(38 nodes) Activation of protein kinase activity network (Necator americanus)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	NECAME_15077	Kinase domain protein; Belongs to the protein kinase superfamily. (341 aa)
	NECAME_11475	Uncharacterized protein. (213 aa)
	NECAME_15891	Uncharacterized protein. (415 aa)
	NECAME_14922	Mob1/phocein family protein. (275 aa)
	NECAME_11869	Uncharacterized protein. (1034 aa)
	NECAME_11472	Raptor_N domain-containing protein. (305 aa)
	NECAME_03382	Uncharacterized protein. (671 aa)
	NECAME_11473	Uncharacterized protein. (250 aa)
	NECAME_10649	Protein phosphatase 2C. (391 aa)
	NECAME_18581	DUF4071 domain-containing protein. (122 aa)
	NECAME_11164	Cyclin domain protein. (463 aa)
	NECAME_00369	Cyclin domain protein; Belongs to the cyclin family. (267 aa)
	NECAME_15408	CDK-activating kinase assembly factor MAT1. (172 aa)
	NECAME_15413	MATH domain protein. (381 aa)
	NECAME_15079	Uncharacterized protein. (71 aa)
	NECAME_15838	Kinase domain protein. (435 aa)
	NECAME_05687	Mo25-like protein. (335 aa)
	NECAME_02602	Protein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (568 aa)
	NECAME_18037	INCENP_ARK-bind domain-containing protein. (459 aa)
	NECAME_07968	Cyclin-dependent kinase 5 activator protein. (310 aa)
	NECAME_01968	Uncharacterized protein. (361 aa)
	NECAME_07707	N-acetyltransferase domain-containing protein. (263 aa)
	NECAME_07969	Uncharacterized protein. (83 aa)
	NECAME_07446	Mob1/phocein family protein. (135 aa)
	NECAME_17080	Transforming growth factor beta like domain protein. (313 aa)
	NECAME_06644	RICTOR_V domain-containing protein. (517 aa)
	NECAME_06642	RICTOR_N domain-containing protein. (690 aa)
	NECAME_00159	Kinase domain protein; Belongs to the protein kinase superfamily. (347 aa)
	NECAME_00065	Uncharacterized protein. (102 aa)
	NECAME_13060	Cyclin domain protein; Belongs to the cyclin family. (368 aa)
	NECAME_00580	Uncharacterized protein. (289 aa)
	NECAME_11954	Uncharacterized protein. (168 aa)
	NECAME_11955	Uncharacterized protein. (396 aa)
	NECAME_03425	Uncharacterized protein. (792 aa)
	NECAME_18455	Uncharacterized protein. (141 aa)
	NECAME_13656	Cyclin-dependent kinases regulatory subunit; Binds to the catalytic subunit of the cyclin dependent kinases and is essential for their biological function. (124 aa)
	NECAME_14085	DH domain-containing protein. (146 aa)
	NECAME_15037	Protein kinase domain-containing protein. (213 aa)

Your Current Organism:

Necator americanus

NCBI taxonomy Id: 51031
Other names: N. americanus

Send network to Cytoscape

Export your current network:

... as a bitmap image:

download

file format is 'PNG': portable network graphic

... as a high-resolution bitmap:

download

same PNG format, but at higher resolution

... as a vector graphic:

download

SVG: scalable vector graphic - can be opened and edited in Illustrator, CorelDraw, Dia, etc

... as short tabular text output:

download

TSV: tab separated values - can be opened in Excel and Cytoscape (lists only one-way edges: A-B)

... as tabular text output:

download

TSV: tab separated values - can be opened in Excel (lists reciprocal edges: A-B,B-A)

... as an XML summary:

download

structured XML interaction data, according to the 'PSI-MI' data standard

... protein node degrees:

download

node degree of proteins in your network (given the current score cut-off)

... network coordinates:

download

a flat-file format describing the coordinates and colors of nodes in the network

... protein sequences:

download

MFA: multi-fasta format - containing the aminoacid sequences in the network

... protein annotations:

download

a tab-delimited file describing the names, domains and descriptions of proteins in your network

... functional annotations:

download

a tab-delimited file containing all known functional terms of proteins in your network

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
NECAME_00159	NECAME_10649	W2TZ17	W2T7X0	Kinase domain protein; Belongs to the protein kinase superfamily.	Protein phosphatase 2C.	0.636
NECAME_00159	NECAME_11869	W2TZ17	W2T5D6	Kinase domain protein; Belongs to the protein kinase superfamily.	Uncharacterized protein.	0.576
NECAME_00159	NECAME_15077	W2TZ17	W2SM85	Kinase domain protein; Belongs to the protein kinase superfamily.	Kinase domain protein; Belongs to the protein kinase superfamily.	0.721
NECAME_00159	NECAME_15079	W2TZ17	W2SJK9	Kinase domain protein; Belongs to the protein kinase superfamily.	Uncharacterized protein.	0.679
NECAME_00159	NECAME_15413	W2TZ17	W2SKB0	Kinase domain protein; Belongs to the protein kinase superfamily.	MATH domain protein.	0.493
NECAME_00159	NECAME_18581	W2TZ17	W2SVX5	Kinase domain protein; Belongs to the protein kinase superfamily.	DUF4071 domain-containing protein.	0.679
NECAME_00369	NECAME_13060	W2TAD4	W2SZD0	Cyclin domain protein; Belongs to the cyclin family.	Cyclin domain protein; Belongs to the cyclin family.	0.775
NECAME_00369	NECAME_15408	W2TAD4	W2SKP3	Cyclin domain protein; Belongs to the cyclin family.	CDK-activating kinase assembly factor MAT1.	0.763
NECAME_03425	NECAME_06642	W2T4J2	W2TSW0	Uncharacterized protein.	RICTOR_N domain-containing protein.	0.405
NECAME_03425	NECAME_06644	W2T4J2	W2TS13	Uncharacterized protein.	RICTOR_V domain-containing protein.	0.405
NECAME_05687	NECAME_07446	W2SFH2	W2TNJ6	Mo25-like protein.	Mob1/phocein family protein.	0.517
NECAME_05687	NECAME_15037	W2SFH2	W2SMC2	Mo25-like protein.	Protein kinase domain-containing protein.	0.983
NECAME_06642	NECAME_03425	W2TSW0	W2T4J2	RICTOR_N domain-containing protein.	Uncharacterized protein.	0.405
NECAME_06642	NECAME_06644	W2TSW0	W2TS13	RICTOR_N domain-containing protein.	RICTOR_V domain-containing protein.	0.568
NECAME_06642	NECAME_11472	W2TSW0	W2T6I9	RICTOR_N domain-containing protein.	Raptor_N domain-containing protein.	0.819
NECAME_06642	NECAME_11473	W2TSW0	W2T704	RICTOR_N domain-containing protein.	Uncharacterized protein.	0.819
NECAME_06642	NECAME_11475	W2TSW0	W2T5A7	RICTOR_N domain-containing protein.	Uncharacterized protein.	0.819
NECAME_06642	NECAME_15891	W2TSW0	W2SFE6	RICTOR_N domain-containing protein.	Uncharacterized protein.	0.405
NECAME_06642	NECAME_18455	W2TSW0	W2SU91	RICTOR_N domain-containing protein.	Uncharacterized protein.	0.819
NECAME_06644	NECAME_03425	W2TS13	W2T4J2	RICTOR_V domain-containing protein.	Uncharacterized protein.	0.405