(11 nodes) Mixed, incl. Oxysterol-binding protein, and Endoplasmic reticulum-endosome membrane contact site network (Necator americanus)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	NECAME_14515	Major sperm protein; Central component in molecular interactions underlying sperm crawling. Forms an extensive filament system that extends from sperm villipoda, along the leading edge of the pseudopod. (124 aa)
	NECAME_04286	PH domain-containing protein. (97 aa)
	NECAME_04287	Oxysterol-binding protein; Belongs to the OSBP family. (633 aa)
	NECAME_03672	MENTAL domain-containing protein. (328 aa)
	NECAME_00613	MSP domain-containing protein. (219 aa)
	NECAME_11162	Oxysterol-binding protein; Belongs to the OSBP family. (635 aa)
	NECAME_09261	Major sperm protein; Central component in molecular interactions underlying sperm crawling. Forms an extensive filament system that extends from sperm villipoda, along the leading edge of the pseudopod. (269 aa)
	NECAME_08432	Uncharacterized protein. (67 aa)
	NECAME_08431	Uncharacterized protein. (258 aa)
	NECAME_08235	Major sperm protein; Central component in molecular interactions underlying sperm crawling. Forms an extensive filament system that extends from sperm villipoda, along the leading edge of the pseudopod. (230 aa)
	NECAME_06239	Uncharacterized protein. (160 aa)

Your Current Organism:

Necator americanus

NCBI taxonomy Id: 51031
Other names: N. americanus

Send network to Cytoscape

Export your current network:

... as a bitmap image:

download

file format is 'PNG': portable network graphic

... as a high-resolution bitmap:

download

same PNG format, but at higher resolution

... as a vector graphic:

download

SVG: scalable vector graphic - can be opened and edited in Illustrator, CorelDraw, Dia, etc

... as short tabular text output:

download

TSV: tab separated values - can be opened in Excel and Cytoscape (lists only one-way edges: A-B)

... as tabular text output:

download

TSV: tab separated values - can be opened in Excel (lists reciprocal edges: A-B,B-A)

... as an XML summary:

download

structured XML interaction data, according to the 'PSI-MI' data standard

... protein node degrees:

download

node degree of proteins in your network (given the current score cut-off)

... network coordinates:

download

a flat-file format describing the coordinates and colors of nodes in the network

... protein sequences:

download

MFA: multi-fasta format - containing the aminoacid sequences in the network

... protein annotations:

download

a tab-delimited file describing the names, domains and descriptions of proteins in your network

... functional annotations:

download

a tab-delimited file containing all known functional terms of proteins in your network

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
NECAME_00613	NECAME_08431	W2T2J3	W2TIZ9	MSP domain-containing protein.	Uncharacterized protein.	0.427
NECAME_00613	NECAME_08432	W2T2J3	W2THM9	MSP domain-containing protein.	Uncharacterized protein.	0.588
NECAME_00613	NECAME_11162	W2T2J3	W2T6M7	MSP domain-containing protein.	Oxysterol-binding protein; Belongs to the OSBP family.	0.427
NECAME_03672	NECAME_08235	W2T122	W2TJP8	MENTAL domain-containing protein.	Major sperm protein; Central component in molecular interactions underlying sperm crawling. Forms an extensive filament system that extends from sperm villipoda, along the leading edge of the pseudopod.	0.918
NECAME_03672	NECAME_09261	W2T122	W2TH91	MENTAL domain-containing protein.	Major sperm protein; Central component in molecular interactions underlying sperm crawling. Forms an extensive filament system that extends from sperm villipoda, along the leading edge of the pseudopod.	0.913
NECAME_04286	NECAME_08235	W2SVD0	W2TJP8	PH domain-containing protein.	Major sperm protein; Central component in molecular interactions underlying sperm crawling. Forms an extensive filament system that extends from sperm villipoda, along the leading edge of the pseudopod.	0.566
NECAME_04286	NECAME_08432	W2SVD0	W2THM9	PH domain-containing protein.	Uncharacterized protein.	0.567
NECAME_04286	NECAME_09261	W2SVD0	W2TH91	PH domain-containing protein.	Major sperm protein; Central component in molecular interactions underlying sperm crawling. Forms an extensive filament system that extends from sperm villipoda, along the leading edge of the pseudopod.	0.618
NECAME_04287	NECAME_08235	W2SXJ2	W2TJP8	Oxysterol-binding protein; Belongs to the OSBP family.	Major sperm protein; Central component in molecular interactions underlying sperm crawling. Forms an extensive filament system that extends from sperm villipoda, along the leading edge of the pseudopod.	0.566
NECAME_04287	NECAME_08432	W2SXJ2	W2THM9	Oxysterol-binding protein; Belongs to the OSBP family.	Uncharacterized protein.	0.567
NECAME_04287	NECAME_09261	W2SXJ2	W2TH91	Oxysterol-binding protein; Belongs to the OSBP family.	Major sperm protein; Central component in molecular interactions underlying sperm crawling. Forms an extensive filament system that extends from sperm villipoda, along the leading edge of the pseudopod.	0.618
NECAME_06239	NECAME_08431	W2TXC7	W2TIZ9	Uncharacterized protein.	Uncharacterized protein.	0.427
NECAME_06239	NECAME_08432	W2TXC7	W2THM9	Uncharacterized protein.	Uncharacterized protein.	0.588
NECAME_06239	NECAME_11162	W2TXC7	W2T6M7	Uncharacterized protein.	Oxysterol-binding protein; Belongs to the OSBP family.	0.427
NECAME_08235	NECAME_03672	W2TJP8	W2T122	Major sperm protein; Central component in molecular interactions underlying sperm crawling. Forms an extensive filament system that extends from sperm villipoda, along the leading edge of the pseudopod.	MENTAL domain-containing protein.	0.918
NECAME_08235	NECAME_04286	W2TJP8	W2SVD0	Major sperm protein; Central component in molecular interactions underlying sperm crawling. Forms an extensive filament system that extends from sperm villipoda, along the leading edge of the pseudopod.	PH domain-containing protein.	0.566
NECAME_08235	NECAME_04287	W2TJP8	W2SXJ2	Major sperm protein; Central component in molecular interactions underlying sperm crawling. Forms an extensive filament system that extends from sperm villipoda, along the leading edge of the pseudopod.	Oxysterol-binding protein; Belongs to the OSBP family.	0.566
NECAME_08235	NECAME_08431	W2TJP8	W2TIZ9	Major sperm protein; Central component in molecular interactions underlying sperm crawling. Forms an extensive filament system that extends from sperm villipoda, along the leading edge of the pseudopod.	Uncharacterized protein.	0.839
NECAME_08235	NECAME_08432	W2TJP8	W2THM9	Major sperm protein; Central component in molecular interactions underlying sperm crawling. Forms an extensive filament system that extends from sperm villipoda, along the leading edge of the pseudopod.	Uncharacterized protein.	0.802
NECAME_08235	NECAME_09261	W2TJP8	W2TH91	Major sperm protein; Central component in molecular interactions underlying sperm crawling. Forms an extensive filament system that extends from sperm villipoda, along the leading edge of the pseudopod.	Major sperm protein; Central component in molecular interactions underlying sperm crawling. Forms an extensive filament system that extends from sperm villipoda, along the leading edge of the pseudopod.	0.593