(12 nodes) DNA replication factor C complex, and Ctf18 RFC-like complex network (Necator americanus)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	NECAME_04463	Replication factor. (218 aa)
	NECAME_12475	Putative replication factor C small subunit. (371 aa)
	NECAME_03628	Uncharacterized protein. (316 aa)
	NECAME_03627	AAA domain-containing protein. (367 aa)
	NECAME_09310	RFC1 domain-containing protein. (218 aa)
	NECAME_09728	Replication factor C small subunit domain protein. (124 aa)
	NECAME_09729	Replication factor. (158 aa)
	NECAME_09309	Replication factor C subunit 1. (822 aa)
	NECAME_08230	Ctf8. (98 aa)
	NECAME_07595	Proliferating cell nuclear antigen; This protein is an auxiliary protein of DNA polymerase delta and is involved in the control of eukaryotic DNA replication by increasing the polymerase's processibility during elongation of the leading strand; Belongs to the PCNA family. (271 aa)
	NECAME_07567	Replication factor C subunit 3 family protein. (332 aa)
	NECAME_01515	Uncharacterized protein. (460 aa)

Your Current Organism:

Necator americanus

NCBI taxonomy Id: 51031
Other names: N. americanus

Send network to Cytoscape

Export your current network:

... as a bitmap image:

download

file format is 'PNG': portable network graphic

... as a high-resolution bitmap:

download

same PNG format, but at higher resolution

... as a vector graphic:

download

SVG: scalable vector graphic - can be opened and edited in Illustrator, CorelDraw, Dia, etc

... as short tabular text output:

download

TSV: tab separated values - can be opened in Excel and Cytoscape (lists only one-way edges: A-B)

... as tabular text output:

download

TSV: tab separated values - can be opened in Excel (lists reciprocal edges: A-B,B-A)

... as an XML summary:

download

structured XML interaction data, according to the 'PSI-MI' data standard

... protein node degrees:

download

node degree of proteins in your network (given the current score cut-off)

... network coordinates:

download

a flat-file format describing the coordinates and colors of nodes in the network

... protein sequences:

download

MFA: multi-fasta format - containing the aminoacid sequences in the network

... protein annotations:

download

a tab-delimited file describing the names, domains and descriptions of proteins in your network

... functional annotations:

download

a tab-delimited file containing all known functional terms of proteins in your network

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
NECAME_01515	NECAME_03627	W2TT44	W2T2R9	Uncharacterized protein.	AAA domain-containing protein.	0.980
NECAME_01515	NECAME_03628	W2TT44	W2T1I5	Uncharacterized protein.	Uncharacterized protein.	0.980
NECAME_01515	NECAME_04463	W2TT44	W2SSF2	Uncharacterized protein.	Replication factor.	0.955
NECAME_01515	NECAME_07567	W2TT44	W2TPU0	Uncharacterized protein.	Replication factor C subunit 3 family protein.	0.987
NECAME_01515	NECAME_07595	W2TT44	W2TMK5	Uncharacterized protein.	Proliferating cell nuclear antigen; This protein is an auxiliary protein of DNA polymerase delta and is involved in the control of eukaryotic DNA replication by increasing the polymerase's processibility during elongation of the leading strand; Belongs to the PCNA family.	0.674
NECAME_01515	NECAME_08230	W2TT44	W2TJP3	Uncharacterized protein.	Ctf8.	0.996
NECAME_01515	NECAME_09309	W2TT44	W2TF39	Uncharacterized protein.	Replication factor C subunit 1.	0.751
NECAME_01515	NECAME_09310	W2TT44	W2TDT3	Uncharacterized protein.	RFC1 domain-containing protein.	0.751
NECAME_01515	NECAME_09728	W2TT44	W2TEI4	Uncharacterized protein.	Replication factor C small subunit domain protein.	0.906
NECAME_01515	NECAME_09729	W2TT44	W2TF13	Uncharacterized protein.	Replication factor.	0.906
NECAME_01515	NECAME_12475	W2TT44	W2SZY6	Uncharacterized protein.	Putative replication factor C small subunit.	0.946
NECAME_03627	NECAME_01515	W2T2R9	W2TT44	AAA domain-containing protein.	Uncharacterized protein.	0.980
NECAME_03627	NECAME_03628	W2T2R9	W2T1I5	AAA domain-containing protein.	Uncharacterized protein.	0.914
NECAME_03627	NECAME_04463	W2T2R9	W2SSF2	AAA domain-containing protein.	Replication factor.	0.951
NECAME_03627	NECAME_07567	W2T2R9	W2TPU0	AAA domain-containing protein.	Replication factor C subunit 3 family protein.	0.962
NECAME_03627	NECAME_07595	W2T2R9	W2TMK5	AAA domain-containing protein.	Proliferating cell nuclear antigen; This protein is an auxiliary protein of DNA polymerase delta and is involved in the control of eukaryotic DNA replication by increasing the polymerase's processibility during elongation of the leading strand; Belongs to the PCNA family.	0.887
NECAME_03627	NECAME_08230	W2T2R9	W2TJP3	AAA domain-containing protein.	Ctf8.	0.976
NECAME_03627	NECAME_09309	W2T2R9	W2TF39	AAA domain-containing protein.	Replication factor C subunit 1.	0.721
NECAME_03627	NECAME_09310	W2T2R9	W2TDT3	AAA domain-containing protein.	RFC1 domain-containing protein.	0.691
NECAME_03627	NECAME_09728	W2T2R9	W2TEI4	AAA domain-containing protein.	Replication factor C small subunit domain protein.	0.883