(78 nodes) Negative regulation of translation network (Necator americanus)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	NECAME_10695	Uncharacterized protein. (85 aa)
	NECAME_02571	Uncharacterized protein. (400 aa)
	NECAME_09832	Dcp1-like decapping family protein. (358 aa)
	NECAME_09704	Uncharacterized protein. (190 aa)
	NECAME_02684	Protein kinase domain-containing protein. (453 aa)
	NECAME_10280	RNA polymerase Rpb4. (142 aa)
	NECAME_10640	NOT2 / NOT3 / NOT5 family protein. (289 aa)
	NECAME_18242	RNase_PH domain-containing protein. (209 aa)
	NECAME_10694	Endo/exonuclease/phosphatase domain-containing protein. (360 aa)
	NECAME_02784	RRM domain-containing protein. (494 aa)
	NECAME_18203	CAF1 family ribonuclease. (312 aa)
	NECAME_10438	KH domain protein. (407 aa)
	NECAME_10696	Uncharacterized protein. (121 aa)
	NECAME_12182	Uncharacterized protein. (259 aa)
	NECAME_11572	PAP/25A associated domain protein. (969 aa)
	NECAME_03483	B-box zinc finger. (843 aa)
	NECAME_12742	CAF1 family ribonuclease. (311 aa)
	NECAME_12658	Uncharacterized protein. (169 aa)
	NECAME_12600	HEAT repeat protein. (114 aa)
	NECAME_12183	Protein kinase domain-containing protein. (142 aa)
	NECAME_12659	S1 motif domain-containing protein. (307 aa)
	NECAME_12022	DIS3-like exonuclease 2; 3'-5'-exoribonuclease that specifically recognizes RNAs polyuridylated at their 3' end and mediates their degradation. Component of an exosome-independent RNA degradation pathway that mediates degradation of cytoplasmic mRNAs that have been deadenylated and subsequently uridylated at their 3'. (1038 aa)
	NECAME_12184	Uncharacterized protein. (208 aa)
	NECAME_09897	Uncharacterized protein. (361 aa)
	NECAME_09724	Cell differentiation family, Rcd1. (307 aa)
	NECAME_02391	Caprin-1_dimer domain-containing protein. (446 aa)
	NECAME_02570	Uncharacterized protein. (369 aa)
	NECAME_09277	KH domain protein. (547 aa)
	NECAME_08960	Uncharacterized protein. (1370 aa)
	LSM1	U6 snRNA-associated Sm-like protein LSm1; Probably involved with other LSm subunits in the general process of degradation of mRNAs. (127 aa)
	NECAME_08575	Uncharacterized protein. (357 aa)
	NECAME_08482	Protein kinase domain-containing protein; Belongs to the protein kinase superfamily. (482 aa)
	NECAME_08483	PQQ enzyme repeat protein. (421 aa)
	NECAME_08440	Not1 domain, CCR4-Not complex component. (728 aa)
	NECAME_12656	Uncharacterized protein. (110 aa)
	NECAME_00621	Uncharacterized protein. (705 aa)
	NECAME_04040	Zinc finger, C3HC4 type. (1006 aa)
	NECAME_12597	Uncharacterized protein. (128 aa)
	NECAME_12518	USP domain-containing protein. (702 aa)
	NECAME_12599	Uncharacterized protein. (92 aa)
	NECAME_12935	3' exoribonuclease family, domain 1. (431 aa)
	NECAME_04095	Uncharacterized protein. (180 aa)
	NECAME_04349	3' exoribonuclease family, domain 1. (304 aa)
	NECAME_04094	Uncharacterized protein. (290 aa)
	NECAME_00779	Nanos-type domain-containing protein; Belongs to the nanos family. (171 aa)
	NECAME_13939	Ribosomal protein L13; Belongs to the universal ribosomal protein uL13 family. (203 aa)
	NECAME_13634	Leucine Rich repeat-containing domain protein. (728 aa)
	NECAME_04685	Uncharacterized protein. (178 aa)
	NECAME_19041	Uncharacterized protein. (131 aa)
	NECAME_19410	NOT2_3_5 domain-containing protein. (99 aa)
	NECAME_04686	Uncharacterized protein. (491 aa)
	NECAME_04687	Uncharacterized protein. (122 aa)
	NECAME_14523	Uncharacterized protein. (126 aa)
	NECAME_15085	CNOT1_HEAT domain-containing protein. (492 aa)
	NECAME_14808	RNB-like protein; Belongs to the RNR ribonuclease family. (1185 aa)
	NECAME_15462	Scavenger mRNA decapping enzyme. (323 aa)
	NECAME_15040	ROQ_II domain-containing protein. (234 aa)
	NECAME_15039	Uncharacterized protein. (233 aa)
	NECAME_15084	CNOT1_TTP_bind domain-containing protein. (243 aa)
	NECAME_15083	CCR4-Not complex component, Not1. (1308 aa)
	NECAME_05630	Uncharacterized protein. (438 aa)
	NECAME_05544	Hydrolase, NUDIX family. (321 aa)
	NECAME_05543	Uncharacterized protein. (108 aa)
	NECAME_04041	Signal recognition particle 9 kDa protein; Signal-recognition-particle assembly has a crucial role in targeting secretory proteins to the rough endoplasmic reticulum membrane. SRP9 together with SRP14 and the Alu portion of the SRP RNA, constitutes the elongation arrest domain of SRP. The complex of SRP9 and SRP14 is required for SRP RNA binding. (77 aa)
	NECAME_12598	Uncharacterized protein. (666 aa)
	NECAME_12517	Exonuclease. (284 aa)
	NECAME_08050	Uncharacterized protein. (490 aa)
	NECAME_07177	S1 domain-containing protein. (294 aa)
	NECAME_01619	Uncharacterized protein. (209 aa)
	NECAME_16824	DEAD/DEAH box helicase; Belongs to the DEAD box helicase family. (437 aa)
	NECAME_01620	NHL repeat protein. (580 aa)
	NECAME_06419	Uncharacterized protein. (164 aa)
	NECAME_06418	Uncharacterized protein. (155 aa)
	NECAME_16578	Uncharacterized protein. (70 aa)
	NECAME_06420	Uncharacterized protein. (97 aa)
	NECAME_06416	Uncharacterized protein. (182 aa)
	NECAME_16375	Serine hydroxymethyltransferase; Interconversion of serine and glycine. Belongs to the SHMT family. (433 aa)
	NECAME_16261	Uncharacterized protein. (233 aa)

Your Current Organism:

Necator americanus

NCBI taxonomy Id: 51031
Other names: N. americanus

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
LSM1	NECAME_04094	W2THD7	W2SWT4	U6 snRNA-associated Sm-like protein LSm1; Probably involved with other LSm subunits in the general process of degradation of mRNAs.	Uncharacterized protein.	0.997
LSM1	NECAME_04095	W2THD7	W2SX61	U6 snRNA-associated Sm-like protein LSm1; Probably involved with other LSm subunits in the general process of degradation of mRNAs.	Uncharacterized protein.	0.973
LSM1	NECAME_05543	W2THD7	W2SG28	U6 snRNA-associated Sm-like protein LSm1; Probably involved with other LSm subunits in the general process of degradation of mRNAs.	Uncharacterized protein.	0.903
LSM1	NECAME_05544	W2THD7	W2SG53	U6 snRNA-associated Sm-like protein LSm1; Probably involved with other LSm subunits in the general process of degradation of mRNAs.	Hydrolase, NUDIX family.	0.945
LSM1	NECAME_09704	W2THD7	W2TCT6	U6 snRNA-associated Sm-like protein LSm1; Probably involved with other LSm subunits in the general process of degradation of mRNAs.	Uncharacterized protein.	0.424
LSM1	NECAME_09832	W2THD7	W2TCV8	U6 snRNA-associated Sm-like protein LSm1; Probably involved with other LSm subunits in the general process of degradation of mRNAs.	Dcp1-like decapping family protein.	0.886
LSM1	NECAME_12742	W2THD7	W2T0K6	U6 snRNA-associated Sm-like protein LSm1; Probably involved with other LSm subunits in the general process of degradation of mRNAs.	CAF1 family ribonuclease.	0.480
LSM1	NECAME_13634	W2THD7	W2STY8	U6 snRNA-associated Sm-like protein LSm1; Probably involved with other LSm subunits in the general process of degradation of mRNAs.	Leucine Rich repeat-containing domain protein.	0.400
LSM1	NECAME_16578	W2THD7	W2TVT0	U6 snRNA-associated Sm-like protein LSm1; Probably involved with other LSm subunits in the general process of degradation of mRNAs.	Uncharacterized protein.	0.976
LSM1	NECAME_16824	W2THD7	W2TT92	U6 snRNA-associated Sm-like protein LSm1; Probably involved with other LSm subunits in the general process of degradation of mRNAs.	DEAD/DEAH box helicase; Belongs to the DEAD box helicase family.	0.995
NECAME_00621	NECAME_08440	W2SZM9	W2TIW2	Uncharacterized protein.	Not1 domain, CCR4-Not complex component.	0.435
NECAME_00621	NECAME_10280	W2SZM9	W2TBH3	Uncharacterized protein.	RNA polymerase Rpb4.	0.746
NECAME_00621	NECAME_10640	W2SZM9	W2TAH6	Uncharacterized protein.	NOT2 / NOT3 / NOT5 family protein.	0.430
NECAME_00621	NECAME_12742	W2SZM9	W2T0K6	Uncharacterized protein.	CAF1 family ribonuclease.	0.461
NECAME_00621	NECAME_16578	W2SZM9	W2TVT0	Uncharacterized protein.	Uncharacterized protein.	0.422
NECAME_00621	NECAME_16824	W2SZM9	W2TT92	Uncharacterized protein.	DEAD/DEAH box helicase; Belongs to the DEAD box helicase family.	0.556
NECAME_00621	NECAME_19410	W2SZM9	W2SQ84	Uncharacterized protein.	NOT2_3_5 domain-containing protein.	0.430
NECAME_00779	NECAME_08050	W2SVK9	W2TKP1	Nanos-type domain-containing protein; Belongs to the nanos family.	Uncharacterized protein.	0.412
NECAME_00779	NECAME_08440	W2SVK9	W2TIW2	Nanos-type domain-containing protein; Belongs to the nanos family.	Not1 domain, CCR4-Not complex component.	0.462
NECAME_00779	NECAME_15083	W2SVK9	W2SJH4	Nanos-type domain-containing protein; Belongs to the nanos family.	CCR4-Not complex component, Not1.	0.490