(8 nodes) 5-flap endonuclease activity network (Necator americanus)

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Your Input:
	NECAME_14972	Fanconi-associated nuclease; Nuclease required for the repair of DNA interstrand cross- links (ICL). Acts as a 5'-3' exonuclease that anchors at a cut end of DNA and cleaves DNA successively at every third nucleotide, allowing to excise an ICL from one strand through flanking incisions. Belongs to the FAN1 family. (660 aa)
	NECAME_07959	XPG I-region. (684 aa)
	NECAME_17803	XPG I-region. (389 aa)
	NECAME_19202	Uncharacterized protein. (72 aa)
	NECAME_00524	AAA_12 domain-containing protein. (228 aa)
	FEN1	Flap endonuclease 1; Structure-specific nuclease with 5'-flap endonuclease and 5'- 3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. It enters the flap from the 5'-end and then tracks to cleave the flap base, leaving a nick for ligation. Also involved in the long patch base excision repair (LP-BER) pathway, by cleaving within the apurinic/apyrimidinic (AP) site- terminated flap. Acts as [...] (312 aa)
	NECAME_01589	XPG protein. (66 aa)
	NECAME_19337	Uncharacterized protein. (85 aa)

Your Current Organism:

Necator americanus

NCBI taxonomy Id: 51031
Other names: N. americanus

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
FEN1	NECAME_00524	W2TRS6	W2T513	Flap endonuclease 1; Structure-specific nuclease with 5'-flap endonuclease and 5'- 3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. It enters the flap from the 5'-end and then tracks to cleave the flap base, leaving a nick for ligation. Also involved in the long patch base excision repair (LP-BER) pathway, by cleaving within the apurinic/apyrimidinic (AP) site- terminated flap. Acts as [...]	AAA_12 domain-containing protein.	0.905
FEN1	NECAME_17803	W2TRS6	W2TIX7	Flap endonuclease 1; Structure-specific nuclease with 5'-flap endonuclease and 5'- 3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. It enters the flap from the 5'-end and then tracks to cleave the flap base, leaving a nick for ligation. Also involved in the long patch base excision repair (LP-BER) pathway, by cleaving within the apurinic/apyrimidinic (AP) site- terminated flap. Acts as [...]	XPG I-region.	0.648
FEN1	NECAME_19202	W2TRS6	W2SSB8	Flap endonuclease 1; Structure-specific nuclease with 5'-flap endonuclease and 5'- 3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. It enters the flap from the 5'-end and then tracks to cleave the flap base, leaving a nick for ligation. Also involved in the long patch base excision repair (LP-BER) pathway, by cleaving within the apurinic/apyrimidinic (AP) site- terminated flap. Acts as [...]	Uncharacterized protein.	0.648
FEN1	NECAME_19337	W2TRS6	W2SRW4	Flap endonuclease 1; Structure-specific nuclease with 5'-flap endonuclease and 5'- 3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. It enters the flap from the 5'-end and then tracks to cleave the flap base, leaving a nick for ligation. Also involved in the long patch base excision repair (LP-BER) pathway, by cleaving within the apurinic/apyrimidinic (AP) site- terminated flap. Acts as [...]	Uncharacterized protein.	0.648
NECAME_00524	FEN1	W2T513	W2TRS6	AAA_12 domain-containing protein.	Flap endonuclease 1; Structure-specific nuclease with 5'-flap endonuclease and 5'- 3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. It enters the flap from the 5'-end and then tracks to cleave the flap base, leaving a nick for ligation. Also involved in the long patch base excision repair (LP-BER) pathway, by cleaving within the apurinic/apyrimidinic (AP) site- terminated flap. Acts as [...]	0.905
NECAME_00524	NECAME_01589	W2T513	W2TRF6	AAA_12 domain-containing protein.	XPG protein.	0.905
NECAME_00524	NECAME_07959	W2T513	W2TMR7	AAA_12 domain-containing protein.	XPG I-region.	0.720
NECAME_00524	NECAME_17803	W2T513	W2TIX7	AAA_12 domain-containing protein.	XPG I-region.	0.878
NECAME_00524	NECAME_19202	W2T513	W2SSB8	AAA_12 domain-containing protein.	Uncharacterized protein.	0.878
NECAME_00524	NECAME_19337	W2T513	W2SRW4	AAA_12 domain-containing protein.	Uncharacterized protein.	0.878
NECAME_01589	NECAME_00524	W2TRF6	W2T513	XPG protein.	AAA_12 domain-containing protein.	0.905
NECAME_01589	NECAME_17803	W2TRF6	W2TIX7	XPG protein.	XPG I-region.	0.648
NECAME_01589	NECAME_19202	W2TRF6	W2SSB8	XPG protein.	Uncharacterized protein.	0.648
NECAME_01589	NECAME_19337	W2TRF6	W2SRW4	XPG protein.	Uncharacterized protein.	0.648
NECAME_07959	NECAME_00524	W2TMR7	W2T513	XPG I-region.	AAA_12 domain-containing protein.	0.720
NECAME_17803	FEN1	W2TIX7	W2TRS6	XPG I-region.	Flap endonuclease 1; Structure-specific nuclease with 5'-flap endonuclease and 5'- 3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. It enters the flap from the 5'-end and then tracks to cleave the flap base, leaving a nick for ligation. Also involved in the long patch base excision repair (LP-BER) pathway, by cleaving within the apurinic/apyrimidinic (AP) site- terminated flap. Acts as [...]	0.648
NECAME_17803	NECAME_00524	W2TIX7	W2T513	XPG I-region.	AAA_12 domain-containing protein.	0.878
NECAME_17803	NECAME_01589	W2TIX7	W2TRF6	XPG I-region.	XPG protein.	0.648
NECAME_19202	FEN1	W2SSB8	W2TRS6	Uncharacterized protein.	Flap endonuclease 1; Structure-specific nuclease with 5'-flap endonuclease and 5'- 3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. It enters the flap from the 5'-end and then tracks to cleave the flap base, leaving a nick for ligation. Also involved in the long patch base excision repair (LP-BER) pathway, by cleaving within the apurinic/apyrimidinic (AP) site- terminated flap. Acts as [...]	0.648
NECAME_19202	NECAME_00524	W2SSB8	W2T513	Uncharacterized protein.	AAA_12 domain-containing protein.	0.878