node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
FEN1 | N301_00100 | A0A0A0B1V7 | A0A0A0A8A6 | Flap endonuclease 1; Structure-specific nuclease with 5'-flap endonuclease and 5'- 3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. It enters the flap from the 5'-end and then tracks to cleave the flap base, leaving a nick for ligation. Also involved in the long patch base excision repair (LP-BER) pathway, by cleaving within the apurinic/apyrimidinic (AP) site- terminated flap. Acts as [...] | Double-strand break repair protein MRE11; Belongs to the MRE11/RAD32 family. | 0.980 |
FEN1 | N301_05300 | A0A0A0B1V7 | A0A0A0AYL7 | Flap endonuclease 1; Structure-specific nuclease with 5'-flap endonuclease and 5'- 3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. It enters the flap from the 5'-end and then tracks to cleave the flap base, leaving a nick for ligation. Also involved in the long patch base excision repair (LP-BER) pathway, by cleaving within the apurinic/apyrimidinic (AP) site- terminated flap. Acts as [...] | DNA ligase. | 0.911 |
FEN1 | N301_05919 | A0A0A0B1V7 | A0A0A0A425 | Flap endonuclease 1; Structure-specific nuclease with 5'-flap endonuclease and 5'- 3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. It enters the flap from the 5'-end and then tracks to cleave the flap base, leaving a nick for ligation. Also involved in the long patch base excision repair (LP-BER) pathway, by cleaving within the apurinic/apyrimidinic (AP) site- terminated flap. Acts as [...] | X-ray repair cross-complementing protein 5. | 0.811 |
FEN1 | N301_07915 | A0A0A0B1V7 | A0A0A0ACJ5 | Flap endonuclease 1; Structure-specific nuclease with 5'-flap endonuclease and 5'- 3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. It enters the flap from the 5'-end and then tracks to cleave the flap base, leaving a nick for ligation. Also involved in the long patch base excision repair (LP-BER) pathway, by cleaving within the apurinic/apyrimidinic (AP) site- terminated flap. Acts as [...] | Protein artemis. | 0.494 |
FEN1 | N301_09246 | A0A0A0B1V7 | A0A099ZZ55 | Flap endonuclease 1; Structure-specific nuclease with 5'-flap endonuclease and 5'- 3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. It enters the flap from the 5'-end and then tracks to cleave the flap base, leaving a nick for ligation. Also involved in the long patch base excision repair (LP-BER) pathway, by cleaving within the apurinic/apyrimidinic (AP) site- terminated flap. Acts as [...] | DNA repair protein RAD50. | 0.943 |
FEN1 | N301_09588 | A0A0A0B1V7 | A0A0A0AMD0 | Flap endonuclease 1; Structure-specific nuclease with 5'-flap endonuclease and 5'- 3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. It enters the flap from the 5'-end and then tracks to cleave the flap base, leaving a nick for ligation. Also involved in the long patch base excision repair (LP-BER) pathway, by cleaving within the apurinic/apyrimidinic (AP) site- terminated flap. Acts as [...] | X-ray repair cross-complementing protein 5. | 0.719 |
FEN1 | N301_10607 | A0A0A0B1V7 | A0A0A0AT06 | Flap endonuclease 1; Structure-specific nuclease with 5'-flap endonuclease and 5'- 3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. It enters the flap from the 5'-end and then tracks to cleave the flap base, leaving a nick for ligation. Also involved in the long patch base excision repair (LP-BER) pathway, by cleaving within the apurinic/apyrimidinic (AP) site- terminated flap. Acts as [...] | DNA nucleotidylexotransferase; Template-independent DNA polymerase which catalyzes the random addition of deoxynucleoside 5'-triphosphate to the 3'-end of a DNA initiator. | 0.776 |
FEN1 | N301_13797 | A0A0A0B1V7 | A0A099ZZ28 | Flap endonuclease 1; Structure-specific nuclease with 5'-flap endonuclease and 5'- 3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. It enters the flap from the 5'-end and then tracks to cleave the flap base, leaving a nick for ligation. Also involved in the long patch base excision repair (LP-BER) pathway, by cleaving within the apurinic/apyrimidinic (AP) site- terminated flap. Acts as [...] | Enkurin domain-containing protein 1. | 0.776 |
FEN1 | N301_14659 | A0A0A0B1V7 | A0A0A0A008 | Flap endonuclease 1; Structure-specific nuclease with 5'-flap endonuclease and 5'- 3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. It enters the flap from the 5'-end and then tracks to cleave the flap base, leaving a nick for ligation. Also involved in the long patch base excision repair (LP-BER) pathway, by cleaving within the apurinic/apyrimidinic (AP) site- terminated flap. Acts as [...] | DNA polymerase; DNA polymerase that functions in several pathways of DNA repair. Involved in base excision repair (BER) responsible for repair of lesions that give rise to abasic (AP) sites in DNA. Also contributes to DNA double-strand break repair by non-homologous end joining and homologous recombination. Has both template-dependent and template- independent (terminal transferase) DNA polymerase activities. Has also a 5'-deoxyribose-5-phosphate lyase (dRP lyase) activity. | 0.802 |
N301_00100 | FEN1 | A0A0A0A8A6 | A0A0A0B1V7 | Double-strand break repair protein MRE11; Belongs to the MRE11/RAD32 family. | Flap endonuclease 1; Structure-specific nuclease with 5'-flap endonuclease and 5'- 3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. It enters the flap from the 5'-end and then tracks to cleave the flap base, leaving a nick for ligation. Also involved in the long patch base excision repair (LP-BER) pathway, by cleaving within the apurinic/apyrimidinic (AP) site- terminated flap. Acts as [...] | 0.980 |
N301_00100 | N301_05300 | A0A0A0A8A6 | A0A0A0AYL7 | Double-strand break repair protein MRE11; Belongs to the MRE11/RAD32 family. | DNA ligase. | 0.863 |
N301_00100 | N301_05513 | A0A0A0A8A6 | A0A0A0A9E0 | Double-strand break repair protein MRE11; Belongs to the MRE11/RAD32 family. | DNA-dependent protein kinase catalytic subunit; Belongs to the PI3/PI4-kinase family. | 0.800 |
N301_00100 | N301_05919 | A0A0A0A8A6 | A0A0A0A425 | Double-strand break repair protein MRE11; Belongs to the MRE11/RAD32 family. | X-ray repair cross-complementing protein 5. | 0.985 |
N301_00100 | N301_07915 | A0A0A0A8A6 | A0A0A0ACJ5 | Double-strand break repair protein MRE11; Belongs to the MRE11/RAD32 family. | Protein artemis. | 0.797 |
N301_00100 | N301_09246 | A0A0A0A8A6 | A0A099ZZ55 | Double-strand break repair protein MRE11; Belongs to the MRE11/RAD32 family. | DNA repair protein RAD50. | 0.999 |
N301_00100 | N301_09588 | A0A0A0A8A6 | A0A0A0AMD0 | Double-strand break repair protein MRE11; Belongs to the MRE11/RAD32 family. | X-ray repair cross-complementing protein 5. | 0.982 |
N301_00301 | N301_05300 | A0A099ZVV0 | A0A0A0AYL7 | Non-homologous end-joining factor 1. | DNA ligase. | 0.983 |
N301_00301 | N301_05513 | A0A099ZVV0 | A0A0A0A9E0 | Non-homologous end-joining factor 1. | DNA-dependent protein kinase catalytic subunit; Belongs to the PI3/PI4-kinase family. | 0.965 |
N301_00301 | N301_05757 | A0A099ZVV0 | A0A0A0AP34 | Non-homologous end-joining factor 1. | DNA repair protein XRCC4. | 0.734 |
N301_00301 | N301_05919 | A0A099ZVV0 | A0A0A0A425 | Non-homologous end-joining factor 1. | X-ray repair cross-complementing protein 5. | 0.966 |