(57 nodes) Ubiquitin-dependent ERAD pathway network (Necator americanus)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	NECAME_15154	Ubiquitin family protein. (247 aa)
	NECAME_15601	Uncharacterized protein. (130 aa)
	NECAME_15277	alpha-1,2-Mannosidase; Belongs to the glycosyl hydrolase 47 family. (494 aa)
	NECAME_05275	Zinc finger, C3HC4 type. (552 aa)
	NECAME_05615	Putative chaperone protein DnaK; Belongs to the heat shock protein 70 family. (624 aa)
	NECAME_13260	UBX domain protein. (451 aa)
	NECAME_04155	Transitional endoplasmic reticulum ATPase; Belongs to the AAA ATPase family. (809 aa)
	NECAME_04051	Low-density lipoprotein receptor domain class A. (186 aa)
	NECAME_12565	Uncharacterized protein. (258 aa)
	NECAME_11558	Ubiquitin family protein. (120 aa)
	NECAME_11974	Uncharacterized protein. (727 aa)
	NECAME_11242	Hsp90 protein. (772 aa)
	NECAME_11557	Uncharacterized protein. (448 aa)
	NECAME_03033	Zinc finger, C3HC4 type. (449 aa)
	NECAME_02794	Glucosidase II beta subunit-like protein. (207 aa)
	NECAME_02793	PRKCSH domain-containing protein. (161 aa)
	NECAME_09953	F-box associated region. (155 aa)
	NECAME_09831	DnaJ domain protein. (930 aa)
	NECAME_09703	Calreticulin family protein. (592 aa)
	NECAME_05833	alpha-1,2-Mannosidase; Belongs to the glycosyl hydrolase 47 family. (140 aa)
	NECAME_05834	Uncharacterized protein. (139 aa)
	NECAME_05835	alpha-1,2-Mannosidase; Belongs to the glycosyl hydrolase 47 family. (237 aa)
	NECAME_16007	26S proteasome subunit P45 family protein; Belongs to the AAA ATPase family. (429 aa)
	NECAME_08897	Uncharacterized protein. (139 aa)
	NECAME_09169	Uncharacterized protein. (548 aa)
	NECAME_09377	U-box domain protein. (1018 aa)
	NECAME_08895	DB module. (143 aa)
	NECAME_08896	Uncharacterized protein. (285 aa)
	NECAME_08593	Uncharacterized protein. (115 aa)
	NECAME_09171	Uncharacterized protein. (201 aa)
	NECAME_08499	Heat shock cognate protein 1; Belongs to the heat shock protein 70 family. (657 aa)
	NECAME_09172	Uncharacterized protein. (178 aa)
	NECAME_08591	Uncharacterized protein. (252 aa)
	NECAME_08898	Uncharacterized protein. (88 aa)
	NECAME_02265	UBX domain-containing protein. (451 aa)
	NECAME_08592	Uncharacterized protein. (82 aa)
	NECAME_00205	Derlin; May be involved in the degradation of misfolded endoplasmic reticulum (ER) luminal proteins; Belongs to the derlin family. (287 aa)
	NECAME_08899	Uncharacterized protein. (79 aa)
	NECAME_08318	Tetratricopeptide repeat protein. (342 aa)
	NECAME_08594	Uncharacterized protein. (109 aa)
	NECAME_13335	Uncharacterized protein. (113 aa)
	NECAME_01932	RDD domain-containing protein. (277 aa)
	NECAME_17090	Uncharacterized protein. (197 aa)
	NECAME_17091	Uncharacterized protein. (102 aa)
	NECAME_06481	Sel1 repeat protein. (592 aa)
	NECAME_15419	alpha-1,2-Mannosidase; Belongs to the glycosyl hydrolase 47 family. (487 aa)
	NECAME_15602	Uncharacterized protein. (89 aa)
	NECAME_15185	alpha-1,2-Mannosidase; Belongs to the glycosyl hydrolase 47 family. (163 aa)
	NECAME_15186	Uncharacterized protein. (169 aa)
	NECAME_15152	Uncharacterized protein. (159 aa)
	NECAME_15133	Zinc finger, C2H2 type. (904 aa)
	NECAME_14953	UBX domain protein. (527 aa)
	NECAME_14009	VATC domain-containing protein. (144 aa)
	NECAME_14008	Uncharacterized protein. (373 aa)
	NECAME_19025	Uncharacterized protein. (120 aa)
	NECAME_18551	Uncharacterized protein. (335 aa)
	NECAME_13334	UBIQUITIN_CONJUGAT_2 domain-containing protein. (64 aa)

Your Current Organism:

Necator americanus

NCBI taxonomy Id: 51031
Other names: N. americanus

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
NECAME_00205	NECAME_02265	W2TID2	W2TI73	Derlin; May be involved in the degradation of misfolded endoplasmic reticulum (ER) luminal proteins; Belongs to the derlin family.	UBX domain-containing protein.	0.854
NECAME_00205	NECAME_02793	W2TID2	W2TBF7	Derlin; May be involved in the degradation of misfolded endoplasmic reticulum (ER) luminal proteins; Belongs to the derlin family.	PRKCSH domain-containing protein.	0.896
NECAME_00205	NECAME_02794	W2TID2	W2TA75	Derlin; May be involved in the degradation of misfolded endoplasmic reticulum (ER) luminal proteins; Belongs to the derlin family.	Glucosidase II beta subunit-like protein.	0.896
NECAME_00205	NECAME_03033	W2TID2	W2T9J4	Derlin; May be involved in the degradation of misfolded endoplasmic reticulum (ER) luminal proteins; Belongs to the derlin family.	Zinc finger, C3HC4 type.	0.939
NECAME_00205	NECAME_04155	W2TID2	W2SYU7	Derlin; May be involved in the degradation of misfolded endoplasmic reticulum (ER) luminal proteins; Belongs to the derlin family.	Transitional endoplasmic reticulum ATPase; Belongs to the AAA ATPase family.	0.902
NECAME_00205	NECAME_05275	W2TID2	W2SIL2	Derlin; May be involved in the degradation of misfolded endoplasmic reticulum (ER) luminal proteins; Belongs to the derlin family.	Zinc finger, C3HC4 type.	0.535
NECAME_00205	NECAME_05615	W2TID2	W2SI51	Derlin; May be involved in the degradation of misfolded endoplasmic reticulum (ER) luminal proteins; Belongs to the derlin family.	Putative chaperone protein DnaK; Belongs to the heat shock protein 70 family.	0.940
NECAME_00205	NECAME_06481	W2TID2	W2TT69	Derlin; May be involved in the degradation of misfolded endoplasmic reticulum (ER) luminal proteins; Belongs to the derlin family.	Sel1 repeat protein.	0.971
NECAME_00205	NECAME_08499	W2TID2	W2TH94	Derlin; May be involved in the degradation of misfolded endoplasmic reticulum (ER) luminal proteins; Belongs to the derlin family.	Heat shock cognate protein 1; Belongs to the heat shock protein 70 family.	0.940
NECAME_00205	NECAME_09377	W2TID2	W2TG20	Derlin; May be involved in the degradation of misfolded endoplasmic reticulum (ER) luminal proteins; Belongs to the derlin family.	U-box domain protein.	0.580
NECAME_00205	NECAME_09703	W2TID2	W2TF57	Derlin; May be involved in the degradation of misfolded endoplasmic reticulum (ER) luminal proteins; Belongs to the derlin family.	Calreticulin family protein.	0.675
NECAME_00205	NECAME_11242	W2TID2	W2T679	Derlin; May be involved in the degradation of misfolded endoplasmic reticulum (ER) luminal proteins; Belongs to the derlin family.	Hsp90 protein.	0.516
NECAME_00205	NECAME_11557	W2TID2	W2T6I6	Derlin; May be involved in the degradation of misfolded endoplasmic reticulum (ER) luminal proteins; Belongs to the derlin family.	Uncharacterized protein.	0.512
NECAME_00205	NECAME_11558	W2TID2	W2T3X5	Derlin; May be involved in the degradation of misfolded endoplasmic reticulum (ER) luminal proteins; Belongs to the derlin family.	Ubiquitin family protein.	0.512
NECAME_00205	NECAME_12565	W2TID2	W2T0C5	Derlin; May be involved in the degradation of misfolded endoplasmic reticulum (ER) luminal proteins; Belongs to the derlin family.	Uncharacterized protein.	0.679
NECAME_00205	NECAME_13334	W2TID2	W2SVZ1	Derlin; May be involved in the degradation of misfolded endoplasmic reticulum (ER) luminal proteins; Belongs to the derlin family.	UBIQUITIN_CONJUGAT_2 domain-containing protein.	0.601
NECAME_00205	NECAME_13335	W2TID2	W2SWB4	Derlin; May be involved in the degradation of misfolded endoplasmic reticulum (ER) luminal proteins; Belongs to the derlin family.	Uncharacterized protein.	0.601
NECAME_00205	NECAME_14953	W2TID2	W2SN52	Derlin; May be involved in the degradation of misfolded endoplasmic reticulum (ER) luminal proteins; Belongs to the derlin family.	UBX domain protein.	0.854
NECAME_00205	NECAME_15185	W2TID2	W2SLA1	Derlin; May be involved in the degradation of misfolded endoplasmic reticulum (ER) luminal proteins; Belongs to the derlin family.	alpha-1,2-Mannosidase; Belongs to the glycosyl hydrolase 47 family.	0.435
NECAME_00205	NECAME_15186	W2TID2	W2SLN9	Derlin; May be involved in the degradation of misfolded endoplasmic reticulum (ER) luminal proteins; Belongs to the derlin family.	Uncharacterized protein.	0.435