STRINGSTRING
dnaN dnaN pnp pnp AEI04784.1 AEI04784.1 rpoN rpoN rph rph dnaQ dnaQ AEI04896.1 AEI04896.1 cph cph AEI04933.1 AEI04933.1 AEI05031.1 AEI05031.1 glnD glnD polA polA dnaX dnaX kdsB kdsB cysN cysN cysD cysD AEI05472.1 AEI05472.1 ribF ribF AEI05735.1 AEI05735.1 AEI05806.1 AEI05806.1 moaB moaB sua5 sua5 AEI05889.1 AEI05889.1 mdcG mdcG yddV yddV AEI06024.1 AEI06024.1 AEI06034.1 AEI06034.1 mobA mobA AEI06133.1 AEI06133.1 glnE glnE AEI06278.1 AEI06278.1 AEI06328.1 AEI06328.1 AEI06350.1 AEI06350.1 AEI06393.1 AEI06393.1 AEI06405.1 AEI06405.1 coaD coaD glmU glmU AEI06536.1 AEI06536.1 AEI06615.1 AEI06615.1 manC1 manC1 ispDF ispDF AEI06727.1 AEI06727.1 cdsA cdsA dnaE1 dnaE1 AEI06825.1 AEI06825.1 rpoZ rpoZ pleD pleD dinB dinB rpoA rpoA rpoC rpoC rpoB rpoB AEI07185.1 AEI07185.1 manC2 manC2 hldE hldE dnaE2 dnaE2 imuB imuB dnaG dnaG mog mog fbiD fbiD galU galU AEI07711.1 AEI07711.1 rfbF rfbF nadD nadD rfbA rfbA
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
dnaNDNA polymerase III subunit beta; Confers DNA tethering and processivity to DNA polymerases and other proteins. Acts as a clamp, forming a ring around DNA (a reaction catalyzed by the clamp-loading complex) which diffuses in an ATP- independent manner freely and bidirectionally along dsDNA. Initially characterized for its ability to contact the catalytic subunit of DNA polymerase III (Pol III), a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria; Pol III exhibits 3'-5' exonuclease proofreading activity. The beta chain is required for initiation of [...] (372 aa)
pnpPolyribonucleotide nucleotidyltransferase Pnp; Involved in mRNA degradation. Catalyzes the phosphorolysis of single-stranded polyribonucleotides processively in the 3'- to 5'- direction. (714 aa)
AEI04784.1Nucleotidyl transferase. (240 aa)
rpoNRNA polymerase sigma-54 factor RpoN; Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released. (549 aa)
rphRibonuclease PH; Phosphorolytic 3'-5' exoribonuclease that plays an important role in tRNA 3'-end maturation. Removes nucleotide residues following the 3'-CCA terminus of tRNAs; can also add nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates, but this may not be physiologically important. Probably plays a role in initiation of 16S rRNA degradation (leading to ribosome degradation) during starvation. (238 aa)
dnaQDNA polymerase III subunit epsilon; DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'- 5' exonuclease. (230 aa)
AEI04896.1Putative DNA polymerase III, delta subunit. (342 aa)
cphPhytochrome-like protein Cph. (564 aa)
AEI04933.1GGDEF domain protein. (348 aa)
AEI05031.1Hypothetical protein. (347 aa)
glnD[protein-PII] uridylyltransferase GlnD. (939 aa)
polADNA polymerase I; In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity; Belongs to the DNA polymerase type-A family. (1003 aa)
dnaXDNA polymerase III subunit tau; DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity. (632 aa)
kdsB3-deoxy-manno-octulosonate cytidylyltransferase KdsB; Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria. (247 aa)
cysNSulfate adenylyltransferase, large subunit CysN; Catalyzes the synthesis of activated sulfate. (640 aa)
cysDSulfate adenylyltransferase, small subunit CysD. (264 aa)
AEI05472.1GGDEF domain protein. (344 aa)
ribFRiboflavin biosynthesis protein RibF; Belongs to the ribF family. (327 aa)
AEI05735.1GGDEF domain protein. (397 aa)
AEI05806.1tRNA-nucleotidyltransferase, poly(A) polymerase family; Belongs to the tRNA nucleotidyltransferase/poly(A) polymerase family. (422 aa)
moaBMolybdenum cofactor biosynthesis protein B; May be involved in the biosynthesis of molybdopterin. Belongs to the MoaB/Mog family. (185 aa)
sua5Putative translation factor protein Sua5; Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. (326 aa)
AEI05889.1Putative ATP-dependent DNA ligase. (889 aa)
mdcGMalonate holo-ACP synthase MdcG. (223 aa)
yddVDiguanylate cyclase YddV. (463 aa)
AEI06024.1GGDEF domain protein. (405 aa)
AEI06034.1GGDEF domain protein. (541 aa)
mobAMolybdopterin-guanine dinucleotide biosynthesis protein MobA; Transfers a GMP moiety from GTP to Mo-molybdopterin (Mo-MPT) cofactor (Moco or molybdenum cofactor) to form Mo-molybdopterin guanine dinucleotide (Mo-MGD) cofactor; Belongs to the MobA family. (215 aa)
AEI06133.1GGDEF domain protein. (379 aa)
glnEGlutamate-ammonia-ligase adenylyltransferase GlnE; Involved in the regulation of glutamine synthetase GlnA, a key enzyme in the process to assimilate ammonia. When cellular nitrogen levels are high, the C-terminal adenylyl transferase (AT) inactivates GlnA by covalent transfer of an adenylyl group from ATP to specific tyrosine residue of GlnA, thus reducing its activity. Conversely, when nitrogen levels are low, the N-terminal adenylyl removase (AR) activates GlnA by removing the adenylyl group by phosphorolysis, increasing its activity. The regulatory region of GlnE binds the signal t [...] (988 aa)
AEI06278.1Hypothetical protein. (80 aa)
AEI06328.1Hypothetical protein. (83 aa)
AEI06350.1Hypothetical protein. (313 aa)
AEI06393.1Hypothetical protein. (295 aa)
AEI06405.1Putative DNA polymerase III, chi subunit. (154 aa)
coaDPhosphopantetheine adenylyltransferase CoaD; Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate. Belongs to the bacterial CoaD family. (165 aa)
glmUBifunctional protein GlmU; Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP-GlcNAc). The C- terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N- acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5-monophosphate (from uridine 5- triphosphate), a reaction catalyzed by the N-terminal domain. In the C-terminal section; belongs to the transferase hexapeptide repeat family. (451 aa)
AEI06536.1Hypothetical protein. (411 aa)
AEI06615.1Putative DNA polymerase III subunit. (347 aa)
manC1Mannose-1-phosphate guanylyltransferase, bifunctional protein ManC; Belongs to the mannose-6-phosphate isomerase type 2 family. (477 aa)
ispDFBifunctional enzyme ispD/ispF; Bifunctional enzyme that catalyzes the formation of 4- diphosphocytidyl-2-C-methyl-D-erythritol from CTP and 2-C-methyl-D- erythritol 4-phosphate (MEP) (IspD), and catalyzes the conversion of 4- diphosphocytidyl-2-C-methyl-D-erythritol 2-phosphate (CDP-ME2P) to 2-C- methyl-D-erythritol 2,4-cyclodiphosphate (ME-CPP) with a corresponding release of cytidine 5-monophosphate (CMP) (IspF). (401 aa)
AEI06727.1GGDEF domain protein. (355 aa)
cdsAPhosphatidate cytidylyltransferase CdsA; Belongs to the CDS family. (248 aa)
dnaE1DNA polymerase III subunit alpha. (1157 aa)
AEI06825.1GGDEF domain protein. (414 aa)
rpoZDNA-directed RNA polymerase subunit omega; Promotes RNA polymerase assembly. Latches the N- and C- terminal regions of the beta' subunit thereby facilitating its interaction with the beta and alpha subunits. (130 aa)
pleDResponse regulator. (457 aa)
dinBDNA polymerase IV; Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII. (435 aa)
rpoADNA-directed RNA polymerase subunit alpha; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. (339 aa)
rpoCDNA-directed RNA polymerase subunit beta; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. (1399 aa)
rpoBDNA-directed RNA polymerase subunit beta; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. (1377 aa)
AEI07185.1Hypothetical protein. (345 aa)
manC2Mannose-1-phosphate guanylyltransferase, mannose-6-phosphate isomerase ManC; Belongs to the mannose-6-phosphate isomerase type 2 family. (469 aa)
hldED-beta-D-heptose 1-phosphate adenylyltransferase; Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno-heptose. In the N-terminal section; belongs to the carbohydrate kinase PfkB family. (490 aa)
dnaE2Error-prone DNA polymerase DnaE; DNA polymerase involved in damage-induced mutagenesis and translesion synthesis (TLS). It is not the major replicative DNA polymerase. (1107 aa)
imuBPutative protein ImuB. (481 aa)
dnaGDNA primase DnaG; RNA polymerase that catalyzes the synthesis of short RNA molecules used as primers for DNA polymerase during DNA replication. Belongs to the DnaG primase family. (720 aa)
mogMolybdopterin adenylyltransferase Mog. (189 aa)
fbiDHypothetical protein; Guanylyltransferase that catalyzes the activation of phosphoenolpyruvate (PEP) as enolpyruvoyl-2-diphospho-5'-guanosine, via the condensation of PEP with GTP. It is involved in the biosynthesis of coenzyme F420, a hydride carrier cofactor. (237 aa)
galUUTP--glucose-1-phosphate uridylyltransferase GalU. (308 aa)
AEI07711.1Diguanylate cyclase. (489 aa)
rfbFGlucose-1-phosphate cytidylyltransferase RfbF. (256 aa)
nadDNicotinate-nucleotide adenylyltransferase NadD; Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD). (204 aa)
rfbAGlucose-1-phosphate thymidylyltransferase RfbA; Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis. Belongs to the glucose-1-phosphate thymidylyltransferase family. (297 aa)
Your Current Organism:
Oligotropha carboxidovorans
NCBI taxonomy Id: 504832
Other names: O. carboxidovorans OM5, Oligotropha carboxidovorans OM5, Oligotropha carboxidovorans str. OM5, Oligotropha carboxidovorans strain OM5
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