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degP degP lptD lptD rraB rraB EFC57218.1 EFC57218.1 SmrA SmrA lolB lolB fadR fadR EFC56644.1 EFC56644.1 EFC56670.1 EFC56670.1 proQ proQ ndpA ndpA EFC55968.1 EFC55968.1 EFC55969.1 EFC55969.1 EFC56035.1 EFC56035.1 EFC56073.1 EFC56073.1 EFC56074.1 EFC56074.1 EFC56075.1 EFC56075.1 mepA mepA prmB prmB EFC56079.1 EFC56079.1 sixA sixA nlpB nlpB EFC56148.1 EFC56148.1 EFC56149.1 EFC56149.1 yfgL yfgL EFC56181.1 EFC56181.1 hisS hisS rodZ rodZ EFC56239.1 EFC56239.1 EFC56240.1 EFC56240.1 rseA rseA rpoE rpoE EFC56243.1 EFC56243.1 EFC55718.1 EFC55718.1 EFC55495.1 EFC55495.1 lptE lptE EFC55530.1 EFC55530.1 seqA seqA EFC54685.1 EFC54685.1 slyX slyX dam dam yfiO yfiO EFC54636.1 EFC54636.1 EFC54637.1 EFC54637.1 smpA smpA syd syd rlmM rlmM EFC54502.1 EFC54502.1 gcvA gcvA mutH mutH EFC54061.1 EFC54061.1 glnE glnE EFC54064.1 EFC54064.1 EFC54065.1 EFC54065.1 cca cca nlpI nlpI EFC54221.1 EFC54221.1 EFC54222.1 EFC54222.1 ttg2D ttg2D MlaD MlaD EFC54225.1 EFC54225.1 EFC54226.1 EFC54226.1 EFC54227.1 EFC54227.1 lptC lptC lptA lptA lptB lptB lptG lptG lptF lptF EFC54273.1 EFC54273.1 degS degS smg smg yihI yihI metJ metJ trmA trmA EFC53533.1 EFC53533.1 hemY hemY EFC53563.1 EFC53563.1
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
degPPeptidase Do; KEGG: ent:Ent638_0701 1.9e-234 serine endoprotease; K04771 serine protease Do; Psort location: Periplasmic, score: 10.00; Belongs to the peptidase S1C family. (479 aa)
lptDOrganic solvent tolerance protein; Together with LptE, is involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane. (783 aa)
rraBHypothetical protein; Globally modulates RNA abundance by binding to RNase E (Rne) and regulating its endonucleolytic activity. Can modulate Rne action in a substrate-dependent manner by altering the composition of the degradosome. (141 aa)
EFC57218.1Hypothetical protein. (90 aa)
SmrASmr domain protein; Psort location: Cytoplasmic, score: 8.96. (187 aa)
lolBOuter membrane lipoprotein LolB; Plays a critical role in the incorporation of lipoproteins in the outer membrane after they are released by the LolA protein. (203 aa)
fadRFatty acid metabolism transcriptional regulator FadR; Multifunctional regulator of fatty acid metabolism. (239 aa)
EFC56644.1Outer membrane lipoprotein, Slp family. (193 aa)
EFC56670.1Peptidase, S41 family; KEGG: ent:Ent638_2400 0. carboxy-terminal protease K03797; Psort location: OuterMembrane, score: 9.49; Belongs to the peptidase S41A family. (682 aa)
proQProQ activator of osmoprotectant transporter ProP; RNA chaperone with significant RNA binding, RNA strand exchange and RNA duplexing activities. May regulate ProP activity through an RNA-based, post-transcriptional mechanism. Belongs to the ProQ family. (228 aa)
ndpANucleoid-associated protein NdpA; Psort location: Cytoplasmic, score: 8.96. (335 aa)
EFC55968.1Hypothetical protein; Belongs to the UPF0352 family. (75 aa)
EFC55969.1Arylsulfatase; KEGG: ecf:ECH74115_3327 4.5e-272 sulfatase family protein K07014; Psort location: CytoplasmicMembrane, score: 10.00. (586 aa)
EFC56035.1Hypothetical protein. (151 aa)
EFC56073.1YfcL protein; Psort location: Cytoplasmic, score: 8.96. (93 aa)
EFC56074.1Hypothetical protein; Psort location: Cytoplasmic, score: 8.96. (181 aa)
EFC56075.1Hypothetical protein; KEGG: hip:CGSHiEE_07500 0.0031 thyA; thymidylate synthase; Psort location: CytoplasmicMembrane, score: 10.00. (269 aa)
mepAPeptidoglycan amidase MepA; Murein endopeptidase that cleaves the D-alanyl-meso-2,6- diamino-pimelyl amide bond that connects peptidoglycan strands. Likely plays a role in the removal of murein from the sacculus. Belongs to the peptidase M74 family. (274 aa)
prmB(glutamine-N5) methyltransferase, ribosomal protein L3-specific; Specifically methylates the 50S ribosomal protein L3 on a specific glutamine residue; Belongs to the protein N5-glutamine methyltransferase family. PrmB subfamily. (310 aa)
EFC56079.1Smr domain protein; Psort location: Cytoplasmic, score: 8.96; Belongs to the UPF0115 family. (183 aa)
sixAKEGG: cko:CKO_00450 3.9e-76 phosphohistidine phosphatase; K08296 phosphohistidine phosphatase. (161 aa)
nlpBLipoprotein 34; Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane. (344 aa)
EFC56148.1ACT domain protein; KEGG: eci:UTI89_C2806 4.4e-61 gcvR; glycine cleavage system transcriptional repressor K03567; Psort location: Cytoplasmic, score: 9.97. (147 aa)
EFC56149.1KEGG: cko:CKO_00307 2.5e-81 thioredoxin-dependent thiol peroxidase; K03564 peroxiredoxin Q/BCP; Psort location: Cytoplasmic, score: 8.96. (156 aa)
yfgLOuter membrane assembly lipoprotein YfgL; Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane. (392 aa)
EFC56181.1Hypothetical protein. (206 aa)
hisShistidine--tRNA ligase; KEGG: ent:Ent638_3008 8.2e-218 hisS; histidyl-tRNA synthetase K01892. (440 aa)
rodZDNA-binding helix-turn-helix protein; Cytoskeletal protein that is involved in cell-shape control through regulation of the length of the long axis. (337 aa)
EFC56239.1Positive regulator of sigma(E), RseC/MucC. (158 aa)
EFC56240.1MucB/RseB family protein; Psort location: Periplasmic, score: 9.44. (317 aa)
rseAsigma-E factor negative regulatory protein; An anti-sigma factor for extracytoplasmic function (ECF) sigma factor sigma-E (RpoE). ECF sigma factors are held in an inactive form by an anti-sigma factor until released by regulated intramembrane proteolysis (RIP). RIP occurs when an extracytoplasmic signal triggers a concerted proteolytic cascade to transmit information and elicit cellular responses. The membrane-spanning regulatory substrate protein is first cut periplasmically (site-1 protease, S1P, DegS), then within the membrane itself (site-2 protease, S2P, RseP), while cytoplasmic p [...] (216 aa)
rpoEKEGG: reh:H16_A2563 4.0e-58 rpoE1; DNA-directed RNA polymerase sigma subunit (RpoE,sigma24) K03088; Psort location: Cytoplasmic, score: 8.96; Belongs to the sigma-70 factor family. ECF subfamily. (191 aa)
EFC56243.1Hypothetical protein. (46 aa)
EFC55718.1Methyltransferase domain protein; KEGG: vfi:VF_1937 1.4e-46 yafS; S-adenosyl-L-methionine-dependent methyltransferase K00599. (238 aa)
EFC55495.1Hypothetical protein; KEGG: dme:Dmel_CG10495 0.0060 CG10495; K05545 tRNA-dihydrouridine synthase 4; Belongs to the UPF0250 family. (87 aa)
lptERare lipoprotein B family protein; Together with LptD, is involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane. Required for the proper assembly of LptD. Binds LPS and may serve as the LPS recognition site at the outer membrane. (157 aa)
EFC55530.1Ribbon-helix-helix protein, CopG family; Psort location: Cytoplasmic, score: 8.96. (95 aa)
seqASeqA protein; Negative regulator of replication initiation, which contributes to regulation of DNA replication and ensures that replication initiation occurs exactly once per chromosome per cell cycle. Binds to pairs of hemimethylated GATC sequences in the oriC region, thus preventing assembly of replication proteins and re- initiation at newly replicated origins. Repression is relieved when the region becomes fully methylated. (182 aa)
EFC54685.1Domain amino terminal to FKBP-type peptidyl-prolyl isomerase; KEGG: ent:Ent638_3764 1.2e-129 FKBP-type peptidyl-prolyl cis-trans isomerase; K03772 FKBP-type peptidyl-prolyl cis-trans isomerase FkpA; Psort location: Periplasmic, score: 10.00. (273 aa)
slyXSlyX family protein; Belongs to the SlyX family. (73 aa)
damKEGG: cko:CKO_04808 1.6e-134 DNA adenine methylase; K06223 DNA adenine methylase. (270 aa)
yfiOOuter membrane assembly lipoprotein YfiO; Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane. Constitutes, with BamA, the core component of the assembly machinery. (245 aa)
EFC54636.1Cytochrome c assembly protein; KEGG: sab:SAB1531c 0.00035 membrane uroporphyrinogen III methylase; Psort location: CytoplasmicMembrane, score: 10.00. (288 aa)
EFC54637.1Hypothetical protein; KEGG: ece:Z3906m 2.2e-192 yfjD; hypothetical protein; K00638 chloramphenicol O-acetyltransferase; Psort location: CytoplasmicMembrane, score: 10.00. (413 aa)
smpASmall protein A; Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane. (112 aa)
sydSyd protein; Interacts with the SecY protein in vivo. May bind preferentially to an uncomplexed state of SecY, thus functioning either as a chelating agent for excess SecY in the cell or as a regulatory factor that negatively controls the translocase function. Belongs to the Syd family. (181 aa)
rlmMPutative RNA 2'-O-ribose methyltransferase YgdE; Catalyzes the 2'-O-methylation at nucleotide C2498 in 23S rRNA; Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA methyltransferase RlmE family. RlmM subfamily. (366 aa)
EFC54502.1Hypothetical protein; KEGG: hip:CGSHiEE_06720 7.3e-20 CTP synthetase; Psort location: CytoplasmicMembrane, score: 9.46. (131 aa)
gcvAGlycine cleavage system transcriptional activator; KEGG: hiq:CGSHiGG_09680 1.5e-74 DNA-binding transcriptional activator GcvA K03566; Psort location: Cytoplasmic, score: 9.97; Belongs to the LysR transcriptional regulatory family. (305 aa)
mutHDNA mismatch repair endonuclease MutH; Sequence-specific endonuclease that cleaves unmethylated GATC sequences. It is involved in DNA mismatch repair. Belongs to the MutH family. (245 aa)
EFC54061.1Hypothetical protein; Psort location: Cytoplasmic, score: 8.96. (127 aa)
glnE[Glutamate--ammonia-ligase] adenylyltransferase; Involved in the regulation of glutamine synthetase GlnA, a key enzyme in the process to assimilate ammonia. When cellular nitrogen levels are high, the C-terminal adenylyl transferase (AT) inactivates GlnA by covalent transfer of an adenylyl group from ATP to specific tyrosine residue of GlnA, thus reducing its activity. Conversely, when nitrogen levels are low, the N-terminal adenylyl removase (AR) activates GlnA by removing the adenylyl group by phosphorolysis, increasing its activity. The regulatory region of GlnE binds the signal tra [...] (949 aa)
EFC54064.1Adenylate cyclase; KEGG: sew:SeSA_A3392 7.2e-171 adenylate cyclase. (433 aa)
EFC54065.1KEGG: vfi:VF_2241 9.5e-34 htrG; signal transduction protein K07184. (230 aa)
cca2',3'-cyclic phosphodiesterase; Catalyzes the addition and repair of the essential 3'- terminal CCA sequence in tRNAs without using a nucleic acid template. Adds these three nucleotides in the order of C, C, and A to the tRNA nucleotide-73, using CTP and ATP as substrates and producing inorganic pyrophosphate. Also shows phosphatase, 2'-nucleotidase and 2',3'-cyclic phosphodiesterase activities. These phosphohydrolase activities are probably involved in the repair of the tRNA 3'-CCA terminus degraded by intracellular RNases. (415 aa)
nlpILipoprotein NlpI; May be involved in cell division. (294 aa)
EFC54221.1BolA-like protein; KEGG: hip:CGSHiEE_06655 1.8e-16 ligA; NAD-dependent DNA ligase LigA; Belongs to the BolA/IbaG family. (97 aa)
EFC54222.1Hypothetical protein. (97 aa)
ttg2DToluene tolerance protein Ttg2D; KEGG: rcm:A1E_00450 2.7e-07 aspartate aminotransferase. (211 aa)
MlaDHypothetical protein; KEGG: bba:Bd3413 3.9e-10 ABC transporter substrate binding protein K02067. (182 aa)
EFC54225.1Hypothetical protein; KEGG: cco:CCC13826_0092 1.3e-19 MTA/SAH nucleosidase K02066; Psort location: CytoplasmicMembrane, score: 10.00. (260 aa)
EFC54226.1KEGG: pha:PSHAa2544 5.7e-91 ABC transporter ATP-binding protein K02065; Psort location: Cytoplasmic, score: 9.12. (270 aa)
EFC54227.1K+-dependent Na+/Ca+ exchanger family protein; Psort location: CytoplasmicMembrane, score: 10.00. (325 aa)
lptCLipopolysaccharide export system protein LptC; Involved in the assembly of lipopolysaccharide (LPS). Required for the translocation of LPS from the inner membrane to the outer membrane. Facilitates the transfer of LPS from the inner membrane to the periplasmic protein LptA. Could be a docking site for LptA. Belongs to the LptC family. (191 aa)
lptALipopolysaccharide transport periplasmic protein LptA; Involved in the assembly of lipopolysaccharide (LPS). Required for the translocation of LPS from the inner membrane to the outer membrane. May form a bridge between the inner membrane and the outer membrane, via interactions with LptC and LptD, thereby facilitating LPS transfer across the periplasm. (184 aa)
lptBKEGG: cko:CKO_04604 5.9e-121 putative ABC transporter ATP-binding protein YhbG; K06861 lipopolysaccharide export system ATP-binding protein; Psort location: Cytoplasmic, score: 9.12. (241 aa)
lptGLipopolysaccharide export system permease protein LptG; KEGG: hip:CGSHiEE_03515 6.2e-101 leucyl aminopeptidase K11720; Psort location: CytoplasmicMembrane, score: 10.00. (360 aa)
lptFLipopolysaccharide export system permease protein LptF; KEGG: hiq:CGSHiGG_02270 5.7e-91 5-methyltetrahydropteroyltriglutamate--homocysteine methyltransferase K07091; Psort location: CytoplasmicMembrane, score: 10.00. (366 aa)
EFC54273.1Peptidase Do; KEGG: ent:Ent638_3669 1.1e-213 serine endoprotease; K04772 serine protease DegQ; Psort location: Periplasmic, score: 9.44; Belongs to the peptidase S1C family. (455 aa)
degSPeriplasmic serine peptidase DegS; KEGG: ent:Ent638_3670 5.5e-173 serine endoprotease; K04691 serine protease DegS; Psort location: Periplasmic, score: 9.44. (355 aa)
smgHypothetical protein; Psort location: Cytoplasmic, score: 8.96; Belongs to the Smg family. (157 aa)
yihIHypothetical protein; A GTPase-activating protein (GAP) that modifies Der/EngA GTPase function. May play a role in ribosome biogenesis. Belongs to the YihI family. (171 aa)
metJMet Apo-repressor, MetJ; This regulatory protein, when combined with SAM (S- adenosylmethionine) represses the expression of the methionine regulon and of enzymes involved in SAM synthesis; Belongs to the MetJ family. (105 aa)
trmAtRNA (uracil-5-)-methyltransferase; Dual-specificity methyltransferase that catalyzes the formation of 5-methyluridine at position 54 (m5U54) in all tRNAs, and that of position 341 (m5U341) in tmRNA (transfer-mRNA). (366 aa)
EFC53533.1Hypothetical protein; Psort location: Cytoplasmic, score: 8.96. (112 aa)
hemYhemY protein; KEGG: ent:Ent638_3990 8.5e-200 putative protoheme IX biogenesis protein K02498. (401 aa)
EFC53563.1HemX; KEGG: ent:Ent638_3989 1.3e-180 putative uroporphyrinogen III C-methyltransferase; K02496 uroporphyrin-III C-methyltransferase. (393 aa)
Your Current Organism:
Enterobacter cancerogenus
NCBI taxonomy Id: 500639
Other names: E. cancerogenus ATCC 35316, Enterobacter cancerogenus ATCC 35316, Enterobacter cancerogenus str. ATCC 35316, Enterobacter cancerogenus strain ATCC 35316
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