STRINGSTRING
acsA acsA OBX10022.1 OBX10022.1 OBX09934.1 OBX09934.1 pckA pckA plsY plsY OBX09630.1 OBX09630.1 fumC fumC prs prs ppc ppc OBX09105.1 OBX09105.1 OBX09113.1 OBX09113.1 pgk pgk OBX09115.1 OBX09115.1 zwf zwf pgl pgl OBX09141.1 OBX09141.1 OBX08825.1 OBX08825.1 OBX08833.1 OBX08833.1 mdh mdh OBX08771.1 OBX08771.1 OBX08773.1 OBX08773.1 aceF aceF aceE aceE gpsA gpsA gpmA gpmA eno eno OBX08586.1 OBX08586.1 OBX08587.1 OBX08587.1 OBX08588.1 OBX08588.1 OBX08554.1 OBX08554.1 OBX08428.1 OBX08428.1 OBX08489.1 OBX08489.1 OBX08493.1 OBX08493.1 glpK glpK OBX08532.1 OBX08532.1 plsB plsB OBX08192.1 OBX08192.1 OBX08193.1 OBX08193.1 frdC frdC frdD frdD idnK idnK edd edd pgi pgi aspA aspA OBX08083.1 OBX08083.1 OBX08154.1 OBX08154.1 OBX08165.1 OBX08165.1 OBX08031.1 OBX08031.1 ackA ackA OBX07964.1 OBX07964.1 fbp fbp OBX07880.1 OBX07880.1 OBX07766.1 OBX07766.1 OBX07686.1 OBX07686.1 OBX07723.1 OBX07723.1 OBX07516.1 OBX07516.1 rpiA rpiA OBX07518.1 OBX07518.1 tal tal OBX07129.1 OBX07129.1 glpB glpB glpC glpC OBX07144.1 OBX07144.1 pfkA pfkA gltA gltA OBX06957.1 OBX06957.1 OBX06958.1 OBX06958.1 sucC sucC sucD sucD OBX06857.1 OBX06857.1 OBX06750.1 OBX06750.1 OBX06621.1 OBX06621.1 OBX06622.1 OBX06622.1 OBX06588.1 OBX06588.1 OBX06345.1 OBX06345.1 OBX06161.1 OBX06161.1 OBX06140.1 OBX06140.1 OBX06141.1 OBX06141.1 OBX06149.1 OBX06149.1 tpiA tpiA
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
acsA3-hydroxypropionyl-CoA synthetase; Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA; Belongs to the ATP-dependent AMP-binding enzyme family. (654 aa)
OBX10022.1Converts isocitrate to alpha ketoglutarate; Derived by automated computational analysis using gene prediction method: Protein Homology. (416 aa)
OBX09934.1Phosphodiesterase; Derived by automated computational analysis using gene prediction method: Protein Homology. (364 aa)
pckAPhosphoenolpyruvate carboxykinase; Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA. Belongs to the phosphoenolpyruvate carboxykinase (ATP) family. (537 aa)
plsYGlycerol-3-phosphate acyltransferase; Catalyzes the transfer of an acyl group from acyl-phosphate (acyl-PO(4)) to glycerol-3-phosphate (G3P) to form lysophosphatidic acid (LPA). This enzyme utilizes acyl-phosphate as fatty acyl donor, but not acyl-CoA or acyl-ACP. (202 aa)
OBX09630.1Membrane protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (1022 aa)
fumCFumarate hydratase; Involved in the TCA cycle. Catalyzes the stereospecific interconversion of fumarate to L-malate; Belongs to the class-II fumarase/aspartase family. Fumarase subfamily. (464 aa)
prsRibose-phosphate pyrophosphokinase; Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib- 5-P); Belongs to the ribose-phosphate pyrophosphokinase family. Class I subfamily. (316 aa)
ppcPhosphoenolpyruvate carboxylase; Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle; Belongs to the PEPCase type 1 family. (878 aa)
OBX09105.1Keto-deoxy-phosphogluconate aldolase; Catalyzes the formation of pyruvate and glyoxylate from 4-hydroxy-2-oxoglutarate; or pyruvate and D-glyceraldehyde 3-phosphate from 2-dehydro-3-deoxy-D-glyconate 6-phosphate; Derived by automated computational analysis using gene prediction method: Protein Homology. (215 aa)
OBX09113.1Ferredoxin; Derived by automated computational analysis using gene prediction method: Protein Homology. (86 aa)
pgkPhosphoglycerate kinase; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the phosphoglycerate kinase family. (387 aa)
OBX09115.1Fructose-bisphosphate aldolase; Catalyzes the aldol condensation of dihydroxyacetone phosphate (DHAP or glycerone-phosphate) with glyceraldehyde 3-phosphate (G3P) to form fructose 1,6-bisphosphate (FBP) in gluconeogenesis and the reverse reaction in glycolysis; Belongs to the class II fructose-bisphosphate aldolase family. (360 aa)
zwfGlucose-6-phosphate dehydrogenase; Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone. (499 aa)
pgl6-phosphogluconolactonase; Hydrolysis of 6-phosphogluconolactone to 6-phosphogluconate. (237 aa)
OBX09141.16-phosphogluconate dehydrogenase; Catalyzes the oxidative decarboxylation of 6-phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH. (484 aa)
OBX08825.1Long-chain fatty acid--CoA ligase; Activates fatty acids by binding to coenzyme A; Derived by automated computational analysis using gene prediction method: Protein Homology. (568 aa)
OBX08833.1Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (299 aa)
mdhMalate dehydrogenase; Catalyzes the reversible oxidation of malate to oxaloacetate. (310 aa)
OBX08771.1Peptidylprolyl isomerase; Derived by automated computational analysis using gene prediction method: Protein Homology. (622 aa)
OBX08773.1E3 component of pyruvate and 2-oxoglutarate dehydrogenase complex; catalyzes the oxidation of dihydrolipoamide to lipoamide; Derived by automated computational analysis using gene prediction method: Protein Homology. (474 aa)
aceFPyruvate dehydrogenase; The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2). (628 aa)
aceEPyruvate dehydrogenase; Component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2). (887 aa)
gpsAGlycerol-3-phosphate dehydrogenase; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the NAD-dependent glycerol-3-phosphate dehydrogenase family. (334 aa)
gpmAPhosphoglyceromutase; Catalyzes the interconversion of 2-phosphoglycerate and 3- phosphoglycerate; Belongs to the phosphoglycerate mutase family. BPG- dependent PGAM subfamily. (227 aa)
enoEnolase; Catalyzes the reversible conversion of 2-phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis. (433 aa)
OBX08586.1Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (240 aa)
OBX08587.1Amino acid dehydrogenase; Derived by automated computational analysis using gene prediction method: Protein Homology. (468 aa)
OBX08588.1Lactate utilization protein B/C; Derived by automated computational analysis using gene prediction method: Protein Homology. (238 aa)
OBX08554.1Fatty-acid oxidation protein subunit alpha; Derived by automated computational analysis using gene prediction method: Protein Homology; In the N-terminal section; belongs to the enoyl-CoA hydratase/isomerase family. (710 aa)
OBX08428.1acetyl-CoA acetyltransferase; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the thiolase-like superfamily. Thiolase family. (435 aa)
OBX08489.1Aerobic respiration control protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (752 aa)
OBX08493.1Glyceraldehyde-3-phosphate dehydrogenase; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the glyceraldehyde-3-phosphate dehydrogenase family. (331 aa)
glpKGlycerol kinase; Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate; Belongs to the FGGY kinase family. (506 aa)
OBX08532.1Glycerol uptake facilitator GlpF; Involved in the transport of glycerol into the cell; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the MIP/aquaporin (TC 1.A.8) family. (266 aa)
plsBGlycerol-3-phosphate acyltransferase; PlsB; catalyzes the formation of 1-acyl-sn-glycerol 3-phosphate by transfering the acyl moiety from acyl-CoA; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the GPAT/DAPAT family. (806 aa)
OBX08192.1Part of four member fumarate reductase enzyme complex FrdABCD which catalyzes the reduction of fumarate to succinate during anaerobic respiration; FrdAB are the catalytic subcomplex consisting of a flavoprotein subunit and an iron-sulfur subunit, respectively; FrdCD are the membrane components which interact with quinone and are involved in electron transfer; the catalytic subunits are similar to succinate dehydrogenase SdhAB; Derived by automated computational analysis using gene prediction method: Protein Homology. (598 aa)
OBX08193.1Fumarate reductase; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the succinate dehydrogenase/fumarate reductase iron-sulfur protein family. (257 aa)
frdCFumarate reductase; Seems to be involved in the anchoring of the catalytic components of the fumarate reductase complex to the cytoplasmic membrane. (131 aa)
frdDFumarate reductase; Seems to be involved in the anchoring of the catalytic components of the fumarate reductase complex to the cytoplasmic membrane. (114 aa)
idnKGluconate kinase; Derived by automated computational analysis using gene prediction method: Protein Homology. (172 aa)
eddPhosphogluconate dehydratase; Catalyzes the dehydration of 6-phospho-D-gluconate to 2- dehydro-3-deoxy-6-phospho-D-gluconate; Belongs to the IlvD/Edd family. (599 aa)
pgiGlucose-6-phosphate isomerase; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the GPI family. (548 aa)
aspAAspartate ammonia-lyase; Catalyzes the formation of fumarate from aspartate; Derived by automated computational analysis using gene prediction method: Protein Homology. (472 aa)
OBX08083.1Zinc-binding dehydrogenase; Derived by automated computational analysis using gene prediction method: Protein Homology. (346 aa)
OBX08154.1Methylmalonate-semialdehyde dehydrogenase; Derived by automated computational analysis using gene prediction method: Protein Homology. (504 aa)
OBX08165.1Alcohol dehydrogenase; Derived by automated computational analysis using gene prediction method: Protein Homology. (387 aa)
OBX08031.1Phosphate acetyltransferase; Involved in acetate metabolism. In the N-terminal section; belongs to the CobB/CobQ family. (712 aa)
ackAAcetate kinase; Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction; Belongs to the acetokinase family. (402 aa)
OBX07964.1Phosphoglycerate mutase; Derived by automated computational analysis using gene prediction method: Protein Homology. (220 aa)
fbpCatalyzes the formation of D-fructose 6-phosphate from fructose-1,6-bisphosphate; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the FBPase class 1 family. (334 aa)
OBX07880.1Tyrosine transporter; Derived by automated computational analysis using gene prediction method: Protein Homology. (402 aa)
OBX07766.1Pyruvate kinase; Catalyzes the formation of phosphoenolpyruvate from pyruvate; Derived by automated computational analysis using gene prediction method: Protein Homology. (479 aa)
OBX07686.1Catalyzes the reduction of 2 glutathione to glutathione disulfide; maintains high levels of reduced glutathione in the cytosol; involved in redox regulation and oxidative defense; Derived by automated computational analysis using gene prediction method: Protein Homology. (450 aa)
OBX07723.1Isocitrate dehydrogenase; NADP-specific, catalyzes the formation of 2-oxoglutarate from isocitrate or oxalosuccinate; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the monomeric-type IDH family. (734 aa)
OBX07516.1Coproporphyrinogen III oxidase; Probably acts as a heme chaperone, transferring heme to an unknown acceptor. Binds one molecule of heme per monomer, possibly covalently. Binds 1 [4Fe-4S] cluster. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine. Belongs to the anaerobic coproporphyrinogen-III oxidase family. (378 aa)
rpiARibose-5-phosphate isomerase A; Catalyzes the reversible conversion of ribose-5-phosphate to ribulose 5-phosphate. (219 aa)
OBX07518.13-phosphoglycerate dehydrogenase; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family. (412 aa)
talTransaldolase; Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway. (316 aa)
OBX07129.1Glycerol-3-phosphate dehydrogenase; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family. (557 aa)
glpBGlycerol-3-phosphate dehydrogenase; Conversion of glycerol 3-phosphate to dihydroxyacetone. Uses fumarate or nitrate as electron acceptor. (425 aa)
glpCGlycerol-3-phosphate dehydrogenase; Anaerobic; with GlpAB catalyzes the conversion of glycerol-3-phosphate to dihydroxyacetone phosphate; Derived by automated computational analysis using gene prediction method: Protein Homology. (421 aa)
OBX07144.1Ribulose-phosphate 3-epimerase; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the ribulose-phosphate 3-epimerase family. (224 aa)
pfkA6-phosphofructokinase; Catalyzes the phosphorylation of D-fructose 6-phosphate to fructose 1,6-bisphosphate by ATP, the first committing step of glycolysis. (321 aa)
gltAType II enzyme; in Escherichia coli this enzyme forms a trimer of dimers which is allosterically inhibited by NADH and competitively inhibited by alpha-ketoglutarate; allosteric inhibition is lost when Cys206 is chemically modified which also affects hexamer formation; forms oxaloacetate and acetyl-CoA and water from citrate and coenzyme A; functions in TCA cycle, glyoxylate cycle and respiration; enzyme from Helicobacter pylori is not inhibited by NADH; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the citrate synthase family. (429 aa)
OBX06957.12-oxoglutarate dehydrogenase; Derived by automated computational analysis using gene prediction method: Protein Homology. (937 aa)
OBX06958.1Dihydrolipoamide succinyltransferase; E2 component of the 2-oxoglutarate dehydrogenase (OGDH) complex which catalyzes the second step in the conversion of 2- oxoglutarate to succinyl-CoA and CO(2). (401 aa)
sucCsuccinyl-CoA synthetase subunit beta; Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The beta subunit provides nucleotide specificity of the enzyme and binds the substrate succinate, while the binding sites for coenzyme A and phosphate are found in the alpha subunit. (388 aa)
sucDsuccinyl-CoA synthetase subunit alpha; Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit. (289 aa)
OBX06857.1Bifunctional aconitate hydratase 2/2-methylisocitrate dehydratase; Catalyzes the conversion of citrate to isocitrate and the conversion of 2-methylaconitate to 2-methylisocitrate; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the aconitase/IPM isomerase family. (868 aa)
OBX06750.1Acetaldehyde dehydrogenase; Derived by automated computational analysis using gene prediction method: Protein Homology; In the C-terminal section; belongs to the iron-containing alcohol dehydrogenase family. (871 aa)
OBX06621.1Membrane protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (217 aa)
OBX06622.1Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the UPF0267 family. (108 aa)
OBX06588.1Malic enzyme; NADP-dependent; catalyzes the oxidative decarboxylation of malate to form pyruvate; decarboxylates oxaloacetate; Derived by automated computational analysis using gene prediction method: Protein Homology. (756 aa)
OBX06345.1Malate dehydrogenase; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the LDH/MDH superfamily. (319 aa)
OBX06161.1Transketolase; Catalyzes the formation of ribose 5-phosphate and xylulose 5-phosphate from sedoheptulose 7-phosphate and glyceraldehyde 3-phosphate; can transfer ketol groups between several groups; in Escherichia coli there are two tkt genes, tktA expressed during exponential growth and the tktB during stationary phase; Derived by automated computational analysis using gene prediction method: Protein Homology. (255 aa)
OBX06140.1Membrane protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (258 aa)
OBX06141.1Membrane protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (155 aa)
OBX06149.1Fructose 1,6-bisphosphatase; Derived by automated computational analysis using gene prediction method: Protein Homology. (338 aa)
tpiATriosephosphate isomerase; Involved in the gluconeogenesis. Catalyzes stereospecifically the conversion of dihydroxyacetone phosphate (DHAP) to D- glyceraldehyde-3-phosphate (G3P); Belongs to the triosephosphate isomerase family. (255 aa)
Your Current Organism:
Gallibacterium salpingitidis
NCBI taxonomy Id: 505341
Other names: CCUG 15564, CCUG 36325, G. salpingitidis, Gallibacterium salpingitidis Bisgaard et al. 2009, Gallibacterium sp. 18469/18, Gallibacterium sp. 19987/2, Gallibacterium sp. BK1010/1, Gallibacterium sp. F150, NCTC 11414, strain F150
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