(70 nodes) DNA integrity checkpoint signaling network (Necator americanus)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	NECAME_12370	Uncharacterized protein. (131 aa)
	NECAME_15901	Kinase domain protein. (618 aa)
	NECAME_15460	Uncharacterized protein. (466 aa)
	NECAME_15264	Uncharacterized protein. (176 aa)
	NECAME_15262	BRCT domain-containing protein. (125 aa)
	NECAME_04869	Uncharacterized protein. (115 aa)
	NECAME_14475	Uncharacterized protein. (334 aa)
	NECAME_14280	Leucine Rich repeat-containing domain protein. (212 aa)
	NECAME_18918	Uncharacterized protein. (83 aa)
	NECAME_18300	Uncharacterized protein. (99 aa)
	NECAME_13259	U1-type domain-containing protein. (264 aa)
	NECAME_03907	Uncharacterized protein. (140 aa)
	NECAME_03912	Uncharacterized protein. (329 aa)
	NECAME_03905	FAT domain-containing protein. (473 aa)
	NECAME_03910	Uncharacterized protein. (298 aa)
	NECAME_03915	Uncharacterized protein. (91 aa)
	NECAME_12523	Uncharacterized protein. (757 aa)
	NECAME_03851	Uncharacterized protein. (220 aa)
	NECAME_03906	Uncharacterized protein. (124 aa)
	NECAME_03911	Uncharacterized protein. (149 aa)
	NECAME_12986	Kinase domain protein. (286 aa)
	NECAME_03908	Uncharacterized protein. (104 aa)
	NECAME_03913	Uncharacterized protein. (61 aa)
	NECAME_12524	Uncharacterized protein. (754 aa)
	NECAME_03904	Uncharacterized protein. (371 aa)
	NECAME_03909	Uncharacterized protein. (178 aa)
	NECAME_03914	Uncharacterized protein. (189 aa)
	NECAME_12520	FATC domain protein; Belongs to the PI3/PI4-kinase family. (290 aa)
	NECAME_12459	Kinase domain protein; Belongs to the protein kinase superfamily. (444 aa)
	NECAME_11706	Uncharacterized protein. (1261 aa)
	NECAME_12219	Uncharacterized protein. (440 aa)
	NECAME_11271	Histone-lysine N-methyltransferase, H3 lysine-79 specific. (1724 aa)
	NECAME_11109	Timeless protein. (580 aa)
	NECAME_03141	Uncharacterized protein. (224 aa)
	NECAME_03139	Uncharacterized protein. (568 aa)
	NECAME_03382	Uncharacterized protein. (671 aa)
	NECAME_11108	TIMELESS_C domain-containing protein. (400 aa)
	NECAME_11052	Transposase. (809 aa)
	NECAME_03140	Uncharacterized protein. (218 aa)
	NECAME_11050	HTH_48 domain-containing protein. (325 aa)
	NECAME_11055	Uncharacterized protein. (290 aa)
	NECAME_02888	Origin recognition complex subunit 1; Component of the origin recognition complex (ORC) that binds origins of replication. DNA-binding is ATP-dependent, however specific DNA sequences that define origins of replication have not been identified so far. ORC is required to assemble the pre-replication complex necessary to initiate DNA replication. (380 aa)
	NECAME_02748	Prefoldin, alpha subunit. (594 aa)
	NECAME_09938	WD domain, G-beta repeat protein. (307 aa)
	NECAME_10309	Rad17 cell cycle checkpoint protein. (559 aa)
	NECAME_02889	Origin recognition complex subunit 1; Component of the origin recognition complex (ORC) that binds origins of replication. DNA-binding is ATP-dependent, however specific DNA sequences that define origins of replication have not been identified so far. ORC is required to assemble the pre-replication complex necessary to initiate DNA replication. (175 aa)
	NECAME_10160	Hus1-like protein. (394 aa)
	NECAME_02407	Uncharacterized protein. (444 aa)
	NECAME_02353	Uncharacterized protein. (105 aa)
	NECAME_17999	Uncharacterized protein. (99 aa)
	NECAME_02354	Uncharacterized protein. (155 aa)
	NECAME_02355	Uncharacterized protein. (128 aa)
	NECAME_08628	Double-strand break repair protein; Involved in DNA double-strand break repair (DSBR). Possesses single-strand endonuclease activity and double-strand-specific 3'-5' exonuclease activity. Also involved in meiotic DSB processing. (597 aa)
	NECAME_00235	Uncharacterized protein. (90 aa)
	NECAME_00236	TIMELESS-interacting protein; Plays an important role in the control of DNA replication and the maintenance of replication fork stability. Belongs to the CSM3 family. (215 aa)
	NECAME_01737	ERCC4 domain protein. (267 aa)
	NECAME_17109	Uncharacterized protein. (99 aa)
	NECAME_07189	Uncharacterized protein. (135 aa)
	NECAME_01735	AAA domain-containing protein. (177 aa)
	NECAME_06294	PI3K/PI4K domain-containing protein; Belongs to the PI3/PI4-kinase family. (519 aa)
	NECAME_06292	Uncharacterized protein. (113 aa)
	NECAME_06130	Tyrosine-protein kinase. (1208 aa)
	NECAME_06293	PI3K/PI4K domain-containing protein; Belongs to the PI3/PI4-kinase family. (921 aa)
	NECAME_06133	Protein kinase domain-containing protein. (261 aa)
	NECAME_16465	Uncharacterized protein. (545 aa)
	NECAME_05879	ATP-dependent DNA helicase; Belongs to the helicase family. RecQ subfamily. (883 aa)
	NECAME_05899	Uncharacterized protein. (101 aa)
	NECAME_05735	Uncharacterized protein. (350 aa)
	NECAME_05729	Uncharacterized protein. (426 aa)
	NECAME_05731	Uncharacterized protein. (371 aa)

Your Current Organism:

Necator americanus

NCBI taxonomy Id: 51031
Other names: N. americanus

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structured XML interaction data, according to the 'PSI-MI' data standard

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a flat-file format describing the coordinates and colors of nodes in the network

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... protein annotations:

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a tab-delimited file describing the names, domains and descriptions of proteins in your network

... functional annotations:

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a tab-delimited file containing all known functional terms of proteins in your network

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
NECAME_00235	NECAME_01735	W2TIG5	W2TSE9	Uncharacterized protein.	AAA domain-containing protein.	0.590
NECAME_00235	NECAME_02888	W2TIG5	W2TB73	Uncharacterized protein.	Origin recognition complex subunit 1; Component of the origin recognition complex (ORC) that binds origins of replication. DNA-binding is ATP-dependent, however specific DNA sequences that define origins of replication have not been identified so far. ORC is required to assemble the pre-replication complex necessary to initiate DNA replication.	0.453
NECAME_00235	NECAME_02889	W2TIG5	W2TBS4	Uncharacterized protein.	Origin recognition complex subunit 1; Component of the origin recognition complex (ORC) that binds origins of replication. DNA-binding is ATP-dependent, however specific DNA sequences that define origins of replication have not been identified so far. ORC is required to assemble the pre-replication complex necessary to initiate DNA replication.	0.453
NECAME_00235	NECAME_03382	W2TIG5	W2T6T4	Uncharacterized protein.	Uncharacterized protein.	0.751
NECAME_00235	NECAME_03851	W2TIG5	W2SZQ1	Uncharacterized protein.	Uncharacterized protein.	0.734
NECAME_00235	NECAME_05879	W2TIG5	W2TWW6	Uncharacterized protein.	ATP-dependent DNA helicase; Belongs to the helicase family. RecQ subfamily.	0.630
NECAME_00235	NECAME_05899	W2TIG5	W2TWY7	Uncharacterized protein.	Uncharacterized protein.	0.634
NECAME_00235	NECAME_10160	W2TIG5	W2TCQ6	Uncharacterized protein.	Hus1-like protein.	0.630
NECAME_00235	NECAME_10309	W2TIG5	W2TBG1	Uncharacterized protein.	Rad17 cell cycle checkpoint protein.	0.673
NECAME_00235	NECAME_11108	W2TIG5	W2T6V7	Uncharacterized protein.	TIMELESS_C domain-containing protein.	0.910
NECAME_00235	NECAME_11109	W2TIG5	W2T5S3	Uncharacterized protein.	Timeless protein.	0.910
NECAME_00235	NECAME_11706	W2TIG5	W2T317	Uncharacterized protein.	Uncharacterized protein.	0.543
NECAME_00235	NECAME_12459	W2TIG5	W2T2Z0	Uncharacterized protein.	Kinase domain protein; Belongs to the protein kinase superfamily.	0.603
NECAME_00235	NECAME_14280	W2TIG5	W2SNT0	Uncharacterized protein.	Leucine Rich repeat-containing domain protein.	0.539
NECAME_00235	NECAME_15262	W2TIG5	W2SKU7	Uncharacterized protein.	BRCT domain-containing protein.	0.412
NECAME_00235	NECAME_15264	W2TIG5	W2SIU2	Uncharacterized protein.	Uncharacterized protein.	0.412
NECAME_00235	NECAME_17109	W2TIG5	W2TR62	Uncharacterized protein.	Uncharacterized protein.	0.501
NECAME_00235	NECAME_17999	W2TIG5	W2TH43	Uncharacterized protein.	Uncharacterized protein.	0.501
NECAME_00235	NECAME_18918	W2TIG5	W2STZ2	Uncharacterized protein.	Uncharacterized protein.	0.630
NECAME_00236	NECAME_01735	W2TL63	W2TSE9	TIMELESS-interacting protein; Plays an important role in the control of DNA replication and the maintenance of replication fork stability. Belongs to the CSM3 family.	AAA domain-containing protein.	0.590