(28 nodes) Mitotic G2/M transition checkpoint network (Necator americanus)

Nodes:

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

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empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	NECAME_07189	Uncharacterized protein. (135 aa)
	NECAME_15460	Uncharacterized protein. (466 aa)
	NECAME_15264	Uncharacterized protein. (176 aa)
	NECAME_15262	BRCT domain-containing protein. (125 aa)
	NECAME_14475	Uncharacterized protein. (334 aa)
	NECAME_14280	Leucine Rich repeat-containing domain protein. (212 aa)
	NECAME_04285	Zinc finger, C2H2 type. (804 aa)
	NECAME_18300	Uncharacterized protein. (99 aa)
	NECAME_04284	Uncharacterized protein. (1097 aa)
	NECAME_13259	U1-type domain-containing protein. (264 aa)
	NECAME_12986	Kinase domain protein. (286 aa)
	NECAME_12219	Uncharacterized protein. (440 aa)
	NECAME_03382	Uncharacterized protein. (671 aa)
	NECAME_02888	Origin recognition complex subunit 1; Component of the origin recognition complex (ORC) that binds origins of replication. DNA-binding is ATP-dependent, however specific DNA sequences that define origins of replication have not been identified so far. ORC is required to assemble the pre-replication complex necessary to initiate DNA replication. (380 aa)
	NECAME_09938	WD domain, G-beta repeat protein. (307 aa)
	NECAME_10309	Rad17 cell cycle checkpoint protein. (559 aa)
	NECAME_02889	Origin recognition complex subunit 1; Component of the origin recognition complex (ORC) that binds origins of replication. DNA-binding is ATP-dependent, however specific DNA sequences that define origins of replication have not been identified so far. ORC is required to assemble the pre-replication complex necessary to initiate DNA replication. (175 aa)
	NECAME_10160	Hus1-like protein. (394 aa)
	NECAME_02407	Uncharacterized protein. (444 aa)
	NECAME_02353	Uncharacterized protein. (105 aa)
	NECAME_02354	Uncharacterized protein. (155 aa)
	NECAME_02355	Uncharacterized protein. (128 aa)
	NECAME_08628	Double-strand break repair protein; Involved in DNA double-strand break repair (DSBR). Possesses single-strand endonuclease activity and double-strand-specific 3'-5' exonuclease activity. Also involved in meiotic DSB processing. (597 aa)
	NECAME_01735	AAA domain-containing protein. (177 aa)
	NECAME_06294	PI3K/PI4K domain-containing protein; Belongs to the PI3/PI4-kinase family. (519 aa)
	NECAME_05735	Uncharacterized protein. (350 aa)
	NECAME_05729	Uncharacterized protein. (426 aa)
	NECAME_05731	Uncharacterized protein. (371 aa)

Your Current Organism:

Necator americanus

NCBI taxonomy Id: 51031
Other names: N. americanus

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
NECAME_01735	NECAME_02888	W2TSE9	W2TB73	AAA domain-containing protein.	Origin recognition complex subunit 1; Component of the origin recognition complex (ORC) that binds origins of replication. DNA-binding is ATP-dependent, however specific DNA sequences that define origins of replication have not been identified so far. ORC is required to assemble the pre-replication complex necessary to initiate DNA replication.	0.995
NECAME_01735	NECAME_02889	W2TSE9	W2TBS4	AAA domain-containing protein.	Origin recognition complex subunit 1; Component of the origin recognition complex (ORC) that binds origins of replication. DNA-binding is ATP-dependent, however specific DNA sequences that define origins of replication have not been identified so far. ORC is required to assemble the pre-replication complex necessary to initiate DNA replication.	0.996
NECAME_01735	NECAME_03382	W2TSE9	W2T6T4	AAA domain-containing protein.	Uncharacterized protein.	0.831
NECAME_01735	NECAME_09938	W2TSE9	W2TBE0	AAA domain-containing protein.	WD domain, G-beta repeat protein.	0.960
NECAME_01735	NECAME_10309	W2TSE9	W2TBG1	AAA domain-containing protein.	Rad17 cell cycle checkpoint protein.	0.575
NECAME_01735	NECAME_12986	W2TSE9	W2T0E6	AAA domain-containing protein.	Kinase domain protein.	0.850
NECAME_01735	NECAME_15262	W2TSE9	W2SKU7	AAA domain-containing protein.	BRCT domain-containing protein.	0.542
NECAME_01735	NECAME_15264	W2TSE9	W2SIU2	AAA domain-containing protein.	Uncharacterized protein.	0.542
NECAME_02888	NECAME_01735	W2TB73	W2TSE9	Origin recognition complex subunit 1; Component of the origin recognition complex (ORC) that binds origins of replication. DNA-binding is ATP-dependent, however specific DNA sequences that define origins of replication have not been identified so far. ORC is required to assemble the pre-replication complex necessary to initiate DNA replication.	AAA domain-containing protein.	0.995
NECAME_02888	NECAME_02889	W2TB73	W2TBS4	Origin recognition complex subunit 1; Component of the origin recognition complex (ORC) that binds origins of replication. DNA-binding is ATP-dependent, however specific DNA sequences that define origins of replication have not been identified so far. ORC is required to assemble the pre-replication complex necessary to initiate DNA replication.	Origin recognition complex subunit 1; Component of the origin recognition complex (ORC) that binds origins of replication. DNA-binding is ATP-dependent, however specific DNA sequences that define origins of replication have not been identified so far. ORC is required to assemble the pre-replication complex necessary to initiate DNA replication.	0.724
NECAME_02888	NECAME_03382	W2TB73	W2T6T4	Origin recognition complex subunit 1; Component of the origin recognition complex (ORC) that binds origins of replication. DNA-binding is ATP-dependent, however specific DNA sequences that define origins of replication have not been identified so far. ORC is required to assemble the pre-replication complex necessary to initiate DNA replication.	Uncharacterized protein.	0.812
NECAME_02888	NECAME_09938	W2TB73	W2TBE0	Origin recognition complex subunit 1; Component of the origin recognition complex (ORC) that binds origins of replication. DNA-binding is ATP-dependent, however specific DNA sequences that define origins of replication have not been identified so far. ORC is required to assemble the pre-replication complex necessary to initiate DNA replication.	WD domain, G-beta repeat protein.	0.776
NECAME_02888	NECAME_12986	W2TB73	W2T0E6	Origin recognition complex subunit 1; Component of the origin recognition complex (ORC) that binds origins of replication. DNA-binding is ATP-dependent, however specific DNA sequences that define origins of replication have not been identified so far. ORC is required to assemble the pre-replication complex necessary to initiate DNA replication.	Kinase domain protein.	0.593
NECAME_02889	NECAME_01735	W2TBS4	W2TSE9	Origin recognition complex subunit 1; Component of the origin recognition complex (ORC) that binds origins of replication. DNA-binding is ATP-dependent, however specific DNA sequences that define origins of replication have not been identified so far. ORC is required to assemble the pre-replication complex necessary to initiate DNA replication.	AAA domain-containing protein.	0.996
NECAME_02889	NECAME_02888	W2TBS4	W2TB73	Origin recognition complex subunit 1; Component of the origin recognition complex (ORC) that binds origins of replication. DNA-binding is ATP-dependent, however specific DNA sequences that define origins of replication have not been identified so far. ORC is required to assemble the pre-replication complex necessary to initiate DNA replication.	Origin recognition complex subunit 1; Component of the origin recognition complex (ORC) that binds origins of replication. DNA-binding is ATP-dependent, however specific DNA sequences that define origins of replication have not been identified so far. ORC is required to assemble the pre-replication complex necessary to initiate DNA replication.	0.724
NECAME_02889	NECAME_03382	W2TBS4	W2T6T4	Origin recognition complex subunit 1; Component of the origin recognition complex (ORC) that binds origins of replication. DNA-binding is ATP-dependent, however specific DNA sequences that define origins of replication have not been identified so far. ORC is required to assemble the pre-replication complex necessary to initiate DNA replication.	Uncharacterized protein.	0.812
NECAME_02889	NECAME_09938	W2TBS4	W2TBE0	Origin recognition complex subunit 1; Component of the origin recognition complex (ORC) that binds origins of replication. DNA-binding is ATP-dependent, however specific DNA sequences that define origins of replication have not been identified so far. ORC is required to assemble the pre-replication complex necessary to initiate DNA replication.	WD domain, G-beta repeat protein.	0.776
NECAME_02889	NECAME_12986	W2TBS4	W2T0E6	Origin recognition complex subunit 1; Component of the origin recognition complex (ORC) that binds origins of replication. DNA-binding is ATP-dependent, however specific DNA sequences that define origins of replication have not been identified so far. ORC is required to assemble the pre-replication complex necessary to initiate DNA replication.	Kinase domain protein.	0.593
NECAME_03382	NECAME_01735	W2T6T4	W2TSE9	Uncharacterized protein.	AAA domain-containing protein.	0.831
NECAME_03382	NECAME_02888	W2T6T4	W2TB73	Uncharacterized protein.	Origin recognition complex subunit 1; Component of the origin recognition complex (ORC) that binds origins of replication. DNA-binding is ATP-dependent, however specific DNA sequences that define origins of replication have not been identified so far. ORC is required to assemble the pre-replication complex necessary to initiate DNA replication.	0.812