(59 nodes) Macroautophagy network (Necator americanus)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	NECAME_06187	Prohibitin. (297 aa)
	NECAME_16201	RING-type domain-containing protein. (890 aa)
	NECAME_05912	Kinase domain protein; Belongs to the protein kinase superfamily. (408 aa)
	NECAME_05913	Uncharacterized protein. (123 aa)
	NECAME_15928	HEAT repeat protein. (283 aa)
	NECAME_16108	SEP domain protein. (332 aa)
	NECAME_15927	WD domain, G-beta repeat protein. (502 aa)
	NECAME_15620	Uncharacterized protein. (99 aa)
	NECAME_15926	Uncharacterized protein. (78 aa)
	NECAME_05342	PUB domain protein. (567 aa)
	NECAME_05187	GTP-binding domain protein. (567 aa)
	NECAME_15093	Phosphatidylinositol 3-kinase catalytic subunit type 3. (757 aa)
	NECAME_05015	ATG11 domain-containing protein. (109 aa)
	NECAME_05014	Uncharacterized protein. (930 aa)
	NECAME_04715	Uncharacterized protein. (155 aa)
	NECAME_04962	DUF4206 domain-containing protein. (76 aa)
	NECAME_04718	Uncharacterized protein. (108 aa)
	NECAME_14167	Uncharacterized protein. (118 aa)
	NECAME_14166	Uncharacterized protein. (255 aa)
	NECAME_04716	Uncharacterized protein. (652 aa)
	NECAME_04717	Uncharacterized protein. (124 aa)
	NECAME_18884	Uncharacterized protein. (71 aa)
	NECAME_13711	Gamma-aminobutyric acid receptor-associated protein. (118 aa)
	NECAME_13868	Uncharacterized protein. (214 aa)
	NECAME_18739	Uncharacterized protein. (136 aa)
	NECAME_18346	Uncharacterized protein. (129 aa)
	NECAME_13285	Uncharacterized protein. (163 aa)
	NECAME_04155	Transitional endoplasmic reticulum ATPase; Belongs to the AAA ATPase family. (809 aa)
	NECAME_12622	Ubiquitin-like protein ATG12; Ubiquitin-like protein involved in autophagic vesicle formation; Belongs to the ATG12 family. (96 aa)
	NECAME_12737	Autophagy-related protein 3. (310 aa)
	NECAME_03648	Autophagy protein Apg6. (322 aa)
	NECAME_12697	Sorting nexin. (220 aa)
	NECAME_11919	Vesicle transport v-SNARE protein. (197 aa)
	NECAME_03712	WD domain, G-beta repeat protein. (461 aa)
	NECAME_03318	Kinase domain protein. (780 aa)
	NECAME_11072	Uncharacterized protein. (258 aa)
	NECAME_03375	Uncharacterized protein. (286 aa)
	NECAME_11138	WD domain, G-beta repeat protein. (295 aa)
	NECAME_11073	Uncharacterized protein. (122 aa)
	NECAME_11016	Uncharacterized protein. (75 aa)
	NECAME_10568	Ubiquitin-like modifier-activating enzyme ATG7; E1-like activating enzyme involved in the 2 ubiquitin-like systems required for autophagy. (786 aa)
	NECAME_10905	Autophagy-related protein 9; Involved in autophagy and cytoplasm to vacuole transport (Cvt) vesicle formation. Plays a key role in the organization of the preautophagosomal structure/phagophore assembly site (PAS), the nucleating site for formation of the sequestering vesicle. Belongs to the ATG9 family. (553 aa)
	NECAME_02899	60S ribosomal protein L36; Belongs to the eukaryotic ribosomal protein eL36 family. (416 aa)
	NECAME_00223	Autophagy protein 5; Involved in autophagic vesicle formation. (513 aa)
	NECAME_08056	Kinase domain protein; Belongs to the protein kinase superfamily. (308 aa)
	NECAME_15945	Cysteine protease; Cysteine protease required for the cytoplasm to vacuole transport (Cvt) and autophagy; Belongs to the peptidase C54 family. (277 aa)
	NECAME_07554	Uncharacterized protein. (383 aa)
	NECAME_17624	Uncharacterized protein. (195 aa)
	NECAME_01758	N_BRCA1_IG domain-containing protein. (274 aa)
	NECAME_06868	ATG protein. (123 aa)
	NECAME_19615	Uncharacterized protein. (155 aa)
	NECAME_07005	Ras family protein. (239 aa)
	NECAME_06871	Chorein_N domain-containing protein. (723 aa)
	NECAME_06814	Uncharacterized protein. (194 aa)
	NECAME_06815	Uncharacterized protein. (178 aa)
	NECAME_16975	Putative gamma-aminobutyric acid receptor-associated protein. (141 aa)
	NECAME_06869	Uncharacterized protein. (714 aa)
	NECAME_06870	Uncharacterized protein. (486 aa)
	NECAME_06813	Uncharacterized protein. (150 aa)

Your Current Organism:

Necator americanus

NCBI taxonomy Id: 51031
Other names: N. americanus

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structured XML interaction data, according to the 'PSI-MI' data standard

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a flat-file format describing the coordinates and colors of nodes in the network

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a tab-delimited file describing the names, domains and descriptions of proteins in your network

... functional annotations:

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a tab-delimited file containing all known functional terms of proteins in your network

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
NECAME_00223	NECAME_01758	W2TJA7	W2TQQ3	Autophagy protein 5; Involved in autophagic vesicle formation.	N_BRCA1_IG domain-containing protein.	0.640
NECAME_00223	NECAME_03375	W2TJA7	W2T6B2	Autophagy protein 5; Involved in autophagic vesicle formation.	Uncharacterized protein.	0.859
NECAME_00223	NECAME_03648	W2TJA7	W2T1K4	Autophagy protein 5; Involved in autophagic vesicle formation.	Autophagy protein Apg6.	0.884
NECAME_00223	NECAME_03712	W2TJA7	W2T3G4	Autophagy protein 5; Involved in autophagic vesicle formation.	WD domain, G-beta repeat protein.	0.999
NECAME_00223	NECAME_04716	W2TJA7	W2SQ58	Autophagy protein 5; Involved in autophagic vesicle formation.	Uncharacterized protein.	0.471
NECAME_00223	NECAME_04718	W2TJA7	W2SNB0	Autophagy protein 5; Involved in autophagic vesicle formation.	Uncharacterized protein.	0.471
NECAME_00223	NECAME_05014	W2TJA7	W2SKW0	Autophagy protein 5; Involved in autophagic vesicle formation.	Uncharacterized protein.	0.634
NECAME_00223	NECAME_05015	W2TJA7	W2SKJ4	Autophagy protein 5; Involved in autophagic vesicle formation.	ATG11 domain-containing protein.	0.634
NECAME_00223	NECAME_05912	W2TJA7	W2TXL0	Autophagy protein 5; Involved in autophagic vesicle formation.	Kinase domain protein; Belongs to the protein kinase superfamily.	0.944
NECAME_00223	NECAME_05913	W2TJA7	W2TY50	Autophagy protein 5; Involved in autophagic vesicle formation.	Uncharacterized protein.	0.944
NECAME_00223	NECAME_06187	W2TJA7	W2TVP3	Autophagy protein 5; Involved in autophagic vesicle formation.	Prohibitin.	0.574
NECAME_00223	NECAME_07005	W2TJA7	W2TR82	Autophagy protein 5; Involved in autophagic vesicle formation.	Ras family protein.	0.470
NECAME_00223	NECAME_08056	W2TJA7	W2TKT9	Autophagy protein 5; Involved in autophagic vesicle formation.	Kinase domain protein; Belongs to the protein kinase superfamily.	0.858
NECAME_00223	NECAME_10568	W2TJA7	W2T929	Autophagy protein 5; Involved in autophagic vesicle formation.	Ubiquitin-like modifier-activating enzyme ATG7; E1-like activating enzyme involved in the 2 ubiquitin-like systems required for autophagy.	0.909
NECAME_00223	NECAME_10905	W2TJA7	W2T9G0	Autophagy protein 5; Involved in autophagic vesicle formation.	Autophagy-related protein 9; Involved in autophagy and cytoplasm to vacuole transport (Cvt) vesicle formation. Plays a key role in the organization of the preautophagosomal structure/phagophore assembly site (PAS), the nucleating site for formation of the sequestering vesicle. Belongs to the ATG9 family.	0.703
NECAME_00223	NECAME_11072	W2TJA7	W2T695	Autophagy protein 5; Involved in autophagic vesicle formation.	Uncharacterized protein.	0.575
NECAME_00223	NECAME_11073	W2TJA7	W2T6Z2	Autophagy protein 5; Involved in autophagic vesicle formation.	Uncharacterized protein.	0.575
NECAME_00223	NECAME_11138	W2TJA7	W2T6V2	Autophagy protein 5; Involved in autophagic vesicle formation.	WD domain, G-beta repeat protein.	0.965
NECAME_00223	NECAME_12622	W2TJA7	W2SZ01	Autophagy protein 5; Involved in autophagic vesicle formation.	Ubiquitin-like protein ATG12; Ubiquitin-like protein involved in autophagic vesicle formation; Belongs to the ATG12 family.	0.999
NECAME_00223	NECAME_12737	W2TJA7	W2T0K1	Autophagy protein 5; Involved in autophagic vesicle formation.	Autophagy-related protein 3.	0.998