(99 nodes) Protein folding, and IRE1alpha activates chaperones network (Necator americanus)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	NECAME_05567	Uncharacterized protein. (63 aa)
	NECAME_15776	Thermosome subunit alpha domain protein; Belongs to the TCP-1 chaperonin family. (241 aa)
	NECAME_05566	Uncharacterized protein. (191 aa)
	NECAME_05411	Prefoldin subunit 4; Binds specifically to cytosolic chaperonin (c-CPN) and transfers target proteins to it. Binds to nascent polypeptide chain and promotes folding in an environment in which there are many competing pathways for nonnative proteins; Belongs to the prefoldin subunit beta family. (126 aa)
	NECAME_01085	Protein disulfide-isomerase. (493 aa)
	NECAME_05615	Putative chaperone protein DnaK; Belongs to the heat shock protein 70 family. (624 aa)
	NECAME_15657	Thioredoxin. (176 aa)
	NECAME_15183	DnaJ domain protein. (154 aa)
	NECAME_15182	DnaJ domain protein. (251 aa)
	NECAME_05426	Uncharacterized protein. (408 aa)
	NECAME_15134	T-complex protein 1, zeta subunit. (530 aa)
	NECAME_05116	DnaK family protein. (554 aa)
	NECAME_14982	Uncharacterized protein. (105 aa)
	NECAME_15322	Peptidyl-prolyl cis-trans isomerase; PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides; Belongs to the cyclophilin-type PPIase family. (210 aa)
	NECAME_14789	Uncharacterized protein. (46 aa)
	NECAME_05115	Uncharacterized protein. (317 aa)
	NECAME_14285	Peptidyl-prolyl cis-trans isomerase; PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides; Belongs to the cyclophilin-type PPIase family. (228 aa)
	NECAME_14763	Tetratricopeptide repeat protein. (499 aa)
	NECAME_04607	T-complex protein 1, theta subunit. (548 aa)
	NECAME_04685	Uncharacterized protein. (178 aa)
	NECAME_04519	DnaJ region. (291 aa)
	NECAME_14190	Putative chaperone protein DnaK; Belongs to the heat shock protein 70 family. (643 aa)
	NECAME_18779	DnaJ domain protein. (166 aa)
	NECAME_14070	Uncharacterized protein. (121 aa)
	NECAME_18674	Thermosome subunit alpha domain protein; Belongs to the TCP-1 chaperonin family. (222 aa)
	NECAME_18917	T-complex protein 1 subunit eta; Molecular chaperone; assists the folding of proteins upon ATP hydrolysis. Known to play a role, in vitro, in the folding of actin and tubulin. (53 aa)
	NECAME_13360	Uncharacterized protein. (79 aa)
	NECAME_13187	T-complex protein 1, gamma subunit. (562 aa)
	NECAME_18515	Uncharacterized protein. (83 aa)
	NECAME_04134	Uncharacterized protein. (170 aa)
	NECAME_18482	Uncharacterized protein. (89 aa)
	NECAME_04339	Uncharacterized protein. (78 aa)
	NECAME_04063	Chaperonin GroS; Belongs to the GroES chaperonin family. (110 aa)
	NECAME_12934	Prefoldin, alpha subunit. (157 aa)
	NECAME_04340	Uncharacterized protein. (338 aa)
	NECAME_04064	Chaperonin GroL. (524 aa)
	NECAME_04074	Myb-like DNA-binding domain protein. (300 aa)
	NECAME_00785	HSF-type DNA-binding domain protein. (256 aa)
	NECAME_04072	Tetratricopeptide repeat protein. (157 aa)
	NECAME_13454	Prefoldin subunit. (118 aa)
	NECAME_12706	T-complex protein 1 subunit delta. (508 aa)
	NECAME_12727	Hsp90 protein. (720 aa)
	NECAME_12361	Chaperone protein DnaK; Belongs to the heat shock protein 70 family. (691 aa)
	NECAME_00652	Peptidylprolyl isomerase. (252 aa)
	NECAME_11884	CS domain protein. (143 aa)
	NECAME_12103	PQQ enzyme repeat protein. (349 aa)
	NECAME_11672	T-complex protein 1, beta subunit. (498 aa)
	NECAME_12100	Kinase domain protein. (449 aa)
	NECAME_11689	Tetratricopeptide repeat protein. (186 aa)
	NECAME_12101	Uncharacterized protein. (197 aa)
	NECAME_12042	Protein disulfide-isomerase domain protein. (787 aa)
	NECAME_11559	Protein disulfide-isomerase. (485 aa)
	NECAME_11933	Peptidylprolyl isomerase. (131 aa)
	NECAME_11069	Activator of Hsp90 ATPase. (343 aa)
	NECAME_11074	HpcH/HpaI aldolase/citrate lyase family protein. (327 aa)
	NECAME_11242	Hsp90 protein. (772 aa)
	NECAME_11247	Prefoldin subunit. (118 aa)
	NECAME_10660	Putative T-complex protein 1, epsilon subunit. (409 aa)
	NECAME_10616	Basic region leucine zipper. (334 aa)
	NECAME_10342	DnaJ domain protein. (386 aa)
	NECAME_10617	DnaJ domain protein. (387 aa)
	NECAME_09948	Calreticulin family protein. (351 aa)
	NECAME_09831	DnaJ domain protein. (930 aa)
	NECAME_09545	Mesencephalic astrocyte-derived neurotrophic factor-like family protein. (167 aa)
	NECAME_02547	DnaK family protein. (750 aa)
	NECAME_18114	Thioredoxin. (80 aa)
	NECAME_02688	Protein disulfide-isomerase domain protein; Belongs to the protein disulfide isomerase family. (435 aa)
	NECAME_09226	DUF775 domain-containing protein. (205 aa)
	NECAME_18115	Thioredoxin. (66 aa)
	NECAME_09213	EGF-like domain protein. (1390 aa)
	NECAME_09703	Calreticulin family protein. (592 aa)
	NECAME_08499	Heat shock cognate protein 1; Belongs to the heat shock protein 70 family. (657 aa)
	NECAME_08554	Endoplasmic Reticulum Oxidoreductin 1. (485 aa)
	NECAME_08172	DnaJ domain protein. (340 aa)
	NECAME_08452	DnaJ domain protein. (246 aa)
	NECAME_02045	Tetratricopeptide repeat protein. (387 aa)
	NECAME_08400	T6PP_N domain-containing protein. (466 aa)
	NECAME_08410	Tetratricopeptide repeat protein. (490 aa)
	NECAME_02036	Uncharacterized protein. (163 aa)
	NECAME_17673	Protein disulfide-isomerase domain protein; Belongs to the protein disulfide isomerase family. (349 aa)
	NECAME_02038	Uncharacterized protein. (173 aa)
	NECAME_07297	DUF3715 domain-containing protein. (1237 aa)
	NECAME_07393	DnaK family protein. (412 aa)
	NECAME_17448	Uncharacterized protein. (118 aa)
	NECAME_07351	Putative heat shock protein 90. (689 aa)
	NECAME_07296	Uncharacterized protein. (188 aa)
	NECAME_17581	Uncharacterized protein. (131 aa)
	NECAME_07145	Co-chaperone GrpE; Belongs to the GrpE family. (298 aa)
	NECAME_06912	DnaJ domain protein. (479 aa)
	NECAME_07386	Uncharacterized protein. (210 aa)
	NECAME_19568	T-complex protein 1 subunit eta; Molecular chaperone; assists the folding of proteins upon ATP hydrolysis. Known to play a role, in vitro, in the folding of actin and tubulin. (181 aa)
	NECAME_16815	Cdc37 Hsp90 binding domain protein. (420 aa)
	NECAME_16671	Uncharacterized protein. (68 aa)
	NECAME_06229	Reverse transcriptase. (1073 aa)
	NECAME_16211	Uncharacterized protein. (130 aa)
	NECAME_16518	DnaJ domain protein. (321 aa)
	NECAME_00084	Uncharacterized protein. (767 aa)
	NECAME_16302	Prefoldin subunit 3; Binds specifically to cytosolic chaperonin (c-CPN) and transfers target proteins to it. Binds to nascent polypeptide chain and promotes folding in an environment in which there are many competing pathways for nonnative proteins; Belongs to the prefoldin subunit alpha family. (201 aa)
	NECAME_16222	HpcH/HpaI aldolase/citrate lyase family protein. (280 aa)

Your Current Organism:

Necator americanus

NCBI taxonomy Id: 51031
Other names: N. americanus

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
NECAME_00084	NECAME_00785	W2TYS3	W2SXT4	Uncharacterized protein.	HSF-type DNA-binding domain protein.	0.589
NECAME_00084	NECAME_01085	W2TYS3	W2SH94	Uncharacterized protein.	Protein disulfide-isomerase.	0.467
NECAME_00084	NECAME_02036	W2TYS3	W2TL02	Uncharacterized protein.	Uncharacterized protein.	0.552
NECAME_00084	NECAME_02038	W2TYS3	W2TME3	Uncharacterized protein.	Uncharacterized protein.	0.552
NECAME_00084	NECAME_02688	W2TYS3	W2TE41	Uncharacterized protein.	Protein disulfide-isomerase domain protein; Belongs to the protein disulfide isomerase family.	0.632
NECAME_00084	NECAME_04063	W2TYS3	W2SXA6	Uncharacterized protein.	Chaperonin GroS; Belongs to the GroES chaperonin family.	0.753
NECAME_00084	NECAME_04064	W2TYS3	W2SXM7	Uncharacterized protein.	Chaperonin GroL.	0.552
NECAME_00084	NECAME_04074	W2TYS3	W2SXN6	Uncharacterized protein.	Myb-like DNA-binding domain protein.	0.577
NECAME_00084	NECAME_04134	W2TYS3	W2SWU2	Uncharacterized protein.	Uncharacterized protein.	0.530
NECAME_00084	NECAME_04519	W2TYS3	W2SRI4	Uncharacterized protein.	DnaJ region.	0.669
NECAME_00084	NECAME_04685	W2TYS3	W2SQZ5	Uncharacterized protein.	Uncharacterized protein.	0.724
NECAME_00084	NECAME_05116	W2TYS3	W2SJT1	Uncharacterized protein.	DnaK family protein.	0.903
NECAME_00084	NECAME_05566	W2TYS3	W2SG20	Uncharacterized protein.	Uncharacterized protein.	0.489
NECAME_00084	NECAME_05615	W2TYS3	W2SI51	Uncharacterized protein.	Putative chaperone protein DnaK; Belongs to the heat shock protein 70 family.	0.872
NECAME_00084	NECAME_06229	W2TYS3	W2TVY8	Uncharacterized protein.	Reverse transcriptase.	0.532
NECAME_00084	NECAME_06912	W2TYS3	W2TQL8	Uncharacterized protein.	DnaJ domain protein.	0.718
NECAME_00084	NECAME_07145	W2TYS3	W2TQ05	Uncharacterized protein.	Co-chaperone GrpE; Belongs to the GrpE family.	0.841
NECAME_00084	NECAME_07296	W2TYS3	W2TPN1	Uncharacterized protein.	Uncharacterized protein.	0.490
NECAME_00084	NECAME_07297	W2TYS3	W2TNG0	Uncharacterized protein.	DUF3715 domain-containing protein.	0.490
NECAME_00084	NECAME_07351	W2TYS3	W2TPB2	Uncharacterized protein.	Putative heat shock protein 90.	0.724