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lipA lipA Slin_0529 Slin_0529 sucC sucC Slin_1009 Slin_1009 Slin_1010 Slin_1010 Slin_1098 Slin_1098 Slin_1356 Slin_1356 Slin_1729 Slin_1729 Slin_1829 Slin_1829 Slin_1914 Slin_1914 Slin_2025 Slin_2025 mqo mqo fumC fumC Slin_2911 Slin_2911 sucD sucD Slin_3335 Slin_3335 Slin_3535 Slin_3535 Slin_3550 Slin_3550 Slin_3972 Slin_3972 Slin_4313 Slin_4313 gcvT gcvT Slin_4454 Slin_4454 mdh mdh Slin_4767 Slin_4767 Slin_4914 Slin_4914 glyA glyA Slin_5009 Slin_5009 Slin_5010 Slin_5010 Slin_5011 Slin_5011 Slin_5027 Slin_5027 Slin_5028 Slin_5028 Slin_5036 Slin_5036 Slin_5165 Slin_5165 gcvP gcvP Slin_5294 Slin_5294 pdhA pdhA Slin_5563 Slin_5563 purU purU Slin_5752 Slin_5752 lipB lipB Slin_5897 Slin_5897 leuB leuB Slin_5900 Slin_5900 Slin_5901 Slin_5901 Slin_5902 Slin_5902 ilvA ilvA Slin_5912 Slin_5912 Slin_5913 Slin_5913 Slin_5914 Slin_5914 ilvD ilvD Slin_6035 Slin_6035 Slin_6370 Slin_6370 gcvH gcvH
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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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query proteins and first shell of interactors
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second shell of interactors
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proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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lipALipoic acid synthetase; Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives. (302 aa)
Slin_0529Pyruvate dehydrogenase complex dihydrolipoamide acetyltransferase; The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2). (586 aa)
sucCsuccinyl-CoA synthetase, beta subunit; Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The beta subunit provides nucleotide specificity of the enzyme and binds the substrate succinate, while the binding sites for coenzyme A and phosphate are found in the alpha subunit. (405 aa)
Slin_1009PFAM: Xylose isomerase domain protein TIM barrel; KEGG: sde:Sde_1709 hypothetical protein. (308 aa)
Slin_1010PFAM: Pyridoxal-5'-phosphate-dependent protein beta subunit; KEGG: rhi:NGR_b19540 serine racemase. (315 aa)
Slin_1098TIGRFAM: branched-chain amino acid aminotransferase; PFAM: aminotransferase class IV; KEGG: dat:HRM2_10750 branched-chain amino acid aminotransferase. (356 aa)
Slin_1356PFAM: catalytic domain of components of various dehydrogenase complexes; biotin/lipoyl attachment domain- containing protein; E3 binding domain protein; KEGG: nmu:Nmul_A0856 2-oxoglutarate dehydrogenase, E2 component, dihydrolipoamide succinyltransferase. (500 aa)
Slin_1729Threonine aldolase; PFAM: aromatic amino acid beta-eliminating lyase/threonine aldolase; KEGG: threonine aldolase family protein. (343 aa)
Slin_1829PFAM: dihydroxy-acid and 6-phosphogluconate dehydratase; KEGG: hypothetical protein LOC100209598; Belongs to the IlvD/Edd family. (568 aa)
Slin_1914PFAM: aminotransferase class I and II; KEGG: pfs:PFLU1731 putative aminotransferase. (403 aa)
Slin_2025TIGRFAM: aconitate hydratase; PFAM: aconitate hydratase domain protein; KEGG: acnB; aconitase; K01681 aconitate hydratase 1. (755 aa)
mqoKEGG: avn:Avin_04080 malate:quinone-oxidoreductase; TIGRFAM: malate/quinone oxidoreductase; PFAM: Malate:quinone-oxidoreductase; FAD dependent oxidoreductase. (510 aa)
fumCFumarate hydratase, class II; Involved in the TCA cycle. Catalyzes the stereospecific interconversion of fumarate to L-malate; Belongs to the class-II fumarase/aspartase family. Fumarase subfamily. (466 aa)
Slin_2911Malate dehydrogenase (oxaloacetate- decarboxylating) (NADP(+))., Phosphate acetyltransferase; PFAM: malic protein NAD-binding; malic protein domain protein; phosphate acetyl/butaryl transferase; KEGG: gsu:GSU1700 malic enzyme. (755 aa)
sucDsuccinyl-CoA synthetase, alpha subunit; Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit. (291 aa)
Slin_3335KEGG: rbo:A1I_06360 isocitrate dehydrogenase; TIGRFAM: isocitrate dehydrogenase; PFAM: isocitrate/isopropylmalate dehydrogenase. (482 aa)
Slin_3535Glycine C-acetyltransferase; PFAM: aminotransferase class I and II; aminotransferase class-III; KEGG: gbm:Gbem_0049 pyridoxal phosphate-dependent acyltransferase. (434 aa)
Slin_3550PFAM: D-isomer specific 2-hydroxyacid dehydrogenase NAD-binding; D-isomer specific 2-hydroxyacid dehydrogenase catalytic region; KEGG: hypothetical protein; K03778 D-lactate dehydrogenase. (329 aa)
Slin_3972KEGG: atc:AGR_L_1216 hypothetical protein. (595 aa)
Slin_4313KEGG: hypothetical protein; K00031 isocitrate dehydrogenase; TIGRFAM: isocitrate dehydrogenase; PFAM: isocitrate/isopropylmalate dehydrogenase. (456 aa)
gcvTGlycine cleavage system T protein; The glycine cleavage system catalyzes the degradation of glycine. (364 aa)
Slin_4454Pyruvate carboxylase; Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second. (1149 aa)
mdhMalate dehydrogenase, NAD-dependent; Catalyzes the reversible oxidation of malate to oxaloacetate. Belongs to the LDH/MDH superfamily. MDH type 3 family. (313 aa)
Slin_4767KEGG: bba:Bd3723 isocitrate dehydrogenase; TIGRFAM: isocitrate dehydrogenase, NADP-dependent; PFAM: isocitrate/isopropylmalate dehydrogenase; Belongs to the isocitrate and isopropylmalate dehydrogenases family. (405 aa)
Slin_4914PFAM: Transketolase domain protein; dehydrogenase E1 component; Transketolase central region; KEGG: hypothetical protein. (801 aa)
glyAGlycine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. (428 aa)
Slin_5009TIGRFAM: succinate dehydrogenase and fumarate reductase iron-sulfur protein; KEGG: bba:Bd0026 succinate dehydrogenase/fumarate reductase iron-sulfur subunit. (252 aa)
Slin_5010KEGG: scl:sce6554 succinate dehydrogenase flavoprotein subunit; TIGRFAM: succinate dehydrogenase or fumarate reductase, flavoprotein subunit; PFAM: fumarate reductase/succinate dehydrogenase flavoprotein domain protein. (645 aa)
Slin_5011TIGRFAM: succinate dehydrogenase (or fumarate reductase) cytochrome b subunit, b558 family; KEGG: bba:Bd0024 putative cytochrome b subunit. (231 aa)
Slin_5027KEGG: pap:PSPA7_3689 2-oxoglutarate dehydrogenase E1 component; TIGRFAM: 2-oxoglutarate dehydrogenase, E1 subunit; PFAM: Transketolase central region; dehydrogenase E1 component. (932 aa)
Slin_50282-oxoglutarate dehydrogenase, E2 subunit, dihydrolipoamide succinyltransferase; E2 component of the 2-oxoglutarate dehydrogenase (OGDH) complex which catalyzes the second step in the conversion of 2- oxoglutarate to succinyl-CoA and CO(2). (540 aa)
Slin_5036Citrate synthase I; KEGG: scl:sce8281 hypothetical protein; TIGRFAM: citrate synthase I; PFAM: Citrate synthase. (428 aa)
Slin_5165Transketolase central region; The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO2. (326 aa)
gcvPGlycine dehydrogenase; The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO(2) is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein; Belongs to the GcvP family. (967 aa)
Slin_5294TIGRFAM: succinate dehydrogenase and fumarate reductase iron-sulfur protein; PFAM: ferredoxin; KEGG: bba:Bd0026 succinate dehydrogenase/fumarate reductase iron-sulfur subunit. (246 aa)
pdhAPyruvate dehydrogenase (acetyl-transferring) E1 component, alpha subunit; The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2). (352 aa)
Slin_5563PFAM: aminotransferase class IV; KEGG: dat:HRM2_24560 IlvE. (283 aa)
purUFormyltetrahydrofolate deformylase; Catalyzes the hydrolysis of 10-formyltetrahydrofolate (formyl-FH4) to formate and tetrahydrofolate (FH4). (306 aa)
Slin_5752TIGRFAM: dihydrolipoamide dehydrogenase; PFAM: pyridine nucleotide-disulphide oxidoreductase dimerisation region; FAD-dependent pyridine nucleotide- disulphide oxidoreductase; glucose-inhibited division protein A; FAD dependent oxidoreductase; fumarate reductase/succinate dehydrogenase flavoprotein domain protein; KEGG: ara:Arad_2251 dihydrolipoamide dehydrogenase. (466 aa)
lipBLipoate-protein ligase B; Catalyzes the transfer of endogenously produced octanoic acid from octanoyl-acyl-carrier-protein onto the lipoyl domains of lipoate- dependent enzymes. Lipoyl-ACP can also act as a substrate although octanoyl-ACP is likely to be the physiological substrate. (245 aa)
Slin_5897PFAM: pyruvate carboxyltransferase; KEGG: pat:Patl_3268 2-isopropylmalate synthase; Belongs to the alpha-IPM synthase/homocitrate synthase family. (379 aa)
leuB3-isopropylmalate dehydrogenase; Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate. (358 aa)
Slin_5900PFAM: pyruvate carboxyltransferase; LeuA allosteric (dimerisation) domain; KEGG: mpo:Mpop_2796 2-isopropylmalate synthase; Belongs to the alpha-IPM synthase/homocitrate synthase family. (506 aa)
Slin_59013-isopropylmalate dehydratase, small subunit; Catalyzes the isomerization between 2-isopropylmalate and 3- isopropylmalate, via the formation of 2-isopropylmaleate. Belongs to the LeuD family. LeuD type 1 subfamily. (198 aa)
Slin_59023-isopropylmalate dehydratase, large subunit; Catalyzes the isomerization between 2-isopropylmalate and 3- isopropylmalate, via the formation of 2-isopropylmaleate. (470 aa)
ilvAThreonine dehydratase; Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short-lived. The second step is the nonenzymatic hydrolysis of the enamine/imine intermediates to form 2- ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA. (424 aa)
Slin_5912KEGG: fph:Fphi_1550 ketol-acid reductoisomerase; TIGRFAM: ketol-acid reductoisomerase; PFAM: Acetohydroxy acid isomeroreductase catalytic domain protein; acetohydroxy acid isomeroreductase. (347 aa)
Slin_5913TIGRFAM: acetolactate synthase, small subunit; PFAM: amino acid-binding ACT domain protein; Acetolactate synthase, small subunit-like; KEGG: afw:Anae109_1878 acetolactate synthase, small subunit. (177 aa)
Slin_5914TIGRFAM: acetolactate synthase, large subunit, biosynthetic type; PFAM: thiamine pyrophosphate protein TPP binding domain protein; thiamine pyrophosphate protein domain protein TPP-binding; thiamine pyrophosphate protein central region; KEGG: ftn:FTN_1042 acetolactate synthase large subunit. (588 aa)
ilvDKEGG: pin:Ping_2151 dihydroxy-acid dehydratase; TIGRFAM: dihydroxy-acid dehydratase; PFAM: dihydroxy-acid and 6-phosphogluconate dehydratase; Belongs to the IlvD/Edd family. (569 aa)
Slin_6035TIGRFAM: dihydrolipoamide dehydrogenase; PFAM: pyridine nucleotide-disulphide oxidoreductase dimerisation region; FAD-dependent pyridine nucleotide- disulphide oxidoreductase; KEGG: mch:Mchl_1930 dihydrolipoamide dehydrogenase. (466 aa)
Slin_6370PFAM: thiamine pyrophosphate protein domain protein TPP-binding; thiamine pyrophosphate protein central region; thiamine pyrophosphate protein TPP binding domain protein; KEGG: sme:SM_b20095 putative pyruvate oxidase protein; Belongs to the TPP enzyme family. (599 aa)
gcvHGlycine cleavage system H protein; The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein. (127 aa)
Your Current Organism:
Spirosoma linguale
NCBI taxonomy Id: 504472
Other names: S. linguale DSM 74, Spirosoma linguale DSM 74, Spirosoma linguale str. DSM 74, Spirosoma linguale strain DSM 74
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