(26 nodes) Proteasome network (Necator americanus)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	NECAME_15981	Peptidase, T1 family. (261 aa)
	NECAME_19515	Peptidase, T1 family. (204 aa)
	NECAME_05226	Proteasome subunit alpha type; The proteasome is a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH; Belongs to the peptidase T1A family. (256 aa)
	NECAME_15466	Mov34/MPN/PAD-1 family protein. (272 aa)
	NECAME_14338	Ubiquitin carboxyl-terminal hydrolase. (445 aa)
	NECAME_13407	26S proteasome subunit P45 family protein; Belongs to the AAA ATPase family. (435 aa)
	NECAME_13338	PCI domain protein. (387 aa)
	NECAME_12594	26S proteasome subunit P45 family protein; Belongs to the AAA ATPase family. (433 aa)
	NECAME_03839	Ribosomal protein L13; Belongs to the mitochondrial carrier (TC 2.A.29) family. (1405 aa)
	NECAME_12708	Proteasome subunit beta. (205 aa)
	NECAME_03342	Proteasome subunit alpha type; The proteasome is a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH; Belongs to the peptidase T1A family. (242 aa)
	NECAME_00440	PCI domain protein. (416 aa)
	NECAME_03408	Proteasome subunit alpha type; The proteasome is a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH; Belongs to the peptidase T1A family. (247 aa)
	NECAME_11128	ATPase, AAA family; Belongs to the AAA ATPase family. (274 aa)
	NECAME_03081	Proteasome endopeptidase complex; Belongs to the peptidase T1A family. (469 aa)
	NECAME_10321	26S proteasome non-ATPase regulatory subunit 2; Component of the 26S proteasome, a multiprotein complex involved in the ATP-dependent degradation of ubiquitinated proteins. This complex plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins, which could impair cellular functions, and by removing proteins whose functions are no longer required. Therefore, the proteasome participates in numerous cellular processes, including cell cycle progression, apoptosis, or DNA damage repair; Belongs to the proteasome subunit S2 family. (866 aa)
	NECAME_09520	Proteasome subunit alpha type; The proteasome is a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH; Belongs to the peptidase T1A family. (241 aa)
	NECAME_02546	Ribosomal protein L32. (668 aa)
	NECAME_09404	Proteasome subunit beta. (244 aa)
	NECAME_02222	Proteasome subunit beta. (203 aa)
	NECAME_19668	Uncharacterized protein. (189 aa)
	NECAME_07553	ATPase, AAA family; Belongs to the AAA ATPase family. (325 aa)
	NECAME_01685	26S proteasome non-ATPase regulatory subunit 7 family protein. (360 aa)
	NECAME_06590	Proteasome subunit alpha type; The proteasome is a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH; Belongs to the peptidase T1A family. (250 aa)
	NECAME_17169	Multicatalytic endopeptidase family protein. (277 aa)
	NECAME_16007	26S proteasome subunit P45 family protein; Belongs to the AAA ATPase family. (429 aa)

Your Current Organism:

Necator americanus

NCBI taxonomy Id: 51031
Other names: N. americanus

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
NECAME_00440	NECAME_01685	W2T4G1	W2TSA9	PCI domain protein.	26S proteasome non-ATPase regulatory subunit 7 family protein.	0.999
NECAME_00440	NECAME_02222	W2T4G1	W2THW0	PCI domain protein.	Proteasome subunit beta.	0.996
NECAME_00440	NECAME_02546	W2T4G1	W2TD14	PCI domain protein.	Ribosomal protein L32.	0.999
NECAME_00440	NECAME_03081	W2T4G1	W2T6Z9	PCI domain protein.	Proteasome endopeptidase complex; Belongs to the peptidase T1A family.	0.998
NECAME_00440	NECAME_03342	W2T4G1	W2T437	PCI domain protein.	Proteasome subunit alpha type; The proteasome is a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH; Belongs to the peptidase T1A family.	0.993
NECAME_00440	NECAME_03408	W2T4G1	W2T673	PCI domain protein.	Proteasome subunit alpha type; The proteasome is a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH; Belongs to the peptidase T1A family.	0.996
NECAME_00440	NECAME_03839	W2T4G1	W2T1I7	PCI domain protein.	Ribosomal protein L13; Belongs to the mitochondrial carrier (TC 2.A.29) family.	0.999
NECAME_00440	NECAME_05226	W2T4G1	W2SIW4	PCI domain protein.	Proteasome subunit alpha type; The proteasome is a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH; Belongs to the peptidase T1A family.	0.997
NECAME_00440	NECAME_06590	W2T4G1	W2TTC5	PCI domain protein.	Proteasome subunit alpha type; The proteasome is a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH; Belongs to the peptidase T1A family.	0.997
NECAME_00440	NECAME_07553	W2T4G1	W2TQ33	PCI domain protein.	ATPase, AAA family; Belongs to the AAA ATPase family.	0.999
NECAME_00440	NECAME_09404	W2T4G1	W2TDF7	PCI domain protein.	Proteasome subunit beta.	0.990
NECAME_00440	NECAME_09520	W2T4G1	W2TCZ2	PCI domain protein.	Proteasome subunit alpha type; The proteasome is a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH; Belongs to the peptidase T1A family.	0.998
NECAME_00440	NECAME_10321	W2T4G1	W2TBX4	PCI domain protein.	26S proteasome non-ATPase regulatory subunit 2; Component of the 26S proteasome, a multiprotein complex involved in the ATP-dependent degradation of ubiquitinated proteins. This complex plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins, which could impair cellular functions, and by removing proteins whose functions are no longer required. Therefore, the proteasome participates in numerous cellular processes, including cell cycle progression, apoptosis, or DNA damage repair; Belongs to the proteasome subunit S2 family.	0.999
NECAME_00440	NECAME_11128	W2T4G1	W2T6U3	PCI domain protein.	ATPase, AAA family; Belongs to the AAA ATPase family.	0.999
NECAME_00440	NECAME_12594	W2T4G1	W2SZ46	PCI domain protein.	26S proteasome subunit P45 family protein; Belongs to the AAA ATPase family.	0.999
NECAME_00440	NECAME_12708	W2T4G1	W2T1J6	PCI domain protein.	Proteasome subunit beta.	0.992
NECAME_00440	NECAME_13338	W2T4G1	W2SWN8	PCI domain protein.	PCI domain protein.	0.999
NECAME_00440	NECAME_13407	W2T4G1	W2SWD0	PCI domain protein.	26S proteasome subunit P45 family protein; Belongs to the AAA ATPase family.	0.999
NECAME_00440	NECAME_14338	W2T4G1	W2SNI4	PCI domain protein.	Ubiquitin carboxyl-terminal hydrolase.	0.997
NECAME_00440	NECAME_15466	W2T4G1	W2SJZ4	PCI domain protein.	Mov34/MPN/PAD-1 family protein.	0.996