(30 nodes) Mitotic DNA damage checkpoint signaling network (Necator americanus)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	NECAME_01737	ERCC4 domain protein. (267 aa)
	NECAME_05731	Uncharacterized protein. (371 aa)
	NECAME_05729	Uncharacterized protein. (426 aa)
	NECAME_05735	Uncharacterized protein. (350 aa)
	NECAME_05899	Uncharacterized protein. (101 aa)
	NECAME_06294	PI3K/PI4K domain-containing protein; Belongs to the PI3/PI4-kinase family. (519 aa)
	NECAME_15901	Kinase domain protein. (618 aa)
	NECAME_15460	Uncharacterized protein. (466 aa)
	NECAME_15264	Uncharacterized protein. (176 aa)
	NECAME_15262	BRCT domain-containing protein. (125 aa)
	NECAME_14475	Uncharacterized protein. (334 aa)
	NECAME_18300	Uncharacterized protein. (99 aa)
	NECAME_13259	U1-type domain-containing protein. (264 aa)
	NECAME_12986	Kinase domain protein. (286 aa)
	NECAME_12459	Kinase domain protein; Belongs to the protein kinase superfamily. (444 aa)
	NECAME_12219	Uncharacterized protein. (440 aa)
	NECAME_03141	Uncharacterized protein. (224 aa)
	NECAME_03139	Uncharacterized protein. (568 aa)
	NECAME_03382	Uncharacterized protein. (671 aa)
	NECAME_03140	Uncharacterized protein. (218 aa)
	NECAME_09938	WD domain, G-beta repeat protein. (307 aa)
	NECAME_10160	Hus1-like protein. (394 aa)
	NECAME_02407	Uncharacterized protein. (444 aa)
	NECAME_02353	Uncharacterized protein. (105 aa)
	NECAME_02354	Uncharacterized protein. (155 aa)
	NECAME_02355	Uncharacterized protein. (128 aa)
	NECAME_08628	Double-strand break repair protein; Involved in DNA double-strand break repair (DSBR). Possesses single-strand endonuclease activity and double-strand-specific 3'-5' exonuclease activity. Also involved in meiotic DSB processing. (597 aa)
	NECAME_00235	Uncharacterized protein. (90 aa)
	NECAME_00236	TIMELESS-interacting protein; Plays an important role in the control of DNA replication and the maintenance of replication fork stability. Belongs to the CSM3 family. (215 aa)
	NECAME_07189	Uncharacterized protein. (135 aa)

Your Current Organism:

Necator americanus

NCBI taxonomy Id: 51031
Other names: N. americanus

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a tab-delimited file describing the names, domains and descriptions of proteins in your network

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a tab-delimited file containing all known functional terms of proteins in your network

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
NECAME_00235	NECAME_03382	W2TIG5	W2T6T4	Uncharacterized protein.	Uncharacterized protein.	0.751
NECAME_00235	NECAME_05899	W2TIG5	W2TWY7	Uncharacterized protein.	Uncharacterized protein.	0.634
NECAME_00235	NECAME_10160	W2TIG5	W2TCQ6	Uncharacterized protein.	Hus1-like protein.	0.630
NECAME_00235	NECAME_12459	W2TIG5	W2T2Z0	Uncharacterized protein.	Kinase domain protein; Belongs to the protein kinase superfamily.	0.603
NECAME_00235	NECAME_15262	W2TIG5	W2SKU7	Uncharacterized protein.	BRCT domain-containing protein.	0.412
NECAME_00235	NECAME_15264	W2TIG5	W2SIU2	Uncharacterized protein.	Uncharacterized protein.	0.412
NECAME_00236	NECAME_03382	W2TL63	W2T6T4	TIMELESS-interacting protein; Plays an important role in the control of DNA replication and the maintenance of replication fork stability. Belongs to the CSM3 family.	Uncharacterized protein.	0.751
NECAME_00236	NECAME_05899	W2TL63	W2TWY7	TIMELESS-interacting protein; Plays an important role in the control of DNA replication and the maintenance of replication fork stability. Belongs to the CSM3 family.	Uncharacterized protein.	0.634
NECAME_00236	NECAME_10160	W2TL63	W2TCQ6	TIMELESS-interacting protein; Plays an important role in the control of DNA replication and the maintenance of replication fork stability. Belongs to the CSM3 family.	Hus1-like protein.	0.630
NECAME_00236	NECAME_12459	W2TL63	W2T2Z0	TIMELESS-interacting protein; Plays an important role in the control of DNA replication and the maintenance of replication fork stability. Belongs to the CSM3 family.	Kinase domain protein; Belongs to the protein kinase superfamily.	0.603
NECAME_00236	NECAME_15262	W2TL63	W2SKU7	TIMELESS-interacting protein; Plays an important role in the control of DNA replication and the maintenance of replication fork stability. Belongs to the CSM3 family.	BRCT domain-containing protein.	0.412
NECAME_00236	NECAME_15264	W2TL63	W2SIU2	TIMELESS-interacting protein; Plays an important role in the control of DNA replication and the maintenance of replication fork stability. Belongs to the CSM3 family.	Uncharacterized protein.	0.412
NECAME_01737	NECAME_03139	W2TQJ1	W2T6G5	ERCC4 domain protein.	Uncharacterized protein.	0.613
NECAME_01737	NECAME_03140	W2TQJ1	W2T766	ERCC4 domain protein.	Uncharacterized protein.	0.613
NECAME_01737	NECAME_03141	W2TQJ1	W2T637	ERCC4 domain protein.	Uncharacterized protein.	0.613
NECAME_01737	NECAME_05899	W2TQJ1	W2TWY7	ERCC4 domain protein.	Uncharacterized protein.	0.698
NECAME_01737	NECAME_06294	W2TQJ1	W2TUA4	ERCC4 domain protein.	PI3K/PI4K domain-containing protein; Belongs to the PI3/PI4-kinase family.	0.583
NECAME_01737	NECAME_08628	W2TQJ1	W2TI85	ERCC4 domain protein.	Double-strand break repair protein; Involved in DNA double-strand break repair (DSBR). Possesses single-strand endonuclease activity and double-strand-specific 3'-5' exonuclease activity. Also involved in meiotic DSB processing.	0.849
NECAME_01737	NECAME_10160	W2TQJ1	W2TCQ6	ERCC4 domain protein.	Hus1-like protein.	0.701
NECAME_01737	NECAME_12459	W2TQJ1	W2T2Z0	ERCC4 domain protein.	Kinase domain protein; Belongs to the protein kinase superfamily.	0.896