STRINGSTRING
dnaN dnaN ybeY ybeY addB addB addA addA AEI04811.1 AEI04811.1 nth nth rph rph AEI04871.1 AEI04871.1 dnaQ dnaQ leuS leuS xthA1 xthA1 tesB tesB AEI04924.1 AEI04924.1 AEI05009.1 AEI05009.1 AEI05013.1 AEI05013.1 AEI05080.1 AEI05080.1 glnD glnD gloB gloB AEI05175.1 AEI05175.1 AEI05197.1 AEI05197.1 AEI05201.1 AEI05201.1 AEI05261.1 AEI05261.1 polA polA AEI05330.1 AEI05330.1 rnpA rnpA AEI05355.1 AEI05355.1 AEI05396.1 AEI05396.1 AEI05470.1 AEI05470.1 rnhA1 rnhA1 suhB suhB ruvC ruvC AEI05569.1 AEI05569.1 AEI05582.1 AEI05582.1 AEI05583.1 AEI05583.1 xseA xseA ileS ileS AEI05617.1 AEI05617.1 uvrC uvrC AEI05640.1 AEI05640.1 pth pth uvrB uvrB cysQ cysQ cheB cheB AEI05740.1 AEI05740.1 AEI05755.1 AEI05755.1 AEI05758.1 AEI05758.1 AEI05815.1 AEI05815.1 rnhB rnhB AEI05866.1 AEI05866.1 AEI05882.1 AEI05882.1 AEI05889.1 AEI05889.1 xseB xseB AEI05945.1 AEI05945.1 AEI06128.1 AEI06128.1 AEI06171.1 AEI06171.1 AEI06172.1 AEI06172.1 glnE glnE AEI06216.1 AEI06216.1 gph gph AEI06251.1 AEI06251.1 trbD trbD AEI06354.1 AEI06354.1 AEI06393.1 AEI06393.1 rnd rnd xthA2 xthA2 AEI06472.1 AEI06472.1 surE surE uvrA uvrA AEI06617.1 AEI06617.1 valS valS recJ recJ AEI06715.1 AEI06715.1 glpX glpX rne rne dnaE1 dnaE1 rnj rnj AEI06828.1 AEI06828.1 rnc rnc AEI06884.1 AEI06884.1 AEI06920.1 AEI06920.1 rnr rnr AEI06940.1 AEI06940.1 AEI07117.1 AEI07117.1 AEI07137.1 AEI07137.1 AEI07148.1 AEI07148.1 rnhA2 rnhA2 AEI07161.1 AEI07161.1 AEI07251.1 AEI07251.1 AEI07307.1 AEI07307.1 AEI07323.1 AEI07323.1 gmhB gmhB serB serB AEI07423.1 AEI07423.1 yciA yciA soxB soxB dnaE2 dnaE2 AEI07490.1 AEI07490.1 AEI07509.1 AEI07509.1 pgl pgl AEI07587.1 AEI07587.1 AEI07685.1 AEI07685.1 AEI07693.1 AEI07693.1 pldB pldB AEI07704.1 AEI07704.1 AEI07710.1 AEI07710.1 AEI07810.1 AEI07810.1 AEI07883.1 AEI07883.1 AEI07893.1 AEI07893.1 AEI07895.1 AEI07895.1 ybaK ybaK AEI07963.1 AEI07963.1 AEI07964.1 AEI07964.1 otsB otsB AEI08039.1 AEI08039.1 AEI08040.1 AEI08040.1
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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query proteins and first shell of interactors
white nodes:
second shell of interactors
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empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
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textmining
co-expression
protein homology
Your Input:
dnaNDNA polymerase III subunit beta; Confers DNA tethering and processivity to DNA polymerases and other proteins. Acts as a clamp, forming a ring around DNA (a reaction catalyzed by the clamp-loading complex) which diffuses in an ATP- independent manner freely and bidirectionally along dsDNA. Initially characterized for its ability to contact the catalytic subunit of DNA polymerase III (Pol III), a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria; Pol III exhibits 3'-5' exonuclease proofreading activity. The beta chain is required for initiation of [...] (372 aa)
ybeYPutative metalloprotease; Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA. (167 aa)
addBDouble-strand break repair protein AddB. (1057 aa)
addADouble-strand break repair helicase AddA; Belongs to the helicase family. UvrD subfamily. (1161 aa)
AEI04811.13'-5' exonuclease. (204 aa)
nthEndonuclease III; DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N-glycosidic bond, leaving an AP (apurinic/apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'- phosphate. (249 aa)
rphRibonuclease PH; Phosphorolytic 3'-5' exoribonuclease that plays an important role in tRNA 3'-end maturation. Removes nucleotide residues following the 3'-CCA terminus of tRNAs; can also add nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates, but this may not be physiologically important. Probably plays a role in initiation of 16S rRNA degradation (leading to ribosome degradation) during starvation. (238 aa)
AEI04871.1Smr domain protein. (199 aa)
dnaQDNA polymerase III subunit epsilon; DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'- 5' exonuclease. (230 aa)
leuSleucin-tRNA ligase LeuS; Belongs to the class-I aminoacyl-tRNA synthetase family. (879 aa)
xthA1Exodeoxyribonuclease III. (271 aa)
tesBacyl-CoA thioesterase 2. (295 aa)
AEI04924.1Hypothetical protein. (187 aa)
AEI05009.1Beta-lactamase hydrolase-like protein. (429 aa)
AEI05013.1Protein-tyrosine-phosphatase; Belongs to the low molecular weight phosphotyrosine protein phosphatase family. (175 aa)
AEI05080.1Restriction endonuclease. (354 aa)
glnD[protein-PII] uridylyltransferase GlnD. (939 aa)
gloBHydroxyacylglutathione hydrolase GloB; Thiolesterase that catalyzes the hydrolysis of S-D-lactoyl- glutathione to form glutathione and D-lactic acid. (255 aa)
AEI05175.1Putative nuclease. (272 aa)
AEI05197.1Putative plasmid stability protein. (148 aa)
AEI05201.1Protein-tyrosine-phosphatase; Belongs to the low molecular weight phosphotyrosine protein phosphatase family. (180 aa)
AEI05261.1Hypothetical protein. (93 aa)
polADNA polymerase I; In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity; Belongs to the DNA polymerase type-A family. (1003 aa)
AEI05330.1Pyrimidine 5'-nucleotidase. (245 aa)
rnpAPutative ribonuclease P protein component RnpA; RNaseP catalyzes the removal of the 5'-leader sequence from pre-tRNA to produce the mature 5'-terminus. It can also cleave other RNA substrates such as 4.5S RNA. The protein component plays an auxiliary but essential role in vivo by binding to the 5'-leader sequence and broadening the substrate specificity of the ribozyme. (132 aa)
AEI05355.1GGDEF/EAL domain protein. (649 aa)
AEI05396.1Hypothetical protein. (284 aa)
AEI05470.1Hypothetical protein. (193 aa)
rnhA1Ribonuclease H; Endonuclease that specifically degrades the RNA of RNA-DNA hybrids. (149 aa)
suhBInositol-1-monophosphatase SuhB. (262 aa)
ruvCHolliday junction DNA nuclease RuvC; Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group. (171 aa)
AEI05569.1Hypothetical protein. (255 aa)
AEI05582.1Inositol monophosphatase family protein. (254 aa)
AEI05583.1Hypothetical protein. (82 aa)
xseAExodeoxyribonuclease 7 large subunit XseA; Bidirectionally degrades single-stranded DNA into large acid- insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides; Belongs to the XseA family. (486 aa)
ileSisoleucin-tRNA ligase IleS; Catalyzes the attachment of isoleucine to tRNA(Ile). As IleRS can inadvertently accommodate and process structurally similar amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile). (989 aa)
AEI05617.1Ribonuclease; Belongs to the RNase T2 family. (233 aa)
uvrCuvrABC system protein C; The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision. (610 aa)
AEI05640.1Putative response regulator protein. (360 aa)
pthpeptidyl-tRNA hydrolase Pth; The natural substrate for this enzyme may be peptidyl-tRNAs which drop off the ribosome during protein synthesis. Belongs to the PTH family. (201 aa)
uvrBuvrABC system protein B; The UvrABC repair system catalyzes the recognition and processing of DNA lesions. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. Upon binding of the UvrA(2)B(2) complex to a putative damaged site, the DNA wraps around one UvrB monomer. DNA wrap is dependent on ATP binding by UvrB and probably causes local melting of the DNA helix, facilitating insertion of UvrB beta-hairpin between the DNA strands. Then UvrB probes one DNA strand for the presence of a lesion. If a lesion is found the UvrA subunits dissociate and [...] (981 aa)
cysQInositol monophosphatase family protein; Converts adenosine-3',5'-bisphosphate (PAP) to AMP. Belongs to the inositol monophosphatase superfamily. CysQ family. (289 aa)
cheBChemotaxis response regulator protein-glutamate methylesterase 1; Involved in chemotaxis. Part of a chemotaxis signal transduction system that modulates chemotaxis in response to various stimuli. Catalyzes the demethylation of specific methylglutamate residues introduced into the chemoreceptors (methyl-accepting chemotaxis proteins or MCP) by CheR. Also mediates the irreversible deamidation of specific glutamine residues to glutamic acid. Belongs to the CheB family. (388 aa)
AEI05740.1Hypothetical protein. (153 aa)
AEI05755.1Putative carboxymethylenebutenolidase. (304 aa)
AEI05758.1Hypothetical protein. (98 aa)
AEI05815.1Dienelactone hydrolase. (224 aa)
rnhBRibonuclease HII; Endonuclease that specifically degrades the RNA of RNA-DNA hybrids. (259 aa)
AEI05866.1Putative protein phosphatase. (168 aa)
AEI05882.1Putative beta-lactamase. (309 aa)
AEI05889.1Putative ATP-dependent DNA ligase. (889 aa)
xseBExodeoxyribonuclease 7 small subunit XseB; Bidirectionally degrades single-stranded DNA into large acid- insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides; Belongs to the XseB family. (83 aa)
AEI05945.1Phosphonoacetate hydrolase. (418 aa)
AEI06128.1Hypothetical protein. (612 aa)
AEI06171.1Putative terminase. (434 aa)
AEI06172.1Putative endonuclease. (95 aa)
glnEGlutamate-ammonia-ligase adenylyltransferase GlnE; Involved in the regulation of glutamine synthetase GlnA, a key enzyme in the process to assimilate ammonia. When cellular nitrogen levels are high, the C-terminal adenylyl transferase (AT) inactivates GlnA by covalent transfer of an adenylyl group from ATP to specific tyrosine residue of GlnA, thus reducing its activity. Conversely, when nitrogen levels are low, the N-terminal adenylyl removase (AR) activates GlnA by removing the adenylyl group by phosphorolysis, increasing its activity. The regulatory region of GlnE binds the signal t [...] (988 aa)
AEI06216.1Hydroxypyruvate isomerase; Belongs to the hyi family. (256 aa)
gphPhosphoglycolate phosphatase Gph; Specifically catalyzes the dephosphorylation of 2- phosphoglycolate. Is involved in the dissimilation of the intracellular 2-phosphoglycolate formed during the DNA repair of 3'-phosphoglycolate ends, a major class of DNA lesions induced by oxidative stress. Belongs to the HAD-like hydrolase superfamily. CbbY/CbbZ/Gph/YieH family. (225 aa)
AEI06251.1Metal-dependent hydrolase. (315 aa)
trbDPutative conjugal transfer protein TrbD. (87 aa)
AEI06354.1Hypothetical protein. (184 aa)
AEI06393.1Hypothetical protein. (295 aa)
rndRibonuclease D; Exonuclease involved in the 3' processing of various precursor tRNAs. Initiates hydrolysis at the 3'-terminus of an RNA molecule and releases 5'-mononucleotides; Belongs to the RNase D family. (386 aa)
xthA2Exodeoxyribonuclease III. (260 aa)
AEI06472.1Deoxyguanosinetriphosphate; Belongs to the dGTPase family. Type 2 subfamily. (402 aa)
surE5'-nucleotidase SurE; Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates; Belongs to the SurE nucleotidase family. (258 aa)
uvrAExcinuclease ABC system, subunit A; The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate. (992 aa)
AEI06617.1Putative deoxyribonuclease, TatD family. (264 aa)
valSvaline-tRNA ligase ValS; Catalyzes the attachment of valine to tRNA(Val). As ValRS can inadvertently accommodate and process structurally similar amino acids such as threonine, to avoid such errors, it has a 'posttransfer' editing activity that hydrolyzes mischarged Thr-tRNA(Val) in a tRNA- dependent manner; Belongs to the class-I aminoacyl-tRNA synthetase family. ValS type 1 subfamily. (961 aa)
recJsingle-stranded-DNA-specific exonuclease RecJ. (613 aa)
AEI06715.1Putative haloacid dehalogenase. (236 aa)
glpXFructose-1,6-bisphosphatase GlpX. (331 aa)
rneRibonuclease E; Endoribonuclease that plays a central role in RNA processing and decay. Required for the maturation of 5S and 16S rRNAs and the majority of tRNAs. Also involved in the degradation of most mRNAs. Belongs to the RNase E/G family. RNase E subfamily. (1017 aa)
dnaE1DNA polymerase III subunit alpha. (1157 aa)
rnjRibonuclease J. (556 aa)
AEI06828.1Putative thioesterase. (142 aa)
rncRibonuclease 3; Digests double-stranded RNA. Involved in the processing of primary rRNA transcript to yield the immediate precursors to the large and small rRNAs (23S and 16S). Processes some mRNAs, and tRNAs when they are encoded in the rRNA operon. Processes pre-crRNA and tracrRNA of type II CRISPR loci if present in the organism. (278 aa)
AEI06884.1Hypothetical protein. (213 aa)
AEI06920.1Putative holliday junction resolvase; Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA; Belongs to the YqgF HJR family. (204 aa)
rnrRibonuclease R; 3'-5' exoribonuclease that releases 5'-nucleoside monophosphates and is involved in maturation of structured RNAs. (782 aa)
AEI06940.1Glycerophosphoryl diester phosphodiesterase. (255 aa)
AEI07117.1Hypothetical protein. (586 aa)
AEI07137.1Hypothetical protein. (174 aa)
AEI07148.1Putative endonuclease. (311 aa)
rnhA2Ribonuclease H; Endonuclease that specifically degrades the RNA of RNA-DNA hybrids. (255 aa)
AEI07161.1Putative esterase. (177 aa)
AEI07251.1Hypothetical protein. (606 aa)
AEI07307.1Putative phosphohistidine phosphatase protein. (176 aa)
AEI07323.1Hypothetical protein. (455 aa)
gmhBD,D-heptose 1,7-bisphosphate phosphatase GmhB. (177 aa)
serBPhosphoserine phosphatase SerB. (297 aa)
AEI07423.1Putative nuclease. (111 aa)
yciAacyl-CoA thioester hydrolase YciA. (146 aa)
soxB5'-nucleotidase, putative sulfur oxidation protein SoxB; Belongs to the 5'-nucleotidase family. (581 aa)
dnaE2Error-prone DNA polymerase DnaE; DNA polymerase involved in damage-induced mutagenesis and translesion synthesis (TLS). It is not the major replicative DNA polymerase. (1107 aa)
AEI07490.1Putative cleavage and polyadenylation specificity factor. (346 aa)
AEI07509.1Hypothetical protein. (369 aa)
pgl6-phosphogluconolactonase Pgl; Hydrolysis of 6-phosphogluconolactone to 6-phosphogluconate. (245 aa)
AEI07587.1Putative hydrolase. (267 aa)
AEI07685.1Hypothetical protein. (326 aa)
AEI07693.1Inositol monophosphatase family protein. (260 aa)
pldBLysophospholipase. (314 aa)
AEI07704.1Hypothetical protein. (528 aa)
AEI07710.1Putative lipase/esterase. (250 aa)
AEI07810.1Terminase, large subunit. (657 aa)
AEI07883.1HNH endonuclease domain protein. (185 aa)
AEI07893.1GGDEF/EAL domain protein. (763 aa)
AEI07895.1Protein-tyrosine-phosphatase; Belongs to the low molecular weight phosphotyrosine protein phosphatase family. (155 aa)
ybaKPutative cys-tRNA(Pro)/Cys-tRNA(Cys) deacylase YbaK; Belongs to the prolyl-tRNA editing family. YbaK/EbsC subfamily. (157 aa)
AEI07963.1Putative lipase/esterase. (309 aa)
AEI07964.1Hypothetical protein. (253 aa)
otsBTrehalose-phosphate phosphatase OtsB; Removes the phosphate from trehalose 6-phosphate to produce free trehalose. (265 aa)
AEI08039.12'-5' RNA ligase family protein; Hydrolyzes RNA 2',3'-cyclic phosphodiester to an RNA 2'- phosphomonoester; Belongs to the 2H phosphoesterase superfamily. ThpR family. (192 aa)
AEI08040.1Putative esterase. (235 aa)
Your Current Organism:
Oligotropha carboxidovorans
NCBI taxonomy Id: 504832
Other names: O. carboxidovorans OM5, Oligotropha carboxidovorans OM5, Oligotropha carboxidovorans str. OM5, Oligotropha carboxidovorans strain OM5
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