(24 nodes) Organelle membrane contact site network (Necator americanus)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	NECAME_16481	Uncharacterized protein. (333 aa)
	NECAME_06980	Nematode cuticle collagen domain protein. (1700 aa)
	NECAME_08565	START domain protein. (153 aa)
	NECAME_09261	Major sperm protein; Central component in molecular interactions underlying sperm crawling. Forms an extensive filament system that extends from sperm villipoda, along the leading edge of the pseudopod. (269 aa)
	NECAME_11494	GRAM domain protein. (203 aa)
	NECAME_03375	Uncharacterized protein. (286 aa)
	NECAME_11495	Uncharacterized protein. (232 aa)
	NECAME_03672	MENTAL domain-containing protein. (328 aa)
	NECAME_04168	START domain protein. (221 aa)
	NECAME_18884	Uncharacterized protein. (71 aa)
	NECAME_18940	Vps39_1 domain-containing protein. (227 aa)
	NECAME_04701	Neurotransmitter-gated ion-channel ligand binding domain protein; Belongs to the ligand-gated ion channel (TC 1.A.9) family. (538 aa)
	NECAME_00857	Thioredoxin. (271 aa)
	NECAME_15327	DUF2405 domain-containing protein. (552 aa)
	NECAME_15324	Apt1 domain-containing protein. (577 aa)
	NECAME_15326	Uncharacterized protein. (118 aa)
	NECAME_05260	START domain-containing protein. (204 aa)
	NECAME_15325	Uncharacterized protein. (250 aa)
	NECAME_15926	Uncharacterized protein. (78 aa)
	NECAME_15927	WD domain, G-beta repeat protein. (502 aa)
	NECAME_15928	HEAT repeat protein. (283 aa)
	NECAME_01276	Vps39_2 domain-containing protein. (360 aa)
	NECAME_00108	GPI inositol-deacylase; Involved in inositol deacylation of GPI-anchored proteins which plays important roles in the quality control and ER-associated degradation of GPI-anchored proteins. (506 aa)
	NECAME_06236	Uncharacterized protein; Belongs to the membrane-bound acyltransferase family. (113 aa)

Your Current Organism:

Necator americanus

NCBI taxonomy Id: 51031
Other names: N. americanus

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
NECAME_01276	NECAME_18940	W2U1B6	W2SRV8	Vps39_2 domain-containing protein.	Vps39_1 domain-containing protein.	0.863
NECAME_03375	NECAME_15926	W2T6B2	W2SHR3	Uncharacterized protein.	Uncharacterized protein.	0.903
NECAME_03375	NECAME_15927	W2T6B2	W2SFH3	Uncharacterized protein.	WD domain, G-beta repeat protein.	0.903
NECAME_03375	NECAME_15928	W2T6B2	W2SF89	Uncharacterized protein.	HEAT repeat protein.	0.903
NECAME_03375	NECAME_18884	W2T6B2	W2SRZ2	Uncharacterized protein.	Uncharacterized protein.	0.903
NECAME_03672	NECAME_05260	W2T122	W2SIK0	MENTAL domain-containing protein.	START domain-containing protein.	0.648
NECAME_03672	NECAME_06980	W2T122	W2TSZ3	MENTAL domain-containing protein.	Nematode cuticle collagen domain protein.	0.450
NECAME_03672	NECAME_08565	W2T122	W2TIE6	MENTAL domain-containing protein.	START domain protein.	0.769
NECAME_03672	NECAME_09261	W2T122	W2TH91	MENTAL domain-containing protein.	Major sperm protein; Central component in molecular interactions underlying sperm crawling. Forms an extensive filament system that extends from sperm villipoda, along the leading edge of the pseudopod.	0.913
NECAME_04168	NECAME_09261	W2SZ44	W2TH91	START domain protein.	Major sperm protein; Central component in molecular interactions underlying sperm crawling. Forms an extensive filament system that extends from sperm villipoda, along the leading edge of the pseudopod.	0.441
NECAME_05260	NECAME_03672	W2SIK0	W2T122	START domain-containing protein.	MENTAL domain-containing protein.	0.648
NECAME_05260	NECAME_09261	W2SIK0	W2TH91	START domain-containing protein.	Major sperm protein; Central component in molecular interactions underlying sperm crawling. Forms an extensive filament system that extends from sperm villipoda, along the leading edge of the pseudopod.	0.441
NECAME_06980	NECAME_03672	W2TSZ3	W2T122	Nematode cuticle collagen domain protein.	MENTAL domain-containing protein.	0.450
NECAME_08565	NECAME_03672	W2TIE6	W2T122	START domain protein.	MENTAL domain-containing protein.	0.769
NECAME_08565	NECAME_09261	W2TIE6	W2TH91	START domain protein.	Major sperm protein; Central component in molecular interactions underlying sperm crawling. Forms an extensive filament system that extends from sperm villipoda, along the leading edge of the pseudopod.	0.441
NECAME_09261	NECAME_03672	W2TH91	W2T122	Major sperm protein; Central component in molecular interactions underlying sperm crawling. Forms an extensive filament system that extends from sperm villipoda, along the leading edge of the pseudopod.	MENTAL domain-containing protein.	0.913
NECAME_09261	NECAME_04168	W2TH91	W2SZ44	Major sperm protein; Central component in molecular interactions underlying sperm crawling. Forms an extensive filament system that extends from sperm villipoda, along the leading edge of the pseudopod.	START domain protein.	0.441
NECAME_09261	NECAME_05260	W2TH91	W2SIK0	Major sperm protein; Central component in molecular interactions underlying sperm crawling. Forms an extensive filament system that extends from sperm villipoda, along the leading edge of the pseudopod.	START domain-containing protein.	0.441
NECAME_09261	NECAME_08565	W2TH91	W2TIE6	Major sperm protein; Central component in molecular interactions underlying sperm crawling. Forms an extensive filament system that extends from sperm villipoda, along the leading edge of the pseudopod.	START domain protein.	0.441
NECAME_15324	NECAME_15325	W2SIN8	W2SIF0	Apt1 domain-containing protein.	Uncharacterized protein.	0.937