STRINGSTRING
Slin_1338 Slin_1338 purQ purQ Slin_6324 Slin_6324 Slin_6239 Slin_6239 Slin_6087 Slin_6087 Slin_6005 Slin_6005 purD purD gatB gatB carA carA bioD bioD Slin_5526 Slin_5526 gatC gatC Slin_5361 Slin_5361 Slin_5139 Slin_5139 Slin_4989 Slin_4989 murC murC murD murD murE murE Slin_4524 Slin_4524 gatA gatA Slin_4470 Slin_4470 panC panC murF murF Slin_4152 Slin_4152 Slin_3918 Slin_3918 Slin_3846 Slin_3846 Slin_3345 Slin_3345 purS purS Slin_3003 Slin_3003 guaA guaA purC purC Slin_2496 Slin_2496 Slin_2432 Slin_2432 Slin_2431 Slin_2431 purL purL pyrG pyrG Slin_1996 Slin_1996 purA purA Slin_1316 Slin_1316 Slin_1315 Slin_1315 Slin_1314 Slin_1314 tilS tilS Slin_1305 Slin_1305 purK purK Slin_1108 Slin_1108 nadE nadE Slin_0632 Slin_0632 Slin_0568 Slin_0568 Slin_0407 Slin_0407 Slin_0231 Slin_0231
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Slin_1338KEGG: scl:sce3586 hypothetical protein. (352 aa)
purQPhosphoribosylformylglycinamidine synthase I; Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP- dependent manner. PurS interacts with PurQ and PurL and is thought to assist i [...] (228 aa)
Slin_6324PFAM: Amidase; KEGG: dal:Dalk_0692 amidase. (555 aa)
Slin_6239TIGRFAM: carbamoyl-phosphate synthase, large subunit; PFAM: Carbamoyl-phosphate synthase L chain ATP- binding; ATP-dependent carboxylate-amine ligase domain protein ATP-grasp; phosphoribosylglycinamide synthetase; Carbamoyl-phosphate synthetase large chain oligomerisation; Carbamoyl-phosphate synthetase large chain domain protein; KEGG: tcx:Tcr_0879 carbamoyl-phosphate synthase, large subunit. (958 aa)
Slin_6087TIGRFAM: alpha-L-glutamate ligase, RimK family; PFAM: RimK domain protein ATP-grasp; protein of unknown function DUF201; KEGG: vfi:VF_0658 ribosomal protein S6 modification protein; Belongs to the RimK family. (302 aa)
Slin_6005Phosphoribosylformylglycinamidine cyclo-ligase; PFAM: AIR synthase related protein domain protein; KEGG: predicted protein; K01933 phosphoribosylformylglycinamidine cyclo-ligase. (389 aa)
purDKEGG: msu:MS1296 phosphoribosylamine--glycine ligase; TIGRFAM: phosphoribosylamine/glycine ligase; PFAM: phosphoribosylglycinamide synthetase; protein of unknown function DUF201; Belongs to the GARS family. (428 aa)
gatBglutamyl-tRNA(Gln) amidotransferase, B subunit; Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp-tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl- tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp- tRNA(Asn) or phospho-Glu-tRNA(Gln); Belongs to the GatB/GatE family. GatB subfamily. (493 aa)
carATIGRFAM: carbamoyl-phosphate synthase, small subunit; PFAM: glutamine amidotransferase class-I; Carbamoyl- phosphate synthase small chain; KEGG: vpa:VP0470 carbamoyl phosphate synthase small subunit; Belongs to the CarA family. (367 aa)
bioDDethiobiotin synthase; Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8- diaminopelargonic acid (DAPA) to form an ureido ring. (210 aa)
Slin_5526PFAM: Mur ligase middle domain protein; cytoplasmic peptidoglycan synthetase domain protein; KEGG: dal:Dalk_2211 UDP-N-acetylmuramate. (453 aa)
gatCglutamyl-tRNA(Gln) amidotransferase, C subunit; Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp-tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl- tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp- tRNA(Asn) or phospho-Glu-tRNA(Gln); Belongs to the GatC family. (95 aa)
Slin_5361TIGRFAM: 5-formyltetrahydrofolate cyclo-ligase; PFAM: 5-formyltetrahydrofolate cyclo-ligase; KEGG: ses:SARI_04589 putative ligase; Belongs to the 5-formyltetrahydrofolate cyclo-ligase family. (191 aa)
Slin_5139Glutamate--ammonia ligase; PFAM: glutamine synthetase catalytic region; KEGG: mxa:MXAN_5630 glutamine synthetase family protein. (457 aa)
Slin_4989PFAM: Protein of unknown function YOR215C, mitochondrial; KEGG: nis:NIS_0988 GatB/YqeY domain-containing protein. (149 aa)
murCUDP-N-acetylmuramate/alanine ligase; Cell wall formation; Belongs to the MurCDEF family. (461 aa)
murDUDP-N-acetylmuramoylalanine/D-glutamate ligase; Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA). Belongs to the MurCDEF family. (449 aa)
murEUDP-N-acetylmuramyl-tripeptide synthetase; Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan. Belongs to the MurCDEF family. MurE subfamily. (498 aa)
Slin_4524Biotin carboxylase-like protein; KEGG: bph:Bphy_7724 putative biotin carboxylase. (403 aa)
gatAglutamyl-tRNA(Gln) amidotransferase, A subunit; Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu- tRNA(Gln). (479 aa)
Slin_4470PFAM: Amidase; KEGG: oca:OCAR_4104 peptide amidase. (530 aa)
panCPantoate/beta-alanine ligase; Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate. Belongs to the pantothenate synthetase family. (280 aa)
murFUDP-N-acetylmuramoylalanyl-D-glutamyl-2, 6-diaminopimelate/ D-alanyl-D-alanyl ligase; Involved in cell wall formation. Catalyzes the final step in the synthesis of UDP-N-acetylmuramoyl-pentapeptide, the precursor of murein; Belongs to the MurCDEF family. MurF subfamily. (449 aa)
Slin_4152TIGRFAM: cyanophycin synthetase; PFAM: Mur ligase middle domain protein; cytoplasmic peptidoglycan synthetase domain protein; RimK domain protein ATP-grasp; phosphoribosylglycinamide synthetase; ATP-dependent carboxylate-amine ligase domain protein ATP- grasp; KEGG: csa:Csal_1114 cyanophycin synthetase; Belongs to the MurCDEF family. (895 aa)
Slin_3918PFAM: Amidase; KEGG: dol:Dole_2535 amidase; Belongs to the amidase family. (519 aa)
Slin_3846PFAM: Amidase; KEGG: mxa:MXAN_3566 amidase. (540 aa)
Slin_3345PFAM: Amidase; KEGG: oca:OCAR_4104 peptide amidase. (526 aa)
purSPhosphoribosylformylglycinamidine synthase, purS; Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP- dependent manner. PurS interacts with PurQ and PurL and is thought to assi [...] (83 aa)
Slin_3003TIGRFAM: biotin/acetyl-CoA-carboxylase ligase; PFAM: biotin/lipoate A/B protein ligase; KEGG: pst:PSPTO_0610 biotin--protein ligase. (269 aa)
guaAGMP synthase, large subunit; Catalyzes the synthesis of GMP from XMP. (510 aa)
purCPFAM: SAICAR synthetase; KEGG: mxa:MXAN_2080 phosphoribosylaminoimidazole- succinocarboxamide synthase. (313 aa)
Slin_2496KEGG: vvy:VV0791 hypothetical protein. (371 aa)
Slin_2432Glutamate--ammonia ligase; PFAM: glutamine synthetase catalytic region; glutamine synthetase beta-Grasp; KEGG: mrd:Mrad2831_5128 glutamate--ammonia ligase. (344 aa)
Slin_2431PFAM: glutamine synthetase catalytic region; KEGG: ppd:Ppro_1682 glutamine synthetase, catalytic region. (729 aa)
purLPhosphoribosylformylglycinamidine synthase II; Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP- dependent manner. PurS interacts with PurQ and PurL and is thought to assist [...] (754 aa)
pyrGCTP synthase; Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen. Regulates intracellular CTP levels through interactions with the four ribonucleotide triphosphates. (565 aa)
Slin_1996TIGRFAM: FolC bifunctional protein; PFAM: Mur ligase middle domain protein; KEGG: sfu:Sfum_1671 FolC bifunctional protein; Belongs to the folylpolyglutamate synthase family. (428 aa)
purAAdenylosuccinate synthetase; Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP; Belongs to the adenylosuccinate synthetase family. (428 aa)
Slin_1316Glutamate--cysteine ligase GCS2; ATP-dependent carboxylate-amine ligase which exhibits weak glutamate--cysteine ligase activity; Belongs to the glutamate--cysteine ligase type 2 family. YbdK subfamily. (366 aa)
Slin_1315GMP synthase - Glutamine amidotransferase domain- like protein; KEGG: scl:sce3772 hypothetical protein. (278 aa)
Slin_1314KEGG: scl:sce4393 hypothetical protein. (398 aa)
tilStRNA(Ile)-lysidine synthetase; Ligates lysine onto the cytidine present at position 34 of the AUA codon-specific tRNA(Ile) that contains the anticodon CAU, in an ATP-dependent manner. Cytidine is converted to lysidine, thus changing the amino acid specificity of the tRNA from methionine to isoleucine. Belongs to the tRNA(Ile)-lysidine synthase family. (446 aa)
Slin_1305Phosphopantothenoylcysteine decarboxylase/phosphopantothenate/cysteine ligase; Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4- phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine; In the C-terminal section; belongs to the PPC synthetase family. (412 aa)
purKPhosphoribosylaminoimidazole carboxylase, ATPase subunit; Catalyzes the ATP-dependent conversion of 5-aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5-carboxyaminoimidazole ribonucleotide (N5-CAIR). (363 aa)
Slin_1108D-alanine--D-alanine ligase domain protein; Cell wall formation; Belongs to the D-alanine--D-alanine ligase family. (551 aa)
nadENAD+ synthetase; Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source. (700 aa)
Slin_0632Nicotinate phosphoribosyltransferase; Catalyzes the first step in the biosynthesis of NAD from nicotinic acid, the ATP-dependent synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate. Belongs to the NAPRTase family. (505 aa)
Slin_0568PFAM: asparagine synthase; KEGG: mlo:mll5256 asparagine synthetase. (647 aa)
Slin_0407PFAM: argininosuccinate synthase; Queuosine synthesis-like; KEGG: mxa:MXAN_5108 argininosuccinate synthase. (400 aa)
Slin_0231PFAM: protein of unknown function DUF404; protein of unknown function DUF407; KEGG: dat:HRM2_13790 hypothetical protein. (501 aa)
Your Current Organism:
Spirosoma linguale
NCBI taxonomy Id: 504472
Other names: S. linguale DSM 74, Spirosoma linguale DSM 74, Spirosoma linguale str. DSM 74, Spirosoma linguale strain DSM 74
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