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guaB guaB Slin_1247 Slin_1247 Slin_1260 Slin_1260 Slin_1313 Slin_1313 Slin_1373 Slin_1373 Slin_1508 Slin_1508 hisD hisD Slin_1831 Slin_1831 Slin_6630 Slin_6630 Slin_6419 Slin_6419 Slin_6411 Slin_6411 Slin_6291 Slin_6291 Slin_6198 Slin_6198 Slin_4694 Slin_4694 Slin_6109 Slin_6109 dxr dxr Slin_5912 Slin_5912 leuB leuB Slin_5846 Slin_5846 Slin_5818 Slin_5818 Slin_5790 Slin_5790 fcl fcl Slin_5557 Slin_5557 Slin_5467 Slin_5467 Slin_4601 Slin_4601 Slin_4514 Slin_4514 Slin_4509 Slin_4509 mdh mdh Slin_4313 Slin_4313 Slin_4200 Slin_4200 Slin_4083 Slin_4083 Slin_4077 Slin_4077 Slin_4070 Slin_4070 Slin_4034 Slin_4034 Slin_3998 Slin_3998 Slin_3987 Slin_3987 Slin_3957 Slin_3957 Slin_5413 Slin_5413 Slin_5292 Slin_5292 Slin_5217 Slin_5217 Slin_5183 Slin_5183 murB murB Slin_4815 Slin_4815 Slin_4802 Slin_4802 Slin_4767 Slin_4767 Slin_2192 Slin_2192 Slin_3808 Slin_3808 Slin_3779 Slin_3779 Slin_3739 Slin_3739 Slin_3669 Slin_3669 Slin_3665 Slin_3665 Slin_3550 Slin_3550 Slin_3540 Slin_3540 Slin_3526 Slin_3526 hldD hldD Slin_3404 Slin_3404 Slin_3335 Slin_3335 Slin_3152 Slin_3152 Slin_2975 Slin_2975 Slin_2937 Slin_2937 Slin_2911 Slin_2911 Slin_2838 Slin_2838 Slin_2803 Slin_2803 Slin_2770 Slin_2770 zwf zwf Slin_2608 Slin_2608 Slin_2520 Slin_2520 Slin_2484 Slin_2484 Slin_2303 Slin_2303 Slin_2228 Slin_2228 Slin_0070 Slin_0070 Slin_0197 Slin_0197 Slin_0199 Slin_0199 Slin_0310 Slin_0310 Slin_0324 Slin_0324 Slin_0360 Slin_0360 Slin_0401 Slin_0401 Slin_0415 Slin_0415 Slin_0452 Slin_0452 Slin_0453 Slin_0453 Slin_0484 Slin_0484 Slin_0608 Slin_0608 Slin_0612 Slin_0612 Slin_0705 Slin_0705 Slin_0882 Slin_0882 Slin_1007 Slin_1007 Slin_1056 Slin_1056 gpsA gpsA
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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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query proteins and first shell of interactors
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second shell of interactors
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proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
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textmining
co-expression
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guaBInosine-5'-monophosphate dehydrogenase; Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth. Belongs to the IMPDH/GMPR family. (490 aa)
Slin_1247PFAM: Mannitol dehydrogenase domain; Mannitol dehydrogenase rossman domain; KEGG: yen:YE3707 altronate oxidoreductase. (525 aa)
Slin_1260PFAM: Alcohol dehydrogenase zinc-binding domain protein; Alcohol dehydrogenase GroES domain protein; KEGG: bgl:bglu_2g18520 alcohol dehydrogenase GroES- like protein. (339 aa)
Slin_1313PFAM: short-chain dehydrogenase/reductase SDR; KR domain protein; KEGG: amc:MADE_01007 short chain dehydrogenase. (262 aa)
Slin_13733-oxoacyl-(acyl-carrier-protein) reductase; Catalyzes the NADPH-dependent reduction of beta-ketoacyl-ACP substrates to beta-hydroxyacyl-ACP products, the first reductive step in the elongation cycle of fatty acid biosynthesis. Belongs to the short-chain dehydrogenases/reductases (SDR) family. (248 aa)
Slin_1508PFAM: short-chain dehydrogenase/reductase SDR; KR domain protein; KEGG: pla:Plav_0450 short-chain dehydrogenase/reductase SDR. (294 aa)
hisDHistidinol dehydrogenase; Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine. (429 aa)
Slin_1831PFAM: short-chain dehydrogenase/reductase SDR; KR domain protein; KEGG: tgr:Tgr7_0904 short-chain dehydrogenase/reductase SDR. (259 aa)
Slin_6630TIGRFAM: 6-phosphogluconate dehydrogenase, decarboxylating; PFAM: 6-phosphogluconate dehydrogenase NAD-binding; 6-phosphogluconate dehydrogenase domain protein; KEGG: similar to predicted protein. (298 aa)
Slin_6419PFAM: NAD-dependent epimerase/dehydratase; 3-beta hydroxysteroid dehydrogenase/isomerase; Male sterility domain; KR domain protein; polysaccharide biosynthesis protein CapD; dTDP-4-dehydrorhamnose reductase; short- chain dehydrogenase/reductase SDR; KEGG: geo:Geob_2923 NAD-dependent epimerase/dehydratase. (322 aa)
Slin_6411PFAM: NAD-dependent epimerase/dehydratase; Male sterility domain; KEGG: rsh:Rsph17029_3699 NAD-dependent epimerase/dehydratase. (357 aa)
Slin_6291PFAM: NAD-dependent epimerase/dehydratase; KEGG: rsh:Rsph17029_3699 NAD-dependent epimerase/dehydratase. (357 aa)
Slin_6198PFAM: short-chain dehydrogenase/reductase SDR; KR domain protein; KEGG: ect:ECIAI39_0671 putative short-chain dehydrogenase/reductase SDR precursor. (260 aa)
Slin_4694PFAM: D-isomer specific 2-hydroxyacid dehydrogenase NAD-binding; D-isomer specific 2-hydroxyacid dehydrogenase catalytic region; KEGG: ppd:Ppro_2951 D-isomer specific 2-hydroxyacid dehydrogenase, NAD-binding. (318 aa)
Slin_6109PFAM: 3-hydroxyacyl-CoA dehydrogenase NAD-binding; Enoyl-CoA hydratase/isomerase; 3-hydroxyacyl-CoA dehydrogenase domain protein; KEGG: pla:Plav_0465 3-hydroxyacyl-CoA dehydrogenase NAD-binding. (718 aa)
dxr1-deoxy-D-xylulose 5-phosphate reductoisomerase; Catalyzes the NADP-dependent rearrangement and reduction of 1-deoxy-D-xylulose-5-phosphate (DXP) to 2-C-methyl-D-erythritol 4- phosphate (MEP); Belongs to the DXR family. (390 aa)
Slin_5912KEGG: fph:Fphi_1550 ketol-acid reductoisomerase; TIGRFAM: ketol-acid reductoisomerase; PFAM: Acetohydroxy acid isomeroreductase catalytic domain protein; acetohydroxy acid isomeroreductase. (347 aa)
leuB3-isopropylmalate dehydrogenase; Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate. (358 aa)
Slin_5846PFAM: short-chain dehydrogenase/reductase SDR; KEGG: bba:Bd0506 putative short-chain dehydrogenase/reductase. (262 aa)
Slin_5818PFAM: short-chain dehydrogenase/reductase SDR; KEGG: mex:Mext_1352 short-chain dehydrogenase/reductase SDR. (260 aa)
Slin_5790PFAM: short-chain dehydrogenase/reductase SDR; KR domain protein; KEGG: hypothetical protein. (256 aa)
fclNAD-dependent epimerase/dehydratase; Catalyzes the two-step NADP-dependent conversion of GDP-4- dehydro-6-deoxy-D-mannose to GDP-fucose, involving an epimerase and a reductase reaction. (313 aa)
Slin_5557PFAM: short-chain dehydrogenase/reductase SDR; KR domain protein; KEGG: ppu:PP_1817 short chain dehydrogenase. (272 aa)
Slin_5467PFAM: short-chain dehydrogenase/reductase SDR; KR domain protein; KEGG: dia:Dtpsy_1817 short-chain dehydrogenase/reductase SDR. (305 aa)
Slin_4601TIGRFAM: formaldehyde dehydrogenase, glutathione- independent; PFAM: Alcohol dehydrogenase GroES domain protein; Alcohol dehydrogenase zinc-binding domain protein; KEGG: cps:CPS_4039 putative glutathione-independent formaldehyde dehydrogenase. (396 aa)
Slin_4514Aspartate kinase; KEGG: hypothetical protein; K00003 homoserine dehydrogenase; TIGRFAM: aspartate kinase; PFAM: homoserine dehydrogenase; amino acid-binding ACT domain protein; homoserine dehydrogenase NAD-binding; aspartate/glutamate/uridylate kinase. (818 aa)
Slin_4509PFAM: Alcohol dehydrogenase zinc-binding domain protein; Alcohol dehydrogenase GroES domain protein; KEGG: bcm:Bcenmc03_5781 alcohol dehydrogenase. (343 aa)
mdhMalate dehydrogenase, NAD-dependent; Catalyzes the reversible oxidation of malate to oxaloacetate. Belongs to the LDH/MDH superfamily. MDH type 3 family. (313 aa)
Slin_4313KEGG: hypothetical protein; K00031 isocitrate dehydrogenase; TIGRFAM: isocitrate dehydrogenase; PFAM: isocitrate/isopropylmalate dehydrogenase. (456 aa)
Slin_4200PFAM: Alcohol dehydrogenase GroES domain protein; Alcohol dehydrogenase zinc-binding domain protein; KEGG: scl:sce0475 alcohol dehydrogenase. (385 aa)
Slin_40836-phosphogluconate dehydrogenase, decarboxylating; Catalyzes the oxidative decarboxylation of 6-phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH. (484 aa)
Slin_4077TIGRFAM: nucleotide sugar dehydrogenase; PFAM: UDP-glucose/GDP-mannose dehydrogenase; UDP- glucose/GDP-mannose dehydrogenase dimerisation; UDP- glucose/GDP-mannose dehydrogenase; KEGG: sat:SYN_01113 UDP-N-acetyl-D-galactosamine 6- dehydrogenase. (444 aa)
Slin_4070PFAM: oxidoreductase domain protein; homoserine dehydrogenase NAD-binding; Alcohol dehydrogenase GroES domain protein; Oxidoreductase domain; TrkA-N domain protein; Alcohol dehydrogenase zinc-binding domain protein; KEGG: sat:SYN_02682 oxidoreductase. (734 aa)
Slin_4034PFAM: short-chain dehydrogenase/reductase SDR; KR domain protein; KEGG: bra:BRADO3944 oxidoreductase NAD(P)-binding subunit. (335 aa)
Slin_3998PFAM: short-chain dehydrogenase/reductase SDR; KR domain protein; KEGG: cti:RALTA_A0558 putative 3-hydroxyacyl-CoA dehydrogenase type II oxidoreductase protein; Belongs to the short-chain dehydrogenases/reductases (SDR) family. (259 aa)
Slin_3987PFAM: short-chain dehydrogenase/reductase SDR; KR domain protein; KEGG: bja:bll4353 2-deoxy-D-gluconate 3- dehydrogenase. (261 aa)
Slin_3957PFAM: 3-hydroxyacyl-CoA dehydrogenase NAD-binding; 3-hydroxyacyl-CoA dehydrogenase domain protein; KEGG: mlo:mlr6793 3-hydroxybutyryl-CoA dehydrogenase. (332 aa)
Slin_5413PFAM: short-chain dehydrogenase/reductase SDR; KEGG: mlo:mll2196 short chain oxidoreductase; Belongs to the short-chain dehydrogenases/reductases (SDR) family. (245 aa)
Slin_5292PFAM: short-chain dehydrogenase/reductase SDR; KR domain protein; KEGG: bxe:Bxe_B1317 short-chain dehydrogenase. (300 aa)
Slin_5217PFAM: Alcohol dehydrogenase GroES domain protein; Alcohol dehydrogenase zinc-binding domain protein; KEGG: mch:Mchl_3368 alcohol dehydrogenase GroES domain protein. (384 aa)
Slin_5183PFAM: NAD-dependent epimerase/dehydratase; KEGG: rsh:Rsph17029_3699 NAD-dependent epimerase/dehydratase. (357 aa)
murBUDP-N-acetylenolpyruvoylglucosamine reductase; Cell wall formation. (341 aa)
Slin_4815dTDP-4-dehydrorhamnose reductase; Catalyzes the reduction of dTDP-6-deoxy-L-lyxo-4-hexulose to yield dTDP-L-rhamnose. (299 aa)
Slin_4802PFAM: short-chain dehydrogenase/reductase SDR; KR domain protein; KEGG: hch:HCH_02028 short-chain alcohol dehydrogenase-like protein. (267 aa)
Slin_4767KEGG: bba:Bd3723 isocitrate dehydrogenase; TIGRFAM: isocitrate dehydrogenase, NADP-dependent; PFAM: isocitrate/isopropylmalate dehydrogenase; Belongs to the isocitrate and isopropylmalate dehydrogenases family. (405 aa)
Slin_2192PFAM: short-chain dehydrogenase/reductase SDR; KR domain protein; KEGG: mno:Mnod_8333 short-chain dehydrogenase/reductase SDR. (256 aa)
Slin_3808PFAM: short-chain dehydrogenase/reductase SDR; KR domain protein; NAD-dependent epimerase/dehydratase; KEGG: bja:blr7566 oxidoreductase. (248 aa)
Slin_3779PFAM: Alcohol dehydrogenase zinc-binding domain protein; Alcohol dehydrogenase GroES domain protein; KEGG: psa:PST_3017 oxidoreductase, zinc-binding. (348 aa)
Slin_3739PFAM: short-chain dehydrogenase/reductase SDR; KR domain protein; KEGG: afw:Anae109_3255 short-chain dehydrogenase/reductase SDR. (250 aa)
Slin_3669PFAM: Alcohol dehydrogenase GroES domain protein; Alcohol dehydrogenase zinc-binding domain protein; KEGG: mch:Mchl_3368 alcohol dehydrogenase GroES domain protein. (386 aa)
Slin_3665PFAM: Alcohol dehydrogenase GroES domain protein; Alcohol dehydrogenase zinc-binding domain protein; KEGG: scl:sce5495 alcohol dehydrogenase. (388 aa)
Slin_3550PFAM: D-isomer specific 2-hydroxyacid dehydrogenase NAD-binding; D-isomer specific 2-hydroxyacid dehydrogenase catalytic region; KEGG: hypothetical protein; K03778 D-lactate dehydrogenase. (329 aa)
Slin_3540PFAM: Alcohol dehydrogenase GroES domain protein; Alcohol dehydrogenase zinc-binding domain protein; KEGG: bam:Bamb_3870 alcohol dehydrogenase. (337 aa)
Slin_3526Nucleotide sugar dehydrogenase; KEGG: gur:Gura_2308 UDP-glucose 6-dehydrogenase; TIGRFAM: nucleotide sugar dehydrogenase; PFAM: UDP-glucose/GDP-mannose dehydrogenase; UDP- glucose/GDP-mannose dehydrogenase dimerisation; UDP- glucose/GDP-mannose dehydrogenase; NAD-dependent glycerol- 3-phosphate dehydrogenase domain protein. (443 aa)
hldDADP-L-glycero-D-manno-heptose-6-epimerase; Catalyzes the interconversion between ADP-D-glycero-beta-D- manno-heptose and ADP-L-glycero-beta-D-manno-heptose via an epimerization at carbon 6 of the heptose; Belongs to the NAD(P)-dependent epimerase/dehydratase family. HldD subfamily. (321 aa)
Slin_3404PFAM: short-chain dehydrogenase/reductase SDR; KR domain protein; NAD-dependent epimerase/dehydratase; KEGG: sde:Sde_2646 phosphatidylserine decarboxylase. (257 aa)
Slin_3335KEGG: rbo:A1I_06360 isocitrate dehydrogenase; TIGRFAM: isocitrate dehydrogenase; PFAM: isocitrate/isopropylmalate dehydrogenase. (482 aa)
Slin_3152PFAM: short-chain dehydrogenase/reductase SDR; KEGG: mes:Meso_2224 short-chain dehydrogenase/reductase SDR. (250 aa)
Slin_2975PFAM: NAD-dependent epimerase/dehydratase; Male sterility domain; KEGG: pin:Ping_0777 dNTP-hexose dehydratase/epimerase. (353 aa)
Slin_2937Riboflavin biosynthesis protein RibD; Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'- phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)-pyrimidinedione 5'- phosphate; In the C-terminal section; belongs to the HTP reductase family. (352 aa)
Slin_2911Malate dehydrogenase (oxaloacetate- decarboxylating) (NADP(+))., Phosphate acetyltransferase; PFAM: malic protein NAD-binding; malic protein domain protein; phosphate acetyl/butaryl transferase; KEGG: gsu:GSU1700 malic enzyme. (755 aa)
Slin_2838PFAM: short-chain dehydrogenase/reductase SDR; KR domain protein; KEGG: mlo:mlr3057 3-ketoacyl-(acyl-carrier-protein) reductase. (258 aa)
Slin_2803PFAM: iron-containing alcohol dehydrogenase; KEGG: saz:Sama_1640 alcohol dehydrogenase, iron- containing. (365 aa)
Slin_2770PFAM: short-chain dehydrogenase/reductase SDR; KEGG: xcv:XCV1542 short chain dehydrogenase; Belongs to the short-chain dehydrogenases/reductases (SDR) family. (260 aa)
zwfGlucose-6-phosphate 1-dehydrogenase; Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone. (499 aa)
Slin_26082-dehydropantoate 2-reductase; Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid. (309 aa)
Slin_2520PFAM: short-chain dehydrogenase/reductase SDR; KR domain protein; KEGG: bxe:Bxe_B0443 glucose 1-dehydrogenase. (271 aa)
Slin_2484PFAM: short-chain dehydrogenase/reductase SDR; KR domain protein; KEGG: gsu:GSU0696 glucose 1-dehydrogenase. (249 aa)
Slin_2303PFAM: short-chain dehydrogenase/reductase SDR; KR domain protein; KEGG: bxe:Bxe_B0443 glucose 1-dehydrogenase. (269 aa)
Slin_2228PFAM: D-isomer specific 2-hydroxyacid dehydrogenase NAD-binding; KEGG: scl:sce5485 putative dehydrogenase. (310 aa)
Slin_0070PFAM: 3-hydroxyacyl-CoA dehydrogenase NAD-binding; 3-hydroxyacyl-CoA dehydrogenase domain protein; KEGG: bav:BAV0216 3-hydroxybutyryl-CoA dehydrogenase. (318 aa)
Slin_0197PFAM: short-chain dehydrogenase/reductase SDR; Male sterility domain; NAD-dependent epimerase/dehydratase; KEGG: similar to LOC407663 protein; Belongs to the short-chain dehydrogenases/reductases (SDR) family. (280 aa)
Slin_0199PFAM: short-chain dehydrogenase/reductase SDR; KR domain protein; KEGG: mlo:mll2041 short chain oxidoreductase; Belongs to the short-chain dehydrogenases/reductases (SDR) family. (237 aa)
Slin_0310PFAM: short-chain dehydrogenase/reductase SDR; KR domain protein; KEGG: bmj:BMULJ_04919 3-oxoacyl-[acyl-carrier protein] reductase. (261 aa)
Slin_0324PFAM: D-isomer specific 2-hydroxyacid dehydrogenase NAD-binding; D-isomer specific 2-hydroxyacid dehydrogenase catalytic region; KEGG: har:HEAR3340 putative phosphoglycerate dehydrogenase(partial). (311 aa)
Slin_0360PFAM: Alcohol dehydrogenase GroES domain protein; Alcohol dehydrogenase zinc-binding domain protein; KEGG: mxa:MXAN_7323 zinc-binding dehydrogenase family oxidoreductase. (347 aa)
Slin_0401PFAM: short-chain dehydrogenase/reductase SDR; KR domain protein; NAD-dependent epimerase/dehydratase; KEGG: rfr:Rfer_4047 3-oxoacyl-(acyl-carrier- protein) reductase. (245 aa)
Slin_0415PFAM: short-chain dehydrogenase/reductase SDR; KR domain protein; KEGG: reh:H16_A0743 short chain dehydrogenase. (257 aa)
Slin_0452PFAM: short-chain dehydrogenase/reductase SDR; KR domain protein; KEGG: abb:ABBFA_002101 short chain dehydrogenase family protein. (287 aa)
Slin_0453PFAM: short-chain dehydrogenase/reductase SDR; KEGG: abb:ABBFA_002101 short chain dehydrogenase family protein. (284 aa)
Slin_0484PFAM: short-chain dehydrogenase/reductase SDR; KEGG: hch:HCH_02025 short-chain alcohol dehydrogenase-like protein. (256 aa)
Slin_0608PFAM: short-chain dehydrogenase/reductase SDR; KR domain protein; NAD-dependent epimerase/dehydratase; KEGG: hypothetical protein. (247 aa)
Slin_0612PFAM: 3-hydroxyacyl-CoA dehydrogenase NAD-binding; 3-hydroxyacyl-CoA dehydrogenase domain protein; KEGG: ara:Arad_8405 3-hydroxybutyryl-CoA dehydrogenase protein. (320 aa)
Slin_0705PFAM: Shikimate dehydrogenase substrate binding domain protein; Shikimate/quinate 5-dehydrogenase; KEGG: afr:AFE_0182 shikimate 5-dehydrogenase. (247 aa)
Slin_0882PFAM: short-chain dehydrogenase/reductase SDR; KR domain protein; NAD-dependent epimerase/dehydratase; KEGG: mmw:Mmwyl1_0350 short chain dehydrogenase. (262 aa)
Slin_1007PFAM: short-chain dehydrogenase/reductase SDR; KEGG: azc:AZC_3534 short-chain dehydrogenase. (233 aa)
Slin_1056PFAM: Mannitol dehydrogenase domain; Mannitol dehydrogenase rossman domain; KEGG: tau:Tola_3026 mannitol dehydrogenase domain protein. (513 aa)
gpsAPFAM: NAD-dependent glycerol-3-phosphate dehydrogenase domain protein; KEGG: NAD+ dependent glycerol-3-phosphate dehydrogenase, putative; Belongs to the NAD-dependent glycerol-3-phosphate dehydrogenase family. (334 aa)
Your Current Organism:
Spirosoma linguale
NCBI taxonomy Id: 504472
Other names: S. linguale DSM 74, Spirosoma linguale DSM 74, Spirosoma linguale str. DSM 74, Spirosoma linguale strain DSM 74
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