(48 nodes) Defense response to Gram-positive bacterium network (Necator americanus)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

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Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	NECAME_10006	Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (368 aa)
	NECAME_02625	Lectin C-type domain protein. (237 aa)
	NECAME_00159	Kinase domain protein; Belongs to the protein kinase superfamily. (347 aa)
	NECAME_09312	Surfactant protein B. (187 aa)
	NECAME_00213	G-protein alpha subunit. (320 aa)
	NECAME_08604	UDP-glucose 4-epimerase; Belongs to the NAD(P)-dependent epimerase/dehydratase family. (323 aa)
	NECAME_08253	Uncharacterized protein. (78 aa)
	NECAME_01869	Surfactant protein B. (100 aa)
	NECAME_17495	Lectin C-type domain protein. (175 aa)
	NECAME_17080	Transforming growth factor beta like domain protein. (313 aa)
	NECAME_17339	Lectin C-type domain protein. (229 aa)
	NECAME_16975	Putative gamma-aminobutyric acid receptor-associated protein. (141 aa)
	NECAME_16446	Lectin C-type domain protein. (133 aa)
	NECAME_16319	Lectin C-type domain protein. (102 aa)
	NECAME_16318	Lectin C-type domain protein. (87 aa)
	NECAME_15431	Helix-loop-helix DNA-binding domain protein. (215 aa)
	NECAME_15079	Uncharacterized protein. (71 aa)
	NECAME_15077	Kinase domain protein; Belongs to the protein kinase superfamily. (341 aa)
	NECAME_14995	Animal hem peroxidase. (678 aa)
	NECAME_14860	Transcription factor BTF3. (935 aa)
	NECAME_14275	RNase3 domain protein. (405 aa)
	NECAME_14274	Uncharacterized protein. (374 aa)
	NECAME_14273	Double stranded RNA binding domain protein; Belongs to the helicase family. Dicer subfamily. (830 aa)
	NECAME_13711	Gamma-aminobutyric acid receptor-associated protein. (118 aa)
	NECAME_18581	DUF4071 domain-containing protein. (122 aa)
	NECAME_04103	Uncharacterized protein. (93 aa)
	NECAME_00785	HSF-type DNA-binding domain protein. (256 aa)
	NECAME_04102	Uncharacterized protein. (181 aa)
	NECAME_03934	Uncharacterized protein. (235 aa)
	NECAME_12201	Uncharacterized protein. (130 aa)
	NECAME_03935	Uncharacterized protein; Belongs to the cytochrome P450 family. (172 aa)
	NECAME_03329	Uncharacterized protein. (127 aa)
	NECAME_03284	Unspecific monooxygenase; Belongs to the cytochrome P450 family. (516 aa)
	NECAME_03193	Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (347 aa)
	NECAME_10915	Lectin C-type domain protein. (431 aa)
	NECAME_02917	Uncharacterized protein. (94 aa)
	NECAME_10417	Uncharacterized protein. (323 aa)
	NECAME_02915	V-type proton ATPase subunit a; Essential component of the vacuolar proton pump (V-ATPase), a multimeric enzyme that catalyzes the translocation of protons across the membranes. Required for assembly and activity of the V-ATPase. (292 aa)
	NECAME_02916	V-type proton ATPase subunit a; Essential component of the vacuolar proton pump (V-ATPase), a multimeric enzyme that catalyzes the translocation of protons across the membranes. Required for assembly and activity of the V-ATPase. (210 aa)
	NECAME_10045	Fork-head domain-containing protein. (182 aa)
	NECAME_02913	Uncharacterized protein. (59 aa)
	NECAME_02918	V-type proton ATPase subunit a; Essential component of the vacuolar proton pump (V-ATPase), a multimeric enzyme that catalyzes the translocation of protons across the membranes. Required for assembly and activity of the V-ATPase. (137 aa)
	NECAME_10320	EGF-like domain protein. (1342 aa)
	NECAME_10046	Fork-head domain-containing protein. (347 aa)
	NECAME_02914	V-type proton ATPase subunit a; Essential component of the vacuolar proton pump (V-ATPase), a multimeric enzyme that catalyzes the translocation of protons across the membranes. Required for assembly and activity of the V-ATPase. (130 aa)
	NECAME_10005	Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (375 aa)
	NECAME_16090	UDP-glucose 4-epimerase. (557 aa)
	NECAME_18075	Lectin C-type domain protein. (107 aa)

Your Current Organism:

Necator americanus

NCBI taxonomy Id: 51031
Other names: N. americanus

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
NECAME_00159	NECAME_10005	W2TZ17	W2TD45	Kinase domain protein; Belongs to the protein kinase superfamily.	Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily.	0.866
NECAME_00159	NECAME_10006	W2TZ17	W2TDL8	Kinase domain protein; Belongs to the protein kinase superfamily.	Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily.	0.866
NECAME_00159	NECAME_15077	W2TZ17	W2SM85	Kinase domain protein; Belongs to the protein kinase superfamily.	Kinase domain protein; Belongs to the protein kinase superfamily.	0.721
NECAME_00159	NECAME_15079	W2TZ17	W2SJK9	Kinase domain protein; Belongs to the protein kinase superfamily.	Uncharacterized protein.	0.679
NECAME_00159	NECAME_18581	W2TZ17	W2SVX5	Kinase domain protein; Belongs to the protein kinase superfamily.	DUF4071 domain-containing protein.	0.679
NECAME_00213	NECAME_10005	W2TJ99	W2TD45	G-protein alpha subunit.	Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily.	0.460
NECAME_00213	NECAME_10006	W2TJ99	W2TDL8	G-protein alpha subunit.	Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily.	0.460
NECAME_00785	NECAME_10005	W2SXT4	W2TD45	HSF-type DNA-binding domain protein.	Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily.	0.711
NECAME_00785	NECAME_10006	W2SXT4	W2TDL8	HSF-type DNA-binding domain protein.	Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily.	0.711
NECAME_00785	NECAME_10045	W2SXT4	W2TB31	HSF-type DNA-binding domain protein.	Fork-head domain-containing protein.	0.426
NECAME_00785	NECAME_10046	W2SXT4	W2TBU6	HSF-type DNA-binding domain protein.	Fork-head domain-containing protein.	0.426
NECAME_02914	NECAME_02915	W2TBU9	W2T9D4	V-type proton ATPase subunit a; Essential component of the vacuolar proton pump (V-ATPase), a multimeric enzyme that catalyzes the translocation of protons across the membranes. Required for assembly and activity of the V-ATPase.	V-type proton ATPase subunit a; Essential component of the vacuolar proton pump (V-ATPase), a multimeric enzyme that catalyzes the translocation of protons across the membranes. Required for assembly and activity of the V-ATPase.	0.547
NECAME_02914	NECAME_02916	W2TBU9	W2TA63	V-type proton ATPase subunit a; Essential component of the vacuolar proton pump (V-ATPase), a multimeric enzyme that catalyzes the translocation of protons across the membranes. Required for assembly and activity of the V-ATPase.	V-type proton ATPase subunit a; Essential component of the vacuolar proton pump (V-ATPase), a multimeric enzyme that catalyzes the translocation of protons across the membranes. Required for assembly and activity of the V-ATPase.	0.597
NECAME_02914	NECAME_02918	W2TBU9	W2TBA5	V-type proton ATPase subunit a; Essential component of the vacuolar proton pump (V-ATPase), a multimeric enzyme that catalyzes the translocation of protons across the membranes. Required for assembly and activity of the V-ATPase.	V-type proton ATPase subunit a; Essential component of the vacuolar proton pump (V-ATPase), a multimeric enzyme that catalyzes the translocation of protons across the membranes. Required for assembly and activity of the V-ATPase.	0.519
NECAME_02915	NECAME_02914	W2T9D4	W2TBU9	V-type proton ATPase subunit a; Essential component of the vacuolar proton pump (V-ATPase), a multimeric enzyme that catalyzes the translocation of protons across the membranes. Required for assembly and activity of the V-ATPase.	V-type proton ATPase subunit a; Essential component of the vacuolar proton pump (V-ATPase), a multimeric enzyme that catalyzes the translocation of protons across the membranes. Required for assembly and activity of the V-ATPase.	0.547
NECAME_02915	NECAME_02916	W2T9D4	W2TA63	V-type proton ATPase subunit a; Essential component of the vacuolar proton pump (V-ATPase), a multimeric enzyme that catalyzes the translocation of protons across the membranes. Required for assembly and activity of the V-ATPase.	V-type proton ATPase subunit a; Essential component of the vacuolar proton pump (V-ATPase), a multimeric enzyme that catalyzes the translocation of protons across the membranes. Required for assembly and activity of the V-ATPase.	0.962
NECAME_02915	NECAME_02918	W2T9D4	W2TBA5	V-type proton ATPase subunit a; Essential component of the vacuolar proton pump (V-ATPase), a multimeric enzyme that catalyzes the translocation of protons across the membranes. Required for assembly and activity of the V-ATPase.	V-type proton ATPase subunit a; Essential component of the vacuolar proton pump (V-ATPase), a multimeric enzyme that catalyzes the translocation of protons across the membranes. Required for assembly and activity of the V-ATPase.	0.948
NECAME_02916	NECAME_02914	W2TA63	W2TBU9	V-type proton ATPase subunit a; Essential component of the vacuolar proton pump (V-ATPase), a multimeric enzyme that catalyzes the translocation of protons across the membranes. Required for assembly and activity of the V-ATPase.	V-type proton ATPase subunit a; Essential component of the vacuolar proton pump (V-ATPase), a multimeric enzyme that catalyzes the translocation of protons across the membranes. Required for assembly and activity of the V-ATPase.	0.597
NECAME_02916	NECAME_02915	W2TA63	W2T9D4	V-type proton ATPase subunit a; Essential component of the vacuolar proton pump (V-ATPase), a multimeric enzyme that catalyzes the translocation of protons across the membranes. Required for assembly and activity of the V-ATPase.	V-type proton ATPase subunit a; Essential component of the vacuolar proton pump (V-ATPase), a multimeric enzyme that catalyzes the translocation of protons across the membranes. Required for assembly and activity of the V-ATPase.	0.962
NECAME_02916	NECAME_02918	W2TA63	W2TBA5	V-type proton ATPase subunit a; Essential component of the vacuolar proton pump (V-ATPase), a multimeric enzyme that catalyzes the translocation of protons across the membranes. Required for assembly and activity of the V-ATPase.	V-type proton ATPase subunit a; Essential component of the vacuolar proton pump (V-ATPase), a multimeric enzyme that catalyzes the translocation of protons across the membranes. Required for assembly and activity of the V-ATPase.	0.956