(57 nodes) Response to organic cyclic compound network (Necator americanus)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	NECAME_08575	Uncharacterized protein. (357 aa)
	NECAME_08960	Uncharacterized protein. (1370 aa)
	NECAME_02446	7 transmembrane receptor; Belongs to the G-protein coupled receptor 1 family. (398 aa)
	NECAME_09632	Uncharacterized protein. (402 aa)
	NECAME_02382	G_PROTEIN_RECEP_F1_2 domain-containing protein. (288 aa)
	NECAME_09929	Regulator of G protein signaling domain protein. (436 aa)
	NECAME_09877	Transforming growth factor beta like domain protein. (355 aa)
	NECAME_09633	Uncharacterized protein. (521 aa)
	NECAME_09922	7 transmembrane receptor; Belongs to the G-protein coupled receptor 1 family. (487 aa)
	NECAME_10280	RNA polymerase Rpb4. (142 aa)
	NECAME_11494	GRAM domain protein. (203 aa)
	NECAME_11191	Uncharacterized protein. (2178 aa)
	NECAME_11489	Uncharacterized protein. (69 aa)
	NECAME_03567	7 transmembrane receptor; Belongs to the G-protein coupled receptor 1 family. (416 aa)
	NECAME_11490	G-protein alpha subunit. (334 aa)
	NECAME_16485	Uncharacterized protein. (289 aa)
	NECAME_06151	7 transmembrane receptor; Belongs to the G-protein coupled receptor 1 family. (727 aa)
	NECAME_16402	Regulator of G protein signaling domain protein. (570 aa)
	NECAME_00032	7 transmembrane receptor; Belongs to the G-protein coupled receptor 1 family. (429 aa)
	NECAME_16380	Uncharacterized protein. (211 aa)
	NECAME_00040	G_PROTEIN_RECEP_F1_2 domain-containing protein. (461 aa)
	NECAME_11999	Zinc finger, C4 type. (391 aa)
	NECAME_12023	RWD domain protein. (257 aa)
	NECAME_00607	G_PROTEIN_RECEP_F1_2 domain-containing protein. (695 aa)
	NECAME_12937	Uncharacterized protein. (140 aa)
	NECAME_13056	Uncharacterized protein. (443 aa)
	NECAME_00624	7 transmembrane receptor; Belongs to the G-protein coupled receptor 1 family. (474 aa)
	NECAME_12936	Uncharacterized protein. (200 aa)
	NECAME_00755	WD domain, G-beta repeat protein. (408 aa)
	NECAME_12954	S8_pro-domain domain-containing protein. (116 aa)
	NECAME_00785	HSF-type DNA-binding domain protein. (256 aa)
	NECAME_13057	G_PROTEIN_RECEP_F1_2 domain-containing protein. (144 aa)
	NECAME_12953	Peptidase, S8/S53 family. (265 aa)
	NECAME_13344	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. (1298 aa)
	NECAME_13832	DEAD/DEAH box helicase. (1028 aa)
	NECAME_19007	G_PROTEIN_RECEP_F1_2 domain-containing protein. (151 aa)
	NECAME_19382	Uncharacterized protein. (289 aa)
	NECAME_14758	Muscarinic acetylcholine receptor gar-3 family protein; Belongs to the G-protein coupled receptor 1 family. (516 aa)
	NECAME_15432	Ras family protein. (229 aa)
	NECAME_05434	Uncharacterized protein. (198 aa)
	NECAME_06416	Uncharacterized protein. (182 aa)
	NECAME_06420	Uncharacterized protein. (97 aa)
	NECAME_06418	Uncharacterized protein. (155 aa)
	NECAME_06419	Uncharacterized protein. (164 aa)
	NECAME_17382	OMPdecase domain-containing protein. (126 aa)
	NECAME_17381	Putative orotate phosphoribosyltransferase. (268 aa)
	NECAME_07538	Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family. (230 aa)
	NECAME_02049	Uncharacterized protein. (186 aa)
	NECAME_02048	G_PROTEIN_RECEP_F1_2 domain-containing protein. (254 aa)
	NECAME_08210	Putative tryptophan 5-hydroxylase 1. (417 aa)
	NECAME_01904	Adenylate/guanylate cyclase catalytic domain protein. (285 aa)
	NECAME_07862	Uncharacterized protein. (182 aa)
	NECAME_00201	AB hydrolase-1 domain-containing protein. (421 aa)
	NECAME_01905	Uncharacterized protein. (297 aa)
	NECAME_00213	G-protein alpha subunit. (320 aa)
	NECAME_02078	Von Willebrand factor type A domain protein. (1479 aa)
	NECAME_08398	Diacylglycerol kinase. (878 aa)

Your Current Organism:

Necator americanus

NCBI taxonomy Id: 51031
Other names: N. americanus

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a tab-delimited file containing all known functional terms of proteins in your network

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
NECAME_00032	NECAME_00755	W2TZ93	W2SYG0	7 transmembrane receptor; Belongs to the G-protein coupled receptor 1 family.	WD domain, G-beta repeat protein.	0.540
NECAME_00032	NECAME_11489	W2TZ93	W2T567	7 transmembrane receptor; Belongs to the G-protein coupled receptor 1 family.	Uncharacterized protein.	0.501
NECAME_00032	NECAME_11490	W2TZ93	W2T407	7 transmembrane receptor; Belongs to the G-protein coupled receptor 1 family.	G-protein alpha subunit.	0.501
NECAME_00040	NECAME_00213	W2U1D4	W2TJ99	G_PROTEIN_RECEP_F1_2 domain-containing protein.	G-protein alpha subunit.	0.515
NECAME_00040	NECAME_00607	W2U1D4	W2T1T3	G_PROTEIN_RECEP_F1_2 domain-containing protein.	G_PROTEIN_RECEP_F1_2 domain-containing protein.	0.919
NECAME_00040	NECAME_00755	W2U1D4	W2SYG0	G_PROTEIN_RECEP_F1_2 domain-containing protein.	WD domain, G-beta repeat protein.	0.615
NECAME_00040	NECAME_02048	W2U1D4	W2TMF2	G_PROTEIN_RECEP_F1_2 domain-containing protein.	G_PROTEIN_RECEP_F1_2 domain-containing protein.	0.911
NECAME_00040	NECAME_11489	W2U1D4	W2T567	G_PROTEIN_RECEP_F1_2 domain-containing protein.	Uncharacterized protein.	0.582
NECAME_00040	NECAME_11490	W2U1D4	W2T407	G_PROTEIN_RECEP_F1_2 domain-containing protein.	G-protein alpha subunit.	0.582
NECAME_00040	NECAME_13344	W2U1D4	W2SW98	G_PROTEIN_RECEP_F1_2 domain-containing protein.	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes.	0.406
NECAME_00213	NECAME_00040	W2TJ99	W2U1D4	G-protein alpha subunit.	G_PROTEIN_RECEP_F1_2 domain-containing protein.	0.515
NECAME_00213	NECAME_00624	W2TJ99	W2SZY3	G-protein alpha subunit.	7 transmembrane receptor; Belongs to the G-protein coupled receptor 1 family.	0.968
NECAME_00213	NECAME_00755	W2TJ99	W2SYG0	G-protein alpha subunit.	WD domain, G-beta repeat protein.	0.972
NECAME_00213	NECAME_08398	W2TJ99	W2THQ3	G-protein alpha subunit.	Diacylglycerol kinase.	0.570
NECAME_00213	NECAME_09922	W2TJ99	W2TC78	G-protein alpha subunit.	7 transmembrane receptor; Belongs to the G-protein coupled receptor 1 family.	0.515
NECAME_00213	NECAME_09929	W2TJ99	W2TDE4	G-protein alpha subunit.	Regulator of G protein signaling domain protein.	0.760
NECAME_00213	NECAME_13344	W2TJ99	W2SW98	G-protein alpha subunit.	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes.	0.992
NECAME_00213	NECAME_14758	W2TJ99	W2SP07	G-protein alpha subunit.	Muscarinic acetylcholine receptor gar-3 family protein; Belongs to the G-protein coupled receptor 1 family.	0.978
NECAME_00213	NECAME_16402	W2TJ99	W2TZ43	G-protein alpha subunit.	Regulator of G protein signaling domain protein.	0.686
NECAME_00607	NECAME_00040	W2T1T3	W2U1D4	G_PROTEIN_RECEP_F1_2 domain-containing protein.	G_PROTEIN_RECEP_F1_2 domain-containing protein.	0.919