initiation and elongation in eukaryotic cells. The active ATPase sites in the mcm2-7 ring are formed through the interaction surfaces of two neighboring subunits such that a critical structure of a conserved arginine finger motif is provided in trans relative to the ATP-binding site of the Walker A box of the adjacent subunit. The six ATPase active sites, however, are likely to contribute differential [...]	DNA ligase.	0.459
MCM7	Pc21g10710	B6HQS3	B6HJD4	DNA replication licensing factor MCM7; Acts as component of the mcm2-7 complex (mcm complex) which is the putative replicative helicase essential for 'once per cell cycle' DNA replication initiation and elongation in eukaryotic cells. The active ATPase sites in the mcm2-7 ring are formed through the interaction surfaces of two neighboring subunits such that a critical structure of a conserved arginine finger motif is provided in trans relative to the ATP-binding site of the Walker A box of the adjacent subunit. The six ATPase active sites, however, are likely to contribute differential [...]	DNA helicase; Belongs to the MCM family.	0.999
MCM7	Pc21g11440	B6HQS3	B6HK64	DNA replication licensing factor MCM7; Acts as component of the mcm2-7 complex (mcm complex) which is the putative replicative helicase essential for 'once per cell cycle' DNA replication initiation and elongation in eukaryotic cells. The active ATPase sites in the mcm2-7 ring are formed through the interaction surfaces of two neighboring subunits such that a critical structure of a conserved arginine finger motif is provided in trans relative to the ATP-binding site of the Walker A box of the adjacent subunit. The six ATPase active sites, however, are likely to contribute differential [...]	Replication protein A subunit; As part of the replication protein A (RPA/RP-A), a single- stranded DNA-binding heterotrimeric complex, may play an essential role in DNA replication, recombination and repair. Binds and stabilizes single-stranded DNA intermediates, preventing complementary DNA reannealing and recruiting different proteins involved in DNA metabolism.	0.789
MCM7	Pc21g15220	B6HQS3	B6HJG3	DNA replication licensing factor MCM7; Acts as component of the mcm2-7 complex (mcm complex) which is the putative replicative helicase essential for 'once per cell cycle' DNA replication initiation and elongation in eukaryotic cells. The active ATPase sites in the mcm2-7 ring are formed through the interaction surfaces of two neighboring subunits such that a critical structure of a conserved arginine finger motif is provided in trans relative to the ATP-binding site of the Walker A box of the adjacent subunit. The six ATPase active sites, however, are likely to contribute differential [...]	Pc21g15220 protein.	0.606
MCM7	Pc21g15650	B6HQS3	B6HJW3	DNA replication licensing factor MCM7; Acts as component of the mcm2-7 complex (mcm complex) which is the putative replicative helicase essential for 'once per cell cycle' DNA replication initiation and elongation in eukaryotic cells. The active ATPase sites in the mcm2-7 ring are formed through the interaction surfaces of two neighboring subunits such that a critical structure of a conserved arginine finger motif is provided in trans relative to the ATP-binding site of the Walker A box of the adjacent subunit. The six ATPase active sites, however, are likely to contribute differential [...]	DNA helicase; Belongs to the MCM family.	0.999
MCM7	Pc21g21700	B6HQS3	B6HM78	DNA replication licensing factor MCM7; Acts as component of the mcm2-7 complex (mcm complex) which is the putative replicative helicase essential for 'once per cell cycle' DNA replication initiation and elongation in eukaryotic cells. The active ATPase sites in the mcm2-7 ring are formed through the interaction surfaces of two neighboring subunits such that a critical structure of a conserved arginine finger motif is provided in trans relative to the ATP-binding site of the Walker A box of the adjacent subunit. The six ATPase active sites, however, are likely to contribute differential [...]	Pc21g21700 protein.	0.800
Pc12g03390	Pc21g06060	B6H0W8	B6HIG3	Pc12g03390 protein.	DNA-directed RNA polymerases I, II, and III subunit RPABC3; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Common component of RNA polymerases I, II and III which synthesize ribosomal RNA precursors, mRNA precursors and many functional non- coding RNAs, and small RNAs, such as 5S rRNA and tRNAs, respectively.	0.999
Pc12g03390	Pc21g15220	B6H0W8	B6HJG3	Pc12g03390 protein.	Pc21g15220 protein.	0.940
Pc12g03390	Pc22g09050	B6H0W8	B6HTJ2	Pc12g03390 protein.	mRNA-capping enzyme subunit alpha; Second step of mRNA capping. Transfer of the GMP moiety of GTP to the 5'-end of RNA via an enzyme-GMP covalent reaction intermediate; Belongs to the eukaryotic GTase family.	0.680
Pc12g07200	MCM7	B6GWR3	B6HQS3	Pc12g07200 protein.	DNA replication licensing factor MCM7; Acts as component of the mcm2-7 complex (mcm complex) which is the putative replicative helicase essential for 'once per cell cycle' DNA replication initiation and elongation in eukaryotic cells. The active ATPase sites in the mcm2-7 ring are formed through the interaction surfaces of two neighboring subunits such that a critical structure of a conserved arginine finger motif is provided in trans relative to the ATP-binding site of the Walker A box of the adjacent subunit. The six ATPase active sites, however, are likely to contribute differential [...]	0.748
Pc12g07200	Pc13g09370	B6GWR3	B6H3T7	Pc12g07200 protein.	DNA ligase.	0.500
Pc12g07200	Pc13g10160	B6GWR3	B6H4R6	Pc12g07200 protein.	Pc13g10160 protein.	0.625