STRINGSTRING
acsA acsA sdhB sdhB sdhA sdhA sdhD sdhD sdhC sdhC pckA pckA fmt fmt iolA iolA glcB glcB AEI05504.1 AEI05504.1 AEI05609.1 AEI05609.1 prs prs AEI05693.1 AEI05693.1 AEI05726.1 AEI05726.1 AEI05734.1 AEI05734.1 prpD2 prpD2 prpC prpC prpB prpB gabD gabD aceA aceA ppdK ppdK mmsA mmsA AEI05970.1 AEI05970.1 sucD1 sucD1 sucC1 sucC1 sucD2 sucD2 sucC2 sucC2 sucD3 sucD3 gor gor mmsB mmsB maeA maeA pdhA pdhA pdhB pdhB pdhC pdhC lpd1 lpd1 AEI06533.1 AEI06533.1 AEI06555.1 AEI06555.1 lipA lipA AEI06664.1 AEI06664.1 gltA gltA lipB lipB adhI adhI AEI06990.1 AEI06990.1 icd icd gcvT gcvT gcvH gcvH gcvP gcvP fumA fumA ppc ppc AEI07361.1 AEI07361.1 fumC fumC AEI07547.1 AEI07547.1 dhaS dhaS AEI07631.1 AEI07631.1 betB betB ackA ackA pta pta lpd2 lpd2 sucB sucB sucA sucA mdh mdh acnA acnA
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
acsAAcetate-coenzyme A ligase AcsA; Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA; Belongs to the ATP-dependent AMP-binding enzyme family. (651 aa)
sdhBSuccinate dehydrogenase iron-sulfur subunit SdhB; Belongs to the succinate dehydrogenase/fumarate reductase iron-sulfur protein family. (260 aa)
sdhASuccinate dehydrogenase flavoprotein subunit SdhA; Belongs to the FAD-dependent oxidoreductase 2 family. FRD/SDH subfamily. (604 aa)
sdhDSuccinate dehydrogenase, membrane anchor SdhD. (134 aa)
sdhCSuccinate dehydrogenase, cytochrome b subunit SdhC. (131 aa)
pckAPhosphoenolpyruvate carboxykinase (ATP); Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA. (538 aa)
fmtmethionyl-tRNA formyltransferase Fmt; Attaches a formyl group to the free amino group of methionyl- tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus; Belongs to the Fmt family. (310 aa)
iolAMethylmalonate semialdehyde dehydrogenase IolA. (505 aa)
glcBMalate synthase G; Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl- CoA) and glyoxylate to form malate and CoA; Belongs to the malate synthase family. GlcB subfamily. (720 aa)
AEI05504.1Putative acyl-CoA synthase. (639 aa)
AEI05609.1Omega-amino acid--pyruvate aminotransferase; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. (446 aa)
prsRibose-phosphate pyrophosphokinase Prs; Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib- 5-P); Belongs to the ribose-phosphate pyrophosphokinase family. Class I subfamily. (331 aa)
AEI05693.1Ferredoxin; Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions. (113 aa)
AEI05726.1Transketolase; Component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2). (803 aa)
AEI05734.1Hypothetical protein. (645 aa)
prpD22-methylcitrate dehydratase 2. (505 aa)
prpC2-methylcitrate synthase PrpC; Belongs to the citrate synthase family. (431 aa)
prpBMethylisocitrate lyase PrpB; Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate. (303 aa)
gabDSuccinate-semialdehyde dehydrogenase [NADP+]. (477 aa)
aceAIsocitrate lyase AceA. (545 aa)
ppdKPyruvate, phosphate dikinase PpdK. (981 aa)
mmsAMethylmalonate-semialdehyde dehydrogenase MmsA. (499 aa)
AEI05970.1acyl-CoA synthase. (898 aa)
sucD1Succinate-semialdehyde dehydrogenase, acetylating. (475 aa)
sucC1succinyl-CoA ligase [ADP-forming] subunit beta. (375 aa)
sucD2succinyl-CoA ligase [ADP-forming] subunit alpha; Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit. (296 aa)
sucC2succinyl-CoA ligase [ADP-forming] subunit beta. (390 aa)
sucD3succinyl-CoA ligase [ADP-forming] subunit alpha; Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit. (293 aa)
gorGlutathione reductase Gor; Maintains high levels of reduced glutathione. (461 aa)
mmsB3-hydroxyisobutyrate dehydrogenase MmsB; Belongs to the HIBADH-related family. (295 aa)
maeANAD-dependent malic enzyme MaeA. (771 aa)
pdhAPyruvate dehydrogenase E1 component subunit alpha; The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2). (339 aa)
pdhBPyruvate dehydrogenase E1 component subunit beta; The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO2. (467 aa)
pdhCDihydrolipoyllysine-residue acetyltransferase component of pyruvate dehydrogenase complex; The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2). (457 aa)
lpd1Dihydrolipoyl dehydrogenase Lpd. (473 aa)
AEI06533.1Hypothetical protein. (96 aa)
AEI06555.1Hypothetical protein. (287 aa)
lipALipoyl synthase LipA; Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives. (322 aa)
AEI06664.1Hypothetical protein. (446 aa)
gltACitrate synthase GltA; Belongs to the citrate synthase family. (434 aa)
lipBOctanoyltransferase LipB; Catalyzes the transfer of endogenously produced octanoic acid from octanoyl-acyl-carrier-protein onto the lipoyl domains of lipoate- dependent enzymes. Lipoyl-ACP can also act as a substrate although octanoyl-ACP is likely to be the physiological substrate. (244 aa)
adhIAlcohol dehydrogenase class-3, S-(hydroxymethyl)glutathione dehydrogenase AdhI; Belongs to the zinc-containing alcohol dehydrogenase family. Class-III subfamily. (375 aa)
AEI06990.1Hypothetical protein. (273 aa)
icdIsocitrate dehydrogenase [NADP]; Belongs to the isocitrate and isopropylmalate dehydrogenases family. (405 aa)
gcvTAminomethyltransferase GcvT. (382 aa)
gcvHGlycine cleavage system H protein GcvH; The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein. (121 aa)
gcvPGlycine dehydrogenase (decarboxylating); The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO(2) is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein; Belongs to the GcvP family. (963 aa)
fumAFumarate hydratase class I, aerobic; Catalyzes the reversible hydration of fumarate to (S)-malate. Belongs to the class-I fumarase family. (548 aa)
ppcPhosphoenolpyruvate carboxylase Ppc; Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle; Belongs to the PEPCase type 1 family. (943 aa)
AEI07361.1Hypothetical protein. (296 aa)
fumCFumarate hydratase class II 1; Involved in the TCA cycle. Catalyzes the stereospecific interconversion of fumarate to L-malate; Belongs to the class-II fumarase/aspartase family. Fumarase subfamily. (468 aa)
AEI07547.1FAD dependent oxidoreductase, NAD binding site. (370 aa)
dhaSAldehyde dehydrogenase (NAD); Belongs to the aldehyde dehydrogenase family. (495 aa)
AEI07631.1Hypothetical protein. (80 aa)
betBBetaine aldehyde dehydrogenase BetB; Belongs to the aldehyde dehydrogenase family. (491 aa)
ackAAcetate kinase AckA; Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction; Belongs to the acetokinase family. (400 aa)
ptaPhosphate acetyltransferase Pta. (475 aa)
lpd2Dihydrolipoyl dehydrogenase Lpd. (467 aa)
sucBDihydrolipoamide succinyltransferase SucB; E2 component of the 2-oxoglutarate dehydrogenase (OGDH) complex which catalyzes the second step in the conversion of 2- oxoglutarate to succinyl-CoA and CO(2). (413 aa)
sucA2-oxoglutarate dehydrogenase componentSucA. (983 aa)
mdhMalate dehydrogenase Mdh; Catalyzes the reversible oxidation of malate to oxaloacetate. Belongs to the LDH/MDH superfamily. MDH type 3 family. (322 aa)
acnAAconitate hydratase AcnA; Catalyzes the isomerization of citrate to isocitrate via cis- aconitate. (906 aa)
Your Current Organism:
Oligotropha carboxidovorans
NCBI taxonomy Id: 504832
Other names: O. carboxidovorans OM5, Oligotropha carboxidovorans OM5, Oligotropha carboxidovorans str. OM5, Oligotropha carboxidovorans strain OM5
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