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| | cobT1 | Aerobic cobaltochelatase subunit CobT. (633 aa) |
| | cysJ | Sulfite reductase [NADPH] flavoprotein alpha-componentCysJ; Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L-cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH -> FAD -> FMN to the hemoprotein component. (611 aa) |
| | cysI | Sulfite reductase [NADPH] hemoprotein beta-componentCysI; Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L-cysteine from sulfate. Belongs to the nitrite and sulfite reductase 4Fe-4S domain family. (582 aa) |
| | AEI08054.1 | Hypothetical protein. (280 aa) |
| | proA | Gamma-glutamyl phosphate reductase ProA; Catalyzes the NADPH-dependent reduction of L-glutamate 5- phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5-carboxylate. Belongs to the gamma-glutamyl phosphate reductase family. (428 aa) |
| | proB | Glutamate 5-kinase ProB; Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate. (397 aa) |
| | argD | Acetylornithine aminotransferase ArgD; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. ArgD subfamily. (407 aa) |
| | argF | Ornithine carbamoyltransferase ArgF; Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline. (311 aa) |
| | thrC | Threonine synthase ThrC. (471 aa) |
| | bioB | Biotin synthase BioB; Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical-based mechanism; Belongs to the radical SAM superfamily. Biotin synthase family. (347 aa) |
| | AEI07911.1 | Hypothetical protein. (360 aa) |
| | hisD | Histidinol dehydrogenase HisD; Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine. (431 aa) |
| | AEI07890.1 | Putative methyltransferase. (282 aa) |
| | fabH2 | 3-oxoacyl-[acyl-carrier-protein] synthase FabH. (330 aa) |
| | AEI07877.1 | Cob(I)yrinic acid a,c-diamide adenosyltransferase; Belongs to the Cob(I)alamin adenosyltransferase family. (190 aa) |
| | AEI07873.1 | Putative 3-demethylubiquinone-9 3-methyltransferase. (140 aa) |
| | argH | Argininosuccinate lyase ArgH. (465 aa) |
| | lysA | Diaminopimelate decarboxylase LysA; Specifically catalyzes the decarboxylation of meso- diaminopimelate (meso-DAP) to L-lysine. (422 aa) |
| | tyrC | Arogenate dehydrogenase. (320 aa) |
| | hisC | Histidinol-phosphate aminotransferase HisC; Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily. (364 aa) |
| | AEI07856.1 | Hypothetical protein. (282 aa) |
| | metX | Homoserine O-acetyltransferase MetX; Transfers an acetyl group from acetyl-CoA to L-homoserine, forming acetyl-L-homoserine. (402 aa) |
| | fabI3 | Enoyl-[acyl-carrier-protein] reductase [NADH]. (257 aa) |
| | AEI07743.1 | Hypothetical protein. (171 aa) |
| | AEI07730.1 | Putative cobalamin biosynthesis CobW-like protein. (368 aa) |
| | gltD | Glutamate synthase NADH/NADPH, small subunit GltD. (485 aa) |
| | gltB | Glutamate synthase large subunit. (1588 aa) |
| | fbiC | FO synthase FbiC. (804 aa) |
| | nosD | Copper-binding periplasmic protein NosD. (454 aa) |
| | ubiD | 3-octaprenyl-4-hydroxybenzoate carboxy-lyase UbiD; Belongs to the UbiD family. (535 aa) |
| | AEI07614.1 | Hypothetical protein. (183 aa) |
| | AEI07613.1 | Peptidase U32. (325 aa) |
| | AEI07612.1 | Peptidase U32. (322 aa) |
| | panE | 2-dehydropantoate 2-reductase PanE; Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid. (302 aa) |
| | AEI07587.1 | Putative hydrolase. (267 aa) |
| | tal | Transaldolase Tal; Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway; Belongs to the GPI family. (947 aa) |
| | carB | Carbamoyl-phosphate synthase large chain CarB; Belongs to the CarB family. (1109 aa) |
| | carA | Carbamoyl-phosphate synthase small chain CarA; Belongs to the CarA family. (396 aa) |
| | selD | Selenophosphate synthase SelD; Synthesizes selenophosphate from selenide and ATP. (349 aa) |
| | AEI07471.1 | Hypothetical protein. (167 aa) |
| | AEI07469.1 | TenA/Thi-4 family protein. (223 aa) |
| | AEI07444.1 | Branched-chain-amino-acid aminotransferase. (268 aa) |
| | folA | Dihydrofolate reductase FolA; Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis. (174 aa) |
| | serB | Phosphoserine phosphatase SerB. (297 aa) |
| | ilvH | Acetolactate synthase small subunit IlvH. (185 aa) |
| | ilvC | Ketol-acid reductoisomerase IlvC; Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol-acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3-dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3-hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate. (339 aa) |
| | leuA | 2-isopropylmalate synthase LeuA; Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3- hydroxy-4-methylpentanoate (2-isopropylmalate); Belongs to the alpha-IPM synthase/homocitrate synthase family. LeuA type 1 subfamily. (519 aa) |
| | AEI07366.1 | Hypothetical protein. (355 aa) |
| | thiD | Hydroxymethylpyrimidine/phosphomethylpyrimidine kinase ThiD. (266 aa) |
| | AEI07261.1 | Glyoxalase/bleomycin resistance. (137 aa) |
| | purC | Phosphoribosylaminoimidazole-succinocarboxamide synthase PurC; Belongs to the SAICAR synthetase family. (265 aa) |
| | AEI07182.1 | Usg family protein. (103 aa) |
| | gpt | Xanthine phosphoribosyltransferase Gpt; Acts on guanine, xanthine and to a lesser extent hypoxanthine; Belongs to the purine/pyrimidine phosphoribosyltransferase family. XGPT subfamily. (167 aa) |
| | AEI07177.1 | Alcohol dehydrogenase, zinc-dependent. (352 aa) |
| | cysE | Serine acetyltransferase CysE. (274 aa) |
| | xdhA2 | Xanthine dehydrogenase molybdenum-binding subunit XdhA. (733 aa) |
| | hisI | phosphoribosyl-AMP cyclohydrolase HisI; Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP. (145 aa) |
| | cobT2 | Aerobic cobaltochelatase subunit CobT. (586 aa) |
| | AEI06989.1 | Putative dihydrodipicolinate synthase; Belongs to the DapA family. (309 aa) |
| | AEI06987.1 | Putative oxidoreductase. (211 aa) |
| | dkgB | 2,5-diketo-D-gluconic acid reductase B. (271 aa) |
| | panC | Pantoate-beta-alanine ligase PanC; Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate. Belongs to the pantothenate synthetase family. (284 aa) |
| | AEI06915.1 | Putative chorismate mutase. (99 aa) |
| | dapA2 | Dihydrodipicolinate synthase DapA; Catalyzes the condensation of (S)-aspartate-beta-semialdehyde [(S)-ASA] and pyruvate to 4-hydroxy-tetrahydrodipicolinate (HTPA). (378 aa) |
| | pdxJ | Pyridoxine 5'-phosphate synthase PdxJ; Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino- 2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate. (256 aa) |
| | acpS | Holo-[acyl-carrier-protein] synthase AcpS; Transfers the 4'-phosphopantetheine moiety from coenzyme A to a Ser of acyl-carrier-protein; Belongs to the P-Pant transferase superfamily. AcpS family. (137 aa) |
| | glyA | Serine hydroxymethyltransferase GlyA; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. (433 aa) |
| | ribD | Riboflavin biosynthesis protein RibD; Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'- phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)-pyrimidinedione 5'- phosphate; In the C-terminal section; belongs to the HTP reductase family. (379 aa) |
| | ribE | Riboflavin synthase alpha chain RibE. (202 aa) |
| | ribH | 6,7-dimethyl-8-ribityllumazine synthase RibH; Catalyzes the formation of 6,7-dimethyl-8-ribityllumazine by condensation of 5-amino-6-(D-ribitylamino)uracil with 3,4-dihydroxy-2- butanone 4-phosphate. This is the penultimate step in the biosynthesis of riboflavin. (163 aa) |
| | thiL | Thiamine-monophosphate kinase ThiL; Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1; Belongs to the thiamine-monophosphate kinase family. (323 aa) |
| | plsX | Phosphate acyltransferase PlsX; Catalyzes the reversible formation of acyl-phosphate (acyl- PO(4)) from acyl-[acyl-carrier-protein] (acyl-ACP). This enzyme utilizes acyl-ACP as fatty acyl donor, but not acyl-CoA. (353 aa) |
| | fabH1 | 3-oxoacyl-[acyl-carrier-protein] synthase FabH; Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched-chain and/or straight-chain of fatty acids; Belongs to the thiolase-like superfamily. FabH family. (322 aa) |
| | AEI06830.1 | O-acetylhomoserine/O-acetylserine sulfhydrylase. (426 aa) |
| | glnA | Glutamate-ammonia ligase GlnA. (469 aa) |
| | ttuC2 | Tartrate dehydrogenase/decarboxylase. (362 aa) |
| | uppS | Undecaprenyl pyrophosphate synthase UppS; Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids. (252 aa) |
| | fabZ | (3R)-hydroxymyristoyl-[acyl-carrier-protein] dehydratase FabZ; Involved in unsaturated fatty acids biosynthesis. Catalyzes the dehydration of short chain beta-hydroxyacyl-ACPs and long chain saturated and unsaturated beta-hydroxyacyl-ACPs. (152 aa) |
| | AEI06752.1 | acetyl-CoA carboxylase, biotin carboxylase; This protein is a component of the acetyl coenzyme A carboxylase complex; first, biotin carboxylase catalyzes the carboxylation of the carrier protein and then the transcarboxylase transfers the carboxyl group to form malonyl-CoA. (451 aa) |
| | AEI06751.1 | Biotin carboxyl carrier protein; This protein is a component of the acetyl coenzyme A carboxylase complex; first, biotin carboxylase catalyzes the carboxylation of the carrier protein and then the transcarboxylase transfers the carboxyl group to form malonyl-CoA. (166 aa) |
| | aroQ | 3-dehydroquinate dehydratase AroQ; Catalyzes a trans-dehydration via an enolate intermediate. Belongs to the type-II 3-dehydroquinase family. (151 aa) |
| | AEI06725.1 | FAD-dependent monooxygenase. (426 aa) |
| | argC | N-acetyl-gamma-glutamyl-phosphate reductase ArgC; Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde. Belongs to the NAGSA dehydrogenase family. Type 1 subfamily. (352 aa) |
| | hom | Homoserine dehydrogenase Hom. (438 aa) |
| | glpX | Fructose-1,6-bisphosphatase GlpX. (331 aa) |
| | cysK2 | Cysteine synthase CysK. (345 aa) |
| | ilvD3 | Dihydroxy-acid dehydratase IlvD; Belongs to the IlvD/Edd family. (558 aa) |
| | AEI06657.1 | Methyltransferase. (205 aa) |
| | lipA | Lipoyl synthase LipA; Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives. (322 aa) |
| | AEI06649.1 | Putative oligoketide cyclase/lipid transport. (155 aa) |
| | queC | 7-cyano-7-deazaguanine synthase QueC; Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0)). Belongs to the QueC family. (244 aa) |
| | AEI06636.1 | Hypothetical protein. (323 aa) |
| | rkpK2 | UDP-glucose 6-dehydrogenase RkpK. (439 aa) |
| | AEI06553.1 | Metal-dependent hydrolase. (274 aa) |
| | AEI06542.1 | FAD-dependent monooxygenase. (419 aa) |
| | cysK1 | Cysteine synthase CysK; Belongs to the cysteine synthase/cystathionine beta- synthase family. (326 aa) |
| | tgt | Queuine tRNA-ribosyltransferase Tgt; Catalyzes the base-exchange of a guanine (G) residue with the queuine precursor 7-aminomethyl-7-deazaguanine (PreQ1) at position 34 (anticodon wobble position) in tRNAs with GU(N) anticodons (tRNA-Asp, - Asn, -His and -Tyr). Catalysis occurs through a double-displacement mechanism. The nucleophile active site attacks the C1' of nucleotide 34 to detach the guanine base from the RNA, forming a covalent enzyme-RNA intermediate. The proton acceptor active site deprotonates the incoming PreQ1, allowing a nucleophilic attack on the C1' of the ribose to fo [...] (377 aa) |
| | queA | S-adenosylmethionine:tRNA ribosyltransferase-isomerase QueA; Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA). (361 aa) |
| | serS | serine-tRNA ligase SerS; Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L- seryl-tRNA(Sec), which will be further converted into selenocysteinyl- tRNA(Sec). (439 aa) |
| | ilvD2 | Dihydroxy-acid dehydratase IlvD; Belongs to the IlvD/Edd family. (574 aa) |
| | queF | NADPH-dependent 7-cyano-7-deazaguanine reductase QueF; Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1). Belongs to the GTP cyclohydrolase I family. QueF type 1 subfamily. (158 aa) |
| | kdsA | 2-dehydro-3-deoxyphosphooctonate aldolase KdsA; Belongs to the KdsA family. (279 aa) |
| | tpiA | Triosephosphate isomerase TpiA; Involved in the gluconeogenesis. Catalyzes stereospecifically the conversion of dihydroxyacetone phosphate (DHAP) to D- glyceraldehyde-3-phosphate (G3P); Belongs to the triosephosphate isomerase family. (251 aa) |
| | trpD | Anthranilate phosphoribosyltransferase TrpD; Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'- phosphoribosyl)-anthranilate (PRA). (337 aa) |
| | trpC | Indole-3-glycerol phosphate synthase TrpC; Belongs to the TrpC family. (265 aa) |
| | AEI06422.1 | Hypothetical protein. (181 aa) |
| | adh2 | NAD-dependent alcohol dehydrogenase Adh. (354 aa) |
| | fabF3 | 3-oxoacyl-[acyl-carrier-protein] synthase FabF; Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. (421 aa) |
| | acpP | Acyl carrier protein AcpP; Carrier of the growing fatty acid chain in fatty acid biosynthesis; Belongs to the acyl carrier protein (ACP) family. (79 aa) |
| | fabD2 | Malonyl CoA-acyl carrier protein transacylase FabD. (319 aa) |
| | alr | Alanine racemase Alr; Catalyzes the interconversion of L-alanine and D-alanine. May also act on other amino acids; Belongs to the alanine racemase family. (412 aa) |
| | panB | 3-methyl-2-oxobutanoate hydroxymethyltransferase PanB; Catalyzes the reversible reaction in which hydroxymethyl group from 5,10-methylenetetrahydrofolate is transferred onto alpha- ketoisovalerate to form ketopantoate; Belongs to the PanB family. (276 aa) |
| | AEI06353.1 | Hypothetical protein. (388 aa) |
| | AEI06320.1 | TenA/Thi-4 family protein. (220 aa) |
| | fabF2 | 3-oxoacyl-[acyl-carrier-protein] synthase FabF; Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. (420 aa) |
| | acpXL | Acyl carrier protein AcpXL. (93 aa) |
| | fabA-2 | Beta-hydroxyacyl-(acyl-carrier-protein) dehydratase FabA/FabZ. (155 aa) |
| | AEI06273.1 | Putative 3-oxoacyl-(acyl-carrier-protein) synthase; Belongs to the thiolase-like superfamily. Beta-ketoacyl-ACP synthases family. (399 aa) |
| | fabF1 | 3-oxoacyl-[acyl-carrier-protein] synthase FabF; Belongs to the thiolase-like superfamily. Beta-ketoacyl-ACP synthases family. (426 aa) |
| | AEI06258.1 | 2-isopropylmalate synthase/homocitrate synthase; Belongs to the alpha-IPM synthase/homocitrate synthase family. (532 aa) |
| | AEI06252.1 | Phospho-2-dehydro-3-deoxyheptonate aldolase. (462 aa) |
| | gph | Phosphoglycolate phosphatase Gph; Specifically catalyzes the dephosphorylation of 2- phosphoglycolate. Is involved in the dissimilation of the intracellular 2-phosphoglycolate formed during the DNA repair of 3'-phosphoglycolate ends, a major class of DNA lesions induced by oxidative stress. Belongs to the HAD-like hydrolase superfamily. CbbY/CbbZ/Gph/YieH family. (225 aa) |
| | AEI06218.1 | Putative 2-dehydropantoate 2-reductase; Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid. (339 aa) |
| | folP | Dihydropteroate synthase FolP; Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8- dihydropteroate (H2Pte), the immediate precursor of folate derivatives. (284 aa) |
| | folB | Dihydroneopterin aldolase FolB; Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin. (121 aa) |
| | folK | 2-amino-4-hydroxy-6- hydroxymethyldihydropteridine pyrophosphokinase FolK. (161 aa) |
| | AEI06134.1 | TAT uncharacterized repeat protein. (453 aa) |
| | patA | Putrescine aminotransferase PatA; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. (466 aa) |
| | dxs2 | 1-deoxy-D-xylulose-5-phosphate synthase Dxs; Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D- xylulose-5-phosphate (DXP); Belongs to the transketolase family. DXPS subfamily. (638 aa) |
| | AEI06116.1 | Radical SAM domain protein. (400 aa) |
| | AEI06093.1 | Hypothetical protein. (356 aa) |
| | AEI06089.1 | Hypothetical protein. (143 aa) |
| | amaB | N-carbamoyl-L-amino acid hydrolase AmaB. (417 aa) |
| | bioF | 8-amino-7-oxononanoate synthase BioF. (379 aa) |
| | bioD | Dethiobiotin synthase BioD; Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8- diaminopelargonic acid (DAPA) to form an ureido ring. (210 aa) |
| | bioA | Adenosylmethionine-8-amino-7-oxononanoate aminotransferase BioA; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. (420 aa) |
| | metE | 5-methyltetrahydropteroyltriglutamate-- homocysteine methyltransferase MetE; Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation; Belongs to the vitamin-B12 independent methionine synthase family. (787 aa) |
| | queH | Hypothetical protein; Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr). (222 aa) |
| | putA | Bifunctional protein PutA; Oxidizes proline to glutamate for use as a carbon and nitrogen source; In the C-terminal section; belongs to the aldehyde dehydrogenase family. (1234 aa) |
| | AEI05986.1 | malonyl-CoA decarboxylase. (455 aa) |
| | adh1 | Zn-dependent alcohol dehydrogenase Adh. (327 aa) |
| | cysG2 | Multifunctional siroheme synthase CysG; Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD-dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme. (494 aa) |
| | fabD1 | Malonyl CoA-acyl carrier protein transacylase FabD. (306 aa) |
| | AEI05927.1 | Putative malonate decarboxylase, beta subunit. (295 aa) |
| | mdcC | Malonate decarboxylase, delta subunit; Subunit of malonate decarboxylase, it is an acyl carrier protein to which acetyl and malonyl thioester residues are bound via a 2'-(5''-phosphoribosyl)-3'-dephospho-CoA prosthetic group and turn over during the catalytic mechanism. (105 aa) |
| | dxs1 | 1-deoxy-D-xylulose-5-phosphate synthase Dxs; Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D- xylulose-5-phosphate (DXP); Belongs to the transketolase family. DXPS subfamily. (636 aa) |
| | aroC | Chorismate synthase AroC; Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system. (359 aa) |
| | fabI2 | Enoyl-[acyl-carrier-protein] reductase [NADH] 1. (273 aa) |
| | pdxH | Pyridoxine/pyridoxamine 5'-phosphate oxidase PdxH; Catalyzes the oxidation of either pyridoxine 5'-phosphate (PNP) or pyridoxamine 5'-phosphate (PMP) into pyridoxal 5'-phosphate (PLP). (211 aa) |
| | ribB | 3,4-dihydroxy-2-butanone-4-phosphate; Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate; Belongs to the DHBP synthase family. (358 aa) |
| | nadA | Quinolinate synthase A; Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate. (368 aa) |
| | apt | Adenine phosphoribosyltransferase Apt; Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis. (179 aa) |
| | trpE(G) | Anthranilate synthase. (718 aa) |
| | queE | Hypothetical protein; Catalyzes the complex heterocyclic radical-mediated conversion of 6-carboxy-5,6,7,8-tetrahydropterin (CPH4) to 7-carboxy-7- deazaguanine (CDG), a step common to the biosynthetic pathways of all 7-deazapurine-containing compounds. (210 aa) |
| | AEI05810.1 | Putative 6-pyruvoyl tetrahydrobiopterin. (121 aa) |
| | AEI05796.1 | Putative CobW family protein. (413 aa) |
| | thiS | Thiamine-biosynthesis protein ThiS. (65 aa) |
| | thiG | Thiazole synthase ThiG; Catalyzes the rearrangement of 1-deoxy-D-xylulose 5-phosphate (DXP) to produce the thiazole phosphate moiety of thiamine. Sulfur is provided by the thiocarboxylate moiety of the carrier protein ThiS. In vitro, sulfur can be provided by H(2)S. (262 aa) |
| | thiE2 | Thiamine-phosphate pyrophosphorylase ThiE. (202 aa) |
| | thiC | Phosphomethylpyrimidine synthase ThiC; Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction. (632 aa) |
| | AEI05776.1 | Putative hydrolase/acyltransferase; Belongs to the AB hydrolase superfamily. MetX family. (352 aa) |
| | prpB | Methylisocitrate lyase PrpB; Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate. (303 aa) |
| | AEI05733.1 | Putative 2-dehydropantoate 2-reductase. (337 aa) |
| | serA2 | D-3-phosphoglycerate dehydrogenase SerA; Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family. (529 aa) |
| | serC | Phosphoserine aminotransferase SerC; Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine. (390 aa) |
| | aroE | Shikimate dehydrogenase AroE; Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA). (277 aa) |
| | AEI05639.1 | Hypothetical protein. (84 aa) |
| | proC | Pyrroline-5-carboxylate reductase ProC; Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline. (277 aa) |
| | ilvE | Branched-chain-amino-acid aminotransferase IlvE. (370 aa) |
| | AEI05609.1 | Omega-amino acid--pyruvate aminotransferase; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. (446 aa) |
| | ribF | Riboflavin biosynthesis protein RibF; Belongs to the ribF family. (327 aa) |
| | ubiA | 4-hydroxybenzoate-octaprenyl transferase; Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3-octaprenyl-4-hydroxybenzoate. (311 aa) |
| | hisZ | ATP phosphoribosyltransferase regulatory subunit HisZ. (383 aa) |
| | hisG | ATP phosphoribosyltransferase HisG; Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity. Belongs to the ATP phosphoribosyltransferase family. Long subfamily. (325 aa) |
| | thiE1 | Thiamine-phosphate pyrophosphorylase ThiE. (229 aa) |
| | qorA | Quinone oxidoreductase PIG3. (332 aa) |
| | thrB | Homoserine kinase ThrB; Belongs to the pseudomonas-type ThrB family. (326 aa) |
| | AEI05488.1 | Putative Zn-dependent oxidoreductase. (347 aa) |
| | AEI05485.1 | Peptidase M20 family protein. (406 aa) |
| | hisE-2 | phosphoribosyl-ATP pyrophosphatase 2. (133 aa) |
| | cysG1 | Siroheme synthase; Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD-dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme. (474 aa) |
| | pheA | Prephenate dehydratase PheA. (288 aa) |
| | metF | 5,10-methylenetetrahydrofolate reductase MetF; Belongs to the methylenetetrahydrofolate reductase family. (301 aa) |
| | metH | Methionine synthase MetH; Catalyzes the transfer of a methyl group from methyl- cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate. (1286 aa) |
| | AEI05394.1 | Methyltransferase. (505 aa) |
| | AEI05370.1 | Putative asparagine synthase. (598 aa) |
| | argB | Acetylglutamate kinase ArgB; Catalyzes the ATP-dependent phosphorylation of N-acetyl-L- glutamate; Belongs to the acetylglutamate kinase family. ArgB subfamily. (295 aa) |
| | dapD | 2,3,4,5-tetrahydropyridine-2,6-dicarboxylate N-succinyltransferase DapD. (281 aa) |
| | dapE | Succinyl-diaminopimelate desuccinylase DapE; Catalyzes the hydrolysis of N-succinyl-L,L-diaminopimelic acid (SDAP), forming succinate and LL-2,6-diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls; Belongs to the peptidase M20A family. DapE subfamily. (384 aa) |
| | serA1 | D-3-phosphoglycerate dehydrogenase SerA; Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family. (310 aa) |
| | rkpK1 | UDP-glucose 6-dehydrogenase RkpK. (435 aa) |
| | pckA | Phosphoenolpyruvate carboxykinase (ATP); Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA. (538 aa) |
| | AEI05185.1 | Putative amidohydrolase. (270 aa) |
| | AEI05182.1 | Glutamate synthase domain protein; Belongs to the glutamate synthase family. (539 aa) |
| | aroB | 3-dehydroquinate synthase AroB; Catalyzes the conversion of 3-deoxy-D-arabino-heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ). (388 aa) |
| | aroK | Shikimate kinase AroK; Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate; Belongs to the shikimate kinase family. (213 aa) |
| | accA | Acetyl-coenzyme A carboxylase carboxyl transferase subunit alpha; Component of the acetyl coenzyme A carboxylase (ACC) complex. First, biotin carboxylase catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the carboxyltransferase to acetyl-CoA to form malonyl-CoA. (320 aa) |
| | argJ | Arginine biosynthesis bifunctional protein ArgJ; Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis: the synthesis of N-acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate. Belongs to the ArgJ family. (417 aa) |
| | ubiG | 3-demethylubiquinone-9 3-methyltransferase UbiG; O-methyltransferase that catalyzes the 2 O-methylation steps in the ubiquinone biosynthetic pathway; Belongs to the methyltransferase superfamily. UbiG/COQ3 family. (254 aa) |
| | AEI05140.1 | Aspartate kinase; Belongs to the aspartokinase family. (418 aa) |
| | dapF | Diaminopimelate epimerase DapF; Catalyzes the stereoinversion of LL-2,6-diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso-DAP), a precursor of L- lysine and an essential component of the bacterial peptidoglycan. (290 aa) |
| | AEI04976.1 | Glyoxalase/bleomycin resistance. (136 aa) |
| | leuC | 3-isopropylmalate dehydratase large subunit LeuC; Catalyzes the isomerization between 2-isopropylmalate and 3- isopropylmalate, via the formation of 2-isopropylmaleate. (470 aa) |
| | leuD | 3-isopropylmalate dehydratase small subunit LeuD; Catalyzes the isomerization between 2-isopropylmalate and 3- isopropylmalate, via the formation of 2-isopropylmaleate. Belongs to the LeuD family. LeuD type 1 subfamily. (201 aa) |
| | asd | Aspartate-semialdehyde dehydrogenase Asd; Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L-aspartyl- 4-phosphate; Belongs to the aspartate-semialdehyde dehydrogenase family. (344 aa) |
| | leuB | 3-isopropylmalate dehydrogenase LeuB; Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate. (370 aa) |
| | argG | Argininosuccinate synthase ArgG; Belongs to the argininosuccinate synthase family. Type 2 subfamily. (445 aa) |
| | phhB | Pterin-4-alpha-carbinolamine dehydratase. (100 aa) |
| | folD | Bifunctional protein FolD; Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10- methenyltetrahydrofolate to 10-formyltetrahydrofolate. (294 aa) |
| | AEI04930.1 | Hypothetical protein; Catalyzes cyclization of the linear tetrapyrrole, hydroxymethylbilane, to the macrocyclic uroporphyrinogen III. (254 aa) |
| | AEI04911.1 | Ubiquinone biosynthesis hydroxylase UbiH/UbiF/VisC/COQ6 family. (406 aa) |
| | ttuC1 | Tartrate dehydrogenase/decarboxylase. (358 aa) |
| | AEI04884.1 | Hypothetical protein. (202 aa) |
| | hisB | Imidazoleglycerol-phosphate dehydratase HisB. (197 aa) |
| | hisH | Imidazole glycerol phosphate synthase subunit HisH; IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the synthesis of IGP and AICAR. The resulting ammonia molecule is channeled to the active site of HisF. (216 aa) |
| | hisA | 1-(5-phosphoribosyl)-5-[(5- phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomerase HisA. (248 aa) |
| | hisF | Imidazole glycerol phosphate synthase subunit HisF; IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit. (257 aa) |
| | hisE | phosphoribosyl-ATP pyrophosphatase HisE. (109 aa) |
| | dapB | Dihydrodipicolinate reductase DapB; Catalyzes the conversion of 4-hydroxy-tetrahydrodipicolinate (HTPA) to tetrahydrodipicolinate. (272 aa) |
| | gpmA | 2,3-bisphosphoglycerate-dependent phosphoglycerate mutase GpmA; Catalyzes the interconversion of 2-phosphoglycerate and 3- phosphoglycerate; Belongs to the phosphoglycerate mutase family. BPG- dependent PGAM subfamily. (207 aa) |
| | AEI04836.1 | Hypothetical protein. (250 aa) |
| | AEI04816.1 | NADH dehydrogenase (ubiquinone). (321 aa) |
| | ilvD1 | Dihydroxy-acid dehydratase IlvD; Belongs to the IlvD/Edd family. (613 aa) |
| | aroA | 3-phosphoshikimate 1-carboxyvinyltransferase AroA; Catalyzes the transfer of the enolpyruvyl moiety of phosphoenolpyruvate (PEP) to the 5-hydroxyl of shikimate-3-phosphate (S3P) to produce enolpyruvyl shikimate-3-phosphate and inorganic phosphate. (443 aa) |
| | trpF | N-(5'-phosphoribosyl)anthranilate isomerase TrpF; Belongs to the TrpF family. (234 aa) |
| | trpB | Tryptophan synthase beta chain TrpB; The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine. (405 aa) |
| | trpA | Tryptophan synthase alpha chain TrpA; The alpha subunit is responsible for the aldol cleavage of indoleglycerol phosphate to indole and glyceraldehyde 3-phosphate. Belongs to the TrpA family. (278 aa) |
| | accD | Acetyl-coenzyme A carboxylase carboxyl transferase subunit beta; Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl-CoA. (318 aa) |
| | fgs | Folylpolyglutamate synthase Fgs; Belongs to the folylpolyglutamate synthase family. (442 aa) |
| | ubiB | Ubiquinone biosynthesis protein UbiB; Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis. Belongs to the ABC1 family. UbiB subfamily. (519 aa) |
| | ubiE | Ubiquinone/menaquinone biosynthesis methyltransferase UbiE; Methyltransferase required for the conversion of demethylmenaquinol (DMKH2) to menaquinol (MKH2) and the conversion of 2-polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2-polyprenyl-3- methyl-6-methoxy-1,4-benzoquinol (DMQH2). (256 aa) |
| | fabA | 3-hydroxydecanoyl-[acyl-carrier-protein] dehydratase FabA; Necessary for the introduction of cis unsaturation into fatty acids. Catalyzes the dehydration of (3R)-3-hydroxydecanoyl-ACP to E- (2)-decenoyl-ACP and then its isomerization to Z-(3)-decenoyl-ACP. Can catalyze the dehydratase reaction for beta-hydroxyacyl-ACPs with saturated chain lengths up to 16:0, being most active on intermediate chain length. (176 aa) |
| | fabB | 3-oxoacyl-[acyl-carrier-protein] synthase FabB; Belongs to the thiolase-like superfamily. Beta-ketoacyl-ACP synthases family. (407 aa) |
| | fabI1 | Enoyl-[acyl-carrier-protein] reductase [NADH]. (273 aa) |
| | AEI04741.1 | malonyl-CoA decarboxylase. (456 aa) |
