(15 nodes) Proteasome component (PCI) domain network (Necator americanus)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

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proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

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experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	NECAME_16193	Eukaryotic translation initiation factor 3 subunit M; Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is involved in protein synthesis of a specialized repertoire of mRNAs and, together with other initiation factors, stimulates binding of mRNA and methionyl-tRNAi to the 40S ribosome. The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation. (393 aa)
	NECAME_15095	PCI domain protein. (111 aa)
	NECAME_15086	PCI domain protein. (420 aa)
	NECAME_01064	PCI domain protein; Belongs to the eIF-3 subunit C family. (524 aa)
	NECAME_14478	PCI domain-containing protein. (108 aa)
	NECAME_04608	PCI domain protein. (404 aa)
	NECAME_13338	PCI domain protein. (387 aa)
	NECAME_00440	PCI domain protein. (416 aa)
	NECAME_03124	Eukaryotic translation initiation factor 3 subunit A. (999 aa)
	NECAME_02546	Ribosomal protein L32. (668 aa)
	NECAME_02633	PCI domain protein. (140 aa)
	NECAME_08279	Eukaryotic translation initiation factor 3 subunit K; Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is involved in protein synthesis of a specialized repertoire of mRNAs and, together with other initiation factors, stimulates binding of mRNA and methionyl-tRNAi to the 40S ribosome. The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation. (1240 aa)
	NECAME_01652	Eukaryotic translation initiation factor 3 subunit E; Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is involved in protein synthesis of a specialized repertoire of mRNAs and, together with other initiation factors, stimulates binding of mRNA and methionyl-tRNAi to the 40S ribosome. The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation. (427 aa)
	NECAME_01345	PCI domain protein. (407 aa)
	NECAME_16068	PCI domain protein. (510 aa)

Your Current Organism:

Necator americanus

NCBI taxonomy Id: 51031
Other names: N. americanus

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
NECAME_00440	NECAME_01345	W2T4G1	W2TYV4	PCI domain protein.	PCI domain protein.	0.417
NECAME_00440	NECAME_01652	W2T4G1	W2TTJ8	PCI domain protein.	Eukaryotic translation initiation factor 3 subunit E; Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is involved in protein synthesis of a specialized repertoire of mRNAs and, together with other initiation factors, stimulates binding of mRNA and methionyl-tRNAi to the 40S ribosome. The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation.	0.589
NECAME_00440	NECAME_02546	W2T4G1	W2TD14	PCI domain protein.	Ribosomal protein L32.	0.999
NECAME_00440	NECAME_02633	W2T4G1	W2TD42	PCI domain protein.	PCI domain protein.	0.471
NECAME_00440	NECAME_04608	W2T4G1	W2SRU1	PCI domain protein.	PCI domain protein.	0.774
NECAME_00440	NECAME_08279	W2T4G1	W2TLR9	PCI domain protein.	Eukaryotic translation initiation factor 3 subunit K; Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is involved in protein synthesis of a specialized repertoire of mRNAs and, together with other initiation factors, stimulates binding of mRNA and methionyl-tRNAi to the 40S ribosome. The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation.	0.492
NECAME_00440	NECAME_13338	W2T4G1	W2SWN8	PCI domain protein.	PCI domain protein.	0.999
NECAME_00440	NECAME_14478	W2T4G1	W2SQB4	PCI domain protein.	PCI domain-containing protein.	0.984
NECAME_00440	NECAME_15086	W2T4G1	W2SM54	PCI domain protein.	PCI domain protein.	0.989
NECAME_01064	NECAME_01652	W2SMM1	W2TTJ8	PCI domain protein; Belongs to the eIF-3 subunit C family.	Eukaryotic translation initiation factor 3 subunit E; Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is involved in protein synthesis of a specialized repertoire of mRNAs and, together with other initiation factors, stimulates binding of mRNA and methionyl-tRNAi to the 40S ribosome. The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation.	0.999
NECAME_01064	NECAME_03124	W2SMM1	W2T927	PCI domain protein; Belongs to the eIF-3 subunit C family.	Eukaryotic translation initiation factor 3 subunit A.	0.999
NECAME_01064	NECAME_08279	W2SMM1	W2TLR9	PCI domain protein; Belongs to the eIF-3 subunit C family.	Eukaryotic translation initiation factor 3 subunit K; Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is involved in protein synthesis of a specialized repertoire of mRNAs and, together with other initiation factors, stimulates binding of mRNA and methionyl-tRNAi to the 40S ribosome. The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation.	0.995
NECAME_01064	NECAME_16193	W2SMM1	W2TYG0	PCI domain protein; Belongs to the eIF-3 subunit C family.	Eukaryotic translation initiation factor 3 subunit M; Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is involved in protein synthesis of a specialized repertoire of mRNAs and, together with other initiation factors, stimulates binding of mRNA and methionyl-tRNAi to the 40S ribosome. The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation.	0.996
NECAME_01345	NECAME_00440	W2TYV4	W2T4G1	PCI domain protein.	PCI domain protein.	0.417
NECAME_01345	NECAME_02546	W2TYV4	W2TD14	PCI domain protein.	Ribosomal protein L32.	0.542
NECAME_01652	NECAME_00440	W2TTJ8	W2T4G1	Eukaryotic translation initiation factor 3 subunit E; Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is involved in protein synthesis of a specialized repertoire of mRNAs and, together with other initiation factors, stimulates binding of mRNA and methionyl-tRNAi to the 40S ribosome. The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation.	PCI domain protein.	0.589
NECAME_01652	NECAME_01064	W2TTJ8	W2SMM1	Eukaryotic translation initiation factor 3 subunit E; Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is involved in protein synthesis of a specialized repertoire of mRNAs and, together with other initiation factors, stimulates binding of mRNA and methionyl-tRNAi to the 40S ribosome. The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation.	PCI domain protein; Belongs to the eIF-3 subunit C family.	0.999
NECAME_01652	NECAME_03124	W2TTJ8	W2T927	Eukaryotic translation initiation factor 3 subunit E; Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is involved in protein synthesis of a specialized repertoire of mRNAs and, together with other initiation factors, stimulates binding of mRNA and methionyl-tRNAi to the 40S ribosome. The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation.	Eukaryotic translation initiation factor 3 subunit A.	0.997
NECAME_01652	NECAME_04608	W2TTJ8	W2SRU1	Eukaryotic translation initiation factor 3 subunit E; Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is involved in protein synthesis of a specialized repertoire of mRNAs and, together with other initiation factors, stimulates binding of mRNA and methionyl-tRNAi to the 40S ribosome. The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation.	PCI domain protein.	0.588
NECAME_01652	NECAME_08279	W2TTJ8	W2TLR9	Eukaryotic translation initiation factor 3 subunit E; Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is involved in protein synthesis of a specialized repertoire of mRNAs and, together with other initiation factors, stimulates binding of mRNA and methionyl-tRNAi to the 40S ribosome. The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation.	Eukaryotic translation initiation factor 3 subunit K; Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is involved in protein synthesis of a specialized repertoire of mRNAs and, together with other initiation factors, stimulates binding of mRNA and methionyl-tRNAi to the 40S ribosome. The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation.	0.998