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| | trpA | Tryptophan synthase alpha chain TrpA; The alpha subunit is responsible for the aldol cleavage of indoleglycerol phosphate to indole and glyceraldehyde 3-phosphate. Belongs to the TrpA family. (278 aa) |
| | trpB | Tryptophan synthase beta chain TrpB; The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine. (405 aa) |
| | trpF | N-(5'-phosphoribosyl)anthranilate isomerase TrpF; Belongs to the TrpF family. (234 aa) |
| | aroA | 3-phosphoshikimate 1-carboxyvinyltransferase AroA; Catalyzes the transfer of the enolpyruvyl moiety of phosphoenolpyruvate (PEP) to the 5-hydroxyl of shikimate-3-phosphate (S3P) to produce enolpyruvyl shikimate-3-phosphate and inorganic phosphate. (443 aa) |
| | dapB | Dihydrodipicolinate reductase DapB; Catalyzes the conversion of 4-hydroxy-tetrahydrodipicolinate (HTPA) to tetrahydrodipicolinate. (272 aa) |
| | pyrF | Orotidine 5'-phosphate decarboxylase PyrF; Catalyzes the decarboxylation of orotidine 5'-monophosphate (OMP) to uridine 5'-monophosphate (UMP); Belongs to the OMP decarboxylase family. Type 1 subfamily. (235 aa) |
| | hisE | phosphoribosyl-ATP pyrophosphatase HisE. (109 aa) |
| | hisF | Imidazole glycerol phosphate synthase subunit HisF; IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit. (257 aa) |
| | hisA | 1-(5-phosphoribosyl)-5-[(5- phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomerase HisA. (248 aa) |
| | hisH | Imidazole glycerol phosphate synthase subunit HisH; IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the synthesis of IGP and AICAR. The resulting ammonia molecule is channeled to the active site of HisF. (216 aa) |
| | hisB | Imidazoleglycerol-phosphate dehydratase HisB. (197 aa) |
| | purH | Bifunctional purine biosynthesis protein PurH. (557 aa) |
| | folD | Bifunctional protein FolD; Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10- methenyltetrahydrofolate to 10-formyltetrahydrofolate. (294 aa) |
| | argG | Argininosuccinate synthase ArgG; Belongs to the argininosuccinate synthase family. Type 2 subfamily. (445 aa) |
| | asd | Aspartate-semialdehyde dehydrogenase Asd; Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L-aspartyl- 4-phosphate; Belongs to the aspartate-semialdehyde dehydrogenase family. (344 aa) |
| | AEI05140.1 | Aspartate kinase; Belongs to the aspartokinase family. (418 aa) |
| | argJ | Arginine biosynthesis bifunctional protein ArgJ; Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis: the synthesis of N-acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate. Belongs to the ArgJ family. (417 aa) |
| | aroK | Shikimate kinase AroK; Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate; Belongs to the shikimate kinase family. (213 aa) |
| | aroB | 3-dehydroquinate synthase AroB; Catalyzes the conversion of 3-deoxy-D-arabino-heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ). (388 aa) |
| | AEI05182.1 | Glutamate synthase domain protein; Belongs to the glutamate synthase family. (539 aa) |
| | pyrE | Orotate phosphoribosyltransferase PyrE; Catalyzes the transfer of a ribosyl phosphate group from 5- phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP). (214 aa) |
| | AEI05327.1 | Putative nucleoside phosphorylase. (186 aa) |
| | dapE | Succinyl-diaminopimelate desuccinylase DapE; Catalyzes the hydrolysis of N-succinyl-L,L-diaminopimelic acid (SDAP), forming succinate and LL-2,6-diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls; Belongs to the peptidase M20A family. DapE subfamily. (384 aa) |
| | dapD | 2,3,4,5-tetrahydropyridine-2,6-dicarboxylate N-succinyltransferase DapD. (281 aa) |
| | AEI05330.1 | Pyrimidine 5'-nucleotidase. (245 aa) |
| | argB | Acetylglutamate kinase ArgB; Catalyzes the ATP-dependent phosphorylation of N-acetyl-L- glutamate; Belongs to the acetylglutamate kinase family. ArgB subfamily. (295 aa) |
| | AEI05394.1 | Methyltransferase. (505 aa) |
| | metH | Methionine synthase MetH; Catalyzes the transfer of a methyl group from methyl- cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate. (1286 aa) |
| | metF | 5,10-methylenetetrahydrofolate reductase MetF; Belongs to the methylenetetrahydrofolate reductase family. (301 aa) |
| | pheA | Prephenate dehydratase PheA. (288 aa) |
| | hisE-2 | phosphoribosyl-ATP pyrophosphatase 2. (133 aa) |
| | AEI05484.1 | Diaminopropionate ammonia-lyase. (406 aa) |
| | AEI05485.1 | Peptidase M20 family protein. (406 aa) |
| | thrB | Homoserine kinase ThrB; Belongs to the pseudomonas-type ThrB family. (326 aa) |
| | suhB | Inositol-1-monophosphatase SuhB. (262 aa) |
| | tilS | tRNA(Ile)-lysidine synthase TilS; Ligates lysine onto the cytidine present at position 34 of the AUA codon-specific tRNA(Ile) that contains the anticodon CAU, in an ATP-dependent manner. Cytidine is converted to lysidine, thus changing the amino acid specificity of the tRNA from methionine to isoleucine. Belongs to the tRNA(Ile)-lysidine synthase family. (341 aa) |
| | hisG | ATP phosphoribosyltransferase HisG; Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity. Belongs to the ATP phosphoribosyltransferase family. Long subfamily. (325 aa) |
| | hisZ | ATP phosphoribosyltransferase regulatory subunit HisZ. (383 aa) |
| | AEI05582.1 | Inositol monophosphatase family protein. (254 aa) |
| | AEI05583.1 | Hypothetical protein. (82 aa) |
| | purD | Phosphoribosylamine--glycine ligase PurD; Belongs to the GARS family. (421 aa) |
| | proC | Pyrroline-5-carboxylate reductase ProC; Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline. (277 aa) |
| | aatA | Aspartate aminotransferase A. (400 aa) |
| | aroE | Shikimate dehydrogenase AroE; Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA). (277 aa) |
| | purA | Adenylosuccinate synthase PurA; Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP; Belongs to the adenylosuccinate synthetase family. (430 aa) |
| | cysQ | Inositol monophosphatase family protein; Converts adenosine-3',5'-bisphosphate (PAP) to AMP. Belongs to the inositol monophosphatase superfamily. CysQ family. (289 aa) |
| | gdh | NADP-specific glutamate dehydrogenase Gdh; Belongs to the Glu/Leu/Phe/Val dehydrogenases family. (447 aa) |
| | AEI05776.1 | Putative hydrolase/acyltransferase; Belongs to the AB hydrolase superfamily. MetX family. (352 aa) |
| | trpE(G) | Anthranilate synthase. (718 aa) |
| | apt | Adenine phosphoribosyltransferase Apt; Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis. (179 aa) |
| | pyrC1 | Dihydroorotase PyrC. (444 aa) |
| | aroC | Chorismate synthase AroC; Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system. (359 aa) |
| | AEI05912.1 | Putative glutamine amidotransferase. (241 aa) |
| | AEI05951.1 | CBS domain protein. (169 aa) |
| | AEI05980.1 | Transcriptional regulator, MocR family. (448 aa) |
| | AEI06003.1 | FAD/NAD(P)-dependent oxidoreductase. (350 aa) |
| | putA | Bifunctional protein PutA; Oxidizes proline to glutamate for use as a carbon and nitrogen source; In the C-terminal section; belongs to the aldehyde dehydrogenase family. (1234 aa) |
| | metE | 5-methyltetrahydropteroyltriglutamate-- homocysteine methyltransferase MetE; Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation; Belongs to the vitamin-B12 independent methionine synthase family. (787 aa) |
| | patA | Putrescine aminotransferase PatA; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. (466 aa) |
| | AEI06252.1 | Phospho-2-dehydro-3-deoxyheptonate aldolase. (462 aa) |
| | cysS | cysteine-tRNA ligase CysS; Belongs to the class-I aminoacyl-tRNA synthetase family. (464 aa) |
| | guaB | Inosine-5'-monophosphate dehydrogenase GuaB; Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth. Belongs to the IMPDH/GMPR family. (496 aa) |
| | guaA | GMP synthase (glutamine-hydrolyzing); Catalyzes the synthesis of GMP from XMP. (531 aa) |
| | purF | Amidophosphoribosyltransferase PurF; Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine; In the C-terminal section; belongs to the purine/pyrimidine phosphoribosyltransferase family. (501 aa) |
| | AEI06379.1 | Putative colicin V production protein. (214 aa) |
| | gmk | Guanylate kinase Gmk; Essential for recycling GMP and indirectly, cGMP. (216 aa) |
| | purN | Phosphoribosylglycinamide formyltransferase PurN; Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate. (217 aa) |
| | purM | Phosphoribosylformylglycinamidine cyclo-ligase PurM. (356 aa) |
| | trpC | Indole-3-glycerol phosphate synthase TrpC; Belongs to the TrpC family. (265 aa) |
| | trpD | Anthranilate phosphoribosyltransferase TrpD; Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'- phosphoribosyl)-anthranilate (PRA). (337 aa) |
| | pyrG | CTP synthase PyrG; Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen. Regulates intracellular CTP levels through interactions with the four ribonucleotide triphosphates. (542 aa) |
| | surE | 5'-nucleotidase SurE; Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates; Belongs to the SurE nucleotidase family. (258 aa) |
| | cysK1 | Cysteine synthase CysK; Belongs to the cysteine synthase/cystathionine beta- synthase family. (326 aa) |
| | cysK2 | Cysteine synthase CysK. (345 aa) |
| | metC | Cystathionine beta-lyase MetC. (399 aa) |
| | hom | Homoserine dehydrogenase Hom. (438 aa) |
| | AEI06718.1 | Aminotransferase. (405 aa) |
| | argC | N-acetyl-gamma-glutamyl-phosphate reductase ArgC; Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde. Belongs to the NAGSA dehydrogenase family. Type 1 subfamily. (352 aa) |
| | aroQ | 3-dehydroquinate dehydratase AroQ; Catalyzes a trans-dehydration via an enolate intermediate. Belongs to the type-II 3-dehydroquinase family. (151 aa) |
| | glnA | Glutamate-ammonia ligase GlnA. (469 aa) |
| | AEI06829.1 | Putative CoA-binding protein. (204 aa) |
| | AEI06830.1 | O-acetylhomoserine/O-acetylserine sulfhydrylase. (426 aa) |
| | glyA | Serine hydroxymethyltransferase GlyA; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. (433 aa) |
| | dapA2 | Dihydrodipicolinate synthase DapA; Catalyzes the condensation of (S)-aspartate-beta-semialdehyde [(S)-ASA] and pyruvate to 4-hydroxy-tetrahydrodipicolinate (HTPA). (378 aa) |
| | AEI06915.1 | Putative chorismate mutase. (99 aa) |
| | pyrB | Aspartate carbamoyltransferase PyrB; Belongs to the aspartate/ornithine carbamoyltransferase superfamily. ATCase family. (317 aa) |
| | pyrC2 | Dihydroorotase PyrC. (433 aa) |
| | adk | Adenylate kinase Adk; Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism; Belongs to the adenylate kinase family. (350 aa) |
| | hisI | phosphoribosyl-AMP cyclohydrolase HisI; Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP. (145 aa) |
| | AEI07085.1 | CBS domain protein. (142 aa) |
| | cysE | Serine acetyltransferase CysE. (274 aa) |
| | gpt | Xanthine phosphoribosyltransferase Gpt; Acts on guanine, xanthine and to a lesser extent hypoxanthine; Belongs to the purine/pyrimidine phosphoribosyltransferase family. XGPT subfamily. (167 aa) |
| | purB | Adenylosuccinate lyase PurB; Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily. (435 aa) |
| | purL | Phosphoribosylformylglycinamidine synthase 2; Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP- dependent manner. PurS interacts with PurQ and PurL and is thought to assist i [...] (735 aa) |
| | purQ | Phosphoribosylformylglycinamidine synthase 1; Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP- dependent manner. PurS interacts with PurQ and PurL and is thought to assist i [...] (233 aa) |
| | purS | Phosphoribosylformylglycinamidine synthase; Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP- dependent manner. PurS interacts with PurQ and PurL and is thought to assist in [...] (80 aa) |
| | purC | Phosphoribosylaminoimidazole-succinocarboxamide synthase PurC; Belongs to the SAICAR synthetase family. (265 aa) |
| | ahcY | Adenosylhomocysteinase AhcY; May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine. (472 aa) |
| | metK | S-adenosylmethionine synthase MetK; Belongs to the AdoMet synthase family. (397 aa) |
| | purU | Formyltetrahydrofolate deformylase PurU; Catalyzes the hydrolysis of 10-formyltetrahydrofolate (formyl-FH4) to formate and tetrahydrofolate (FH4). (287 aa) |
| | pabB | Para-aminobenzoate synthase PabB. (699 aa) |
| | carA | Carbamoyl-phosphate synthase small chain CarA; Belongs to the CarA family. (396 aa) |
| | carB | Carbamoyl-phosphate synthase large chain CarB; Belongs to the CarB family. (1109 aa) |
| | purE | Phosphoribosylaminoimidazole carboxylase catalytic subunit PurE; Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR). (158 aa) |
| | purK | Phosphoribosylaminoimidazole carboxylase ATPase subunit PurK; Catalyzes the ATP-dependent conversion of 5-aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5-carboxyaminoimidazole ribonucleotide (N5-CAIR). (365 aa) |
| | AEI07693.1 | Inositol monophosphatase family protein. (260 aa) |
| | gltB | Glutamate synthase large subunit. (1588 aa) |
| | gltD | Glutamate synthase NADH/NADPH, small subunit GltD. (485 aa) |
| | AEI07854.1 | Methionine biosynthesis MetW. (217 aa) |
| | metX | Homoserine O-acetyltransferase MetX; Transfers an acetyl group from acetyl-CoA to L-homoserine, forming acetyl-L-homoserine. (402 aa) |
| | AEI07856.1 | Hypothetical protein. (282 aa) |
| | hisC | Histidinol-phosphate aminotransferase HisC; Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily. (364 aa) |
| | tyrC | Arogenate dehydrogenase. (320 aa) |
| | lysA | Diaminopimelate decarboxylase LysA; Specifically catalyzes the decarboxylation of meso- diaminopimelate (meso-DAP) to L-lysine. (422 aa) |
| | argH | Argininosuccinate lyase ArgH. (465 aa) |
| | hisD | Histidinol dehydrogenase HisD; Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine. (431 aa) |
| | thrC | Threonine synthase ThrC. (471 aa) |
| | pyrD | Dihydroorotate dehydrogenase PyrD; Catalyzes the conversion of dihydroorotate to orotate with quinone as electron acceptor; Belongs to the dihydroorotate dehydrogenase family. Type 2 subfamily. (364 aa) |
| | metZ | O-succinylhomoserine sulfhydrylase MetZ; Catalyzes the formation of L-homocysteine from O-succinyl-L- homoserine (OSHS) and hydrogen sulfide. (403 aa) |
| | argF | Ornithine carbamoyltransferase ArgF; Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline. (311 aa) |
| | argD | Acetylornithine aminotransferase ArgD; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. ArgD subfamily. (407 aa) |
| | proB | Glutamate 5-kinase ProB; Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate. (397 aa) |
| | proA | Gamma-glutamyl phosphate reductase ProA; Catalyzes the NADPH-dependent reduction of L-glutamate 5- phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5-carboxylate. Belongs to the gamma-glutamyl phosphate reductase family. (428 aa) |
