(17 nodes) Sterol transporter activity, and Endoplasmic reticulum membrane organization network (Necator americanus)

Nodes:

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

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proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

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Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

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experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

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textmining

co-expression

protein homology

Your Input:
	NECAME_05260	START domain-containing protein. (204 aa)
	NECAME_14515	Major sperm protein; Central component in molecular interactions underlying sperm crawling. Forms an extensive filament system that extends from sperm villipoda, along the leading edge of the pseudopod. (124 aa)
	NECAME_04286	PH domain-containing protein. (97 aa)
	NECAME_04287	Oxysterol-binding protein; Belongs to the OSBP family. (633 aa)
	NECAME_12634	MSP domain protein. (76 aa)
	NECAME_03672	MENTAL domain-containing protein. (328 aa)
	NECAME_12635	Uncharacterized protein. (111 aa)
	NECAME_00613	MSP domain-containing protein. (219 aa)
	NECAME_11163	PH domain-containing protein. (91 aa)
	NECAME_11162	Oxysterol-binding protein; Belongs to the OSBP family. (635 aa)
	NECAME_09261	Major sperm protein; Central component in molecular interactions underlying sperm crawling. Forms an extensive filament system that extends from sperm villipoda, along the leading edge of the pseudopod. (269 aa)
	NECAME_08432	Uncharacterized protein. (67 aa)
	NECAME_08431	Uncharacterized protein. (258 aa)
	NECAME_08235	Major sperm protein; Central component in molecular interactions underlying sperm crawling. Forms an extensive filament system that extends from sperm villipoda, along the leading edge of the pseudopod. (230 aa)
	NECAME_01425	Major sperm protein; Central component in molecular interactions underlying sperm crawling. Forms an extensive filament system that extends from sperm villipoda, along the leading edge of the pseudopod. (183 aa)
	NECAME_06239	Uncharacterized protein. (160 aa)
	NECAME_06240	MSP domain-containing protein. (59 aa)

Your Current Organism:

Necator americanus

NCBI taxonomy Id: 51031
Other names: N. americanus

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
NECAME_00613	NECAME_08431	W2T2J3	W2TIZ9	MSP domain-containing protein.	Uncharacterized protein.	0.427
NECAME_00613	NECAME_08432	W2T2J3	W2THM9	MSP domain-containing protein.	Uncharacterized protein.	0.588
NECAME_00613	NECAME_11162	W2T2J3	W2T6M7	MSP domain-containing protein.	Oxysterol-binding protein; Belongs to the OSBP family.	0.427
NECAME_00613	NECAME_11163	W2T2J3	W2T5J7	MSP domain-containing protein.	PH domain-containing protein.	0.427
NECAME_01425	NECAME_08431	W2TV61	W2TIZ9	Major sperm protein; Central component in molecular interactions underlying sperm crawling. Forms an extensive filament system that extends from sperm villipoda, along the leading edge of the pseudopod.	Uncharacterized protein.	0.427
NECAME_01425	NECAME_08432	W2TV61	W2THM9	Major sperm protein; Central component in molecular interactions underlying sperm crawling. Forms an extensive filament system that extends from sperm villipoda, along the leading edge of the pseudopod.	Uncharacterized protein.	0.588
NECAME_01425	NECAME_11162	W2TV61	W2T6M7	Major sperm protein; Central component in molecular interactions underlying sperm crawling. Forms an extensive filament system that extends from sperm villipoda, along the leading edge of the pseudopod.	Oxysterol-binding protein; Belongs to the OSBP family.	0.427
NECAME_01425	NECAME_11163	W2TV61	W2T5J7	Major sperm protein; Central component in molecular interactions underlying sperm crawling. Forms an extensive filament system that extends from sperm villipoda, along the leading edge of the pseudopod.	PH domain-containing protein.	0.427
NECAME_03672	NECAME_05260	W2T122	W2SIK0	MENTAL domain-containing protein.	START domain-containing protein.	0.648
NECAME_03672	NECAME_08235	W2T122	W2TJP8	MENTAL domain-containing protein.	Major sperm protein; Central component in molecular interactions underlying sperm crawling. Forms an extensive filament system that extends from sperm villipoda, along the leading edge of the pseudopod.	0.918
NECAME_03672	NECAME_09261	W2T122	W2TH91	MENTAL domain-containing protein.	Major sperm protein; Central component in molecular interactions underlying sperm crawling. Forms an extensive filament system that extends from sperm villipoda, along the leading edge of the pseudopod.	0.913
NECAME_04286	NECAME_08235	W2SVD0	W2TJP8	PH domain-containing protein.	Major sperm protein; Central component in molecular interactions underlying sperm crawling. Forms an extensive filament system that extends from sperm villipoda, along the leading edge of the pseudopod.	0.566
NECAME_04286	NECAME_08432	W2SVD0	W2THM9	PH domain-containing protein.	Uncharacterized protein.	0.567
NECAME_04286	NECAME_09261	W2SVD0	W2TH91	PH domain-containing protein.	Major sperm protein; Central component in molecular interactions underlying sperm crawling. Forms an extensive filament system that extends from sperm villipoda, along the leading edge of the pseudopod.	0.618
NECAME_04287	NECAME_08235	W2SXJ2	W2TJP8	Oxysterol-binding protein; Belongs to the OSBP family.	Major sperm protein; Central component in molecular interactions underlying sperm crawling. Forms an extensive filament system that extends from sperm villipoda, along the leading edge of the pseudopod.	0.566
NECAME_04287	NECAME_08432	W2SXJ2	W2THM9	Oxysterol-binding protein; Belongs to the OSBP family.	Uncharacterized protein.	0.567
NECAME_04287	NECAME_09261	W2SXJ2	W2TH91	Oxysterol-binding protein; Belongs to the OSBP family.	Major sperm protein; Central component in molecular interactions underlying sperm crawling. Forms an extensive filament system that extends from sperm villipoda, along the leading edge of the pseudopod.	0.618
NECAME_05260	NECAME_03672	W2SIK0	W2T122	START domain-containing protein.	MENTAL domain-containing protein.	0.648
NECAME_05260	NECAME_09261	W2SIK0	W2TH91	START domain-containing protein.	Major sperm protein; Central component in molecular interactions underlying sperm crawling. Forms an extensive filament system that extends from sperm villipoda, along the leading edge of the pseudopod.	0.441
NECAME_06239	NECAME_08431	W2TXC7	W2TIZ9	Uncharacterized protein.	Uncharacterized protein.	0.427