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pdxJ pdxJ rlmN rlmN moaA moaA Slin_4454 Slin_4454 Slin_4419 Slin_4419 Slin_4391 Slin_4391 Slin_4269 Slin_4269 Slin_3955 Slin_3955 Slin_3571 Slin_3571 thiE thiE Slin_3318 Slin_3318 tal-2 tal-2 Slin_3023 Slin_3023 Slin_2837 Slin_2837 Slin_2802 Slin_2802 bioB bioB Slin_2392 Slin_2392 Slin_2319 Slin_2319 Slin_1907 Slin_1907 Slin_1817 Slin_1817 queE queE Slin_1777 Slin_1777 Slin_1479 Slin_1479 Slin_1419 Slin_1419 Slin_1380 Slin_1380 Slin_1245 Slin_1245 guaB guaB trpF-2 trpF-2 Slin_0901 Slin_0901 Slin_0897 Slin_0897 Slin_2469 Slin_2469 Slin_0858 Slin_0858 Slin_0707 Slin_0707 Slin_0632 Slin_0632 Slin_0609 Slin_0609 lipA lipA Slin_0435 Slin_0435 trpF trpF tal tal Slin_0254 Slin_0254 Slin_0240 Slin_0240 Slin_0058 Slin_0058 Slin_2625 Slin_2625 Slin_2540 Slin_2540 dapA dapA thiG thiG Slin_6575 Slin_6575 Slin_6577 Slin_6577 Slin_6589 Slin_6589 thiE-2 thiE-2 Slin_6347 Slin_6347 Slin_5900 Slin_5900 Slin_5897 Slin_5897 pyrD pyrD Slin_5731 Slin_5731 Slin_5726 Slin_5726 tpiA tpiA hisF hisF hisA hisA trpA trpA trpF-3 trpF-3 trpC trpC Slin_5386 Slin_5386 Slin_5167 Slin_5167
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query proteins and first shell of interactors
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second shell of interactors
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proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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pdxJPyridoxal phosphate biosynthetic protein PdxJ; Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino- 2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate. (245 aa)
rlmNRadical SAM enzyme, Cfr family; Specifically methylates position 2 of adenine 2503 in 23S rRNA and position 2 of adenine 37 in tRNAs; Belongs to the radical SAM superfamily. RlmN family. (349 aa)
moaAMolybdenum cofactor biosynthesis protein A; Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate. (326 aa)
Slin_4454Pyruvate carboxylase; Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second. (1149 aa)
Slin_4419Deoxyribose-phosphate aldolase/phospho-2-dehydro- 3-deoxyheptonate aldolase; Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy-D-ribose 5- phosphate; Belongs to the DeoC/FbaB aldolase family. DeoC type 1 subfamily. (217 aa)
Slin_4391PFAM: Radical SAM domain protein; KEGG: gur:Gura_0505 radical SAM domain-containing protein. (327 aa)
Slin_4269Pseudaminic acid synthase; KEGG: bph:Bphy_3008 N-acylneuraminate-9-phosphate synthase; TIGRFAM: pseudaminic acid synthase; PFAM: N-acetylneuraminic acid synthase domain; SAF domain protein. (351 aa)
Slin_3955TIGRFAM: 2-dehydro-3-deoxyphosphogluconate aldolase/4-hydroxy-2-oxoglutarate aldolase; PFAM: KDPG and KHG aldolase; KEGG: scl:sce5154 KDPG and KHG aldolase. (215 aa)
Slin_3571KEGG: bba:Bd3454 coproporphyrinogen III oxidase; TIGRFAM: oxygen-independent coproporphyrinogen III oxidase; PFAM: HemN domain protein; Radical SAM domain protein; SMART: Elongator protein 3/MiaB/NifB; Belongs to the anaerobic coproporphyrinogen-III oxidase family. (460 aa)
thiEThiamine-phosphate pyrophosphorylase; Condenses 4-methyl-5-(beta-hydroxyethyl)thiazole monophosphate (THZ-P) and 2-methyl-4-amino-5-hydroxymethyl pyrimidine pyrophosphate (HMP-PP) to form thiamine monophosphate (TMP). Belongs to the thiamine-phosphate synthase family. (206 aa)
Slin_3318PFAM: NADH:flavin oxidoreductase/NADH oxidase; KEGG: gsu:GSU1371 oxidoreductase, FAD/FMN-binding. (356 aa)
tal-2Transaldolase; Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway; Belongs to the transaldolase family. Type 3B subfamily. (221 aa)
Slin_3023Hydroxymethylglutaryl-CoA lyase; PFAM: pyruvate carboxyltransferase; KEGG: hydroxymethylglutaryl-CoA lyase; K01640 hydroxymethylglutaryl-CoA lyase. (280 aa)
Slin_2837PFAM: NADH:flavin oxidoreductase/NADH oxidase; KEGG: dds:Ddes_1649 NADH:flavin oxidoreductase/NADH oxidase. (481 aa)
Slin_2802TIGRFAM: 2-dehydro-3-deoxyphosphooctonate aldolase; PFAM: DAHP synthetase I/KDSA; KEGG: glo:Glov_2172 2-dehydro-3- deoxyphosphooctonate aldolase. (283 aa)
bioBBiotin synthase; Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical-based mechanism; Belongs to the radical SAM superfamily. Biotin synthase family. (330 aa)
Slin_2392TIM-barrel protein, nifR3 family; Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines; Belongs to the dus family. (329 aa)
Slin_2319PFAM: ferredoxin-dependent glutamate synthase; glutamate synthase alpha subunit domain protein; glutamate synthase; glutamine amidotransferase class-II; KEGG: vvu:VV1_0553 glutamate synthase, large subunit. (1524 aa)
Slin_1907PFAM: glycoside hydrolase clan GH-D; KEGG: melibiase, putative. (730 aa)
Slin_1817PFAM: FMN-dependent alpha-hydroxy acid dehydrogenase; KEGG: prw:PsycPRwf_1462 FMN-dependent alpha-hydroxy acid dehydrogenase. (349 aa)
queEOrganic radical activating enzyme; Catalyzes the complex heterocyclic radical-mediated conversion of 6-carboxy-5,6,7,8-tetrahydropterin (CPH4) to 7-carboxy-7- deazaguanine (CDG), a step common to the biosynthetic pathways of all 7-deazapurine-containing compounds. (216 aa)
Slin_1777PFAM: Radical SAM domain protein; SMART: Elongator protein 3/MiaB/NifB; KEGG: azo:azo2509 hypothetical protein. (737 aa)
Slin_1479PFAM: dihydrodipicolinate synthetase; KEGG: bpy:Bphyt_4559 dihydrodipicolinate synthetase; Belongs to the DapA family. (304 aa)
Slin_1419PFAM: Glycoside hydrolase 97; KEGG: cja:CJA_0817 alpha-glucosidase, putative, adg97A. (648 aa)
Slin_1380PFAM: Ethanolamine ammonia lyase large subunit; KEGG: bph:Bphy_0007 ethanolamine ammonia lyase large subunit. (459 aa)
Slin_1245PFAM: KDPG and KHG aldolase; KEGG: ccs:CCNA_01562 4-hydroxy-2-oxoglutarate aldolase/2-dehydro-3-deoxyphosphogluconate aldolase. (222 aa)
guaBInosine-5'-monophosphate dehydrogenase; Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth. Belongs to the IMPDH/GMPR family. (490 aa)
trpF-2PFAM: N-(5'phosphoribosyl)anthranilate isomerase (PRAI); KEGG: nwi:Nwi_0056 N-(5'- phosphoribosyl)anthranilate isomerase; Belongs to the TrpF family. (211 aa)
Slin_0901PFAM: Radical SAM domain protein; KEGG: pzu:PHZ_c2389 hypothetical protein. (414 aa)
Slin_0897PFAM: Radical SAM domain protein; KEGG: cvi:CV_0072 hypothetical protein. (454 aa)
Slin_2469PFAM: Glycoside hydrolase 97; KEGG: sde:Sde_2499 putative alpha-glucosidase. (641 aa)
Slin_0858PFAM: Radical SAM domain protein; KEGG: bid:Bind_2162 radical SAM domain-containing protein. (349 aa)
Slin_0707PFAM: (2R)-phospho-3-sulfolactate synthase ComA; KEGG: (2r)-phospho-3-sulfolactate synthase; K01767. (254 aa)
Slin_0632Nicotinate phosphoribosyltransferase; Catalyzes the first step in the biosynthesis of NAD from nicotinic acid, the ATP-dependent synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate. Belongs to the NAPRTase family. (505 aa)
Slin_0609PFAM: dihydrodipicolinate synthetase; KEGG: rpi:Rpic_3006 dihydrodipicolinate synthetase; Belongs to the DapA family. (317 aa)
lipALipoic acid synthetase; Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives. (302 aa)
Slin_0435KEGG: pol:Bpro_4616 orotidine 5'-phosphate decarboxylase; TIGRFAM: orotidine 5'-phosphate decarboxylase; PFAM: Orotidine 5'-phosphate decarboxylase. (279 aa)
trpFPFAM: N-(5'phosphoribosyl)anthranilate isomerase (PRAI); KEGG: lch:Lcho_3196 N- (5'phosphoribosyl)anthranilate isomerase (PRAI); Belongs to the TrpF family. (220 aa)
talTransaldolase; Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway; Belongs to the transaldolase family. Type 3B subfamily. (219 aa)
Slin_0254Fructose-bisphosphate aldolase, class II; Catalyzes the aldol condensation of dihydroxyacetone phosphate (DHAP or glycerone-phosphate) with glyceraldehyde 3-phosphate (G3P) to form fructose 1,6-bisphosphate (FBP) in gluconeogenesis and the reverse reaction in glycolysis; Belongs to the class II fructose-bisphosphate aldolase family. (359 aa)
Slin_0240PFAM: Radical SAM domain protein; KEGG: cbg:CbuG_1165 radical SAM superfamily protein. (340 aa)
Slin_0058PFAM: Glycoside hydrolase 97; KEGG: sfr:Sfri_1777 alpha-glucosidase. (693 aa)
Slin_2625PFAM: dihydrodipicolinate synthetase; KEGG: vcj:VCD_002594 N-acetylneuraminate lyase; Belongs to the DapA family. (315 aa)
Slin_2540KEGG: vcj:VCD_001738 ribulose-phosphate 3-epimerase; TIGRFAM: ribulose-phosphate 3-epimerase; PFAM: ribulose-phosphate 3-epimerase; Belongs to the ribulose-phosphate 3-epimerase family. (223 aa)
dapADihydrodipicolinate synthase; Catalyzes the condensation of (S)-aspartate-beta-semialdehyde [(S)-ASA] and pyruvate to 4-hydroxy-tetrahydrodipicolinate (HTPA). (298 aa)
thiGThiazole biosynthesis family protein; Catalyzes the rearrangement of 1-deoxy-D-xylulose 5-phosphate (DXP) to produce the thiazole phosphate moiety of thiamine. Sulfur is provided by the thiocarboxylate moiety of the carrier protein ThiS. In vitro, sulfur can be provided by H(2)S. (259 aa)
Slin_6575TIGRFAM: thiazole biosynthesis protein ThiH; PFAM: biotin and thiamin synthesis associated; Radical SAM domain protein; KEGG: vpa:VP3022 thiamine biosynthesis protein ThiH. (378 aa)
Slin_6577PFAM: thiamine monophosphate synthase; KEGG: mch:Mchl_0613 thiamine monophosphate synthase. (201 aa)
Slin_6589PFAM: dihydrodipicolinate synthetase; KEGG: hypothetical protein; Belongs to the DapA family. (308 aa)
thiE-2Thiamine-phosphate pyrophosphorylase; Condenses 4-methyl-5-(beta-hydroxyethyl)thiazole monophosphate (THZ-P) and 2-methyl-4-amino-5-hydroxymethyl pyrimidine pyrophosphate (HMP-PP) to form thiamine monophosphate (TMP). Belongs to the thiamine-phosphate synthase family. (212 aa)
Slin_6347PFAM: NADH:flavin oxidoreductase/NADH oxidase; KEGG: pol:Bpro_5550 NADH:flavin oxidoreductase/NADH oxidase. (363 aa)
Slin_5900PFAM: pyruvate carboxyltransferase; LeuA allosteric (dimerisation) domain; KEGG: mpo:Mpop_2796 2-isopropylmalate synthase; Belongs to the alpha-IPM synthase/homocitrate synthase family. (506 aa)
Slin_5897PFAM: pyruvate carboxyltransferase; KEGG: pat:Patl_3268 2-isopropylmalate synthase; Belongs to the alpha-IPM synthase/homocitrate synthase family. (379 aa)
pyrDDihydroorotate dehydrogenase; Catalyzes the conversion of dihydroorotate to orotate with quinone as electron acceptor; Belongs to the dihydroorotate dehydrogenase family. Type 2 subfamily. (349 aa)
Slin_5731PFAM: DAHP synthetase I/KDSA; Chorismate mutase; KEGG: sdn:Sden_0622 DAHP synthetase I/KdsA. (367 aa)
Slin_5726PFAM: Glycoside hydrolase 97; KEGG: slo:Shew_2298 putative alpha-glucosidase. (656 aa)
tpiATriosephosphate isomerase; Involved in the gluconeogenesis. Catalyzes stereospecifically the conversion of dihydroxyacetone phosphate (DHAP) to D- glyceraldehyde-3-phosphate (G3P); Belongs to the triosephosphate isomerase family. (254 aa)
hisFImidazoleglycerol phosphate synthase, cyclase subunit; IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit. (251 aa)
hisA1-(5-phosphoribosyl)-5-((5-phosphoribosylamino) methylideneamino)imidazole-4-carboxamideisomerase; PFAM: histidine biosynthesis protein; KEGG: hypothetical protein; K01814 phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase. (240 aa)
trpATryptophan synthase, alpha subunit; The alpha subunit is responsible for the aldol cleavage of indoleglycerol phosphate to indole and glyceraldehyde 3-phosphate. Belongs to the TrpA family. (278 aa)
trpF-3PFAM: N-(5'phosphoribosyl)anthranilate isomerase (PRAI); KEGG: hypothetical protein; K01817 phosphoribosylanthranilate isomerase; Belongs to the TrpF family. (214 aa)
trpCPFAM: Indole-3-glycerol phosphate synthase; KEGG: similar to predicted protein; Belongs to the TrpC family. (269 aa)
Slin_5386Porphobilinogen synthase; PFAM: delta-aminolevulinic acid dehydratase; KEGG: bba:Bd3444 delta-aminolevulinic acid dehydratase; Belongs to the ALAD family. (327 aa)
Slin_5167KEGG: gur:Gura_2818 nicotinate-nucleotide pyrophosphorylase; TIGRFAM: nicotinate-nucleotide pyrophosphorylase; PFAM: Quinolinate phosphoribosyl transferase; Belongs to the NadC/ModD family. (277 aa)
Your Current Organism:
Spirosoma linguale
NCBI taxonomy Id: 504472
Other names: S. linguale DSM 74, Spirosoma linguale DSM 74, Spirosoma linguale str. DSM 74, Spirosoma linguale strain DSM 74
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