(5 nodes) MCM N-terminal domain network (Necator americanus)

Nodes:

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

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second shell of interactors

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proteins of unknown 3D structure

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textmining

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protein homology

Your Input:
	NECAME_15211	DNA helicase; Belongs to the MCM family. (760 aa)
	NECAME_09868	DNA helicase; Belongs to the MCM family. (799 aa)
	NECAME_09435	DNA helicase; Belongs to the MCM family. (910 aa)
	NECAME_07211	DNA helicase; Belongs to the MCM family. (842 aa)
	MCM7	DNA replication licensing factor MCM7; Acts as component of the mcm2-7 complex (mcm complex) which is the putative replicative helicase essential for 'once per cell cycle' DNA replication initiation and elongation in eukaryotic cells. The active ATPase sites in the mcm2-7 ring are formed through the interaction surfaces of two neighboring subunits such that a critical structure of a conserved arginine finger motif is provided in trans relative to the ATP-binding site of the Walker A box of the adjacent subunit. The six ATPase active sites, however, are likely to contribute differential [...] (733 aa)

Your Current Organism:

Necator americanus

NCBI taxonomy Id: 51031
Other names: N. americanus

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
MCM7	NECAME_07211	W2TXD5	W2TPU7	DNA replication licensing factor MCM7; Acts as component of the mcm2-7 complex (mcm complex) which is the putative replicative helicase essential for 'once per cell cycle' DNA replication initiation and elongation in eukaryotic cells. The active ATPase sites in the mcm2-7 ring are formed through the interaction surfaces of two neighboring subunits such that a critical structure of a conserved arginine finger motif is provided in trans relative to the ATP-binding site of the Walker A box of the adjacent subunit. The six ATPase active sites, however, are likely to contribute differential [...]	DNA helicase; Belongs to the MCM family.	0.999
MCM7	NECAME_09435	W2TXD5	W2TDZ7	DNA replication licensing factor MCM7; Acts as component of the mcm2-7 complex (mcm complex) which is the putative replicative helicase essential for 'once per cell cycle' DNA replication initiation and elongation in eukaryotic cells. The active ATPase sites in the mcm2-7 ring are formed through the interaction surfaces of two neighboring subunits such that a critical structure of a conserved arginine finger motif is provided in trans relative to the ATP-binding site of the Walker A box of the adjacent subunit. The six ATPase active sites, however, are likely to contribute differential [...]	DNA helicase; Belongs to the MCM family.	0.999
MCM7	NECAME_09868	W2TXD5	W2TBG3	DNA replication licensing factor MCM7; Acts as component of the mcm2-7 complex (mcm complex) which is the putative replicative helicase essential for 'once per cell cycle' DNA replication initiation and elongation in eukaryotic cells. The active ATPase sites in the mcm2-7 ring are formed through the interaction surfaces of two neighboring subunits such that a critical structure of a conserved arginine finger motif is provided in trans relative to the ATP-binding site of the Walker A box of the adjacent subunit. The six ATPase active sites, however, are likely to contribute differential [...]	DNA helicase; Belongs to the MCM family.	0.999
MCM7	NECAME_15211	W2TXD5	W2SJ37	DNA replication licensing factor MCM7; Acts as component of the mcm2-7 complex (mcm complex) which is the putative replicative helicase essential for 'once per cell cycle' DNA replication initiation and elongation in eukaryotic cells. The active ATPase sites in the mcm2-7 ring are formed through the interaction surfaces of two neighboring subunits such that a critical structure of a conserved arginine finger motif is provided in trans relative to the ATP-binding site of the Walker A box of the adjacent subunit. The six ATPase active sites, however, are likely to contribute differential [...]	DNA helicase; Belongs to the MCM family.	0.999
NECAME_07211	MCM7	W2TPU7	W2TXD5	DNA helicase; Belongs to the MCM family.	DNA replication licensing factor MCM7; Acts as component of the mcm2-7 complex (mcm complex) which is the putative replicative helicase essential for 'once per cell cycle' DNA replication initiation and elongation in eukaryotic cells. The active ATPase sites in the mcm2-7 ring are formed through the interaction surfaces of two neighboring subunits such that a critical structure of a conserved arginine finger motif is provided in trans relative to the ATP-binding site of the Walker A box of the adjacent subunit. The six ATPase active sites, however, are likely to contribute differential [...]	0.999
NECAME_07211	NECAME_09435	W2TPU7	W2TDZ7	DNA helicase; Belongs to the MCM family.	DNA helicase; Belongs to the MCM family.	0.999
NECAME_07211	NECAME_09868	W2TPU7	W2TBG3	DNA helicase; Belongs to the MCM family.	DNA helicase; Belongs to the MCM family.	0.999
NECAME_07211	NECAME_15211	W2TPU7	W2SJ37	DNA helicase; Belongs to the MCM family.	DNA helicase; Belongs to the MCM family.	0.999
NECAME_09435	MCM7	W2TDZ7	W2TXD5	DNA helicase; Belongs to the MCM family.	DNA replication licensing factor MCM7; Acts as component of the mcm2-7 complex (mcm complex) which is the putative replicative helicase essential for 'once per cell cycle' DNA replication initiation and elongation in eukaryotic cells. The active ATPase sites in the mcm2-7 ring are formed through the interaction surfaces of two neighboring subunits such that a critical structure of a conserved arginine finger motif is provided in trans relative to the ATP-binding site of the Walker A box of the adjacent subunit. The six ATPase active sites, however, are likely to contribute differential [...]	0.999
NECAME_09435	NECAME_07211	W2TDZ7	W2TPU7	DNA helicase; Belongs to the MCM family.	DNA helicase; Belongs to the MCM family.	0.999
NECAME_09435	NECAME_09868	W2TDZ7	W2TBG3	DNA helicase; Belongs to the MCM family.	DNA helicase; Belongs to the MCM family.	0.999
NECAME_09435	NECAME_15211	W2TDZ7	W2SJ37	DNA helicase; Belongs to the MCM family.	DNA helicase; Belongs to the MCM family.	0.999
NECAME_09868	MCM7	W2TBG3	W2TXD5	DNA helicase; Belongs to the MCM family.	DNA replication licensing factor MCM7; Acts as component of the mcm2-7 complex (mcm complex) which is the putative replicative helicase essential for 'once per cell cycle' DNA replication initiation and elongation in eukaryotic cells. The active ATPase sites in the mcm2-7 ring are formed through the interaction surfaces of two neighboring subunits such that a critical structure of a conserved arginine finger motif is provided in trans relative to the ATP-binding site of the Walker A box of the adjacent subunit. The six ATPase active sites, however, are likely to contribute differential [...]	0.999
NECAME_09868	NECAME_07211	W2TBG3	W2TPU7	DNA helicase; Belongs to the MCM family.	DNA helicase; Belongs to the MCM family.	0.999
NECAME_09868	NECAME_09435	W2TBG3	W2TDZ7	DNA helicase; Belongs to the MCM family.	DNA helicase; Belongs to the MCM family.	0.999
NECAME_09868	NECAME_15211	W2TBG3	W2SJ37	DNA helicase; Belongs to the MCM family.	DNA helicase; Belongs to the MCM family.	0.999
NECAME_15211	MCM7	W2SJ37	W2TXD5	DNA helicase; Belongs to the MCM family.	DNA replication licensing factor MCM7; Acts as component of the mcm2-7 complex (mcm complex) which is the putative replicative helicase essential for 'once per cell cycle' DNA replication initiation and elongation in eukaryotic cells. The active ATPase sites in the mcm2-7 ring are formed through the interaction surfaces of two neighboring subunits such that a critical structure of a conserved arginine finger motif is provided in trans relative to the ATP-binding site of the Walker A box of the adjacent subunit. The six ATPase active sites, however, are likely to contribute differential [...]	0.999
NECAME_15211	NECAME_07211	W2SJ37	W2TPU7	DNA helicase; Belongs to the MCM family.	DNA helicase; Belongs to the MCM family.	0.999
NECAME_15211	NECAME_09435	W2SJ37	W2TDZ7	DNA helicase; Belongs to the MCM family.	DNA helicase; Belongs to the MCM family.	0.999
NECAME_15211	NECAME_09868	W2SJ37	W2TBG3	DNA helicase; Belongs to the MCM family.	DNA helicase; Belongs to the MCM family.	0.999