(6 nodes) Mixed, incl. Proteasomal ATPase OB C-terminal domain, and Rpn11/EIF3F, C-terminal network (Necator americanus)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	NECAME_03839	Ribosomal protein L13; Belongs to the mitochondrial carrier (TC 2.A.29) family. (1405 aa)
	NECAME_00440	PCI domain protein. (416 aa)
	NECAME_11128	ATPase, AAA family; Belongs to the AAA ATPase family. (274 aa)
	NECAME_10321	26S proteasome non-ATPase regulatory subunit 2; Component of the 26S proteasome, a multiprotein complex involved in the ATP-dependent degradation of ubiquitinated proteins. This complex plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins, which could impair cellular functions, and by removing proteins whose functions are no longer required. Therefore, the proteasome participates in numerous cellular processes, including cell cycle progression, apoptosis, or DNA damage repair; Belongs to the proteasome subunit S2 family. (866 aa)
	NECAME_02546	Ribosomal protein L32. (668 aa)
	NECAME_01685	26S proteasome non-ATPase regulatory subunit 7 family protein. (360 aa)

Your Current Organism:

Necator americanus

NCBI taxonomy Id: 51031
Other names: N. americanus

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
NECAME_00440	NECAME_01685	W2T4G1	W2TSA9	PCI domain protein.	26S proteasome non-ATPase regulatory subunit 7 family protein.	0.999
NECAME_00440	NECAME_02546	W2T4G1	W2TD14	PCI domain protein.	Ribosomal protein L32.	0.999
NECAME_00440	NECAME_03839	W2T4G1	W2T1I7	PCI domain protein.	Ribosomal protein L13; Belongs to the mitochondrial carrier (TC 2.A.29) family.	0.999
NECAME_00440	NECAME_10321	W2T4G1	W2TBX4	PCI domain protein.	26S proteasome non-ATPase regulatory subunit 2; Component of the 26S proteasome, a multiprotein complex involved in the ATP-dependent degradation of ubiquitinated proteins. This complex plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins, which could impair cellular functions, and by removing proteins whose functions are no longer required. Therefore, the proteasome participates in numerous cellular processes, including cell cycle progression, apoptosis, or DNA damage repair; Belongs to the proteasome subunit S2 family.	0.999
NECAME_00440	NECAME_11128	W2T4G1	W2T6U3	PCI domain protein.	ATPase, AAA family; Belongs to the AAA ATPase family.	0.999
NECAME_01685	NECAME_00440	W2TSA9	W2T4G1	26S proteasome non-ATPase regulatory subunit 7 family protein.	PCI domain protein.	0.999
NECAME_01685	NECAME_02546	W2TSA9	W2TD14	26S proteasome non-ATPase regulatory subunit 7 family protein.	Ribosomal protein L32.	0.999
NECAME_01685	NECAME_03839	W2TSA9	W2T1I7	26S proteasome non-ATPase regulatory subunit 7 family protein.	Ribosomal protein L13; Belongs to the mitochondrial carrier (TC 2.A.29) family.	0.999
NECAME_01685	NECAME_10321	W2TSA9	W2TBX4	26S proteasome non-ATPase regulatory subunit 7 family protein.	26S proteasome non-ATPase regulatory subunit 2; Component of the 26S proteasome, a multiprotein complex involved in the ATP-dependent degradation of ubiquitinated proteins. This complex plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins, which could impair cellular functions, and by removing proteins whose functions are no longer required. Therefore, the proteasome participates in numerous cellular processes, including cell cycle progression, apoptosis, or DNA damage repair; Belongs to the proteasome subunit S2 family.	0.999
NECAME_01685	NECAME_11128	W2TSA9	W2T6U3	26S proteasome non-ATPase regulatory subunit 7 family protein.	ATPase, AAA family; Belongs to the AAA ATPase family.	0.999
NECAME_02546	NECAME_00440	W2TD14	W2T4G1	Ribosomal protein L32.	PCI domain protein.	0.999
NECAME_02546	NECAME_01685	W2TD14	W2TSA9	Ribosomal protein L32.	26S proteasome non-ATPase regulatory subunit 7 family protein.	0.999
NECAME_02546	NECAME_03839	W2TD14	W2T1I7	Ribosomal protein L32.	Ribosomal protein L13; Belongs to the mitochondrial carrier (TC 2.A.29) family.	0.999
NECAME_02546	NECAME_10321	W2TD14	W2TBX4	Ribosomal protein L32.	26S proteasome non-ATPase regulatory subunit 2; Component of the 26S proteasome, a multiprotein complex involved in the ATP-dependent degradation of ubiquitinated proteins. This complex plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins, which could impair cellular functions, and by removing proteins whose functions are no longer required. Therefore, the proteasome participates in numerous cellular processes, including cell cycle progression, apoptosis, or DNA damage repair; Belongs to the proteasome subunit S2 family.	0.999
NECAME_02546	NECAME_11128	W2TD14	W2T6U3	Ribosomal protein L32.	ATPase, AAA family; Belongs to the AAA ATPase family.	0.999
NECAME_03839	NECAME_00440	W2T1I7	W2T4G1	Ribosomal protein L13; Belongs to the mitochondrial carrier (TC 2.A.29) family.	PCI domain protein.	0.999
NECAME_03839	NECAME_01685	W2T1I7	W2TSA9	Ribosomal protein L13; Belongs to the mitochondrial carrier (TC 2.A.29) family.	26S proteasome non-ATPase regulatory subunit 7 family protein.	0.999
NECAME_03839	NECAME_02546	W2T1I7	W2TD14	Ribosomal protein L13; Belongs to the mitochondrial carrier (TC 2.A.29) family.	Ribosomal protein L32.	0.999
NECAME_03839	NECAME_10321	W2T1I7	W2TBX4	Ribosomal protein L13; Belongs to the mitochondrial carrier (TC 2.A.29) family.	26S proteasome non-ATPase regulatory subunit 2; Component of the 26S proteasome, a multiprotein complex involved in the ATP-dependent degradation of ubiquitinated proteins. This complex plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins, which could impair cellular functions, and by removing proteins whose functions are no longer required. Therefore, the proteasome participates in numerous cellular processes, including cell cycle progression, apoptosis, or DNA damage repair; Belongs to the proteasome subunit S2 family.	0.999
NECAME_03839	NECAME_11128	W2T1I7	W2T6U3	Ribosomal protein L13; Belongs to the mitochondrial carrier (TC 2.A.29) family.	ATPase, AAA family; Belongs to the AAA ATPase family.	0.999